DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Msp300 and clmnb

DIOPT Version :9

Sequence 1:	NP_001188695.1	Gene:	Msp300 / 3771968	FlyBaseID:	FBgn0261836	Length:	13540	Species:	Drosophila melanogaster
Sequence 2:	NP_001003605.1	Gene:	clmnb / 445211	ZFINID:	ZDB-GENE-040801-124	Length:	687	Species:	Danio rerio

Alignment Length:	820	Identity:	149/820 - (18%)
Similarity:	277/820 - (33%)	Gaps:	243/820 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  7506 KAGKEKKSKVQNVEESILESDVPLSVVEPIIGFTTVQKDVPPKTESHTFS-WSSIVAQSVEVPRT 7569
            :.|||||.|.:                         .:|.....:..||: |.::..:|.|.|..
Zfish    11 QVGKEKKCKQR-------------------------AQDERHAVQERTFTKWINMQLKSCEPPLQ 50

  Fly  7570 IPKHV--ESKTGGIQNFIAQEQNYSTVVNDSVKKPKPKK------EKKIVQPIQQPTGESVPVRK 7626
            : .|:  :.:.|.:...:.:|.:...:::..  :|.|.:      ..|::..::......|.:..
Zfish    51 V-HHLFTDIQDGKVLMALLEELSGCNLLDKF--RPFPHRIFRLNNISKVLNFLKDRNISLVNIEA 112

  Fly  7627 DHMREGVTKAVPEPQTLSWSSIVSHNI-DLTPTFTENRVIEAVDEINPDDSSSNQE--------- 7681
            |.:.:|...||   ..|.|:.||.:.| .:|.:..::....::..:..|..||.:.
Zfish   113 DDIADGSPSAV---LRLIWNIIVYYQIKQVTRSLEKSPSTFSLLSLPCDSDSSGRSSPASPGDDI 174

  Fly  7682 -GELPIHVDERKRKPKKDKKRDQNIETSVVYEEIPETERVAVSSTPEFSIQLPAPTKPSVWSSSD 7745
             |.||   .:.|:..|..|.|...|:|.:.:         |.:.|.::.:::....|.  |.|..
Zfish   175 FGTLP---SKGKKSLKNLKYRGTAIKTLLSW---------AQNCTAKYGVEIRDFGKS--WRSGL 225

  Fly  7746 TYAEVVKKSGYNNNTNIKYQKIEAREPIKSEPKHTFVEVQT----HEDLLEFPDPIIPAIERDEA 7806
            .:..:||        ....:.:..|:.:.|||:   :.::|    .::.|..|..:.|   .|.|
Zfish   226 AFVALVK--------FFCPEFVHMRKALSSEPR---LNMETAFRAAQEWLGIPPLLNP---DDVA 276

  Fly  7807 LEKPSQLSWKDLV----------DEDDV---------DPLESWHKGETDSVEIKTQKPIQERHSR 7852
            :..|.:.|....:          |||.:         :..|.|.:..|||........:    |.
Zfish   277 VHSPDEQSIITYIAQFLECCPGHDEDAMSTDSSRGTPNSTERWDRVSTDSDSCVFPSNV----ST 337

  Fly  7853 VSVKPEIQITEVVTETQSQSETDQEFLEITSKKRNRSRSRSQQSQASNIDEKHQKKKSKKPKNTV 7917
            .:::....::|...|.|:....|||.|.:..:......:||:  ...|:     ||.|
Zfish   338 EALRDLYNLSETSEEEQTYHTGDQESLSVCQENIRDLAARSE--SLLNV-----KKTS------- 388

  Fly  7918 PKAPAQQPTEAPEDVQPPKESVPSVEEPSPPPAPSPNTSGMSWAAIAAHNV-----PEPVQHIRP 7977
                  ...:..:.:...|..:.|:|:..       |.|.:|..|:.:.:|     .:...:|
Zfish   389 ------TGGQCCDSIAWRKRWIGSLEDDG-------NCSEVSKEAVYSLSVLDSDEEDAFSYI-- 438

  Fly  7978 LQAEAKPTVVED---------VRKSTNEHTVNIPITFETTEPKTKKPKQKSKRKL-PTDVVDFIN 8032
            |:.:.|.:.:|.         :.....|..:|:...|||.|.:.|....:::|.| .|||.....
Zfish   439 LELDHKDSGLESNIDFGLNTVMDSQAVEFDLNVASIFETQESEIKYCCCEAQRNLKATDVSVRSG 503

  Fly  8033 AEK-----SIHQVIASKPEIVEEPGSIIVEDVNNTLTSWEIKTPLAPFEFVAESEVEPVSES-HM 8091
            ..|     ::.||..:|..|:.|         ||                 .:.:..|.|:: .|
Zfish   504 GGKCTNKITLDQVRPTKSNILTE---------NN-----------------CDEKTLPASDTLLM 542

  Fly  8092 EDLPVEKVLKTEPIVESTAVDESKTTTTVTTTTTTTETTSNVSIPEEPKKVVEPEKKPEEPKKPA 8156
            ....:||:.....:.                  |......|.|:           |..|.....|
Zfish   543 NQNSIEKIENNFKLY------------------TDERPDLNCSL-----------KMKESDSADA 578

  Fly  8157 YAGLPVDDSSNSWMDVLDEPMNFSDDE---EEPVPEPLKEETLVEEVVEEKPIVEVSVVDDSKSI 8218
            :.      .||...|......|..|::   ||....|:||..|..:..|:..:::.||:|.
Zfish   579 FT------HSNGTDDAFVHLDNCVDEDKLREELFLCPVKENLLDNDQYEQNNVLDRSVLDG---- 633

  Fly  8219 TTVTTTTTTTETISELPIPEEPKKVVEPEKKPEEPKKPAY 8258
                             |.|||  .|...|:.|...:.:|
Zfish   634 -----------------ITEEP--AVSHAKRKEGLDQASY 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Msp300	NP_001188695.1	SPEC	17..220	CDD:238103
		SPEC	9546..9732	CDD:295325
		sbcc	11187..12008	CDD:129705
		SMC_prok_B	11614..12442	CDD:274008
		SPEC	11994..12156	CDD:295325
		SPEC	12374..12564	CDD:295325
		Lipase_chap	12376..12529	CDD:281297
		SPEC	12703..12923	CDD:238103
		SPEC	12816..13032	CDD:295325
		SPEC	13196..13374	CDD:238103
		KASH	13484..13540	CDD:287506
clmnb	NP_001003605.1	CH	29..130	CDD:278723	19/106 (18%)
clmnb	NP_001003605.1	CH	197..292	CDD:278723	20/119 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D46at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910