Protein Alignment Msp300 and PPL

DIOPT Version :9

• Sequence 1: NP_001188695.1
• Gene: Msp300 / 3771968
• FlyBaseID: FBgn0261836
• Length: 13540
• Species: Drosophila melanogaster
• Sequence 2: XP_016878863.1
• Gene: PPL / 5493
• HGNCID: 9273
• Length: 1785
• Species: Homo sapiens
• Alignment Length: 1877
• Identity: 393/1877 - (20%)
• Similarity: 707/1877 - (37%)
• Gaps: 498/1877 - (26%)

  Fly 11809 LGRIGLQEPAIEPE-------------KVGELFSLSHKISTQIAEELEGASVLRDQLQAIQEGIS 11860
            :|..|:|||..||.             |:|...|:|:|..:::.|:|:
Human     1 MGGTGVQEPGTEPGVRDSRERGTEATLKLGSAASISNKELSELIEQLQ----------------- 48

  Fly 11861 NQRKHQAKISVILDECEAAERQGADVLEKAVADCQA-------------AGEELVISWQEIMRIR 11912
                                 :.||.:||.:.|.:|             ..|...::.|:::...
Human    49 ---------------------KNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSE 92

  Fly 11913 QMLHTL------PMRLKMSVSPVKLERDISQLQDDHAFLESKCTNIMAILRSRLAV--------W 11963
            ::|:.|      ...:|.....: :..||.||::....|..|...|.     ||||        |
Human    93 KLLYVLEADAAIAKHMKHPQGDM-IAEDIRQLKERVTNLRGKHKQIY-----RLAVKEVDPQVNW 151

  Fly 11964 L-------------RYERQLELVHGSVQETDFMMELIRVHG-----QVDYERLRKATERLEGLAG 12010
            .             .:...|.||...|:|.:.....::..|     ..|.|:..:...:.:.|..
Human   152 AALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHLAKDGDKEQNSELRAKYQKLLA 216

  Fly 12011 DLHNREQLIDELKGAAKPLIESCDVQIVEQIESAVQEAVVAWNDTSENLQQLRTRYQ----RAVE 12071
            ....|:|.:..|    :..::.|..::....:.|.......|:|.:.:....|.:|:    |.:|
Human   217 ASQARQQHLSSL----QDYMQRCTNELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLE 277

  Fly 12072 LWDKYRN-----------ASAAVKNSIDQQMDAVKS-LEQPLDAL----QHAKVCQDNLTTQNDR 12120
            ..::..|           |....:|||:..|:||.: .::.|:.|    .|.|..:|......|
Human   278 AKEERINKLHSEGDQLLAAEHPGRNSIEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQFHED- 341

  Fly 12121 ILELRDIVAKIAADVGLDASALMQGELDALGQRLA-ECKDAITTLANVAETQDKERKELDKEVTL 12184
            :.:.::::.|:.:|               |.|:.. :.||.......:.|..|:| |.|||...:
Human   342 VKDAQELLRKVDSD---------------LNQKYGPDFKDRYQIELLLRELDDQE-KVLDKYEDV 390

  Fly 12185 AKAYFNNVQQDI----SREAPQNP--------KESEEQLAAL---------------RAHLQTLA 12222
            .:......||.:    .||.|..|        .|.|:.|...               |.:..||.
Human   391 VQGLQKRGQQVVPLKYRRETPLKPIPVEALCDFEGEQALRPCRDPDCPACPRQGLISRGYSYTLQ 455

  Fly 12223 RTEEQLRQLKERHQNSEVAPSVASSDDDGILEVLALWQKIFQDTFQEYHRLSTRLARSQNSSEAL 12287
            :...:..:|.:...|..:||:|.........|.|||...:    ..:|..:..:.|.|:.:
Human   456 KNNGESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSL----GSQYRSVRQKAAGSKRT---- 512

  Fly 12288 RLWRQYLQHVQSFLSCAIPEDYSSLREQQQLCAIHQ--NLLISQQSVLS---ETPLE-----SEL 12342
                  ||.....|....|.|.|.|:.:|.|..:.:  :.|..|:..::   ..|||     .:.
Human   513 ------LQQRYEVLKTENPGDASDLQGRQLLAGLDKVASDLDRQEKAITGILRPPLEQGRAVQDS 571

  Fly 12343 SEQYKALTNLHNETLSRIMQRNGELERRVSGWNAYRQQL--AALLDWLRQREAERNALQLRYIHL 12405
            :|:.|.|.|:.||.| ||   ..|..|..:...|:.|.|  :.....||.|..:.|.   :|.||
Human   572 AERAKDLKNITNELL-RI---EPEKTRSTAEGEAFIQALPGSGTTPLLRTRVEDTNR---KYEHL 629

  Fly 12406 KRVPHL-------KHRLDAMIQQ-----------LDQGE---QQSKALQEQQQELARHCDDALAT 12449
            .::..|       .:||:..:||           |:|.:   :.|:.|..:.||||     |:|.
Human   630 LQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELA-----AMAC 689

  Fly 12450 AMRMEQASIGQRISNLRAALKTWQGFLQRVTQLS---ESYEQRVNQLQQEFGAAQKLLDANSESL 12511
            .::.:::.:|:...||:||.:.......|..:..   |..|..|::|.|.|...::.::..::||
Human   690 ELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSL 754

  Fly 12512 PTQPAAIE----------QLLGSLRAQRVQLGAQVSALESLTVTQEELKECISPHDMKTIRQR-- 12564
            .:..||.|          |.|.|:.:...|....:|.:|:....|:.|.:.|:..:.:.  |:
Human   755 QSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEV--QKIC 817

  Fly 12565 -NWLLWQQHADLDYQL-ANLINSI-------------------------EERLSLLSNYQIRYDR 12602
             |...:|| |..||:| |..:.|:                         ||..:|.:.:...|..
Human   818 ANSQQYQQ-AVKDYELEAEKLRSLLDLENGRRSHVSKRARLQSPATKVKEEEAALAAKFTEVYAI 881

  Fly 12603 ISQWLQRLE-----QRVEKDADVTAMT----NPEQAA-------KQLEQQVNSELQLRDKEREWL 12651
            ..|.||.||     .|.:.:.:||..|    .|:...       |:|:::.....||.::.:
Human   882 NRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVK--- 943

  Fly 12652 LSTSRELLTLYSEPEVRSQVQQQSDSLIDRWQRLKYLAKQKATKIGELKMTLLRLEERIALIRAW 12716
             ||..|:.||      |:|..|:|   :.|.:.||             |:....|||..
Human   944 -STQEEIWTL------RNQGPQES---VVRKEVLK-------------KVPDPVLEESF------ 979

  Fly 12717 LFEVESQLDKPLNFESYTPNVIEAKLKEHEQIQRSIEHHSSNVGEVLNLVEMLLNDADSWRTQVN 12781
                 .||.:.|..|.:...:::.:|:..:...|::|..:.:.|:...:.|:|..:.|  |.|
Human   980 -----QQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPD--RAQ-- 1035

  Fly 12782 TSGLAASAQNLEQRWKNVCSQSAERKARILTIWNLLQQLIKLTAEHKNWLGKQ--ESQIAGFERD 12844
                |.....|.:..:.:..|...|:|.:|    ||||.:...||.|:...::  |.::...:.|
Human  1036 ----ADEVLQLREELEALRRQKGAREAEVL----LLQQRVAALAEEKSRAQEKVTEKEVVKLQND 1092

  Fly 12845 QKSHSKH-KLEE---RQMELRAKL-EELESQSVNLRQLEQIYA------------KLAMSAGVEP 12892
            .:..::: :|:|   ||.:||.|. |||......|::||:..|            |:...|..|.
Human  1093 PQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATER 1157

  Fly 12893 ENIQKLTL---------------PTKVMVSMWRQLTPRCHALL-----DAIDKDAKLMREFNNAQ 12937
            | :..||.               .|:::..:|.........::     :.:..|.|...|..|.:
Human  1158 E-VSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLR 1221

  Fly 12938 LE----------ATNSLNAIQKALEQL----PSAENQQTS------KAEPKAVLQRLESLEKKLQ 12982
            ||          |...|.:.|..||.|    |..|.::.:      |.:|: :.:.|:.|.:::.
Human  1222 LELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPE-MEKELQRLREEIV 1285

  Fly 12983 DAQQHVQQAD----NLAQEAKTRTKQQPQLKQLLELVSAYTTLWQTVQTRIVTLKTTWLTRAAQA 13043
            |..:.:::.|    .|.:|.:.....:||: |..|:|.......:..||:             :.
Human  1286 DKTRLIERCDLEIYQLKKEIQALKDTKPQV-QTKEVVQEILQFQEDPQTK-------------EE 1336

  Fly 13044 AASLPVSEAANAAVQVNTLSQRKLRQAQQMQRETSIT-AKDAYIME----------LQTAITECQ 13097
            .|||....:.....||:...:|..::.|..::|..:: .|:..:.:          |:...:...
Human  1337 VASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFA 1401

  Fly 13098 NNLD-ELQRTVVDKTRKPGPQKIAKLLGNAQSSTELVKHLSHLLLTECKADDQAAEVDTVAELTL 13161
            .::| ||::  :||.|       |:|....:..|||.:.|.     |.:.:.||..     |...
Human  1402 ESIDVELRQ--IDKLR-------AELRRLQRRRTELERQLE-----ELERERQARR-----EAER 1447

  Fly 13162 RFDTLQSQWKARQQHDQNASEVGRLTCPLCTQRNWQQI-DNDLWRLEQWLQFAESTQKAQSAPPS 13225
            ....||.:..|.:|.:..|.|....|..:..|::.||. ::.|.|    ||..|...:.|
Human  1448 EVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLR----LQLEEEQHRRQ----- 1503

  Fly 13226 NIELLEDVTQDHREFLLDLESHKSIISSLNVVGDHLATHTLDTE-KARQLRSRLEADNERWNNVC 13289
               |||...:..|..|..||  |:.:....|:.:.:.....||| :.::|:|.||.::.....:.
Human  1504 ---LLEGELETLRRKLAALE--KAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELD 1563

  Fly 13290 INATKWQGLLQTALMGNSEFHQTIGELVEWLQRTEQNIKASEPVD-LTEERSVLETKFKKFKDLR 13353
            :..::.:     |.:...|||               |.|:|:.:| |.||...|:.   :.::|:
Human  1564 VEVSRLE-----ARLSELEFH---------------NSKSSKELDFLREENHKLQL---ERQNLQ 1605

  Fly 13354 AELERCEPRV-VSLQDAADQLLRSVEGSEQQSQHTYERTLSRLTDLRLRLQSLRRLS 13409
            .|..|.:..: ::..:..|  ||::..::..:.|.     |||..|...|..|:|||
Human  1606 LETRRLQSEINMAATETRD--LRNMTVADSGTNHD-----SRLWSLERELDDLKRLS 1655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Msp300	NP_001188695.1	SPEC	17..220	CDD:238103
		SPEC	9546..9732	CDD:295325
		sbcc	11187..12008	CDD:129705	45/256 (18%)
		SMC_prok_B	11614..12442	CDD:274008	156/771 (20%)
		SPEC	11994..12156	CDD:295325	32/182 (18%)
		SPEC	12374..12564	CDD:295325	51/225 (23%)
		Lipase_chap	12376..12529	CDD:281297	45/188 (24%)
		SPEC	12703..12923	CDD:238103	53/258 (21%)
		SPEC	12816..13032	CDD:295325	60/278 (22%)
		SPEC	13196..13374	CDD:238103	40/181 (22%)
		KASH	13484..13540	CDD:287506
PPL	XP_016878863.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900