DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HemK2 and MTQ2

DIOPT Version :9

Sequence 1:	NP_001027221.1	Gene:	HemK2 / 3771966	FlyBaseID:	FBgn0031454	Length:	224	Species:	Drosophila melanogaster
Sequence 2:	NP_010424.3	Gene:	MTQ2 / 851718	SGDID:	S000002547	Length:	221	Species:	Saccharomyces cerevisiae

Alignment Length:	239	Identity:	95/239 - (39%)
Similarity:	127/239 - (53%)	Gaps:	39/239 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 METPYTDHLSPEDFEHVYEPAEDSFLLLDALEKDLEYL-----DRLQPSLCVELGSGSGVIITAL 60
            :.|||...    |::.||||||||||:||.|||:.::|     :||  ::..|:|||||::.|.|
Yeast     2 LPTPYVKC----DYDKVYEPAEDSFLILDCLEKEHDFLKQKFGNRL--AIVCEIGSGSGIVTTFL 60

  Fly    61 AKKL---AGFSLCLATDINPKACNATRRTATRNGAR---LDSIRCSLADALRPRSVDVLLFNPPY 119
            .:..   ...|:.||.||||.|..||..||..|..:   |:.|:..|..::|...||||:|||||
Yeast    61 MQNKIIPQENSIHLAVDINPWALEATLDTAKLNSCKSSFLEVIQADLNSSIRNNQVDVLIFNPPY 125

  Fly   120 VVT--------SDEELQTQQFDSHSESSTDRNLVFSWAGGQDGRRVTDILLKQLDDILSPRGVLY 176
            |..        |.||             .|:.|..:..||:||..:||.||:||:.||||.||.|
Yeast   126 VPAECVPDVPGSREE-------------ADQWLDLALLGGKDGMAITDKLLRQLEQILSPDGVAY 177

  Fly   177 LLLLRENKPEEIIKYLEGLQFRAVKFMERRIPG-EHLCILKVTR 219
            :|....|||:|:||.........||.:|.|..| |.|.:...||
Yeast   178 ILFCARNKPKEVIKRFVDTYKWNVKLIETRKAGWEVLSVYSFTR 221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HemK2	NP_001027221.1	AdoMet_MTases	15..219	CDD:302624	89/223 (40%)
HemK2	NP_001027221.1	HemK	<15..193	CDD:225443	82/196 (42%)
MTQ2	NP_010424.3	AdoMet_MTases	12..221	CDD:418430	89/223 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343735
Domainoid	1	1.000	60	1.000	Domainoid score	I2576
eggNOG	1	0.900	-	-		E1_COG2890
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	132	1.000	Inparanoid score	I1237
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54278
OrthoFinder	1	1.000	-	-		FOG0004328
OrthoInspector	1	1.000	-	-		oto100063
orthoMCL	1	0.900	-	-		OOG6_101563
Panther	1	1.100	-	-	LDO	PTHR45875
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R762
SonicParanoid	1	1.000	-	-		X3597
TreeFam	1	0.960	-	-
	14	13.790