DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HemK2 and n6amt1

DIOPT Version :9

Sequence 1:	NP_001027221.1	Gene:	HemK2 / 3771966	FlyBaseID:	FBgn0031454	Length:	224	Species:	Drosophila melanogaster
Sequence 2:	NP_001002502.1	Gene:	n6amt1 / 436775	ZFINID:	ZDB-GENE-040718-206	Length:	219	Species:	Danio rerio

Alignment Length:	208	Identity:	81/208 - (38%)
Similarity:	110/208 - (52%)	Gaps:	30/208 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FEHVYEPAEDSFLLLDALEKDLEYLDRLQPSLCVELGSGSGVIITALAKKLAGFSLCLATDINPK 78
            |..|||||||||||:||||||.:.|...:|.:|:|:|||||||...||..:...:|.:.||:|..
Zfish    15 FSEVYEPAEDSFLLMDALEKDADRLKDSRPCVCLEVGSGSGVISAFLASLIGAQALYICTDVNAD 79

  Fly    79 ACNATRRTATRNGARLDSIRCSLADALRPR---SVDVLLFNPPYVVTSDEELQTQQFDSHSESST 140
            |...:.:|:..|...:..:...|.:.|.||   .||||:||||||.|..||:     .||...:
Zfish    80 AAQCSMQTSILNNLHVQPVVTDLVECLLPRLNGKVDVLVFNPPYVATPSEEV-----GSHGVEA- 138

  Fly   141 DRNLVFSWAGGQDGRRVTDILLKQLDDILSPRGVLYLLLLRENKPEEIIKYL--EGLQFRAVKFM 203
                  |||||..||.|.:.....:.|:||..|:.||:.:.:|.||.|:..|  .||.
Zfish   139 ------SWAGGLHGREVMNRFFPMIPDLLSEHGLFYLVTVSDNDPEGIVDLLARSGLD------- 190

  Fly   204 ERRIPGEHLCILK 216
                  .|||:.:
Zfish   191 ------GHLCLTR 197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HemK2	NP_001027221.1	AdoMet_MTases	15..219	CDD:302624	80/207 (39%)
HemK2	NP_001027221.1	HemK	<15..193	CDD:225443	75/182 (41%)
n6amt1	NP_001002502.1	HemK	<16..213	CDD:225443	80/207 (39%)
n6amt1	NP_001002502.1	AdoMet_MTases	17..211	CDD:302624	80/206 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580470
Domainoid	1	1.000	80	1.000	Domainoid score	I8572
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5637
Inparanoid	1	1.050	138	1.000	Inparanoid score	I4516
OMA	1	1.010	-	-		QHG54278
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004328
OrthoInspector	1	1.000	-	-		oto39779
orthoMCL	1	0.900	-	-		OOG6_101563
Panther	1	1.100	-	-	LDO	PTHR45875
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3597
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.900