DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Msp300 and Dsp

DIOPT Version :10

Sequence 1:NP_001188695.1 Gene:Msp300 / 3771968 FlyBaseID:FBgn0261836 Length:13540 Species:Drosophila melanogaster
Sequence 2:NP_001406527.1 Gene:Dsp / 306871 RGDID:1305794 Length:2877 Species:Rattus norvegicus


Alignment Length:2636 Identity:491/2636 - (18%)
Similarity:898/2636 - (34%) Gaps:886/2636 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly 11208 EQRILEVNEGLKDLDVAI---------KNGDKTVIQTTVITVIEKVST-----WLETIEYRVYLI 11258
            ::|:|::.|.::.|..||         ..|..|....:......|..|     |:......:.|:
  Rat   148 QKRLLQLQEQMRALYKAISAPRVRRASSKGGYTCQSGSGWDEFTKRLTGECLGWMRQQRAEMDLM 212

  Fly 11259 RQNSNEGPSEEKLDNYNQLNDELSTIKQNVVQLERQLSKAEPEPQLLQCVDSLK----EHVDAVE 11319
            ....:.|..|:.::::..:::.:...:..:.:::..|.:.....||.:..::|.    |.:|.:.
  Rat   213 AWGVDSGSVEQHINSHRSIHNAIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLR 277

  Fly 11320 QVTQQNQVQDSNDLDKWHN---FEVLLYNVS------------------------SVLADLQQSY 11357
            |:  ||.:|.::....|.|   .|.|||:.|                        ..|..|:|..
  Rat   278 QL--QNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQES 340

  Fly 11358 DLLINQEYPLSAKL-AQLDELEQQHEAAQQQL----AHLCQNARAFQ---------------RDF 11402
            |.|:..::|.|.|: |.:|.|:.|.....|..    .||.:||..||               :|.
  Rat   341 DQLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDS 405

  Fly 11403 PGKKMPQDVHNAFETSKNIANNIQAERERVLQLQSLAEEYEQTLKEFTKITVLADKLVESPIVSS 11467
            ..||.|.|        ||            :.||.|.|:.::..||       .:|::|..    
  Rat   406 IRKKYPCD--------KN------------MPLQHLLEQIKELEKE-------REKILEYK---- 439

  Fly 11468 SLEQLNNEVQKQRKFFVNLSHCRAMLESLEENIDSETREKHSELHKEL-------YNRATSLLDK 11525
              .|:.|.|.|.:|.                 :..:.|......:|.:       |.:...::.|
  Rat   440 --RQVQNLVNKSKKI-----------------VQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 485

  Fly 11526 ASERSSKLVQAASRWTVLEKGMRDELQWLQVAQQRVPDLSAV----------TSADYDQY----- 11575
            ..|...|.....|:|.|...|..|.|         ||.:..:          .|...:||     
  Rat   486 GDECILKDNNERSKWYVTGPGGVDML---------VPSVGLIIPPPNPLAVDLSCKIEQYYEAIL 541

  Fly 11576 ---TTLYQSLSNDISHHYVKMTQLSGIANKLQLLVQAPNLVEETNEALIVLLKL--REEVALYLH 11635
               ..||.::.:.:|.||..:.                  :|:.....|..||.  :|:....:.
  Rat   542 ALWNQLYINMKSLVSWHYCMID------------------IEKIRAMTIAKLKTMRQEDYMKTIE 588

  Fly 11636 RLLVFKEIWVQYEQQTD--------KLEAFVREAEQELRN--IQIPSQPTHQ-----PIEHM--- 11682
            .|.:..:.:::..|.::        ::::...:|::..:.  ||:|..|.||     .|.|:   
  Rat   589 DLELHYQDFIKNSQGSEMFGDDDKRRMQSQFTDAQKHYQTLVIQLPGHPQHQTVTKTEITHVGTC 653

  Fly 11683 ------------------------------RQFWEIKARFELHNNVRTDTGLSFEKSLQVIPLAD 11717
                                          ||....:||..|.|.:.||.|.:...::::..|  
  Rat   654 QDVNHNKVIETNRENDKQETWLLMELQKIRRQMEHCEARMTLKNLLLTDQGSTHNITVKINEL-- 716

  Fly 11718 EMLQRQFHAQLEDRWQAVAQAIELIQHNIVECLSSEDVPADEKLKMVERELQEIYLTMTSMKGV- 11781
                    ..:::..||:|:.:..::..:.....|      ||...::.|:..::..:.::.|| 
  Rat   717 --------KSVQNDSQALAEVLNQLKDMLANFRGS------EKYCYLQNEIFGLFQKLENINGVT 767

  Fly 11782 ------------------------------IKNEEELCLYIERVQVLRTRVGFIGNEL------- 11809
                                          :..||.:||.:::|:..|..:..|.|:|       
  Rat   768 DGYLNSLCSVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLL 832

  Fly 11810 --------------GRIGLQEPAIE------PEKVGELFSLSHKISTQI---------------- 11838
                          .:...|.|..:      .|||.:|.....||..||                
  Rat   833 ATMKTELQKAQQIHSQSSQQYPLYDLDLGKFTEKVTQLTDRWQKIDKQIDFRLWDLEKQIKQLRN 897

  Fly 11839 --------AEELEGASVLRDQLQAIQEG------------------ISNQRKHQAKISVILDECE 11877
                    .:.|..|...:|.|::::.|                  ||.:|....::..|.:.|.
  Rat   898 YRDNYQSFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHNEISGKRDKSEEVHKIAELCA 962

  Fly 11878 ----------AAERQGAD------------------VLEKAVADCQAAGEELVISWQEIMR-IRQ 11913
                      |:...|.:                  :|::| ||..|...||:....:..| :.:
  Rat   963 NSIKDYELQLASYTSGLETLLNIPIKRTMVQSPSGVILQEA-ADIHARYIELLTRSGDYYRFLSE 1026

  Fly 11914 MLHTL-PMRLKMSVSPV-----KLERDI-SQLQDDHAFL-------ESKCTNIMAILRSRLAVWL 11964
            ||.:| .::||.:...|     :|.||. |:..:.:.||       :::|:.    .:::|....
  Rat  1027 MLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQ----FKAKLVSLE 1087

  Fly 11965 RYERQLEL-----------VHGSVQETDFMMELIRVHGQVDYERLRKAT--ERLEGLAGDLHNRE 12016
            ..:||.||           .:|.::|.:  .::.|:..:::.|:.|:.|  :|.:....|     
  Rat  1088 ELKRQAELDGKSAKQNLDKCYGQIKELN--EKITRLTYEIEDEKRRRKTVEDRFDQQKND----- 1145

  Fly 12017 QLIDELKGAAKPLIESCDVQIVEQIESAVQEAVVAWNDTSENLQQLRTRYQRAVELWDKYRNASA 12081
              .|:|:.|.:...||...|.:|. |.|::|       ....:::||...|.......:|.|..|
  Rat  1146 --YDQLQKARQCEKESLGWQKLES-EKAIKE-------KEYEIERLRVLLQEEGARKREYENELA 1200

  Fly 12082 AVKNSIDQQMDAVKSLEQPLDALQHAKVCQDNLTTQNDRILELRDIVAKIAADVGLDASALMQGE 12146
            .|:|..:::|                    .||..:.:..:.:.....|..:....|.|..::.:
  Rat  1201 KVRNHYNEEM--------------------SNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQ 1245

  Fly 12147 LDALGQRLAECKDAITTLANVAETQDKERKELDKEVTLAKAYFNNVQQDISREAPQNPKESEEQL 12211
            ||.|.:...:.||.|..|.:......::|:..::.....||..:.:.|.                
  Rat  1246 LDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQK---------------- 1294

  Fly 12212 AALRAHLQT-LARTEEQLRQLKERHQNSEVAPSVASSDDDGILEVLALWQKIFQDTFQEYHRLST 12275
               :.||:. |.:..:|..:...||:.|              ||..|   |..||..:|..||  
  Rat  1295 ---KQHLEVELKQVIQQRSEDNARHKQS--------------LEEAA---KTIQDKNKEIERL-- 1337

  Fly 12276 RLARSQNSSEALRLWRQYLQHVQSFLSCAIPEDYSSLREQQQLCAIHQNLLISQQSVLSETPLES 12340
               :::...||.|.| :| ::..|.:..:..|:..|||.:                      .|:
  Rat  1338 ---KAEYQEEAKRRW-EY-ENELSKVRNSYDEEIISLRNK----------------------FET 1375

  Fly 12341 ELSEQYKALTNLHNETLSRIMQRNGELERRVSGWNAYRQQLAALLDWLRQREAE----RNALQLR 12401
            |:           |.|.:.|.|...:.|...||   ||.|:..|....|....|    :|.|...
  Rat  1376 EI-----------NITKTTIHQLTMQKEEDTSG---YRAQIDNLTRENRSLSEEVKRLKNTLAQT 1426

  Fly 12402 YIHLKRVPHLKHRLDAMIQQLDQGEQQSKALQEQQQELARHCDDALATAMRMEQASIGQRISNLR 12466
            ..:|:||.      :.:.||...|.:.|:..|:.:.||                    :::|.:|
  Rat  1427 TENLRRVE------ENVQQQKASGSEMSQRKQQLEIEL--------------------RQVSQMR 1465

  Fly 12467 AALKTWQGFLQRVTQLSESYEQRVNQLQQEFGAAQKLLDANSESLPTQPAAIEQLLGSLRAQRVQ 12531
                         |:.|..|:|.::.      ||:.:.|.|.|                      
  Rat  1466 -------------TEESMRYKQSLDD------AAKTIQDKNKE---------------------- 1489

  Fly 12532 LGAQVSALESLTVTQEELKECISPHDMKTIRQRNWLLWQQHADLDYQLANLINSIEERLSL---- 12592
                :..|:.|...:...::|:...:.|.          |....|.|.||  ||..|.:|.    
  Rat  1490 ----IERLKQLVDKETNERKCLEDENSKL----------QRVQYDLQKAN--NSATEAMSKLKVQ 1538

  Fly 12593 ---LSNYQIRYDRISQWLQRLEQRVEKDADVTAMTNPEQAAKQLEQQVNSELQLRDKEREWLLST 12654
               |:..:|.|:|:||      :|..||.|:|.:           |....:|||:.::.|..||.
  Rat  1539 EQELTRLRIDYERVSQ------ERTVKDQDITRI-----------QSSLKDLQLQKQKAEEELSR 1586

  Fly 12655 SRELLTLYSEPEVRSQVQQQSDSLIDRWQRLKYLAKQKATKIGELKMTLLRLEERIALIRAWLFE 12719
            .:.  |...|...|..::::.::       ::...|::|.||..|..   :||:...:.:....:
  Rat  1587 LKR--TASDESSKRKMLEEELEA-------MRRSLKEQAVKITNLTQ---QLEQASIVKKRSEDD 1639

  Fly 12720 VESQLDKPLNFESYTPNVIEAKLKEHEQIQRSIEHHSSNVGEVLNLVEMLLNDADSWRTQVNTSG 12784
            :..|.|           |::..::|.::.|..:..        |:|      |.::.|.|     
  Rat  1640 LRQQRD-----------VLDGHVREKQRTQEELRR--------LSL------DVEALRRQ----- 1674

  Fly 12785 LAASAQNLEQ-RWKNVCSQSA-ERKARILTIWNL----LQQLIK-LTAEHKNWLGKQESQIAGFE 12842
            |....:|::| ..:|...|.| |.|:|.|....:    ||.|.: ||.||.              
  Rat  1675 LVQEQENVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHL-------------- 1725

  Fly 12843 RDQKSHSKHKLEERQMELRAKLEELESQSVNLRQLEQIYAKLAMSAGVEPENIQKLTLPTKVMVS 12907
                     .|||....||.:.::|               :...|.....:|.....|.:::.:|
  Rat  1726 ---------MLEEELRNLRLEYDDL---------------RRGRSEADNDKNSTISELRSQLQIS 1766

  Fly 12908 MWRQLTPRCHALLDAIDKDAKLMREFNNAQLEATNSLNAIQKALEQLPSAENQ-QTSKAEPKAVL 12971
            ..|.|               :|....|:.|.|..|....|:|..:|...|.|: |.||::...|:
  Rat  1767 NNRTL---------------ELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKSQCTQVV 1816

  Fly 12972 QRLESLEKKLQDAQQ---HVQQADNLAQEAKTRTKQQPQLKQLLELVSAYTTLWQTVQTRIVTLK 13033
            |..|||..|::..:|   .:|:.::....||...:.:.::||.||...      |.:|..:...|
  Rat  1817 QERESLLVKIKVLEQDKARLQRLEDELNRAKATLEAETRVKQRLECEK------QQIQNDLNQWK 1875

  Fly 13034 TTWLTRAAQAAASLPV-------------SEAANAAVQVNTLSQRKLRQAQQMQRETSITAKDAY 13085
            |.: :|..:....:..             ||......::..:.:|..|:.:...|||.       
  Rat  1876 TQY-SRKEETIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQ------- 1932

  Fly 13086 IMELQTAITECQNNLDELQRTVVDKTRKPGPQ-----KIAKLLGNAQSSTELVKHLSHLLLTECK 13145
             .:|:|.....|..:|:|::......|:...:     ..:||:.:.     |.|.::.:.|.||:
  Rat  1933 -SQLETERCRLQKEIDKLRQRPYGSHRETQTEYEWTVDSSKLVFDG-----LRKKVTAMQLYECQ 1991

  Fly 13146 ADDQAAEVDTVAELTLRFDTLQSQWKARQQHDQNASEV-----------GRLTCPLCTQRNWQQI 13199
            ..|:.              ||....|.::..::.|||:           |....|          
  Rat  1992 LIDKT--------------TLDKLLKGKKSVEEVASEIQPFLRGAGAIAGASASP---------- 2032

  Fly 13200 DNDLWRLEQWLQFAESTQKAQSAPPSNIELLE------DVTQDHR-----------EFLLDLESH 13247
                   ::.....|:.:|....|.|.:.|||      .:...||           ..|:|.:..
  Rat  2033 -------KEKYSLVEAKRKKFITPESTVMLLEAQAATGGIIDPHRNEKLTVDNAIARDLIDFDDR 2090

  Fly 13248 KSIISSLNVV---GDHLATHTLDTEKARQLRSRLEADNERWNNVCINATKWQGLLQTALMG---- 13305
            :.|.::...:   .|..:..|:...:|  ::..|           |:......||:..|..    
  Rat  2091 QQIYTAEKAITGFDDPFSGKTVSVSEA--IKKNL-----------IDRETGMRLLEAQLASGGVV 2142

  Fly 13306 ---NSEFHQTIGELVEWLQRTEQNIKASEPVDLTEERSVLETKFKK---FKDLRAELERC--EPR 13362
               ||.|......|...|...:.....::|.|  .:::.::...||   :..||   |||  ||.
  Rat  2143 DPVNSVFLPKDVALARGLIDRDLYRSLNDPRD--SQKNFVDPITKKKVSYMQLR---ERCRIEPH 2202

  Fly 13363 V--------------------VSLQDAADQ-LLRSVEGSEQQS-QHTYERTLSRLTDLRLRLQSL 13405
            .                    |::.:..|. :||....:|.:| |.:|:....|:.|.   ||..
  Rat  2203 TGLLLLSVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDF---LQGS 2264

  Fly 13406 RRLSGIYIVKLGAVLG-YEGDNLGVPLHMLSSELLD 13440
            ..::|||.......|| ||...:|:.....:.|||:
  Rat  2265 SCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLE 2300

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Msp300NP_001188695.1 SPEC 17..220 CDD:238103
EnvC 194..>393 CDD:443969
PTZ00121 <1704..1881 CDD:173412
SPEC 9546..9732 CDD:413338
rne <10668..10827 CDD:236766
SMC_prok_B 11268..12195 CDD:274008 213/1208 (18%)
YhaN 11930..12426 CDD:443752 103/521 (20%)
SMC_prok_B <12205..12954 CDD:274008 151/767 (20%)
YhaN 12817..>13241 CDD:443752 89/474 (19%)
SPEC 13196..13374 CDD:238103 38/230 (17%)
KASH 13484..13540 CDD:463142
DspNP_001406527.1 Globular 1. /evidence=ECO:0000305 1..1063 176/1010 (17%)
Interaction with PKP1, JUP, PKP2. /evidence=ECO:0000250|UniProtKB:P15924 1..591 97/521 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
SPEC 197..373 CDD:413338 34/177 (19%)
SPEC 292..457 CDD:238103 46/214 (21%)
SH3_10 454..520 CDD:407754 14/74 (19%)
Spectrin_like 555..632 CDD:465730 11/94 (12%)
CCDC158 <855..>1317 CDD:464943 94/522 (18%)
Central fibrous rod domain. /evidence=ECO:0000305 1064..1952 239/1217 (20%)
SMC_prok_B 1129..1919 CDD:274008 217/1105 (20%)
Globular 2. /evidence=ECO:0000305 1953..2877 76/405 (19%)
4.5 X 38 AA tandem repeats (Domain A). /evidence=ECO:0000250|UniProtKB:P15924 1967..2215 52/301 (17%)
Plectin 2055..2093 CDD:459901 7/37 (19%)
PLEC 2091..2128 CDD:197605 6/49 (12%)
Plectin 2131..2169 CDD:459901 8/37 (22%)
4.5 X 38 AA tandem repeats (Domain B). /evidence=ECO:0000250|UniProtKB:P15924 2251..2453 15/53 (28%)
PLEC 2258..2295 CDD:197605 11/39 (28%)
Plectin 2298..2336 CDD:459901 2/3 (67%)
PLEC 2335..2371 CDD:197605
Plectin 2374..2412 CDD:459901
Plectin <2475..2503 CDD:459901
4.5 X 38 AA tandem repeats (Domain C). /evidence=ECO:0000250|UniProtKB:P15924 2616..2828
PLEC 2618..2654 CDD:197605
Plectin 2657..2695 CDD:459901
Plectin 2733..2771 CDD:459901
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2817..2877
6 X 4 AA tandem repeats of G-S-R-[SR]. /evidence=ECO:0000250|UniProtKB:P15924 2830..2853
Blue background indicates that the domain is not in the aligned region.

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