DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Msp300 and GAS2L3

DIOPT Version :9

Sequence 1:	NP_001188695.1	Gene:	Msp300 / 3771968	FlyBaseID:	FBgn0261836	Length:	13540	Species:	Drosophila melanogaster
Sequence 2:	NP_001290059.1	Gene:	GAS2L3 / 283431	HGNCID:	27475	Length:	694	Species:	Homo sapiens

Alignment Length:	781	Identity:	149/781 - (19%)
Similarity:	254/781 - (32%)	Gaps:	232/781 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  3327 ELPISEEPKKVEEPEKIPEEPKKPAYAG--------------------LPVDESSSSWMDVLDEP 3371
            :||:|            |..|..|.:..                    ||:.|..|.|:..|
Human    12 DLPLS------------PRSPLTPRHGPGLANVCQYDEWIAVRHEATLLPMQEDLSIWLSGL--- 61

  Fly  3372 MNFSDDEEEPVPEPVKEETVVKEVVEEKPIVEVSVVDDSKTITTVTTTTTTTETISELPIPEEPK 3436
                      :...||.|.:::|:  :..::...::|    :......|..:|.....|:.:.|.
Human    62 ----------LGIKVKAEKLLEEL--DNGVLLCQLID----VLQNMVKTCNSEESGNFPMRKVPC 110

  Fly  3437 KVVEPEKKAEPSSF---DEPMNF--------SDD----EEEPV---PEPLKEETLVEEV------ 3477
            |     |.|...||   |...||        .|:    |.|.:   .:|.:....:.|:
Human   111 K-----KDAASGSFFARDNTANFLHWCRDIGVDETYLFESEGLVLHKDPRQVYLCLLEIGRIVSR 170

  Fly  3478 --VEPIVESSVVDESKTITTVTTTIVTSTNQTNTLEEENSLPAPAE-------PQIISNVVDDVS 3533
              |||.|   :|...|.|....|.:       ||...|:|:..|..       .:.:.::.:|..
Human   171 YGVEPPV---LVKLEKEIELEETLL-------NTSGPEDSISIPKSCCRHEELHEAVKHIAEDPP 225

  Fly  3534 -------QLEKPLEGPIDTWSSVL-------EDTISNTGNIGYTSTLSADAPEFTPSYLRHTFSD 3584
                   .:|...||.......:|       :..:...|  |...||.....::.|..:.. |:.
Human   226 CSCSHRFSIEYLSEGRYRLGDKILFIRMLHGKHVMVRVG--GGWDTLQGFLLKYDPCRILQ-FAT 287

  Fly  3585 QTHTFLANER-IYNEFIPRNRPEQTIGPHQKPKKA-KPSKRQNKKVEIREKIIDVQPAQEINIVE 3647
            .....||.:: :.||.:|.:.......|...|..| ...::||.|..:
Human   288 LEQKILAFQKGVSNESVPDSPARTPQPPEMNPLSAVNMFQKQNSKPSV----------------- 335

  Fly  3648 PVQIVEEVENVWNMNRDGKSYADVLLNSGVTGDDVPSTELHKEIPHKTDIVKTKAQEPK-KKSKP 3711
            ||.|.:..|      :.|:....::..|.:.|.::.|..:..::|:.    ...:..|| |.||.
Human   336 PVSIPKSKE------KQGRPPGALVPASSLKGGNLGSMSVRSKLPNS----PAASSHPKLKSSKG 390

  Fly  3712 EKRQAEKVIELSSASIESEKSKPNSDSEQSKPTTE---SELSKPTTESSKEPSSDERDVSSTSEL 3773
            ..::.:.....:|:|:.|......:.|..:.|.|.   ||..:....|...|.:......::::|
Human   391 ITKKPQAPSNNASSSLASLNPVGKNTSSPALPRTAPCISESPRKCISSPNTPKAKVIPAQNSADL 455

  Fly  3774 TWSALVQRPGEWSDSTVNKKQTSHTAVTTKE-------THRQKEKEEPKK-------------TT 3818
            ..|.|:  |.:.|..| ..|...|..:::::       .|.....:.||.             .:
Human   456 PESTLL--PNKCSGKT-QPKYLKHNHISSRDNAVSHLAAHSNSSSKCPKLPKANIPVRPKPSFQS 517

  Fly  3819 KAKKTKKSKKPVVDPVSTTSE--DEQPETVPEPVEAM--------PAPIESKPEPEVVQKLESSN 3873
            .||.||.|.|.:...:.|.|:  |..|:..|.|.:.:        |..:.|....:..||.:..|
Human   518 SAKMTKTSSKTIATGLGTQSQPSDGAPQAKPVPAQKLKSALNLNQPVSVSSVSPVKATQKSKDKN 582

  Fly  3874 AFS---------------WASLVKRPGEWIDNTVTHIKTAVTPLPDVKEPIKKDKKPQKP----- 3918
            ..|               ..|.:|.||.             |||..|..|....|....|
Human   583 IVSATKKQPQNKSAFQKTGPSSLKSPGR-------------TPLSIVSLPQSSTKTQTAPKSAQT 634

  Fly  3919 --KKQKATKKP-----TPVAL--PEDEVSSEPSEEIVVECEVEEKETKSIKNTENAFSWASLVKK 3974
              |.|.:||.|     ||.::  |...|....|.        ::|.|...|..::.:...:..||
Human   635 VAKSQHSTKGPPRSGKTPASIRKPPSSVKDADSG--------DKKPTAKKKEDDDHYFVMTGSKK 691

  Fly  3975 P 3975
            |
Human   692 P 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Msp300	NP_001188695.1	SPEC	17..220	CDD:238103
		SPEC	9546..9732	CDD:295325
		sbcc	11187..12008	CDD:129705
		SMC_prok_B	11614..12442	CDD:274008
		SPEC	11994..12156	CDD:295325
		SPEC	12374..12564	CDD:295325
		Lipase_chap	12376..12529	CDD:281297
		SPEC	12703..12923	CDD:238103
		SPEC	12816..13032	CDD:295325
		SPEC	13196..13374	CDD:238103
		KASH	13484..13540	CDD:287506
GAS2L3	NP_001290059.1	CH	49..167	CDD:237981	27/141 (19%)
		GAS2	213..281	CDD:308025	10/69 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	299..694		89/445 (20%)
		Herpes_BLLF1	<309..693	CDD:330317	86/435 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900