DRSC/TRiP Functional Genomics Resources

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Protein Alignment Msp300 and SYNE1

DIOPT Version :9

Sequence 1:NP_001188695.1 Gene:Msp300 / 3771968 FlyBaseID:FBgn0261836 Length:13540 Species:Drosophila melanogaster
Sequence 2:XP_006715470.1 Gene:SYNE1 / 23345 HGNCID:17089 Length:8846 Species:Homo sapiens


Alignment Length:10570 Identity:1910/10570 - (18%)
Similarity:3689/10570 - (34%) Gaps:3031/10570 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly  4266 PKKVAEPVPEPLKEETLVEEVVEEK---------------PIVEVSVVDDSKTITTVTTTTTTTE 4315
            |:.:|. |.:.|::|   :|:|:::               |:|...:.:|.|....:   ....|
Human    11 PRDIAN-VMQRLQDE---QEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKL---LALLE 68

  Fly  4316 TISELPIP-EEPKKVVELEK--------KPEEPKKPAYAGLPVDDSTNSWMDVLD-EP------- 4363
            .:|...:| |:.:::..:..        |..|.:|..:.|.|:.....:..|:.| .|       
Human    69 VLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLGLM 133

  Fly  4364 ----MNFSDDEEEPVPEPVKEETVVQEVVEEKPIVEVSVVDDSKTITTVTTTTTNTETI--SELP 4422
                :.|.                ::|:....|           .:.:::::.::.::|  ||.|
Human   134 WTIILYFQ----------------IEELTSNLP-----------QLQSLSSSASSVDSIVSSETP 171

  Fly  4423 IPEEPKKV---VELEKKPEEPKKPAY-----AGLPVDDSTNSWMDVLDEPMNFSDDEEEPIPEPQ 4479
            .|...:||   ::...|....|...|     .|:.|.|...||...:                  
Human   172 SPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTGIEVKDFGKSWRSGV------------------ 218

  Fly  4480 KEESLVKEVVEEKPIVEVSVVDDSKSITTVTTTTTTTETISEIAIPEEPTKVVEPE----KKPEE 4540
            ...|::..:..|  :|::..|....:...:....|..||  |:.||    ::::||    .||:|
Human   219 AFHSVIHAIRPE--LVDLETVKGRSNRENLEDAFTIAET--ELGIP----RLLDPEDVDVDKPDE 275

  Fly  4541 PKKPAYAGLPVDDSTNSWMDVLDEPMNFSDDEE---------EPVPEPLKEETVVEEVVEEKPIV 4596
            .....|    |......:.|:.:...:..:|:|         ..|....:|:.|:.:  |.|..:
Human   276 KSIMTY----VAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRVIFK--EMKVWI 334

  Fly  4597 EVSVVDDSKTITTVTTTTTTTETISELPIPEEPKKVVEPEKKPEEPKKPAY--AGLPVDDS--TN 4657
            |....|.::.....:......::.....:..|.|:     |:.|...:|.:  ..|.:|.:  ..
Human   335 EQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKR-----KQIEHLIQPLHRDGKLSLDQALVKQ 394

  Fly  4658 SWMDVLDEPMNFSDDEEEPVPEP--------------LKEETVVEEVVEEKPIVEVSFVDDSKSI 4708
            ||..|.....::....::.:|.|              |:||..|::|.||........::..|.:
Human   395 SWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHKDL 459

  Fly  4709 TTVTTT-------TTTTETISELPIPEEPKKVVEPEKKPEEPKKPAYAGLPVDESSSSLMDVLDE 4766
            ...|..       ...|.:::.:|:|        |::..:..::..:.      ||:|.:.::  
Human   460 LQNTDAHKRAFHEIYRTRSVNGIPVP--------PDQLEDMAERFHFV------SSTSELHLM-- 508

  Fly  4767 PMNFSDDEEEPVPEPVKEETLVK---------EVVEEKPIVEVSVVDDSKSITTVTTTTTTTETI 4822
            .|.|.:.:...:...|..|:.:|         |.||:.....||.:::||.......|....:..
Human   509 KMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQT 573

  Fly  4823 SELPIP-----EEPKKVV----------------------------------------------E 4836
            :|:.:.     ||.:.|:                                              :
Human   574 AEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLED 638

  Fly  4837 PEK---KPEEPKKPAYAGLP--------VDDSSNSWMDVLDEPMNFSDDEEEPIPEPLKEETVV- 4889
            .||   :.|..||..:..||        ::|:.|..::..|          |.:...||::.:: 
Human   639 AEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCD----------EMVSRDLKQQLLLL 693

  Fly  4890 -----EEVVEIKPIVEVSVVDDSK---TITTVTTTTITTET---ISE------------------ 4925
                 |..:|:|...:...:|..|   |...||.:...||.   :||                  
Human   694 NGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLED 758

  Fly  4926 ----LPISEEPKKVVE------PEKKPEEPKKPAYAGLPVDDSTNSWMDVLDEPMNFSDDEEEPV 4980
                :|:.:...|::.      .::.|:|..|..:|          .|..|.|.:....:...|:
Human   759 IEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFA----------TMSKLKEQLTKVKECYSPL 813

  Fly  4981 PEPVKEETL-VEEVVEEKPIVEVSVVDDSKTITTVTTTTTTTETISEP-----VISEQPKKTVEP 5039
            ....::..: :||:.::......|:...::.||.:.....::....:.     ...|..|||:..
Human   814 LYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTL 878

  Fly  5040 VKKPEESTE-----------VEPKPLSSNIWELHSSYADVLRHTVDFISLEKNNVEVPTESNLGK 5093
            ::|..:|.:           .:...|...|.::|.::..:::.|.|:    |.:||  |.|.|.|
Human   879 IEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDW----KKHVE--TNSRLMK 937

  Fly  5094 VPTVKEPAKLPEPLIKTKAKKEKPLK------KEKGAKLLTPKDEVLPIERESAKDETKTSWSTM 5152
                    |..|    ::|:.||.|:      :|||     ..:|:|....|             
Human   938 --------KFEE----SRAELEKVLRIAQEGLEEKG-----DPEELLRRHTE------------- 972

  Fly  5153 VENDFDDNVQTNILSADSTLWSSI---VRQGAQEPITKM-TQSADHDGKV--------------- 5198
            ..:..|..|....|.|...|...:   .:||.||.:.|: .|..|..|:.               
Human   973 FFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNR 1037

  Fly  5199 ----LEPAFQNSQEINKFISQERSSTVIEKTKKQKSKKEKKH---NKIESVVEVALE-PYVDSTF 5255
                :|..........|.:.||.|..:|::.:...|.|...|   .:::.:.|:.:: |..|.  
Human  1038 FLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDP-- 1100

  Fly  5256 MRDDPKT------QQNAEIPSVLESLPIQPKSW----------SSIVSQTEVLPPTSIESKISQK 5304
            :||.|.|      :..|.|.|....|...|..|          ||.:|..|    |.::. |..:
Human  1101 VRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNE----TQLKG-IKGE 1160

  Fly  5305 AVDPHRSKEVQEFISKEQIFSTTVNADSKKPEDKKPLEEKPKKQKSKKEKKTKVVEAPEPIVESA 5369
            |:|.....||:..:.:.:      |..:|:.|....|       ||:.:..|:|         |:
Human  1161 AIDTANHGEVKRAVEEIR------NGVTKRGETLSWL-------KSRLKVLTEV---------SS 1203

  Fly  5370 VPEAVVEPTVEVTFVEEPVVEVTTVVEEVTP--ETQPEPTPVSEVAPSQPLSWSSIVSQTTEVTT 5432
            ..||..:.. |:..:......:.|::.||..  ....:.....|:..:   |...::|.:.||..
Human  1204 ENEAQKQGD-ELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKN---SLEELISGSKEVQE 1264

  Fly  5433 NVTETRFTEEPEDKKPL----EEKPKKQKPKK-EKKTKVVEAPEPIVESAVP----------EAV 5482
            ...:...||...:.:.|    ::|.|:...|| :.:.::.:|.:.  |..:|          |:.
Human  1265 QAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQG--EGGLPDRGHEELRKLEST 1327

  Fly  5483 VEPTVEVTFVEEPVVEVTTVVEEVTPETQPEPTPVSEV-----APSQPLSWSSIVSQTTEITTNV 5542
            ::........:|..::||....| ..||..| |.|..:     :..:.||:||:.|.::|:....
Human  1328 LDGLERSRERQERRIQVTLRKWE-RFETNKE-TVVRYLFQTGSSHERFLSFSSLESLSSELEQTK 1390

  Fly  5543 TETRFTEE------------------PEDKKPLEEKPKKQKSKKEKKTKVVEAPEPIVE------ 5583
            ..::.||.                  |::|:.|:::.|..|.:.:|....:|.....:|      
Human  1391 EFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKW 1455

  Fly  5584 -------SAVPEAVVEPTVEVTFVEEPVVEVTTVVEEVTPETQPEPTPVSEVA--PSQPLSWSSI 5639
                   ..:...:.|...|:..:|.....:...:.::....|...:.:|.:.  ..:..|::..
Human  1456 DHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQF 1520

  Fly  5640 VS--QTTEVTTNVTE-TRFTEEPED---------------KKPLEEKPKK-QKPKKEKKTKVVEA 5685
            |:  ::..:...:|: .|:.||..:               ::..||..:| |:...|.:.|:. .
Human  1521 VTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLA-V 1584

  Fly  5686 PEPIVESAVPE-AVVEPTVEVTFVEEPVVEVTTVVEEVTPETQPEPTPVSEVAPSQPLSWSSIVS 5749
            |..|..||... .|::..:::....|.:....|.......:.....:.|.|.|..|. .:..|:.
Human  1585 PIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQ-QYEDILR 1648

  Fly  5750 QTTEVTTNVTE---------------TRFTEEPEDKKPSEEKP-KKQKAKKEKKTKVVEA-PEPI 5797
            :..|..|.:..               ..:.|..|.|..|.|.. ...:.|.|.:.::::| ...:
Human  1649 RAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEV 1713

  Fly  5798 VESAVPEAVVEPTVEVTF---VEEPVVEVTTVVEEVTPETQPEPTPV--------SEVAPSQP-- 5849
            |..|...:.:....|..|   .::.|..:...:|::....:..|..:        |.||..|.  
Human  1714 VSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFD 1778

  Fly  5850 ---LSWS-------SIVSQTTEVTTNVTETRFTEEPEDKKPLEEKPKKQKPKKEKKTKVVEAPEP 5904
               ||:|       |.:..|:|::....:...|...:....:|.|..:.:..:....|:      
Human  1779 ELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKL------ 1837

  Fly  5905 IVESAVPEAVVEPTVEVTFVEEPVVEVTTVVEEVTPETQPEPTPVSEVAP--SQPLSWSSI---V 5964
                    ..:....::..::....:...:.||.:...:.....:|.:|.  ....|.|.|   :
Human  1838 --------GSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQL 1894

  Fly  5965 SQTTEVTTNVTETRFTEEPEDKKPLEEKPKKQKAKKEKKTKVVEAPEPIVESAVPEAVVEPTVEV 6029
            .||.|.|.::.:   .|....:|.|.:..:..||.:.....:    :.|:..|.....:..:.:.
Human  1895 RQTVEATNSMNK---NESDLIEKDLNDALQNAKALESAAVSL----DGILSKAQYHLKIGSSEQR 1952

  Fly  6030 TFVEEPVVEVTTVVEEV-----TPETQPEPTPVSEVAPSQPLSWSSIVSQTTEITTNVTETRFTE 6089
            |.......::...||.:     |.:::.:...|.:.|         ...|..|:..::.:   .|
Human  1953 TSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKA---------FQDQKEELLKSIED---IE 2005

  Fly  6090 EPEDKKPLEEKPK---------------------------KQKSKKEKKTKVVEAPEPIVESAVP 6127
            |..||:.|:|..:                           |.|:|:..:..|..|||  |:..:.
Human  2006 ERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPE--VDREIN 2068

  Fly  6128 EAVVEPTVEVTFVEEPVVEVTTVVEEVTPETQPEPTPVSEVAPSQPLSWSSIVSQTTEVTTNVTE 6192
            .      :|||:.:         .:.:..|.|.:...:.::. .:..:..|.||:..|..::|..
Human  2069 R------LEVTWDD---------TKRLIHENQGQCCGLIDLM-REYQNLKSAVSKVLENASSVIV 2117

  Fly  6193 TRFT-EEPEDKKPLEEKPKKQKPKKEKKTKVVEAPEPIVESAVPE---------AVVEPTVEVTF 6247
            ||.| ::.||.|....|.:..|.|...|.|.::......:..:.|         ::|:..:|.|.
Human  2118 TRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTV 2182

  Fly  6248 VEEPVVEVTTVVEEVTPETQPEPTPVSEVAPSQP--LSWS-SIVSQTTEVTTNVTE--------T 6301
              :..::|:..:||.....:...:...:|..::.  ..|| :.|.|..|..:|:..        .
Human  2183 --DKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLK 2245

  Fly  6302 RFTEEPEDKK-PLEEKPKKQKSKKEKKTKVVEAPEPIVESAVPEAVVEPTVEVTFVEEPVVEVTT 6365
            .|..|.::|. .|||...|....|| .||.:|.|.                ::.|:|..:::...
Human  2246 EFESEVKNKALRLEELHSKVNDLKE-LTKNLETPP----------------DLQFIEADLMQKLE 2293

  Fly  6366 VVEEVTPETQPEPTPVSEVAPSQPLSWSSIVSQTTEVTTNVTE--TRFTEEPEDKKPLEEKPKKP 6428
            ..:|:|           |||..   :.....:|:|:|...:.:  |.||:               
Human  2294 HAKEIT-----------EVAKG---TLKDFTAQSTQVEKFINDITTWFTK--------------- 2329

  Fly  6429 KAKKEKKTKVVEAPEPIVESSVPEAVVEPTVEVTFVEEPVVEVTTVVEEVKPETQPEPTSVSEV- 6492
                             ||.|:          :...:....|....|::::.|.|.:.:::|.. 
Human  2330 -----------------VEESL----------MNCAQNETCEALKKVKDIQKELQSQQSNISSTQ 2367

  Fly  6493 ------------APSQPL--SWSSIVSQTTEVTTNVTETRFTEEPEDKKPLEEKPKKPK-----A 6538
                        |..:.|  :.:.::.:...|:...::|:.:.:...:|...|..::.:     |
Human  2368 ENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGA 2432

  Fly  6539 KKEKKTKVVEAPEPIVESSVPEAVVEPTVEVTFVEEPVVEVTTVVEEVTPETQPEPTPVSEVAPS 6603
            |...|    |:.:...:|.|.||.:.   ::..:.:.|.:..:.::.||.|.|.....:|:    
Human  2433 KAAAK----ESSDRTGDSKVLEAKLH---DLQNILDSVSDGQSKLDAVTQEGQTLYAHLSK---- 2486

  Fly  6604 QPLSWSSIVSQATEVTTNVTE--TRFTEE-PEDKKPLEEKPKKPKAKKEKKTKV------VEA-- 6657
                  .|||...|..|...|  ..|.:: .:||:.|::...:..:.:::..|:      :|.  
Human  2487 ------QIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERF 2545

  Fly  6658 -PEPIVESAVPEDVVEPTVEVTFVEEPVVEVTTVVEEVTPETQ-------------QEPTPVSEV 6708
             .|.:.||  .:.:.|...||..||..:.|:....|.:...:|             ||....|::
Human  2546 NTENLGES--KQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQL 2608

  Fly  6709 APS---------QPLSWSSIVSQTTEVTTNVTETR--FTEEPEDKKPLEEKPKKPKAKKEKKTKV 6762
            ..|         :.|....:..|..|......::.  :.:..:|:....|.....|...||:...
Human  2609 LTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQ 2673

  Fly  6763 VEAPEPIVESSVPEAVVEPTVEVTFVEEPVVEVTTVVEEVTPETQPEPTPVSEVAPSQPLSWSSI 6827
            ::.    :.....|..|:..:.:...|:.:.......:.|. :||.|  .:.||       |:.|
Human  2674 IQD----ILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVI-QTQLE--TLKEV-------WADI 2724

  Fly  6828 VSQTTEVTTNVTE--TRFTEEPEDKKPLE----------EKPKKQKPKKEKKTKVVEAPEPIVES 6880
            :|.:....:.:..  :::.:..|.|..||          |.|.:.:|..::|..:::..:.|:..
Human  2725 MSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSE 2789

  Fly  6881 AVPED--------------VVEPTVEVTFVEEPVVEVTTVVEEVKPETQPEPTPVSEVAPSQPLS 6931
            |  ||              :.|.|.:.:|.:....|:.|...::....:.:...|.|:.... |.
Human  2790 A--EDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDH-LM 2851

  Fly  6932 WSSIVSQTTEVTTNVTET--RFTEEPEDKKPLEEKPKKQKPKKEKKTKVVEAPE------PIVES 6988
            :...|.:.|:...:..|.  |:::...|....::|..|.|       :::::.|      ..|||
Human  2852 YLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIK-------ELIDSREIGASRLSRVES 2909

  Fly  6989 AVPEDVVEPTVEVTFVEEPVVEVTTVVEEVKPETQPEPTPVSEVAPSQPLSWSSIVSQTTEVTTN 7053
            ..||  |:.....:..|....|:..:..:.|                   .|...|.||.....|
Human  2910 LAPE--VKQNTTASGCELMHTEMQALRADWK-------------------QWEDSVFQTQSCLEN 2953

  Fly  7054 VTETRFTEEPED-------KKPLEEKPKKQKPKKEKKTKVVEAPEPIVESA-VPEDVVEPTVEVT 7110
            :.......|.|.       ::.||:.....|...::.|        ::|.. ..|::||      
Human  2954 LVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLT--------LLEGKNTDEEIVE------ 3004

  Fly  7111 FVEEPVVEVTTVVEEVKPETQPEPTPVSEVAP-SQPLS-WSSIVS-----------QTTEVTTN- 7161
             ......|:...:::.:|.|:...:.::|:.. |:.|| :|..||           |.::...| 
Human  3005 -CWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNK 3068

  Fly  7162 --VTETRFTEEPEDKKPLEEKPKKQKPKKEKKTKVVEAPEPIVESA----VPEDVVEPTVEVTFV 7220
              :.:.||                :|..::.:..:|.|.   :.:|    :|:::.|.:..:..:
Human  3069 EQILQQRF----------------RKAFRDFQQWLVNAK---ITTAKCFDIPQNISEVSTSLQKI 3114

  Fly  7221 EEPVVE------------------VTTVVEEVKPETQPEPTPVSEVAPSQPLSWSSIVS---QTT 7264
            :|.:.|                  .|.:.:|.....|.:.|...|       .|.:..|   |..
Human  3115 QEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKE-------DWKNFHSNLHQKE 3172

  Fly  7265 EVTTNVTETRFTEEPEDKKPLEE-KPKKQKPKKEKKTKVVEAPEPIVESAVPEDVVEPTVEVTFV 7328
            ....|: :.:..:.....:|::: ..|.:|...|...::.:.|....|....:.|:|   |:...
Human  3173 SALENL-KIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLE---EIHCY 3233

  Fly  7329 EEPVVEVTTVVQEV---KPETQPEPTPVSEVAPSQPLSWSS-----------IVSQTTEVTTNVT 7379
            |..:..:....|::   :..::.....||::: ||.|:.|:           ||::..:.:..:.
Human  3234 EPQLNRLKEKAQQLWEGQAASKSFRHRVSQLS-SQYLALSNLTKEKVSRLDRIVAEHNQFSLGIK 3297

  Fly  7380 ETR------------FTEEPEDKKPLEEKPKK------QKPKKEKKTK-VVEAPEPIVESAVPED 7425
            |.:            :.....||..|:.:..|      .|.:||.:.| :|...|.::::..||.
Human  3298 ELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEG 3362

  Fly  7426 VVEPTVEVTFVEEPVVEVTTVVEEVTPETQPEPTSVSEVAPSQPLLWSSIVSQTTE--------- 7481
            :  ||:                       |.:..||.:       :|:|::|....         
Human  3363 I--PTI-----------------------QQQLQSVKD-------MWASLLSAGIRCKSQLEGAL 3395

  Fly  7482 -----------------DVAEALITDVAEDQKPLMEKPKKLKAGKEKKSKVQNVEESILESDVPL 7529
                             |..||.:.:.......|.:|...|  ||.|          :|..:|  
Human  3396 SKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTML--GKAK----------LLNEEV-- 3446

  Fly  7530 SVVEPIIGFTTVQKDVPPKTESHTFSWSSIVAQSVEVPRTIPKHVESKTGGIQNFIAQ------E 7588
                                    .|:||:: :::||         ...|..::::.|      :
Human  3447 ------------------------LSYSSLL-ETIEV---------KGAGMTEHYVTQLELQDLQ 3477

  Fly  7589 QNYSTVVNDSVKKPKPKKEKKIVQPIQQPTGESVPVRKDHMREGVTKAVPEPQTLSWSSIVSHNI 7653
            :.| ..:.:..|:...|.||            .|.:.:::.|:  .||..     .|.......:
Human  3478 ERY-RAIQERAKEAVTKSEK------------LVRLHQEYQRD--LKAFE-----VWLGQEQEKL 3522

  Fly  7654 DLTPTFTENRVIEAVDEINPDDSSSNQEGELPIHVDERKRKPKKDKKRDQNIETSVVYEE----- 7713
            |      :..|:|.  :.:..:::.....||.:|..|           .|.:..||::..     
Human  3523 D------QYSVLEG--DAHTHETTLRDLQELQVHCAE-----------GQALLNSVLHTREDVIP 3568

  Fly  7714 --IPETERVAVSSTPEFSIQLPAPTKPSVWSS-----SDTYAEVVKKSGYNNNTN---IKYQKIE 7768
              ||:.|..|:.|..:            .|.:     |:|      ::.:||..|   :..||.:
Human  3569 SGIPQAEDRALESLRQ------------DWQAYQHRLSET------RTQFNNVVNKLRLMEQKFQ 3615

  Fly  7769 AREPIKSEPKHTFVEVQTHEDLLEFPDPIIPAIERDEALEKPSQLSWKDLVDEDDVDPLESWH-- 7831
                            |..|.|....:.:.|...|.      |..:.|::    .:..::.||  
Human  3616 ----------------QVDEWLKTAEEKVSPRTRRQ------SNRATKEI----QLHQMKKWHEE 3654

  Fly  7832 ----KGETDSVEIKTQKPIQERHSRVSVKPEIQITEVVTETQS---QSETDQEFLEITSKKRNRS 7889
                :.|.:.|..:.|:.:.|.|  |:.:...|.|::.:..|:   |.....:|||    :..:|
Human  3655 VTAYRDEVEEVGARAQEILDESH--VNSRMGCQATQLTSRYQALLLQVLEQIKFLE----EEIQS 3713

  Fly  7890 RSRSQQSQASNID---EKHQKKKSKKPKNTVPKAPAQQPTEAPEDVQPPKESVPSVEEPSPPPAP 7951
            ...|:.|.:|..|   ..|     |..||...|..........:.::..:..:..:|:       
Human  3714 LEESESSLSSYSDWYGSTH-----KNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEK------- 3766

  Fly  7952 SPNTSGMSWAAIAAHNVPEPVQHIRPLQAEAKPTVVEDVRKSTNEHTVNIPITFETTEPKTKKPK 8016
                 |.|....|.......|:::...:||.       :||..::|...:            |..
Human  3767 -----GHSLLKSAREKGERAVKYLEEGEAER-------LRKEIHDHMEQL------------KEL 3807

  Fly  8017 QKSKRKLPTDVVDFINAEKSIHQVIASKPEIVEEPGSIIVEDVNNTLTSWEIKTPLAPFEFVAES 8081
            ..:.||      :.:..||.:|        :.:|     ..|....||.|     :|.::.:...
Human  3808 TSTVRK------EHMTLEKGLH--------LAKE-----FSDKCKALTQW-----IAEYQEILHV 3848

  Fly  8082 EVEPVSESHMEDLPVEK-------VLKTEPIVESTAVDESKTTTTVTTTTTTTETTSNV------ 8133
            ..||..|.:.:...:.|       ||..||.|:|.. ::.:....:....|..:....:      
Human  3849 PEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVR-EKGEALLELVQDVTLKDKIDQLQSDYQD 3912

  Fly  8134 --SIPEEPKKVVEPEKKPEEPKKPAYAGLPVDDSSNSWMDVLDEPMNFSDDEEEP-VPEPLKEET 8195
              ||.:|....:|.:.|..|            |.::...:|....:..|.....| :.|....||
Human  3913 LCSIGKEHVFSLEAKVKDHE------------DYNSELQEVEKWLLQMSGRLVAPDLLETSSLET 3965

  Fly  8196 LVEEVVEEKPIV-EVSVVDDSKSITTVTTTTTTTETISELPIPEEPKKVVEPEKKPEEPKKPAYA 8259
            :.:::...|.:: |::..:|..:...:...|...:....|     ..|:.:......:..|.:|:
Human  3966 ITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHL-----QAKLKQNVHAHLQGTKDSYS 4025

  Fly  8260 GL----------------------PVDESSSSWMDVLDEPMNFSDDEEEPVPE-PVKEETLVEEV 8301
            .:                      ...:...:|:..:...:       ||.|: |:.....:::|
Human  4026 AICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDL-------EPSPQPPLSRAEAIKQV 4083

  Fly  8302 VEEKPIVE---------VSVVDDSKSI--TTVTTTTTTTETISKLPISEEPKKVVEPEKKPEEPK 8355
            ...:.:.|         .|:.|.|.:.  ||......|.:||.        :|:|:.:       
Human  4084 KHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIE--------QKLVQAQ------- 4133

  Fly  8356 KPAYAGLPVDDSSNSWMDV---LDEPMNFSDDEEEPVPEPVKEETLVEEVVEEKPIVEVSVVDDS 8417
                      :.:..|.::   ..|...:..|.::.:....:..:.:|..:.:..:.:|.  |..
Human  4134 ----------NLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVK--DFV 4186

  Fly  8418 KSITTVTTTTTTTETISELPIPEEPKKVVEPEKKPEEPKKPAYAGLPVDDSSNSWMDVLDEPMNF 8482
            |.:.:...:..|        |.|:..|:.:.|:.||..:        ::..::.|:|:..:..|.
Human  4187 KKLQSKQASVNT--------IIEKVNKLTKKEESPEHKE--------INHLNDQWLDLCRQSNNL 4235

  Fly  8483 SDDEEEPVPEPVKEETL-------VEEVVEEKPIVEVSVVDDSKSITTVTTTTTTTETISELPIP 8540
            ....||.:     :.|.       |.||..||...|.    |:.:.:...:|....|.:.:|.:.
Human  4236 CLQREEDL-----QRTRDYHDCMNVVEVFLEKFTTEW----DNLARSDAESTAVHLEALKKLALA 4291

  Fly  8541 EEPKKVVEPEKKPEEPKKPAYAGLPVDESSSSWMDVLDEPMNFSDDEEEPVPEPLKEET------ 8599
            .:.:|....:.|.::.|                   :.|.:|..|      .|.:||:|      
Human  4292 LQERKYAIEDLKDQKQK-------------------MIEHLNLDD------KELVKEQTSHLEQR 4331

  Fly  8600 --VVEEVVEKKPIVEVSVVDDSKTITT---------VTTTTTTTETISELPIPEEPEKV---EQA 8650
              .:|:::::|..|.|:.:::...:.:         ........|.:.:.|.|:..:.:   ..|
Human  4332 WFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLA 4396

  Fly  8651 VVKVEEPKKPAYAGLPVDASSSSWMDVLDEPMNFSDSEEEPVPESQTEVTPLAPFKDVAVDKVQK 8715
            :....|.|:.....|..||...    :.|..:|.....::.:.::|:.|..|:       |.|.:
Human  4397 ICSELEAKQMLLKSLIKDADRV----MADLGLNERQVIQKALSDAQSHVNCLS-------DLVGQ 4450

  Fly  8716 PVETANISIDSGNTEAEKTP--LAPFEE-------------------IPDSPLDDAFICETSYWS 8759
            ..:..|.::      :|||.  :|.|:.                   :||........|:::  .
Human  4451 RRKYLNKAL------SEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSA--Q 4507

  Fly  8760 ATLKPGQKPASTV---------ETTETKQEESQPIKVTIPDDEGIDEVAVKSPTDQPTTWSAIVQ 8815
            |:||..|...:.:         |.||  ||:|              ||..|            :|
Human  4508 ASLKTYQNEVTGLWAQGRELMKEVTE--QEKS--------------EVLGK------------LQ 4544

  Fly  8816 TETTVFPTPDVQKDNEKTPDWSTHVVSKTTDFQEPKPLKNVVDSENITTTTTTYVTTTVTTHKDT 8880
            ...:|:.:. :||.:.:..:...::||:       |..|     |:............:.|..:.
Human  4545 ELQSVYDSV-LQKCSHRLQELEKNLVSR-------KHFK-----EDFDKACHWLKQADIVTFPEI 4596

  Fly  8881 SIVENESPATSYVSTVVTSHKNELDLEPEPFELTKPDNLIENLNREAFKVHPQYEFLQGQYQQLK 8945
            ::: |||   |.:.|.:..::|.|:..||      .:||:..|.|....:.|....:...|...|
Human  4597 NLM-NES---SELHTQLAKYQNILEQSPE------YENLLLTLQRTGQTILPSLNEVDHSYLSEK 4651

  Fly  8946 ----------VVNITKEPY--LEEP----KEDVPLVEDYVIIEPEAIPEINSEILALNLYLDQTN 8994
                      :|.:.|:.:  ::|.    ||...|:|    :..:::.|:.::.|.:        
Human  4652 LNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIE----LTTQSLSELEAQFLRM-------- 4704

  Fly  8995 ILPKTRIDVD-TISQLLTLQKSSDPIVEKETVQGETKSVEILVKKSIVESPIEPIADEPLVIETS 9058
                :::..| .:.:.|:||.....|:::....||... |:..||....|             |.
Human  4705 ----SKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVD-ELNQKKEGFRS-------------TG 4751

  Fly  9059 QSPPEPSKLLWNLSQDNFLKLINHYKQTAGDAFALLPRTTTDTTIA-QETQDDKQKTDGITETVV 9122
            | |.:|.|:|      :.:.|.:..|:......:||    .|||.| ||.:...|:.:...::|.
Human  4752 Q-PWQPDKML------HLVTLYHRLKRQTEQRVSLL----EDTTSAYQEHEKMCQQLERQLKSVK 4805

  Fly  9123 TTTTTTITDRVVEKTEPDASSLPIIPTAQPLTAPTLGNLDQ-----LRLNLYLDDWQPASVDAHL 9182
            ...:     :|.|:|.|....|.:..:       ..|:|..     .|:.::|:|..|     ||
Human  4806 EEQS-----KVNEETLPAEEKLKMYHS-------LAGSLQDSGIVLKRVTIHLEDLAP-----HL 4853

  Fly  9183 ADDLFDGLKRVDVAGSEAELDKDKNQEQQPDGDAKKPDGVTGIPDKDDHDSDDDDDDDDDDDDEG 9247
             |.|              ..:|.::|.|...|:.|......|                       
Human  4854 -DPL--------------AYEKARHQIQSWQGELKLLTSAIG----------------------- 4880

  Fly  9248 GKPTVPEIRKPNDDDDKPNDKDPGSGSSGNVTPTPEHDAQYGQNRSCSSEYR-STDLPGGVGHWR 9311
              .||.|...                     ......|.|...:||.....| ..:|.|.|    
Human  4881 --ETVTECES---------------------RMVQSIDFQTEMSRSLDWLRRVKAELSGPV---- 4918

  Fly  9312 DDSTYLALEAEQPQVKLESVPLAPTISGVESVLTETNTTSPAPAPDPVTAPETSPSTTTSSLNVA 9376
                ||.|..:..|.::..:                               :.......|||.:.
Human  4919 ----YLDLNLQDIQEEIRKI-------------------------------QIHQEEVQSSLRIM 4948

  Fly  9377 NALIQLASATTHTLSAKANAAATATHAAALAATSALLPVATAVVDKLTTTTTAAAETPAATSDVA 9441
            |||                                                              
Human  4949 NAL-------------------------------------------------------------- 4951

  Fly  9442 AVNPYVARATPAATTVAEAATAAAAEIPPAATHTETTTTSSSSGEVVALPTENTGAVRRTTTTTT 9506
                                           :|.|....:                         
Human  4952 -------------------------------SHKEKEKFT------------------------- 4960

  Fly  9507 TVTTTTTVETPSTTSNTTTTTTTTSSNELQEQRQKDLITQELDELLQSLSSVEDGIANMNQSSLD 9571
                                            :.|:||:.:|:..|..|            |.||
Human  4961 --------------------------------KAKELISADLEHSLAEL------------SELD 4981

  Fly  9572 GMLHGLKLIQSNLEVHERDAIELKNQAKKLPTDPATERLLNDTVDRIDLLLRRTQQGITMIANAM 9636
            |            ::.|                                .||..|..:|.|    
Human  4982 G------------DIQE--------------------------------ALRTRQATLTEI---- 4998

  Fly  9637 HGQKKRQQEIDEYQQHLLELEQWIIEVSAELASFEPTSDSSTDEQVLKSQVERSQQLLRTLKDRQ 9701
            :.|.:|..::.:.....||..|.:::::..      ..|..:.|:.|||.:|..           
Human  4999 YSQCQRYYQVFQAANDWLEDAQELLQLAGN------GLDVESAEENLKSHMEFF----------- 5046

  Fly  9702 QSMEDLVEQTRQLQSHPDVSPLADTLMEQLQSIITILREQVTVATKRIFTIEKRIVDLRKAKSEE 9766
             |.||        |.|.:        :|:|.|::..|...:....|.  .:|:::..|      |
Human  5047 -STED--------QFHSN--------LEELHSLVATLDPLIKPTGKE--DLEQKVASL------E 5086

  Fly  9767 AQRQRVLADSLIKPPTEAPASPEAHESIESNENTID-----SSSMPEEEIKPTGVYVETQTSLSL 9826
            .:.||:..||..:.......:.:.|:..::.|..|:     ...:.|..:..|....|.:..||.
Human  5087 LRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSE 5151

  Fly  9827 QQPPVQVVTTTTVEAQTSFKEPAVETAEVALQTQKERSPTENIMVTQTVHHGQETIQIDTTRNKD 9891
            .:..|.||        .||.|..|...|.|.|.:|    |.|.....|:.....|:....||.:.
Human  5152 HKALVSVV--------NSFHEKIVALEEKASQLEK----TGNDASKATLSRSMTTVWQRWTRLRA 5204

  Fly  9892 VPDEPEDVQIEARYHQRPKGDVDRATELILKNVPQAFETTFVEPDETTTEVIVGPDGTKHIVLKK 9956
            |..:.|.:..:|         ||..|....|                               :||
Human  5205 VAQDQEKILEDA---------VDEWTGFNNK-------------------------------VKK 5229

  Fly  9957 VTRTRQQVVQQQQISSIETISDSD--GNIEVHSTGQINLENVHTTDTKADPEEGSVHTVITQQTR 10019
            .|....|:..:...||.|..|.::  ..:|.|.|..:.||           ::.|...::.|||.
Human  5230 ATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELE-----------QQQSALGMLRQQTL 5283

  Fly 10020 GAVVDSTQP----EGVILQEFETEPTIETYEEVIAPGSQAQLIPMQPGDVQTQGTIRAVVQQVTR 10080
            ..:.|...|    |..::||.              ...|.:.:.||. .|:|.|  :.|.|::..
Human  5284 SMLQDGAAPTPGEEPPLMQEI--------------TAMQDRCLNMQE-KVKTNG--KLVKQELKD 5331

  Fly 10081 KVIRKTRKIIKRVVIIDGKEHI---TEEVVEEPEEVEITEEETAPHINVNIVRTVDGKVVSEEEF 10142
            :.:.:|:....:..:.:.||::   |.|:..:.||::|...|...| ..||.:      ::||:.
Human  5332 REMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNH-RQNIEK------MAEEQK 5389

  Fly 10143 QRMM-------QEPGVLIEEVATDLQKPTAEPQQEVFDIESTQVTTTTRTTTATTQE-QEQPEQQ 10199
            ::.:       .|..:.:.|||.|| |...:.|.::.::|.::         ||:|| ..|.::.
Human  5390 EKYLGLYTILPSELSLQLAEVALDL-KIRDQIQDKIKEVEQSK---------ATSQELSRQIQKL 5444

  Fly 10200 TQPTTTETTKEAPVELPAPQVDVEQPVVVATTSPVHVPTADVVEPKDSSPT------STTAAVVD 10258
            .:..||..||                        :...|.:||:.|.....      ...:.:::
Human  5445 AKDLTTILTK------------------------LKAKTDNVVQAKTDQKVLGEELDGCNSKLME 5485

  Fly 10259 VEAVVEDINE-----------------------IWPLEHHLKPTNIDFSQHVEEL---------- 10290
            ::|.|:...|                       |...|:.|...| ..:.|:||.          
Human  5486 LDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLN-QAASHLEEYNEMLELILKW 5549

  Fly 10291 AAPAAVTAETEASMPVEEIWPTSPETGNSLTLEQYEFEPQSPHEESTKSDLVKPQETEPQVVAET 10355
            ...|.|.|....:      |.::     |...|||... |:..|||.:.|              :
Human  5550 IEKAKVLAHGTIA------WNSA-----SQLREQYILH-QTLLEESKEID--------------S 5588

  Fly 10356 KPEGITTGSITITKTTTTITSSTEVPE-----ETLVQNVPADEQ--QPPANKIKTDIQSFLEAE- 10412
            :.|.:|.....:|....|...|.:|.|     |.|.|.:....|  |..|.    |::.| ||| 
Human  5589 ELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAK----DMKKF-EAEL 5648

  Fly 10413 QTLAAALKEQSSTPTGASVAEDVQTQPEEIVLEERTVEISTIKTEENQQEPVIVEEVKSLPVEPE 10477
            :.|.|||::..:|.|...|.        .:.|:|:                  :...:.|..|.|
Human  5649 KKLQAALEQAQATLTSPEVG--------RLSLKEQ------------------LSHRQHLLSEME 5687

  Fly 10478 PVEPELEEVAIAIVEQTEEKPEEPVIEKQPASGPIDLRAATQLFISGEAAASTAPQKTFQISAPS 10542
            .::|:::  |:.:.:.....||:.|     ||.|: ..||.:|                      
Human  5688 SLKPKVQ--AVQLCQSALRIPEDVV-----ASLPL-CHAALRL---------------------- 5722

  Fly 10543 LEDNGAGVLKVVLGKESTNEEDTAAPTTGKVSMTIIETAAAPAADAKRRRKKKKRRDTKHEEELE 10607
                              .||.:....|......|::.|..        :.::..::.||.::|.
Human  5723 ------------------QEEASRLQHTAIQQCNIMQEAVV--------QYEQYEQEMKHLQQLI 5761

  Fly 10608 Q--EQETEPEPVAAVKEPEVSSDVPVSPEDSPRDTVRHESIVEISPDSD------------LSSI 10658
            :  .:|.|.:|||.....|:.:.:....|.:.:.....|.|..::....            |:..
Human  5762 EGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVT 5826

  Fly 10659 EIDTKVKIVED---AVVSSPSESPRTPMV------ELVIPTEVVELALVEDEEQQTTPRI----- 10709
            |::...:..||   .::.:||..|...|:      .|:.|  |.|    |..|:.|...|     
Human  5827 EVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSP--VTE----ESGEEGTNSEISSPPA 5885

  Fly 10710 ---PSPTEKSE--VEQDIKSVQ-----------------TSPQ---HQPKLDETA------VQTS 10743
               |||...::  |.|||...|                 ||..   ::|.|:.:|      :|.|
Human  5886 CRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRS 5950

  Fly 10744 LEVQPDNQENESQTLIVEITETEAQTTPRSEEQSVAVEISTTEIQTDVSGQPAETVEISSQTTVT 10808
            .|.. .|..:|.|..:.|  ..|.|...:...||::.::...|::...|.:|..           
Human  5951 WETL-KNVISEKQRTLYE--ALERQQKYQDSLQSISTKMEAIELKLSESPEPGR----------- 6001

  Fly 10809 TTIEKELQTTPKDSPRAPEAGSSDVVESLVQD--LVKDMTTDLPVRTSEQSTVTETTTTTETHVQ 10871
                         ||.:..|.....:::|:.:  :::|...:|      ||::.|     |...:
Human  6002 -------------SPESQMAEHQSFLQALMDEILMLQDEINEL------QSSLAE-----ELVSE 6042

  Fly 10872 TTTPEPREQTEVIKPETA-HEETSTVELVQFADGEMQTTPPGDQQPASLDDSSLTATSISVSE-- 10933
            :...:|.||..:....|. .|..||:.:......::......||......:.:|........|  
Human  6043 SCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELD 6107

  Fly 10934 PYELEVKTTVAIPADSDTSVAEPTVYEYTQTMQLPKQEKKSKKDKKKKQKNVPEVEQQLPEDQQI 10998
            .:.|..|.|:      ||:::.|                          |...::|.||.:.|.:
Human  6108 SWLLSTKATL------DTALSPP--------------------------KEPMDMEAQLMDCQNM 6140

  Fly 10999 SVTVEIAPELLSESGIVVSTNQQIEDVPHVTPVVDTPIESEEVETPKAQRVQLQITKTTVYDEYP 11063
            .|.:|.....|||.. |.:.|..:|...|      |..|:|:: ..|.:|               
Human  6141 LVEIEQKVVALSELS-VHNENLLLEGKAH------TKDEAEQL-AGKLRR--------------- 6182

  Fly 11064 DLPVHITEQNKVLIASQQSKRSGAGPTSSAVTIEEVGSPTEELVVPITPGPDNLSGEPHNIWFSA 11128
             |...:.|..:.|...|.:.:.|        |.:|......:|....:||......:....|...
Human  6183 -LKGSLLELQRALHDKQLNMQQG--------TAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQ 6238

  Fly 11129 TTSVDKTPIELSQALIMSESL-------------QHYPGQQK---------LTQEPILISTKEAI 11171
            ..|..:...||.|.|...:||             ||...:..         |:||..:...|.:.
Human  6239 RQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSA 6303

  Fly 11172 GDRIK----QLKQASPQQATPLSNVLHLATLSEQI----------------KELPTEQR--ILEV 11214
            .|:::    .|.|....:...|.|||...  .||:                .::||:.:  :..:
Human  6304 EDQMRMKWESLHQEFSTKQKLLQNVLEQE--QEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSL 6366

  Fly 11215 NEGLKDL--DVAIKNG----DKTVIQTTVITVIEKVSTWLETIEYRVYLIRQNSNEGPSEEKLDN 11273
            .:||...  :|:.::|    ....::..:...:...||||:.:|.|:::.....   |.|.:...
Human  6367 LDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALL---PEETETCL 6428

  Fly 11274 YNQ--LNDELSTIKQNVVQLERQLSKAEPE--------PQLLQCVDSLKEHVDAVEQVTQQNQVQ 11328
            :||  |..::..:.:.:.:.:...|:|.||        ...|.|   |...:..::.|..|    
Human  6429 FNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGC---LLGRLSLLDSVVNQ---- 6486

  Fly 11329 DSNDLDKWHNFEVLLYNVSSVLADLQQSYDLLINQEYPLSAKLAQLDE--LEQQHEAAQQQLAHL 11391
                  :.|..:..|..:.:...||:..:..|.:.:|.:..|||.:.|  :.:|.||.||....|
Human  6487 ------RCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGL 6545

  Fly 11392 CQ-NARAFQRDFPGKKMPQDVHNAFETSK------NIANNIQAERERVLQLQSLAEEYEQTLKEF 11449
            .: :|...:....|.|:..:..:..|.||      .:...|.:.|..:.|..:|..:||:.|:: 
Human  6546 KEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQD- 6609

  Fly 11450 TKITVLADKLV--------ESPIVSSSLEQLNNEVQKQRKFFVNLSHCRAMLESLEENIDSETRE 11506
                 |||.|.        :..|:.||.|::...:.|.:::|..|.....:.|:|...|.|...:
Human  6610 -----LADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQ 6669

  Fly 11507 KHSELHKELYNRATSLLDKASERSSKLVQAASRWTVLEKGMRDELQWLQVAQQRVPDLSAVTSAD 11571
            |.::.|.||..:|:::|.:|.:|..:|......|:.|::..::..:.|:|.:..:|.:..|...:
Human  6670 KETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENE 6734

  Fly 11572 YDQY---TTLYQSLSNDISHHYVKMTQLSGIANKLQLLVQAPNLVEETNEALIVLLKLREEVALY 11633
             |:.   .||||.|.:.::.:..|:.|:.....:|.:.:...:|..:.|:.....|....:::..
Human  6735 -DRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKE 6798

  Fly 11634 LHRLLVFKEIWVQYEQQTDKLEAFVREAEQEL-----RNIQIPSQPTHQPIEHMRQFWEIKARFE 11693
            ||||....:.|.:|:.::..|..:::.|:..|     :::.:| |......:|:..|.|.....:
Human  6799 LHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVP-QELEMVRDHLNAFLEFSKEVD 6862

  Fly 11694 LHNNVRTDTGLSFEKSLQVIPLADEMLQRQFHAQLEDRWQAVAQAIELIQHNIVECLSSEDVPAD 11758
            ..:::::.. ||....|..:...|....|...::::.:|..:...|..:|..:.: |..:.:|: 
Human  6863 AQSSLKSSV-LSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQ-LQMDKLPS- 6924

  Fly 11759 EKLKMVERELQEIYLTMTSMKGVIKNEEE----------LCLYIER-------VQVLRTRVGFIG 11806
                  ...:.|:...::.|:.||:.:|:          :..|:::       :...:..|.|:.
Human  6925 ------RHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVN 6983

  Fly 11807 NELGRIGLQEPAIE---------PEKVGEL---FSLSHKISTQIAEELEGA----SVLRDQLQAI 11855
            ..:.:|..|:  :|         .|::|.:   :.:...:.|:..:.|||.    |...:.:|.:
Human  6984 QSVLQISSQD--VESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCL 7046

  Fly 11856 QEGISNQRKHQAKISVILDECEAAERQGADVLEKAVADCQAAGEELVISWQEIMRIRQMLHTLPM 11920
            :.....|.|...:...|.|:..         ::.|:.|||...:.:....:|:.:|.|....|..
Human  7047 KTWFETQEKRLKQQHRIGDQAS---------VQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQ 7102

  Fly 11921 RLKMSVSPVKLERDISQLQDDHAFLESKCTNIMAILRSRLAVWLRYERQLELVHGSVQETDFMME 11985
            ..|..||.:.:. .:.:|....|.|:.....:..:|:|.|..|..::...:.::..:.|..:.:.
Human  7103 NKKEDVSSIVMS-TLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLS 7166

  Fly 11986 LIR-VHGQVDYERLRKATERLEGLAGDLHNREQLIDELKGAAKPLIESCDVQIVEQIESAVQEAV 12049
            ..| :.|.:  |.::...:.|:.|..||..:|:.:.:.......|::.|...:.|.:.:.::|..
Human  7167 RFRLLTGSL--EAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVN 7229

  Fly 12050 VAWNDTSENLQQLRTRYQRAVELWDKYRNASAAVKNSIDQQMDAVKSLEQPLDALQHAKVCQD-- 12112
            :.||:..|.:.:.....:..::||.:|::.|....:::.||.|....|   |.|..:..:..|  
Human  7230 MRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL---LKAATNKDIADDEV 7291

  Fly 12113 ------------NLTTQNDRILELRDIVAKIAADVGLDASALMQGELDALGQRL-----AECKDA 12160
                        .|.|..|.:..|.::..::...|...|::.:|.:..:|.|.|     |.||..
Human  7292 ATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQ 7356

  Fly 12161 ITTLANVA--ETQDKERKELDKEVTLAKAYFNNVQQDISREAPQNPKESEEQLAALRAHLQTLAR 12223
            .:..|.|.  ||..|..:.|:..:..|:.....          |:|           :|...|:.
Human  7357 TSLQAGVLDYETFAKSLEALEAWIVEAEEILQG----------QDP-----------SHSSDLST 7400

  Fly 12224 TEEQLRQLK-ERHQNSEVAPSVASSDDDGI------LEVLAL------WQKIFQDTFQEYHRLST 12275
            .:|::.:|| :..:.|.:||.:...::.|.      .|:..:      |..|...|.:.:.:|.:
Human  7401 IQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQS 7465

  Fly 12276 RLARSQNSSEALRLWRQYLQHVQSFLSCAIPEDYSSLREQQQLCAIHQNLLISQQSVLSETPLES 12340
            .|.:.|...|....|.::|...:..|:..|..:|..|.|||:...:.|..:.|:|.:|....::.
Human  7466 FLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDG 7530

  Fly 12341 E-LSEQYKA---------LTNLHNE---TLSRIMQRNGELERRVSGWNAYRQQLAALLDWLRQRE 12392
            : |.||.:.         ||.|.|:   .:.|..||.|.::.::..|..||:....|..||    
Human  7531 QRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWL---- 7591

  Fly 12393 AERNALQLRYIHLKRVPHLKHRLDAMIQQLDQGEQQSKALQEQQ----------QELARHCDDAL 12447
                 :::.|:.:..:..:...|.......|:.:.:.|....||          ::|....|...
Human  7592 -----VEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGA 7651

  Fly 12448 ATAMRMEQASIGQRISNLRAALKTWQGFLQRVTQLSESYEQRVNQLQQEFGAAQKLLDANSESLP 12512
            ..|::.|.|.|.::          |:....|:    |..::::..|.:::...:|.:..:.|.|.
Human  7652 EAALQAELAEIQEK----------WKSASMRL----EEQKKKLAFLLKDWEKCEKGIADSLEKLR 7702

  Fly 12513 TQPAAIEQLL----GSLRAQRVQ-------LGAQVSALESLTVTQEELKECISPHDMKTIRQRNW 12566
            |....:.|.|    ..|.|::::       :|:....|..|::.::.|...||..|:..:.:|..
Human  7703 TFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVE 7767

  Fly 12567 LLWQQHADLDYQLANLINSIEERLSLLSNYQIRYDRISQWLQRLEQRVEKDADVTAMTNPEQAAK 12631
            ||.:|..:|.:||:.....|.|||:..:.:..:...:.:||.::|.:|.::.|:..    |:..:
Human  7768 LLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILI----EEMIE 7828

  Fly 12632 QLEQQVNSELQLRDKEREWLLSTSRELLTLYSEPEVRSQVQQQSDSLIDRWQRLKYLAKQKATKI 12696
            :|::....|:.:. :|.:..|....|.|...|.....|:::.:...:.||||.|..|...:..|:
Human  7829 KLKKDYQEEIAIA-QENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKL 7892

  Fly 12697 GELKMTLLRLEERIALIRAWLFEVESQLDKPLNFESYTPNVIEAKLKEHEQIQRSIEHHSSNVGE 12761
            .|..:.:.:|::.::.:|.||..:||:|.||:.::|.....|:.||.|.:::||.||.||:.|..
Human  7893 KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVAS 7957

  Fly 12762 VLNLVEMLLNDADSWRTQVNTSGLAASAQNLEQRWKNVCSQSAERKARILTIWNLLQQLIKLTAE 12826
            ||||.|:||:|.|:..|......:..:.:||::||:|:|:.|.||:.:|...|.|.|:.:...:.
Human  7958 VLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSR 8022

  Fly 12827 HKNWLGKQESQIAGFERDQ-------KSHSKHKLEERQMELRAKLEELESQSVNLRQLEQIYAKL 12884
            .::|| |...:.|.|....       |...| |.|..|.::...|.:||       .:.:.|.:|
Human  8023 FEDWL-KSSERTAAFPSSSGVIYTVAKEELK-KFEAFQRQVHECLTQLE-------LINKQYRRL 8078

  Fly 12885 AMSAGVEPENIQKLTLPTKVMV----SMWRQLTPRCHALLDAIDKDAKLMREFNNAQ-------- 12937
            |.      ||........|.||    ..|..|..|..::|..:........||..|:        
Human  8079 AR------ENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLT 8137

  Fly 12938 ---LEATN--------------SLNAIQK-------ALEQLPSAENQQTSKAEP----------- 12967
               |:.||              .|.|.|:       .:||:.:...|...|:||           
Human  8138 EMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELD 8202

  Fly 12968 ------KAVLQRLESLEKK-------------------------LQDAQQHVQQADNLAQEAKTR 13001
                  :.|..|:|...||                         |.|...|.:.||:|.      
Human  8203 ELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLL------ 8261

  Fly 13002 TKQQPQLKQLLELVSAYTTLWQTVQTR---------IVTLKTTW-----LTRAAQAAAS--LPVS 13050
               .||....|.|     :|.|.:::.         :.::...|     |:|..::|.|  ||..
Human  8262 ---SPQPSSNLSL-----SLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSE 8318

  Fly 13051 EA---------ANAAVQVNTLSQRKLRQAQQMQRETSI-------TAKDAYIMELQTAITECQNN 13099
            :.         ...||.::.:...:..:|.....|.:|       :|.::.|.:|..|:.:.:..
Human  8319 DEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQ 8383

  Fly 13100 LDELQRTVVDKTRKPGPQ------KIAKLLGNAQSSTELVKHLSHLLLTECKA-----DDQAAEV 13153
            :.:.:..:..|| ..||:      ...||||...||.:.||.|.|.|..|.::     :..:.|.
Human  8384 IQQTENIIRSKT-PTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET 8447

  Fly 13154 DTVAELTLRFDTLQSQWKARQ-QHDQNASEVGRLTCPLCTQRNWQQIDNDLWRLEQWL----QFA 13213
            .|...:. |::.||:|..::: :..||.             :.|||.::||..:..||    :..
Human  8448 QTAGVID-RWELLQAQALSKELRMKQNL-------------QKWQQFNSDLNSIWAWLGDTEEEL 8498

  Fly 13214 ESTQKAQSAPPSNIELLEDVTQDHREFLLDLESHKSIISSLNVVGDHLATHTLDTEKARQLRSRL 13278
            |..|:.:.:  ::|:.:|...:..:|....::..|:||.|:|:......  ..|::::|.|:.||
Human  8499 EQLQRLELS--TDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFT--QADSKESRDLQDRL 8559

  Fly 13279 EADNERWNNVCINATKWQGLLQTALM--------------GNSEFHQTIGELVEWLQRTEQNIKA 13329
            ...|.||:.||....:|:||||.|||              ....||:....|:..|:..::....
Human  8560 SQMNGRWDRVCSLLEEWRGLLQDALMQCQIFTGQVGRPFLNIKGFHEMSHGLLLMLENIDRRKNE 8624

  Fly 13330 SEPVDLTEERSVLETKFKKFKDLRAELERCEPRVVSLQDAADQLLRSVEGSE------------- 13381
            ..|:|...:..:|:...|:...::.||...:.||.||||.:.|||.:.||::             
Human  8625 IVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGN 8689

  Fly 13382 -------QQSQHTYERTLSRLTDLRLRLQSLRRLSGIYIVKLGAVLGYEGDNLG--VPLHMLSSE 13437
                   :.|:|..|  |.:|.|:....|.|...|.          ..|.|..|  .|....|:.
Human  8690 RLKLLLKEVSRHIKE--LEKLLDVSSSQQDLSSWSS----------ADELDTSGSVSPTSGRSTP 8742

  Fly 13438 LLDNTTLSTSSMQAAAP--NTENANNTDGGDAVDGDVINTTVLARGARFLGRVARASLPIQALML 13500
            ....|.....|:....|  ::.::.:|.||.  |..:........|..||.||.||:||:|.|:|
Human  8743 NRQKTPRGKCSLSQPGPSVSSPHSRSTKGGS--DSSLSEPGPGRSGRGFLFRVLRAALPLQLLLL 8805

  Fly 13501 LLLGVATLVPHG-EDYTCMFSNTFARSLEPMLSYPHGPPP 13539
            ||:|:|.|||.. |||:|..||.||||..|||.|.:||||
Human  8806 LLIGLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPP 8845

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Msp300NP_001188695.1 SPEC 17..220 CDD:238103
SPEC 9546..9732 CDD:295325 30/185 (16%)
sbcc 11187..12008 CDD:129705 173/913 (19%)
SMC_prok_B 11614..12442 CDD:274008 170/923 (18%)
SPEC 11994..12156 CDD:295325 34/180 (19%)
SPEC 12374..12564 CDD:295325 37/210 (18%)
Lipase_chap 12376..12529 CDD:281297 29/166 (17%)
SPEC 12703..12923 CDD:238103 69/230 (30%)
SPEC 12816..13032 CDD:295325 59/309 (19%)
SPEC 13196..13374 CDD:238103 52/195 (27%)
KASH 13484..13540 CDD:287506 36/57 (63%)
SYNE1XP_006715470.1 CH 28..141 CDD:237981 17/115 (15%)
CH 187..285 CDD:278723 25/127 (20%)
SPEC 1454..1661 CDD:295325 31/208 (15%)
SPEC 1663..1874 CDD:238103 31/224 (14%)
SPEC 2417..2622 CDD:238103 42/223 (19%)
SPEC 2523..2739 CDD:238103 37/231 (16%)
SPEC 2741..2944 CDD:295325 39/233 (17%)
SPEC 3072..3283 CDD:238103 36/241 (15%)
SPEC 3184..3395 CDD:238103 40/246 (16%)
SPEC 3397..3602 CDD:295325 46/309 (15%)
SPEC 3824..4042 CDD:238103 38/245 (16%)
SPEC 4148..4344 CDD:295325 41/247 (17%)
SPEC 4273..4459 CDD:295325 34/221 (15%)
SPEC 4493..4677 CDD:295325 45/236 (19%)
SPEC 4895..5088 CDD:295325 60/483 (12%)
SPEC 5003..5216 CDD:238103 54/266 (20%)
SPEC 5535..>5697 CDD:295325 48/220 (22%)
SPEC 5643..5842 CDD:295325 48/281 (17%)
SMC_prok_B 5944..6730 CDD:274008 177/911 (19%)
SPEC 5971..6196 CDD:295325 55/315 (17%)
SPEC 6808..7030 CDD:295325 34/233 (15%)
SPEC 6926..7137 CDD:238103 37/222 (17%)
SPEC 7046..7244 CDD:238103 38/209 (18%)
SPEC 7173..7361 CDD:295325 38/192 (20%)
SPEC 7365..7567 CDD:238103 46/222 (21%)
SPEC 7469..7680 CDD:238103 47/233 (20%)
SPEC 7793..8008 CDD:238103 63/219 (29%)
SPEC 8012..8222 CDD:238103 46/224 (21%)
SPEC 8476..8709 CDD:238103 60/238 (25%)
KASH <8814..8845 CDD:287506 18/30 (60%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 73 1.000 Domainoid score I9258
eggNOG 1 0.900 - - E2759_KOG0516
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D46at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_104187
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X5336
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.810

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