DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Msp300 and Gas2l2

DIOPT Version :9

Sequence 1:	NP_001188695.1	Gene:	Msp300 / 3771968	FlyBaseID:	FBgn0261836	Length:	13540	Species:	Drosophila melanogaster
Sequence 2:	NP_001013781.1	Gene:	Gas2l2 / 237891	MGIID:	3652048	Length:	860	Species:	Mus musculus

Alignment Length:	897	Identity:	173/897 - (19%)
Similarity:	283/897 - (31%)	Gaps:	269/897 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   549 RHQHHHAKTGKKLHAPRPERRGRSPRRRPPQQQKPVESSQQP---------SIEIQLERQQPQEQ 604
            ||.:...:......|..|||..:.|.   ||.......:.||         |..||..|::...|
Mouse    67 RHANTVTEAALAFLAEAPERAQKIPM---PQAGVFCNGAAQPGTFQARDNISNFIQWCRKEMGIQ 128

  Fly   605 EQLFLPADDRTRSRSPMWVPGSTSYAEVLRGLELERIRAEQ--QAAQAVQGRSDLTIQDVVDASA 667
            |.|....:|....::...|        ||..|||.| ||.:  .||.|:     :.:::.:|  .
Mouse   129 EVLMFETEDLVLRKNVKSV--------VLCLLELGR-RAWRFGVAAPAL-----VHLEEEID--E 177

  Fly   668 EVAGSIYIPQPDPEPPIKETQQP-----QPPQLEQYITETSTLLDYSTTQQQEQK---------- 717
            |:...:.:|.|||.|||...::|     ....::..::..:..:.:|..:..|.|
Mouse   178 ELRRDLALPSPDPPPPIPPARRPCHFHNLDQMVQSLVSHCTCPVQFSMVKISEGKYRVGDSNTLI 242

  Fly   718 -----------------------------------------------PPINYEVPMTAEEIAATY 735
                                                           ||:.:||     ::....
Mouse   243 FIRILRSHVMVRVGGGWDTLGHYLDKHDPCRCTSLSHKPGSFLKPPGPPVQHEV-----KVQDGP 302

  Fly   736 LQPDPQLYQTMYENVADSGQWGFVTGSTTD--PQQQQAPQNYYE-----------QIMQMQQYPI 787
            .||.|.:..:..::......|...|.|:..  |....:|....|           .:.:.|:.|.
Mouse   303 SQPQPTMTISRSQSPLPPVDWKTYTSSSRKLRPPTPSSPGLRSEPPVRARTLREDPLPRSQEKPT 367

  Fly   788 QYQQVAVPPAATTQYQLLAGYYQPVAQTEAYSTV-------YPAEPNQIYYAPQATEYSQEFSQQ 845
            ..|:::.|..     |..:....|..|    ||:       .|.||      |:..
Mouse   368 PSQRMSSPGP-----QFSSTCRGPDLQ----STLSGKRANRCPGEP------PRGR--------- 408

  Fly   846 QEQQVEPMLEYQQEAVEQ-TYLLDPYRAESTLPSTTGNSVLDR------VVTTLAS-----IVQQ 898
                 .|.|...:||..: |:...|......:|..|......|      ..::|||     ::.|
Mouse   409 -----TPTLWVHKEAGSRGTHTKAPTPQRLQIPEATSKRTSARGPSPPPRSSSLASPHMIWVLHQ 468

  Fly   899 SAEPLTTSTQQIEPLATVVQSEP----YYIEEHVQMLRPVEP------QELELDEPRPDI----- 948
            .|.|     |..||: ||..|.|    ..|...:...||..|      .|.|....|..|
Mouse   469 GASP-----QLSEPM-TVHSSSPGKGLTKIPIRLSPARPPTPGRSSLGTEGEYSTGRGSISSRAL 527

  Fly   949 -------TFGQFEVDAIETIPLDEPQAPQTEVETTESQVRTQQTITTTTYVTETSNVS--EQTQP 1004
                   |.|...|:|        ....||:::|| |:....:::.|..:....::::  .:.:.
Mouse   528 EGNLDRSTHGHHSVEA--------SGDHQTDIQTT-SETEDPRSLGTQKWKERHTSLALGRRREQ 583

  Fly  1005 TVIMQQTQEVIAIPDTPEIPTEEPTNVVVHPKPQRRSNQQVRPQDISTGSTYAEVLFGLHHKEHP 1069
            .:.....:||:|.....|:.|              ...|..|.|.|.....|...|.|    ..|
Mouse   584 ALYDNLKEEVVANMKLLEVGT--------------AYTQGTRSQAIPRSGVYVPSLGG----RWP 630

  Fly  1070 VFQPSSQQPTPVR--LTSSPPLQRKTEQAGPISNTAFTSKTTQPGRQVEKSTTWEHKNDNVDSRN 1132
              :|.......:|  :...|||.:...:|..:.:.........||...||..:.|.......|.|
Mouse   631 --EPGGPYDKVIRELVQGPPPLLKVDLKAWKVGSECLPRPIVDPGSPKEKLGSRETGTRIKASLN 693

  Fly  1133 SRSKRVRH---------EAQPEPLPIKQSTR---------------KDGRTVRKPQSADTNGIAS 1173
            :....||.         ...|....::..||               |..||:||||.     |.|
Mouse   694 AEDTTVRTVSPARGQGCSTPPVSANLEAPTRSCSDPSSDKASVCLGKGKRTLRKPQK-----IPS 753

  Fly  1174 V-ETKVVVDTPAPSVVVEETSKPEPKPRKSKKSKKTTTDNVVESA-----VDISVPSKKDTQSVL 1232
            : :.|:     .|.:......:||.:|.:..|....:...:..:|     :..::..|......:
Mouse   754 IYKLKL-----RPRIRPRRDHRPEKRPSRIPKPLPYSCLVLARTAPGSRLLKATLGGKGGVPCQV 813

  Fly  1233 PSVGKKETVVEKSVIKKTVEPSVEPVEPVPVPSKREKKHKPVKEKETPQSDE 1284
            ...||||...:|.....::|.|::|.|          ..:|:|...||.|.|
Mouse   814 NGTGKKEEEKKKGGSNISLESSIQPAE----------SQEPLKLGGTPLSPE 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Msp300	NP_001188695.1	SPEC	17..220	CDD:238103
		SPEC	9546..9732	CDD:295325
		sbcc	11187..12008	CDD:129705
		SMC_prok_B	11614..12442	CDD:274008
		SPEC	11994..12156	CDD:295325
		SPEC	12374..12564	CDD:295325
		Lipase_chap	12376..12529	CDD:281297
		SPEC	12703..12923	CDD:238103
		SPEC	12816..13032	CDD:295325
		SPEC	13196..13374	CDD:238103
		KASH	13484..13540	CDD:287506
Gas2l2	NP_001013781.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		CH	34..159	CDD:237981	27/103 (26%)
		GAS2	207..274	CDD:280367	3/66 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..459		36/211 (17%)
		Interaction with ADORA2A and GNAS. /evidence=ECO:0000269\|PubMed:23994616	431..860		97/480 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	473..574		25/110 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	697..743		6/45 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..781		5/27 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	801..860		16/65 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900