DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Msp300 and GAS2L2

DIOPT Version :9

Sequence 1:	NP_001188695.1	Gene:	Msp300 / 3771968	FlyBaseID:	FBgn0261836	Length:	13540	Species:	Drosophila melanogaster
Sequence 2:	NP_644814.1	Gene:	GAS2L2 / 246176	HGNCID:	24846	Length:	880	Species:	Homo sapiens

Alignment Length:	958	Identity:	173/958 - (18%)
Similarity:	290/958 - (30%)	Gaps:	394/958 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly 10020 GAVVDSTQPEGVILQEFETEPTIETYEEVI----------APGSQAQLIPM-----------QPG 10063
            |..:|:..    .||..||...:..:..|:          || :|||.|||           |||
Human    47 GLDIDAAN----FLQVLETGLVLCQHANVVTDAALAFLAEAP-AQAQKIPMPRVGVSCNGAAQPG 106

  Fly 10064 DVQTQGTIRAVVQQVTRKV-IRKT----------RKIIKRVV-------------------IIDG 10098
            ..|.:..:...:|...::: |::.          ||.:|.||                   ::..
Human   107 TFQARDNVSNFIQWCRKEMGIQEVLMFETEDLVLRKNVKNVVLCLLELGRRAWRFGVAAPTLVQL 171

  Fly 10099 KEHITEEVVEE-----PEE--------------------VEITEEETAPHINVNIVRTVDGKV-V 10137
            :|.|.|||..|     |:.                    ..:....|.| :..::|:..:||. |
Human   172 EEEIEEEVRRELALPPPDPSPPAPPRRQPCHFRNLDQMVQSLVSHCTCP-VQFSMVKVSEGKYRV 235

  Fly 10138 SEEE---FQRMMQ-------------------------------EPGVLIEEVATDLQKPTAEP- 10167
            .:..   |.|:::                               :||..:        ||.|.|
Human   236 GDSNTLIFIRILRNHVMVRVGGGWDTLGHYLDKHDPCRCTSLSHKPGSFL--------KPPAPPV 292

  Fly 10168 QQEVFDIESTQVTTTTRTTTATTQEQEQPEQQTQPTTTETTKEAPVELPAPQVDVEQPVVVATTS 10232
            |.||                   :.|:.| .|||||.|.:..::|   |.|   |:.....::..
Human   293 QHEV-------------------RVQDGP-SQTQPTMTISRSQSP---PPP---VDWKTYTSSDR 331

  Fly 10233 PVHVPTADVVEPKDSSPTSTTAAVVDVEAVVEDINEIWPL----EHHLKPTNIDFSQHVEELAAP 10293
            .:..||.....|:......|.|:           .|:.|.    |..|.|:   :.|.....:.|
Human   332 RLRPPTPSSPRPRRERGAGTGAS-----------REMAPFLRCQERSLIPS---WRQPTAGDSPP 382

  Fly 10294 AAVTAETEASMPVEEIWPTSPETGNSLTLEQYEFEPQSP---------HEE--STKSDLVKP--- 10344
            :..::.|:..        ..|:..:|...|: .:.|:.|         |||  |..:|...|
Human   383 SPQSSSTQKG--------RDPQCTSSGKREE-RYPPELPRGRIPTSWVHEETDSWGTDAGNPTPQ 438

  Fly 10345 ---------------------------------------------QETEPQVVAETKP------- 10357
                                                         |..||:.|....|
Human   439 RLRAIEATTKGISARGPSPLPRSFGPAECLGLRLPLRDEAKGAFFQFREPESVRSPTPVQGLTKI 503

  Fly 10358 ----------------EGITTGS---------ITITKTTTTITSST------EVPEETLVQNVPA 10391
                            .|.|:||         |.:...|..:..||      ||.:|
Human   504 PIRLPPARPPTPGRSFPGATSGSPRTELGRDPIPLRAVTVDLAGSTHGDCSVEVRQE-------- 560

  Fly 10392 DEQQPPANKIKTDIQSFLEAEQTLAAALKEQ----SSTPTGASVAEDVQTQPEEIVL-EERTVEI 10451
            |:|        .|||...||.::....|:||    :..|.|.:..:.:....||.:| ..:.:|:
Human   561 DQQ--------LDIQVMAEARESWDLGLQEQEGRYTPLPLGGNKEQAIYCSLEEEILGNMKLLEV 617

  Fly 10452 STIKTEENQQEPVIVEEVKSLP----VEPEPVEPELEEVAIAIVEQTEEKPEEPVIEKQPASGPI 10512
            .: ...:..:..||......:|    ..|||..|             .:|..:.:.:..|:...:
Human   618 RS-ACPQGTRSGVIPRSGVYIPRLAGQWPEPGGP-------------YDKAIQELAQGSPSLLKV 668

  Fly 10513 DLRAATQLFISGEAAASTAPQKTFQISAPSLEDNGAGVLKVVLGKESTNEEDTAA---------- 10567
            ||.|       .:||.:.:|:       |::.. |.|.||..||...:.....|:
Human   669 DLEA-------WKAAPTGSPK-------PAVTP-GPGSLKGKLGARQSGPRTKASLSAKGTHMRK 718

  Fly 10568 -PTTGKVSMTIIETAAAPAA----------DAKRRRKKKKRRDTKHEEELEQEQETEPEPVAAVK 10621
             |..|....:....:|:|.|          |..:....|.||..:           :|:.|.::.
Human   719 VPPQGGQDCSASTVSASPEAPTPSPLDPNSDKAKACLSKGRRTLR-----------KPKRVPSIY 772

  Fly 10622 E----PEVSSDVPVSPEDSPRDTVRHESIVEISPDSDLSSIEIDTKVKIVEDAVVSSPSESPRTP 10682
            :    |.:.......||..|....|..:.|.:.|...      ..|.:::...:.|...|:.|
Human   773 KLKLRPRIRPRRDHRPEKQPSRIPRPLAYVFLGPARQ------PPKDRLLRAVLGSKGGEASR-- 829

  Fly 10683 MVELVIPTEVVELALVEDEEQQTTPRIPSPTEKSEVEQDIKSVQTSPQ 10730
                      |:.|.|.:||:          |..|.::....:::|||
Human   830 ----------VDGASVGEEEE----------EGKEEKEPAAPLESSPQ 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Msp300	NP_001188695.1	SPEC	17..220	CDD:238103
		SPEC	9546..9732	CDD:295325
		sbcc	11187..12008	CDD:129705
		SMC_prok_B	11614..12442	CDD:274008
		SPEC	11994..12156	CDD:295325
		SPEC	12374..12564	CDD:295325
		Lipase_chap	12376..12529	CDD:281297
		SPEC	12703..12923	CDD:238103
		SPEC	12816..13032	CDD:295325
		SPEC	13196..13374	CDD:238103
		KASH	13484..13540	CDD:287506
GAS2L2	NP_644814.1	CH	34..159	CDD:237981	26/116 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	180..200		2/19 (11%)
		GAS2	207..274	CDD:280367	8/67 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	283..360		25/121 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..437		14/73 (19%)
		Interaction with ADORA2A. /evidence=ECO:0000250\|UniProtKB:Q5SSG4	438..880		87/504 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	489..533		6/43 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	676..880		42/229 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900