DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment waw and GUF1

DIOPT Version :9

Sequence 1:	NP_001027089.1	Gene:	waw / 3771960	FlyBaseID:	FBgn0024182	Length:	696	Species:	Drosophila melanogaster
Sequence 2:	NP_068746.2	Gene:	GUF1 / 60558	HGNCID:	25799	Length:	669	Species:	Homo sapiens

Alignment Length:	689	Identity:	359/689 - (52%)
Similarity:	479/689 - (69%)	Gaps:	32/689 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 TVTRRTW-CAVTIFFCRQRNVNSAMIRAISIR----WLLQRPGDKRHSAWLVARSKSLLVRNLST 71
            |:..|.| ||                ||::.|    .||..|| .|.:..|.|..:|.      .
Human     3 TLVGRGWGCA----------------RALAPRATGAALLVAPG-PRSAPTLGAAPESW------A 44

  Fly    72 TNQVKGETEEPSQADLLREFAHMPVERIRNFSIIAHVDHGKSTLADRLLELTGAIARNGGQHQVL 136
            |:::....|...:.|:.|    .|||.||||||:|||||||||||||||||||.|.:.....|||
Human    45 TDRLYSSAEFKEKLDMSR----FPVENIRNFSIVAHVDHGKSTLADRLLELTGTIDKTKNNKQVL 105

  Fly   137 DNLQVERERGITVKAQTASIFHRHKGQLYLLNLIDTPGHVDFSNEVSRSLAACDGVVLLVDACHG 201
            |.|||||||||||||||||:|:..:|:.|||||||||||||||.||||||:||.||:|:|||..|
Human   106 DKLQVERERGITVKAQTASLFYNCEGKQYLLNLIDTPGHVDFSYEVSRSLSACQGVLLVVDANEG 170

  Fly   202 VQAQTVANYHLAKQRQLAVVPVLNKIDIKHANPDQVCQDLKLLFGIDPDEVLRVSAKLGTGVSEV 266
            :|||||||:.||.:.||:|:||:||||:|:|:|::|...::.:|.|..||.:::||||||.|..|
Human   171 IQAQTVANFFLAFEAQLSVIPVINKIDLKNADPERVENQIEKVFDIPSDECIKISAKLGTNVESV 235

  Fly   267 LERVIETVPPPQVQRDSDFRALIFDSWFDKYRGALNLIYVLNGKLEQNQDIQSLATKKVYSVKSI 331
            |:.:||.:|||:|.|.:..|||:|||.||:|||.:..:.:.:|.:.:...|.|..|:|.|.|..:
Human   236 LQAIIERIPPPKVHRKNPLRALVFDSTFDQYRGVIANVALFDGVVSKGDKIVSAHTQKTYEVNEV 300

  Fly   332 SVLRPAECPVPDVSAGQVGLIACNMRNSKESIVGDTIHLKNQAVAAAGSYRPQQPLVFAGVFPAD 396
            .||.|.|.|...:.|||||.:...|::..|:.:|||:.|..|.|.....::..:|:||||::|.|
Human   301 GVLNPNEQPTHKLYAGQVGYLIAGMKDVTEAQIGDTLCLHKQPVEPLPGFKSAKPMVFAGMYPLD 365

  Fly   397 QSKHVALRSAIDKMVLNDSAVTVKIDSSPALGQGWRLGFLGLLHMEVFCQRLEQEHGAEPIITAP 461
            ||::..|:|||:|:.||||:|||..|||.|||.|||||||||||||||.||||||:.|..|:|.|
Human   366 QSEYNNLKSAIEKLTLNDSSVTVHRDSSLALGAGWRLGFLGLLHMEVFNQRLEQEYNASVILTTP 430

  Fly   462 SVTYRLVLSNPKMIKQQGRDTMDISNAALFPEPHSIKEYYEPLVLGTIITPTEYVGQVISLCVER 526
            :|.|:.|||:.|:||:.....:.|.|.|.||:...:.||.||:||||||||.||.|:::.||..|
Human   431 TVPYKAVLSSSKLIKEHREKEITIINPAQFPDKSKVTEYLEPVVLGTIITPDEYTGKIMMLCEAR 495

  Fly   527 RGLQQSSVNIDDTRVLMKYVLPLSEIILDFHDRLKSLSSGYASFSYEDHGYHPSHLVRLDIHLNG 591
            |.:|::.:.||..||::||:.||:||::||:|.|||||||||||.|||.||..:.||::||.|||
Human   496 RAVQKNMIFIDQNRVMLKYLFPLNEIVVDFYDSLKSLSSGYASFDYEDAGYQTAELVKMDILLNG 560

  Fly   592 KPVEELCRIVHVSKATGVARQMVLKLRELIPKQMVQIAIQACVGSKVLARETIKAYRKDVTAKLY 656
            ..||||..:||..||..:.:.:..:|::.:|:|:.:|||||.:|||::||||:|||||:|.||.|
Human   561 NTVEELVTVVHKDKAHSIGKAICERLKDSLPRQLFEIAIQAAIGSKIIARETVKAYRKNVLAKCY 625

  Fly   657 GGDVTRRMKLLKQQAEGKKKMRMFANIRVPHETFINVLK 695
            |||:||:|||||:|||||||:|...|:.||.:.||.|||
Human   626 GGDITRKMKLLKRQAEGKKKLRKIGNVEVPKDAFIKVLK 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
waw	NP_001027089.1	PRK05433	94..695	CDD:235462	337/600 (56%)
		LepA	100..277	CDD:206677	116/176 (66%)
		EF4_II	285..370	CDD:293900	33/84 (39%)
		EF4_III	386..461	CDD:293917	51/74 (69%)
		lepA_C	502..581	CDD:239680	47/78 (60%)
		LepA_C	589..695	CDD:283959	59/105 (56%)
GUF1	NP_068746.2	PRK05433	64..665	CDD:235462	339/601 (56%)
		LepA	69..246	CDD:206677	116/176 (66%)
		EF4_II	254..339	CDD:293900	33/84 (39%)
		EF4_III	355..430	CDD:293917	51/74 (69%)
		lepA_C	471..550	CDD:239680	47/78 (60%)
		LepA_C	558..664	CDD:283959	59/105 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145377
Domainoid	1	1.000	235	1.000	Domainoid score	I2379
eggNOG	1	0.900	-	-		E1_COG0481
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6505
Inparanoid	1	1.050	685	1.000	Inparanoid score	I710
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53758
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003399
OrthoInspector	1	1.000	-	-		oto88838
orthoMCL	1	0.900	-	-		OOG6_100972
Panther	1	1.100	-	-	LDO	PTHR43512
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R536
SonicParanoid	1	1.000	-	-		X2295
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790