DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Msp300 and Clmn

DIOPT Version :9

Sequence 1:	NP_001188695.1	Gene:	Msp300 / 3771968	FlyBaseID:	FBgn0261836	Length:	13540	Species:	Drosophila melanogaster
Sequence 2:	XP_017449593.1	Gene:	Clmn / 299285	RGDID:	1306741	Length:	1107	Species:	Rattus norvegicus

Alignment Length:	987	Identity:	193/987 - (19%)
Similarity:	324/987 - (32%)	Gaps:	314/987 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  3259 SSSSWMDVLDEPMNFSDDEEEPVPEPLKEETVVKEVVEEKPIVEVSVVDDSKTITTVTTTTTTTE 3323
            |.||....|......:|.:....|.|..|.:|.           |:|.|..|.|.|:.:..
  Rat   203 SRSSPSSSLSPGSGGTDSDSSYPPTPTTERSVA-----------VAVKDQRKAIKTLLSWV---- 252

  Fly  3324 TISELPISEEPKKVEEPEKIPEEPKKPAYAGLPVDESSSSWM--------------DVLDEPMNF 3374
                                   .:|....|:.|.:.:.||.              .::|.....
  Rat   253 -----------------------QRKTRKYGVAVQDFAGSWRSGLAFLAVIKAIDPSLVDMKQAL 294

  Fly  3375 SDDEEEPVPEPVK---EETVVKEVVEEKPIVEVSVVDDSKTITTVTTTTTTTETISELPIPEEPK 3436
            .|...|.:.:..:   :...:..::|.:.|: |.:.|:...:|.|.
  Rat   295 EDSTRENLEKAFRIAHDSLHIPRLLEPEDIM-VDMPDEQSIVTYVA------------------- 339

  Fly  3437 KVVEPEKKAEPSSFDEPMNFSDDEEEPVPEPLKEETLVEEVVEPIVESSVVDESKTITTVTTTIV 3501
            :.:|...:.:|..|..|     |:|.|:     |.|.|.     |.||....||:       .::
  Rat   340 QFLERFPELDPEDFVNP-----DKEAPI-----ESTFVR-----IKESPSEQESR-------VLL 382

  Fly  3502 TSTN--QTNTLEEENSLPAPAEPQIISNVVDDV---SQLEKPLEGPIDTWSSVLEDTISNTG-NI 3560
            .|.|  |..|:..|.|.|.|          |.|   .|||.|                  || ::
  Rat   383 LSQNGEQPYTVSHETSHPPP----------DKVFVCDQLESP------------------TGFSL 419

  Fly  3561 GYTSTLSADAPEFTPSYLRHTFSDQT-HTFLANERIYNEFIPRNRPEQTIGPHQKPKKAKPSKRQ 3624
            |  |..|...|: :|:...|...||. ...:.|    .|......||.:|     ....|..:|.
  Rat   420 G--SAPSHKLPD-SPTDFMHQIIDQVFQASMGN----TESTTEPTPESSI-----LSTRKDGRRS 472

  Fly  3625 NKKVEIREKIIDVQPAQEINIVEPVQIVEEVENVWNMNRDGKSYADVLLNSGVTGDDVP--STEL 3687
            |.                      :.:.:.|....::::|.....|...:|....:..|  :.||
  Rat   473 NS----------------------LPVKKSVHFETDLHKDASCSKDPFYSSEFRFEGSPKATKEL 515

  Fly  3688 HKEIPHKTDIVKTKAQEPKKKSKPEKRQAEKVIELSS------ASIESEKSKPNSDSEQSKPTTE 3746
            .|:..|      ....|..|:.||| ::|..|:|.:|      ..::::....::...|......
  Rat   516 SKQDGH------ASLAEVSKEKKPE-QEARLVLEAASDKAPEDTIVDTDAMSQDAQLPQDSSFCN 573

  Fly  3747 SELSKPTTESSKEPS----SDERDVSSTSELTWSALVQRPGEWSD--------------STVNKK 3793
            ..:..|.:...|.||    .|...::::.||....|...|.:..|              ..|:..
  Rat   574 GNVENPASLGEKGPSPPSPRDNTILANSVELKVPLLTVEPMDKDDYFECIPLKASKFNRDLVDFA 638

  Fly  3794 QTSHTAVTTKETHRQK--EKEEPKKTTKAKKTKKSKKPVVDPVSTTS--EDEQPETVPEPVE--- 3851
            .||...|....:|::.  |:|..:..|:....:|||.|..:..||.|  |..:.||.|:..|
  Rat   639 STSQAFVEDPSSHKKTPGEEEGSENYTEKPGKRKSKSPHAETESTESRLEPIKLETPPKDPEQED 703

  Fly  3852 ---AMPAPIESKPEPEVVQKL----------ESSNAFSWASLVKRPGEWIDNTVTHIKTAVTPLP 3903
               .:|....:..:|||.:|.          |...|....|.|  .||...|..:...:..|...
  Rat   704 QGHTLPPETAADKKPEVYEKAKRKSTRHHSEEEGEAEGGLSAV--GGEMPSNPPSTSVSLETLRS 766

  Fly  3904 DVKEPIKKDKKPQKPKKQKATKKPTPVALPEDEVSSEPSEEI----VVECEVEEKETKSIKNTEN 3964
            ..:|.:  |.||..|..:.:       .:|.| :...|..|:    |:|...|..|  .:|:.:
  Rat   767 HSEEGL--DFKPSPPLSKIS-------VIPHD-LFYYPHYEVPLAAVLEAYAEGGE--DLKSED- 818

  Fly  3965 AFSWASLVKKPGEWVDDIASRKKPVEIIHEEPKEVH----------------PRKERKI------ 4007
                |.|....|.::.|  ||::..| ..||.:|.|                ||....:
  Rat   819 ----ADLEHPDGSYLQD--SREEEEE-EDEEEEEAHSSHSSCNFSLPVDNSYPRVNDHVSHVDGS 876

  Fly  4008 -------SKPQPKPQSEN----TTKRNNKKETREPVVVHSTSEESDVVEV-LEPTNENTITWAKI 4060
                   |:|...|..|:    .||.|...|:::       |:|....|: .:|..|.
  Rat   877 SEGPTSASEPGSPPSHEDHQPMETKENGPVESQQ-------SQEPPTPELSTKPLEEK------- 927

  Fly  4061 ASQIDHMTDLKPKAKQETKPKQGERVKEQI--------RFDRIEKHPKDHAISSDLSQQKGDSGH 4117
                  :|::...:|::.|.|..:.|:..:        ..|.:|::|.:|.:.|       .:.|
  Rat   928 ------LTEVPTSSKKKEKRKHMDHVESSLFIAPGTVRSSDDLEENPCEHKVPS-------RNSH 979

  Fly  4118 SWSSVVSHQVTD 4129
            |.||:...:.|:
  Rat   980 SDSSIYIRRHTN 991

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
Msp300	NP_001188695.1	SPEC	17..220	CDD:238103
		SPEC	9546..9732	CDD:295325
		sbcc	11187..12008	CDD:129705
		SMC_prok_B	11614..12442	CDD:274008
		SPEC	11994..12156	CDD:295325
		SPEC	12374..12564	CDD:295325
		Lipase_chap	12376..12529	CDD:281297
		SPEC	12703..12923	CDD:238103
		SPEC	12816..13032	CDD:295325
		SPEC	13196..13374	CDD:238103
		KASH	13484..13540	CDD:287506
Clmn	XP_017449593.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D46at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47535
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010