Protein Alignment Msp300 and Gas2l2

DIOPT Version :9

• Sequence 1: NP_001188695.1
• Gene: Msp300 / 3771968
• FlyBaseID: FBgn0261836
• Length: 13540
• Species: Drosophila melanogaster
• Sequence 2: NP_001099293.2
• Gene: Gas2l2 / 287570
• RGDID: 1307868
• Length: 857
• Species: Rattus norvegicus
• Alignment Length: 1016
• Identity: 192/1016 - (18%)
• Similarity: 330/1016 - (32%)
• Gaps: 332/1016 - (32%)

  Fly   549 RHQHHHAKTGKKLHAPRPERRGRSPRRRPPQQQKPVESSQQP---------SIEIQLERQQPQEQ 604
            ||.:...:......|..|||..:.|.   ||.......:.||         |..||..|::...|
  Rat    67 RHANTVTEAALAFLAEAPERVQKIPM---PQVGVFCNGAAQPGTFQARDNISNFIQWCRKEMGIQ 128

  Fly   605 EQLFLPADDRTRSRSPMWVPGSTSYAEVLRGLELERIRAEQQAAQAVQGRSDLTIQDVVDASAEV 669
            |.|....:|....::...|        ||..|||.| ||.:   ..|...|.:.:::.::  .|:
  Rat   129 EVLMFETEDLVLRKNVKSV--------VLCLLELGR-RAWR---FGVAAPSLVYLEEEIE--EEL 179

  Fly   670 AGSIYIPQPDPEPPIKETQQP-QPPQLEQYITETSTLLDYSTTQQQEQKPPINYEVPMTAEEIAA 733
            ...:.:|.|||.||:...::| ....|:|.:   .:|:.:.|.       |:.:.:...::   .
  Rat   180 RRDLDLPSPDPPPPVPPARRPCHFHNLDQMV---QSLVSHCTC-------PVQFSMVKISD---G 231

  Fly   734 TYLQPDPQLYQTMYENVADSGQWGFV----------TGSTTDPQQQQAPQNYYEQIMQMQQYPIQ 788
            .|             .|.||....|:          .|...|.......::...:...:...|..
  Rat   232 KY-------------RVGDSNTLIFIRILRSHVMVRVGGGWDTLGHYLDKHDPCRCTSLSHKPGS 283

  Fly   789 YQQVAVPPAATTQYQLLAGYYQPVAQTEAYSTVYPAEPNQIYYAPQATEYSQEFSQQQEQQVEPM 853
            :.:   ||.             |..|.|......|::|..:            .:..:.|...|.
  Rat   284 FLK---PPG-------------PPVQHEVKVQDGPSQPQPL------------MTISRSQSPLPP 320

  Fly   854 LEYQQEAVEQTYLLDPYRAESTLPSTTGNSVLDRVVTTLASIVQQSAEPLTTSTQQIEPLATVVQ 918
            :::      :||.....:.....||::|               .:|..|....|.:
  Rat   321 VDW------KTYTSSSRKLRPPTPSSSG---------------PRSEFPARARTPR--------- 355

  Fly   919 SEPYYIEEHVQMLRPVEPQEL--ELDEPRPDITFGQFEVDAIETIPLDEPQAPQTEVETTESQVR 981
                   |....||..|...|  .:..|.|.:           :.|...|     ::::|.|:.|
  Rat   356 -------EMAPFLRSQEKPTLSQRMSSPGPQL-----------SSPCRGP-----DLQSTLSERR 397

  Fly   982 TQQT-------ITTTTYVTETSNVSEQTQPTVIMQQTQEVIAIPDTPEIPTEEPTNVVVHPKPQR 1039
            ..::       .|.|::|.:.::.........|.|:.|    ||:|....|  |..   .|.|..
  Rat   398 VNRSPGELPRGRTPTSWVPKEADSQGAHTKAPIPQRLQ----IPETTSKKT--PAR---GPSPPP 453

  Fly  1040 RSNQQVRPQDI---STGSTYAEVLFGLHHKEHPVFQPSSQQPT---------PVRLT-SSPPLQR 1091
            ||:....|..|   ..|::            ..:.:|.|.|.:         |:||: :.||...
  Rat   454 RSSSLASPHTIWLPDQGAS------------PEISEPMSAQSSSPGKGLTKIPIRLSPARPPTPG 506

  Fly  1092 K----TEQAGPISNTAFTSKTTQPGRQVEKSTTWEHKNDNVDSRNSRSKRVRHEAQPE-PLPIKQ 1151
            :    ||..|.:...:.:|:..  ...:::||   |.:.:||......|.::..:..| |..:..
  Rat   507 RGSLGTEGGGSMQRGSLSSRAL--AGNLDRST---HGHHSVDVSKDHQKVIQISSGTEDPRSLGT 566

  Fly  1152 STRKD-------GRTVRKPQSADT-------------NGIASVETKVVVDTPAPSVVVEETSKPE 1196
            ..||:       ||| |:|...|.             .|.|..:.......|...|.|.......
  Rat   567 QERKERYTSLPLGRT-REPALYDNLKEELVANMKLLEVGAACTQGTRSQAIPRSGVYVPSLGGMW 630

  Fly  1197 PKPRKSKKSKKTTTDNVVESAVD-------ISVPSKKDTQSVLPSVGKKETVVEKSVIKKTVEPS 1254
            |:||       ...|.|::..|.       :.:.:.|.....||                  .|.
  Rat   631 PEPR-------GPYDKVIQELVQGPPRLLKVDLKAWKVGSECLP------------------RPI 670

  Fly  1255 VEPVEPVPVPSKRE----KKHKPVKEKETPQSDEP-------VLEVSP--VAPTRK----EKKQV 1302
            |.|..|......||    :|.:|..:..|.::..|       .|.||.  .|||..    ...:.
  Rat   671 VNPGSPKEEQVSRERGTRRKARPSAQGTTVKTTSPARGQDCSTLPVSANLKAPTHSCSDPSSDKA 735

  Fly  1303 KTVVKNVETTIRNEPLIEKETSKPADVPKTQVKQTKSVVETVVEKKVLQPVVTEDAELAKSVTPA 1367
            |..:...:.|:|          ||..||.             :.|..|:|          .:.|
  Rat   736 KVCLGKGKRTLR----------KPQKVPS-------------IYKLKLRP----------RIRP- 766

  Fly  1368 APSKKDKKKNKTVVEPEVIKKPTEIVIEKEVVTPTV--IETTDVSQVQEQPTSPTS------SKK 1424
               ::|.:       ||  |:|:.  |.|.:|.|.:  ..|...|::.:.....|.      .||
  Rat   767 ---RRDHR-------PE--KRPSR--IPKPLVYPFLGPARTAPGSRLLKATLGGTGGDVNGVGKK 817

  Fly  1425 EKKQSKKIVETSVIVTENVEPA-----VQLEAAPPLPTKKD 1460
            |:::.|   |||:.:..:::|:     :||:.. |||.:::
  Rat   818 EEEKKK---ETSISLESSIQPSESREPMQLDGT-PLPPEEE 854

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Msp300	NP_001188695.1	SPEC	17..220	CDD:238103
		SPEC	9546..9732	CDD:295325
		sbcc	11187..12008	CDD:129705
		SMC_prok_B	11614..12442	CDD:274008
		SPEC	11994..12156	CDD:295325
		SPEC	12374..12564	CDD:295325
		Lipase_chap	12376..12529	CDD:281297
		SPEC	12703..12923	CDD:238103
		SPEC	12816..13032	CDD:295325
		SPEC	13196..13374	CDD:238103
		KASH	13484..13540	CDD:287506
Gas2l2	NP_001099293.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		CH	33..159	CDD:237981	27/103 (26%)
		GAS2	206..274	CDD:366964	12/93 (13%)
		PHA03307	278..>527	CDD:223039	60/350 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..572		69/396 (17%)
		Interaction with ADORA2A. /evidence=ECO:0000250|UniProtKB:Q5SSG4	432..857		108/527 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	670..716		10/45 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	759..857		28/125 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900