DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Msp300 and EVPL

DIOPT Version :10

Sequence 1:NP_001188695.1 Gene:Msp300 / 3771968 FlyBaseID:FBgn0261836 Length:13540 Species:Drosophila melanogaster
Sequence 2:NP_001307676.1 Gene:EVPL / 2125 HGNCID:3503 Length:2055 Species:Homo sapiens


Alignment Length:2023 Identity:400/2023 - (19%)
Similarity:733/2023 - (36%) Gaps:645/2023 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly 11383 AAQQQLAHLCQ----NARAFQRDFPGKKMPQDVHNAFETSKNI-ANNIQAERERVLQLQSLAEEY 11442
            ||.|:||.|..    ||...:||.            .||.|.: .:.:.:|:.:.||.|   :|.
Human    34 AATQELALLISRMQANADQVERDI------------LETQKRLQQDRLNSEQSQALQHQ---QET 83

  Fly 11443 EQTLKEFTKITVLADKLVESPIVSSSLEQLNNEVQKQRKFFVNLSHCRAMLESLEENIDSETREK 11507
            .::|||       |:.|         |:.|..:|.|.|:    |.|.:|  |.:|::|       
Human    84 GRSLKE-------AEVL---------LKDLFLDVDKARR----LKHPQA--EEIEKDI------- 119

  Fly 11508 HSELHKELYNRATSLLDKASERSSKLVQAASRWTVLEKGMRDELQWLQVAQQRVPDLSAVTSADY 11572
                 |:|:.|.|   .:.:|     .:|.....||...:...:.|.:|.:|:...:.|      
Human   120 -----KQLHERVT---QECAE-----YRALYEKMVLPPDVGPRVDWARVLEQKQKQVCA------ 165

  Fly 11573 DQYTTLYQSLSNDISHHYVKMTQLSGIANKLQLLV--QAPNLVEETNEALIVLLKL-----REEV 11630
            .||......|...|:.|.:...::.....:|:.||  .|..:..:..:    |||.     :...
Human   166 GQYGPGMAELEQQIAEHNILQKEIDAYGQQLRSLVGPDAATIRSQYRD----LLKAASWRGQSLG 226

  Fly 11631 ALYLHRLLVFKEIWVQYEQQTDKLEAFVREAEQELRNIQIPSQPTHQPIEHMRQFWEIKARFELH 11695
            :||.|.....:::....|||.       |..:|:..::........:..||.:|       .|| 
Human   227 SLYTHLQGCTRQLSALAEQQR-------RILQQDWSDLMADPAGVRREYEHFKQ-------HEL- 276

  Fly 11696 NNVRTDTGLSFEKSLQVIPLADEMLQRQFHAQLEDRWQAVAQAIELIQHNIVECLSSEDVPADEK 11760
                    ||.|:|:.               ||||..:.:.:    ::|..|..:.:.    .|.
Human   277 --------LSQEQSVN---------------QLEDDGERMVE----LRHPAVGPIQAH----QEA 310

  Fly 11761 LKMVERELQEIYLTMTSMKGVIKNEEELCLYIERVQVLRTRVGFIGNELGRIGLQEPAIEPEKVG 11825
            |||   |.|              |...||:..|                                
Human   311 LKM---EWQ--------------NFLNLCICQE-------------------------------- 326

  Fly 11826 ELFSLSHKISTQIAEELEGASVLRDQLQAIQEGISNQRKH-QAKIS-----------VILDECEA 11878
                      ||: :.:|.....:::..::.:.::....: .||.|           .:|.:.||
Human   327 ----------TQL-QHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEA 380

  Fly 11879 AERQGADVLEKAVADCQAAGEELVISWQEIMRIRQMLHTLPMRLKMSVSPVKLER-------DIS 11936
            .|::.| |.|:|..|.|....::.              .||.|......|:.::.       ::.
Human   381 EEKRLA-VTERATGDLQRRSRDVA--------------PLPQRRNPPQQPLHVDSICDWDSGEVQ 430

  Fly 11937 QLQ----------DDHAFL------ESK-----CTNIM-----AILR-SRLAVWLRYERQ----- 11969
            .||          |.||::      |:|     |..|.     |:.| ||||..|:..:|     
Human   431 LLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASELQALKQKLATV 495

  Fly 11970 --------LELVHGSVQETD--------------FMMELIRVHGQVDYERLRKATERLEGLAGDL 12012
                    :|.:..|.|.|.              |.:........:...:.:|...::..|.|||
Human   496 QSRLKASAVESLRPSQQGTQGGPGRGGCGARRSRFRLPTAPSGSDLANPQAQKLLTQMTRLDGDL 560

  Fly 12013 HNREQLIDELKGAAKPLIESCDVQIVEQIESAVQEAVVAWNDTSENLQQLRTRYQRAVELWDKYR 12077
            ...|:.:  |..|..||.....   :|.:|..:.    :...|::.||.|.|..:.|.:..:.:.
Human   561 GQIERQV--LAWARAPLSRPTP---LEDLEGRIH----SHEGTAQRLQSLGTEKETAQKECEAFL 616

  Fly 12078 N----ASAAVK-----NSIDQQMDAVKSL-----EQPLDALQHAKVCQDNLTTQNDRILELRDIV 12128
            :    ..||::     ||:..:...|:.|     |:...||...:..||     .||::.     
Human   617 STRPVGPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQD-----ADRVIR----- 671

  Fly 12129 AKIAADVGLDASALMQGELDALGQRLAECKDAITTLANVAETQDKERKELDKEVTLAKAYFNNVQ 12193
                   |.:|:.:.:..:.|....|.|         .|:|.|.:.|:.|:::..:.:.:     
Human   672 -------GFEATLVQEAPIPAEPGALQE---------RVSELQRQRRELLEQQTCVLRLH----- 715

  Fly 12194 QDISREAPQNPKESEEQLAALRAHL----QTLARTEEQLRQLKERHQNSEVAPSVASSDDDGILE 12254
                    :..|.||...|||:.:.    |.|.|.:.|:|.|.:|:.              .:.:
Human   716 --------RALKASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYH--------------AVGD 758

  Fly 12255 VLALWQKIFQD---TFQEYHRLSTRLA-------RSQ--------NSSEALRLWRQYLQHVQ--- 12298
            .|.|.:|:.||   |:|::......|:       |||        ..:..|:..::..|.:|   
Human   759 QLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQIAYKLQAQKRLTQEIQSRE 823

  Fly 12299 ------SFLSCAIP---EDYSSLREQQQLCAIHQNLLISQQSVLSETPLESELSEQYKALTNLHN 12354
                  |.||.|:.   :|| .|:.....|::...|.:|........||:..:..|.|.|...:.
Human   824 RDRATASHLSQALQAALQDY-ELQADTYRCSLEPTLAVSAPKRPRVAPLQESIQAQEKNLAKAYT 887

  Fly 12355 ETLSRIMQRNGELERRVSGWNAYRQQLAALLDWLRQ----------------------------R 12391
            |..                  |.:|||...|::.|:                            |
Human   888 EVA------------------AAQQQLLQQLEFARKMLEKKELSEDIRRTHDAKQGSESPAQAGR 934

  Fly 12392 EAERNALQLRYIHLKRVPHLKHRLDAMIQQLDQGEQQSKALQEQQQELAR-HCDDALATAMRMEQ 12455
            |:|....||.. ..|||..::|.|:|...||.|...|....:.:::|:.. :.|..|..::...:
Human   935 ESEALKAQLEE-ERKRVARVQHELEAQRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVK 998

  Fly 12456 ASI---GQRISNLRAALKTWQGFLQRVTQLSESYE--------QRVNQLQQEFGAAQKLLDANSE 12509
            |.:   |:|.:.|:|.|:.   ..|:|.||....:        :.|.|::::.|     ||:.:.
Human   999 AQVEEEGKRRAGLQADLEV---AAQKVVQLESKRKTMQPHLLTKEVTQVERDPG-----LDSQAA 1055

  Fly 12510 SLPTQPAAIEQLLGS---LRAQRVQLGAQVSALESLTVTQEE---LKECIS-PHDMKTIRQRNWL 12567
            .|..|   |:||.|.   :.|:...|..::.|||...|..:|   :||.:. ..:::.::....|
Human  1056 QLRIQ---IQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQAL 1117

  Fly 12568 LWQQHADLDYQLANLINSIEERLSLLSNYQIRYDRISQWLQRLEQRVEKDADVTAMTNPE---QA 12629
            ..|...|                      ..|..:..:.:.:|:.|:|......:...|:   :.
Human  1118 RLQMEED----------------------AARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKE 1160

  Fly 12630 AKQLEQ-----QVNSELQ-LRDKEREWLLSTSRELLTLYSE--------PEVR--------SQVQ 12672
            .|::||     |.:|.|: |.::||....:.:|||..|:|:        |:|:        .||.
Human  1161 VKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVD 1225

  Fly 12673 QQSDSLIDRWQRLKYLAKQKATKIGELKMTLLRLEERIALIRAWLFEVESQLDKP-LNFESYTPN 12736
            .:::..|   .|||...::.|.|...::..:.:|...:.::||         .|| :.::..|..
Human  1226 PETEQEI---TRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRA---------QKPTVEYKEVTQE 1278

  Fly 12737 VIEAKLKEHE---QIQRSIEHHSSNVGEVLN--------LVEMLLNDADSW---RTQVNTSG--- 12784
            |:     .||   ::.|.|:...:.:.|::|        |:. |..:.|.|   |.:|.|..   
Human  1279 VV-----RHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIR-LQGERDEWRRERAKVETKTVSK 1337

  Fly 12785 ----------LAASAQNLEQRWKNVCSQSAERKARILTIWNL-----------------LQQLIK 12822
                      |...|:.|.|   .|...:.:|:|....::.|                 :|:::.
Human  1338 EVVRHEKDPVLEKEAERLRQ---EVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVV 1399

  Fly 12823 LTAEHKNWLGKQESQIAGFERDQKSHSKHKLEERQMELRAKLEE-------LESQSVNL---RQL 12877
            ...:.|  |.::.|:::| ..|::...:.:||....:|||.:||       .|.:|..|   |:|
Human  1400 TQKDPK--LREEHSRLSG-SLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVEREL 1461

  Fly 12878 EQIYAKLAMSAGVEPENIQKLTLPTKVMVSMWRQLTPRCHALLDAIDKD----AKLMREFNNAQL 12938
            .|:..::.......|...:|:.:...|.:.....|.....||...:|::    .:|.||..|.|:
Human  1462 RQLTLRIQELEKRPPTVQEKIIMEEVVKLEKDPDLEKSTEALRWDLDQEKTQVTELNRECKNLQV 1526

  Fly 12939 EATNSLNAIQKALEQLPSAENQQTSKAEPKAVLQRLESLEKK--LQDAQQHVQQADNLAQEAKTR 13001
            :    ::.:|||             |::.|.:.:.:..::|.  |:|.:..|.:.  |.:|...|
Human  1527 Q----IDVLQKA-------------KSQEKTIYKEVIRVQKDRVLEDERARVWEM--LNRERTAR 1572

  Fly 13002 TKQQPQLKQLLELVSAYTTLWQTVQTRIVTLKTTW------LTRAAQAAASLPVSEAANAAVQVN 13060
            ..::.:.::|.|.:.           |..||..||      |.||...|.    .|......::.
Human  1573 QAREEEARRLRERID-----------RAETLGRTWSREESELQRARDQAD----QECGRLQQELR 1622

  Fly 13061 TLSQRKLRQAQQMQRETSITA------------KDAYIMELQTAITECQNNLDELQRTVVDKTRK 13113
            .|.::|.:|..|:|.|:.:.:            :...:..|:.||...::.:.|.:||:.|...|
Human  1623 ALERQKQQQTLQLQEESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAK 1687

  Fly 13114 PGPQKIAK 13121
            ...:::::
Human  1688 VSREELSQ 1695

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Msp300NP_001188695.1 SPEC 17..220 CDD:238103
EnvC 194..>393 CDD:443969
PTZ00121 <1704..1881 CDD:173412
SPEC 9546..9732 CDD:413338
rne <10668..10827 CDD:236766
SMC_prok_B 11268..12195 CDD:274008 174/910 (19%)
YhaN 11930..12426 CDD:443752 126/632 (20%)
SMC_prok_B <12205..12954 CDD:274008 191/913 (21%)
YhaN 12817..>13241 CDD:443752 69/339 (20%)
SPEC 13196..13374 CDD:238103
KASH 13484..13540 CDD:463142
EVPLNP_001307676.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..37 2/2 (100%)
4 X 4 AA tandem repeats of K-G-S-P 12..28
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 65..85 5/22 (23%)
SPEC 228..415 CDD:238103 52/307 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 388..418 8/43 (19%)
SH3_10 404..468 CDD:407754 12/63 (19%)
Smc <651..>1154 CDD:440809 121/608 (20%)
Central fibrous rod domain 864..1695 189/940 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 913..938 2/24 (8%)
Smc <930..>1473 CDD:440809 127/600 (21%)
Smc <1348..>1701 CDD:440809 77/388 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1636..1658 2/21 (10%)
Globular 2 1696..2055 400/2023 (20%)
Plectin <1710..1738 CDD:459901
PLEC 1840..1877 CDD:197605
Plectin 1880..1918 CDD:459901
PLEC 1916..1953 CDD:197605
Plectin 1957..1994 CDD:459901
Blue background indicates that the domain is not in the aligned region.

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