DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Msp300 and DSP

DIOPT Version :9

Sequence 1:NP_001188695.1 Gene:Msp300 / 3771968 FlyBaseID:FBgn0261836 Length:13540 Species:Drosophila melanogaster
Sequence 2:NP_004406.2 Gene:DSP / 1832 HGNCID:3052 Length:2871 Species:Homo sapiens


Alignment Length:2691 Identity:503/2691 - (18%)
Similarity:919/2691 - (34%) Gaps:887/2691 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly 11158 LTQEPILISTKEAIGDRIKQLKQASPQQATPLSNVLHLATLSEQIKEL--------PTEQRILEV 11214
            |.:..:::..:...||.|:..:.....:....:|. .:..|...|:|:        ..::|:|::
Human    82 LMRAELIVQPELKYGDGIQLTRSRELDECFAQAND-QMEILDSLIREMRQMGQPCDAYQKRLLQL 145

  Fly 11215 NEGLKDLDVAI----------KNGDKTVIQ--------TTVITVIEKVSTWLETIEYRVYLIRQN 11261
            .|.::.|..||          |.|.....|        |..:|  .:...|:......:.::...
Human   146 QEQMRALYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHVT--SECLGWMRQQRAEMDMVAWG 208

  Fly 11262 SNEGPSEEKLDNYNQLNDELSTIKQNVVQLERQLSKAEPEPQLLQCVDSLK----EHVDAVEQVT 11322
            .:....|:.::::..:::.:...:..:.:::..|.:.....||.:..::|.    |.:|.:.|: 
Human   209 VDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLRQL- 272

  Fly 11323 QQNQVQDSNDLDKWHN---FEVLLYNVS------------------------SVLADLQQSYDLL 11360
             ||.:|.::....|.|   .|.|||:.|                        ..|..|:|..|.|
Human   273 -QNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQL 336

  Fly 11361 INQEYPLSAKL-AQLDELEQQHEAAQQQL----AHLCQNARAFQ---------------RDFPGK 11405
            :..::|.|.|: |.:|.|:.|.....|..    .||.:||..||               :|...|
Human   337 VLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRK 401

  Fly 11406 KMPQDVHNAFETSKNIANNIQAERERVLQLQSLAEEYEQTLKEFTKITVLADKLVESPIVSSSLE 11470
            |.|.|        ||            :.||.|.|:.::..||       .:|::|..      .
Human   402 KYPCD--------KN------------MPLQHLLEQIKELEKE-------REKILEYK------R 433

  Fly 11471 QLNNEVQKQRKFFVNLSHCRAMLESLEENIDSETREKHSELHKEL-------YNRATSLLDKASE 11528
            |:.|.|.|.:|.                 :..:.|......:|.:       |.:...::.|..|
Human   434 QVQNLVNKSKKI-----------------VQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDE 481

  Fly 11529 RSSKLVQAASRWTVLEKGMRDELQWLQVAQQRVPDLSAV----------TSADYDQY-------- 11575
            ...|.....|:|.|...|..|.|         ||.:..:          .|...:||        
Human   482 CILKDNNERSKWYVTGPGGVDML---------VPSVGLIIPPPNPLAVDLSCKIEQYYEAILALW 537

  Fly 11576 TTLYQSLSNDISHHYVKMTQLSGIANKLQLLVQAPNLVEETNEALIVLLK-LREE------VALY 11633
            ..||.::.:.:|.||..:.                  :|:.....|..|| :|:|      ..|.
Human   538 NQLYINMKSLVSWHYCMID------------------IEKIRAMTIAKLKTMRQEDYMKTIADLE 584

  Fly 11634 LHRLLVFKEIWVQYEQQTD--------KLEAFVREAEQELRN--IQIPSQPTHQ-----PIEHMR 11683
            ||    ::| :::..|.::        |:::...:|::..:.  ||:|..|.||     .|.|..
Human   585 LH----YQE-FIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHG 644

  Fly 11684 QFWEIKARFELHNNV--------RTDTGLSFE--------------KSLQVIPLADEMLQRQFHA 11726
            ...::.     ||.|        :.:|.:..|              .:|:.:||||:........
Human   645 TCQDVN-----HNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITV 704

  Fly 11727 QLED--RWQAVAQAIELIQHNIVECLSSEDVPADEKLKMVERELQEIYLTMTSMKGV-------- 11781
            ::.:  ..|..:|||..:.:.:.:.|:  :....||...::.|:..::..:.::.||        
Human   705 KINELKSVQNDSQAIAEVLNQLKDMLA--NFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767

  Fly 11782 -----------------------IKNEEELCLYIERVQVLRTRVGFIGNEL-------------- 11809
                                   :..||.:||.:::|:..|..:..|.|:|              
Human   768 CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTEL 832

  Fly 11810 -------GRIGLQEPAIE------PEKVGELFSLSHKISTQI----------------------- 11838
                   .:...|.|..:      .|||.:|.....:|..||                       
Human   833 QKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQA 897

  Fly 11839 -AEELEGASVLRDQLQAIQEGISN--------QRKHQAKISVILDECEAAER------------- 11881
             .:.|..|...:|.|::::.|.||        |:...::||...|:.|..::             
Human   898 FCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYE 962

  Fly 11882 ------------------------QGADVLEKAVADCQAAGEELVISWQEIMR-IRQMLHTL-PM 11920
                                    ..:.|:.:..||..|...||:....:..| :.:||.:| .:
Human   963 LQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDL 1027

  Fly 11921 RLKMSVSPV-----KLERDI-SQLQDDHAFL-------ESKCTNIMAILRSRLAVWLRYERQLEL 11972
            :||.:...|     :|.||. |:..:.:.||       :::|:.    .:::||.....:||.||
Human  1028 KLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQ----FKAKLASLEELKRQAEL 1088

  Fly 11973 VHGSVQETDFMMELIRVHGQV---------------DYERLRKATE-RLEGLAGDLHNREQLIDE 12021
            ...|.::     .|.:.:||:               |.:|.||:.| |.:....|       .|:
Human  1089 DGKSAKQ-----NLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKND-------YDQ 1141

  Fly 12022 LKGAAKPLIESCDVQIVEQIESAVQEAVVAWNDTSENLQQLRTRYQRAVELWDKYRNASAAVKNS 12086
            |:.|.:...|:...|.:|. |.|::|       ....:::||...|.......:|.|..|.|:|.
Human  1142 LQKARQCEKENLGWQKLES-EKAIKE-------KEYEIERLRVLLQEEGTRKREYENELAKVRNH 1198

  Fly 12087 IDQQMDAVKSLEQPLDALQHAKVCQDNLTTQNDRILELRDIVAKIAADVGLDASALMQGELDALG 12151
            .:::|                    .||..:.:..:.:.....|..:....|.|..::.:||.|.
Human  1199 YNEEM--------------------SNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLS 1243

  Fly 12152 QRLAECKDAITTLANVAETQDKERKELDKEVTLAKAYFNNVQQDISREAPQNPKESEEQLAALRA 12216
            :...:.||.|..|.:......::|:..::.....||..:.:.|.                   :.
Human  1244 RENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQK-------------------KQ 1289

  Fly 12217 HLQ-TLARTEEQLRQLKERHQNSEVAPSVASSDDDGILEVLALWQKIFQDTFQEYHRLSTRLARS 12280
            ||: .|.:..:|..:...||:.|              ||..|   |..||..:|..||     ::
Human  1290 HLEIELKQVMQQRSEDNARHKQS--------------LEEAA---KTIQDKNKEIERL-----KA 1332

  Fly 12281 QNSSEALRLWRQYLQHVQSFLSCAIPEDYSSLREQQQLCAIHQNLLISQQSVLSETPLESELSEQ 12345
            :...||.|.|                 :|     :.:|..:..|.   .:.::|       |..|
Human  1333 EFQEEAKRRW-----------------EY-----ENELSKVRNNY---DEEIIS-------LKNQ 1365

  Fly 12346 YKALTNLHNETLSRI-MQRNGELERRVSGWNAYRQQLAALLDWLRQREAERNALQLRYIHLKRVP 12409
            ::...|:...|:.:: ||:    |...||:.|                                 
Human  1366 FETEINITKTTIHQLTMQK----EEDTSGYRA--------------------------------- 1393

  Fly 12410 HLKHRLDAMIQQLDQGEQQSKALQEQQQELARHCDDALATAMRME-----QASIGQRISNLRAAL 12469
                       |:|...:::::|.|:.:.|............|:|     |.:.|..:|..:..|
Human  1394 -----------QIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQL 1447

  Fly 12470 KTWQGFLQRVTQLSESYEQRVNQLQQEFGAAQKLLDANSESLPTQPAAIEQLLGSLRAQRVQLGA 12534
            :.   .|::|||:..  |:.|...|....||:.:.|.|.|.                        
Human  1448 EV---ELRQVTQMRT--EESVRYKQSLDDAAKTIQDKNKEI------------------------ 1483

  Fly 12535 QVSALESLTVTQEELKECI--SPHDMKTIRQRNWLLWQQHADLDYQLAN-----LINSIEERLSL 12592
                        |.||:.|  ..:|.|.:...|..|  |....|.|.||     .||.::.:...
Human  1484 ------------ERLKQLIDKETNDRKCLEDENARL--QRVQYDLQKANSSATETINKLKVQEQE 1534

  Fly 12593 LSNYQIRYDRISQWLQRLEQRVEKDADVTAMTNPEQAAKQLEQQVNSELQLRDKEREWLLSTSRE 12657
            |:..:|.|:|:||      :|..||.|:|...|..:..:..:|:|..||             :|.
Human  1535 LTRLRIDYERVSQ------ERTVKDQDITRFQNSLKELQLQKQKVEEEL-------------NRL 1580

  Fly 12658 LLTLYSEPEVRSQVQQQSDSLIDRWQRLKYLAKQKATKIGELKMTLLRLEERIALIRAWLFEVES 12722
            ..|...:...|.:::::.:.       ::...|::|.||..|..   :||:...:.:....::..
Human  1581 KRTASEDSCKRKKLEEELEG-------MRRSLKEQAIKITNLTQ---QLEQASIVKKRSEDDLRQ 1635

  Fly 12723 QLDKPLNFESYTPNVIEAKLKEHEQIQRSIEHHSSNVGEVLNLVEMLLNDADSWRTQVNTSGLAA 12787
            |.|           |::..|:|.::.|..:...||   ||..|...||.:.:|.:          
Human  1636 QRD-----------VLDGHLREKQRTQEELRRLSS---EVEALRRQLLQEQESVK---------- 1676

  Fly 12788 SAQNLEQRWKNVCSQSA-ERKARILTIWNL----LQQLIK-LTAEHKNWLGKQESQIAGFERDQK 12846
                 :...:|...|.| |.|:|.|....:    ||.|.: ||.||.                  
Human  1677 -----QAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHL------------------ 1718

  Fly 12847 SHSKHKLEERQMELRAKLEELESQSVNLRQLEQIYAKLAMSAGVEPENIQKLTLPTKVMVSMWRQ 12911
                 .|||....||.:.::|               :...|.....:|...|.|.:::.:|..|.
Human  1719 -----MLEEELRNLRLEYDDL---------------RRGRSEADSDKNATILELRSQLQISNNRT 1763

  Fly 12912 LTPRCHALLDAIDKDAKLMREFNNAQLEATNSLNAIQKALEQLPSAENQ-QTSKAEPKAVLQRLE 12975
            |               :|....|:.|.|..|....|:|..:|...|.|: |.||.:...|:|..|
Human  1764 L---------------ELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERE 1813

  Fly 12976 SLEKKLQDAQQ---HVQQADNLAQEAKTRTKQQPQLKQLLELVSAYTTLWQTVQTRIVTLKTTWL 13037
            ||..|::..:|   .:|:.::....||:..:.:.::||.||...      |.:|..:...||.: 
Human  1814 SLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEK------QQIQNDLNQWKTQY- 1871

  Fly 13038 TRAAQAAASLPV-------------SEAANAAVQVNTLSQRKLRQAQQMQRETSITAKDAYIMEL 13089
            :|..:|...:..             ||......::..:.:|..|:.:...|||.        .:|
Human  1872 SRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQ--------SQL 1928

  Fly 13090 QTAITECQNNLDELQRTVVDKTRKPGPQ-----KIAKLLGNAQSSTELVKHLSHLLLTECKADDQ 13149
            :|..:..|..:|:|::......|:...:     ..:||:.:.     |.|.::.:.|.||:..|:
Human  1929 ETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDG-----LRKKVTAMQLYECQLIDK 1988

  Fly 13150 AAEVDTVAELTLRFDTLQSQWKARQQHDQNASEVGRLTCPLCTQRNWQQIDNDLWRLEQWLQFAE 13214
            .              ||....|.::..::.|||:                       :.:|:.|.
Human  1989 T--------------TLDKLLKGKKSVEEVASEI-----------------------QPFLRGAG 2016

  Fly 13215 STQKAQSAPPSNIELLEDVTQDHREFLLDLESHKSIISSLNVVGDHLATH-----TLDTEKARQL 13274
            |...|.::|.....|:|    ..|:.|:..||...::.:....|..:..|     |:|:..||.|
Human  2017 SIAGASASPKEKYSLVE----AKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDL 2077

  Fly 13275 -----RSRLEA---------DNERWNNVCINATKWQGLL-----------QTALMG-----NSEF 13309
                 |.::.|         |......|.::....:.|:           |.|..|     ||.|
Human  2078 IDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVF 2142

  Fly 13310 HQTIGELVEWLQRTEQNIKASEPVDLTEERSVLETKFKKFKDLRAELERC--EPRV--------- 13363
            ......|...|...:.....::|.|  .:::.::...||........|||  ||..         
Human  2143 LPKDVALARGLIDRDLYRSLNDPRD--SQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQK 2205

  Fly 13364 -----------VSLQDAADQ-LLRSVEGSEQQS-QHTYERTLSRLTDLRLRLQSLRRLSGIYIVK 13415
                       |::.:..|. :||....:|.:| |.:|:....|:.|.   ||....::|||...
Human  2206 RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDF---LQGSSCIAGIYNET 2267

  Fly 13416 LGAVLG-YEGDNLGVPLHMLSSELLD 13440
            ....|| ||...:|:.....:.|||:
Human  2268 TKQKLGIYEAMKIGLVRPGTALELLE 2293

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Msp300NP_001188695.1 SPEC 17..220 CDD:238103
SPEC 9546..9732 CDD:295325
sbcc 11187..12008 CDD:129705 202/1126 (18%)
SMC_prok_B 11614..12442 CDD:274008 181/1033 (18%)
SPEC 11994..12156 CDD:295325 33/162 (20%)
SPEC 12374..12564 CDD:295325 30/196 (15%)
Lipase_chap 12376..12529 CDD:281297 24/157 (15%)
SPEC 12703..12923 CDD:238103 43/225 (19%)
SPEC 12816..13032 CDD:295325 49/224 (22%)
SPEC 13196..13374 CDD:238103 42/235 (18%)
KASH 13484..13540 CDD:287506
DSPNP_004406.2 Globular 1 1..1056 187/1067 (18%)
Interaction with plakophilin 1 and junction plakoglobin 1..584 105/583 (18%)
SPEC 190..366 CDD:295325 32/177 (18%)
SPEC 285..450 CDD:238103 46/214 (21%)
PRK03918 <770..1251 CDD:235175 93/524 (18%)
Cast 1025..1674 CDD:287183 172/899 (19%)
Central fibrous rod domain 1057..1945 238/1221 (19%)
GBP_C <1311..1405 CDD:303769 30/195 (15%)
coiled coil 1375..1386 CDD:293879 3/14 (21%)
coiled coil 1395..1405 CDD:293879 1/9 (11%)
End3 <1507..1655 CDD:289527 40/189 (21%)
Taxilin 1517..1832 CDD:286771 92/425 (22%)
Globular 2 1946..2871 78/399 (20%)
4.5 X 38 AA tandem repeats (Domain A) 1960..2208 54/295 (18%)
Plectin 2048..2086 CDD:279071 8/37 (22%)
PLEC 2084..2121 CDD:197605 4/36 (11%)
Plectin 2123..2164 CDD:279071 8/40 (20%)
4.5 X 38 AA tandem repeats (Domain B) 2244..2446 15/53 (28%)
Plectin 2253..2293 CDD:279071 12/42 (29%)
Plectin 2291..2331 CDD:279071 2/3 (67%)
PLEC 2328..2364 CDD:197605
Plectin 2366..2407 CDD:279071
Plectin <2468..2498 CDD:279071
4.5 X 38 AA tandem repeats (Domain C) 2609..2822
PLEC 2611..2647 CDD:197605
Plectin 2649..2688 CDD:279071
Plectin 2725..2766 CDD:279071
PLEC 2762..2799 CDD:197605
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2810..2871
6 X 4 AA tandem repeats of G-S-R-[SR] 2824..2847
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0516
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.