DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9515 and ASMTL

DIOPT Version :9

Sequence 1:	NP_001027233.1	Gene:	CG9515 / 3771965	FlyBaseID:	FBgn0032077	Length:	209	Species:	Drosophila melanogaster
Sequence 2:	NP_004183.2	Gene:	ASMTL / 8623	HGNCID:	751	Length:	621	Species:	Homo sapiens

Alignment Length:	223	Identity:	93/223 - (41%)
Similarity:	125/223 - (56%)	Gaps:	20/223 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLAPIKHLLGNYRIVLASGSPRRQELVKMLGLNAELCPSTFEENLNLEDFKEFSDYIEATALGKA 65
            :|.|:...|.:.|:||||.||||||::...||..|:.||.|:|.|:...|.....|...||..||
Human     2 VLCPVIGKLLHKRVVLASASPRRQEILSNAGLRFEVVPSKFKEKLDKASFATPYGYAMETAKQKA 66

  Fly    66 EEVYSRLRSTGDSKNL----IVIAADTMVTLGKEIYGKPKDPADAIRMLTNLSGTSNRVFTGVVL 126
            .||.:||.    .|:|    :||.|||:||:|..|..||.|..||.|||:.|||..:.|||||.:
Human    67 LEVANRLY----QKDLRAPDVVIGADTIVTVGGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAI 127

  Fly   127 KHANG--------IRKFTDTADVYFGDLLPEQIQSYVDSGDPLDKAGAYGVQGPAGALIHRIDGD 183
            .|.:.        :.:|.:...|.|.:|..|.:..||.||:|:||||.||:|...|.|:..:.||
Human   128 VHCSSKDHQLDTRVSEFYEETKVKFSELSEELLWEYVHSGEPMDKAGGYGIQALGGMLVESVHGD 192

  Fly   184 FYCVMGLPLHRLCCELNKLFL----EDL 207
            |..|:|.||:..|.:|.||:.    |||
Human   193 FLNVVGFPLNHFCKQLVKLYYPPRPEDL 220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9515	NP_001027233.1	Maf	14..199	CDD:238310	83/196 (42%)
ASMTL	NP_004183.2	MAF-like	11..223		90/214 (42%)
		Maf	15..208	CDD:238310	83/196 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	235..279
		ASMT-like	277..621
		dimerization2	287..371	CDD:374853
		AdoMet_MTases	388..599	CDD:388410
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250	508..510
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	144	1.000	Domainoid score	I4644
eggNOG	1	0.900	-	-		E1_COG0424
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H36273
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001706
OrthoInspector	1	1.000	-	-		oto88758
orthoMCL	1	0.900	-	-		OOG6_101328
Panther	1	1.100	-	-	LDO	PTHR43213
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16714
SonicParanoid	1	1.000	-	-		X343
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.840