DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment waw and eIF5B

DIOPT Version :9

Sequence 1:	NP_001027089.1	Gene:	waw / 3771960	FlyBaseID:	FBgn0024182	Length:	696	Species:	Drosophila melanogaster
Sequence 2:	NP_001246599.1	Gene:	eIF5B / 44261	FlyBaseID:	FBgn0026259	Length:	1144	Species:	Drosophila melanogaster

Alignment Length:	615	Identity:	134/615 - (21%)
Similarity:	230/615 - (37%)	Gaps:	170/615 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 DKRHSAWLVARSKSLLVRNLSTTNQVKGETEEPSQADLLREFAHMPVERIRNFSIIAHVDHGKST 114
            |.|..:.|....:|..:|..:...:.:.|.|:....|.||...         ..::.|||.||:.
  Fly   515 DSREVSVLANDPESRRLRAEARILKRQAEAEKKRSTDELRAGV---------VCVLGHVDTGKTK 570

  Fly   115 LADRLLELTGAIARNGGQHQVL--DNLQVE--RERGITVKAQTASIFHRHKGQLYLLNLIDTPGH 175
            :.|:|.......:..||..|.:  .|:.:|  :|:...||| .|...||..|.|    :||||||
  Fly   571 ILDKLRRTHVQDSEAGGITQQIGATNVPIEAIKEQTKYVKA-AAGFEHRLPGLL----IIDTPGH 630

  Fly   176 VDFSNEVSRSLAACDGVVLLVDACHGVQAQTVANYHLAKQRQLAVVPVLNKI------------D 228
            ..|||..:|..:.||..:|:||..||::.||:.:..|.|:::...:..||||            |
  Fly   631 ESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESIQLLKKKKCPFIVALNKIDRLYDWKQLARRD 695

  Fly   229 IKHANPDQVCQDLKLLFGIDPDEVLRVSAKLGTGVSEVLERV-----IETVPPPQVQRDSDFRAL 288
            ::....:|. .:.:|.|.....:|:...|:.|...:...|..     |..||...:..:.....|
  Fly   696 VRDVLKEQQ-SNTQLEFQQRTKDVILQFAEQGLNAALFYENTDPKTYISLVPTSAISGEGMGNLL 759

  Fly   289 IFDSWFDKYRGALNLIY------------------------VLNGKLEQNQDIQSLATKK--VYS 327
            ...:.|.:...|..|:|                        ::||||.:.|.:....|..  |..
  Fly   760 FMIADFCQNMLAKRLMYSEELQATVLEVKALPGLGTTIDAILINGKLREGQTMVVAGTDGPIVTQ 824

  Fly   328 VKSISVLRP--------AECPVPDVSAGQVGLIACNMRNSKESIVGDTIHLKNQAVAAAG----- 379
            ::|:.:.:|        |.....:|.|.|                |..|..|:...|.||
  Fly   825 IRSLLMPQPMKELRVKNAYVEYKEVKAAQ----------------GVKIAAKDLEKAIAGINLLI 873

  Fly   380 SYRPQQPLVFAGVFPADQSKHVA--LRSAIDKMVLNDSAVTVKIDSSPALG-------------Q 429
            :::|.:..:.        ::.||  |:||:..:.|..:.|.|:..:..:|.             .
  Fly   874 AHKPDEVEIC--------TEEVARELKSALSHIKLAQTGVHVQASTLGSLEALLEFLRTSKIPYS 930

  Fly   430 GWRLG-------------------FLGLLHMEVFCQRLEQEHGAEPI---ITAPSVTYRL---VL 469
            ..|:|                   :..:|..:|..:|..||. |:.:   |....:.|.|   ..
  Fly   931 AIRIGPVVKRDVMKASTMLEHEAQYATILAFDVKIEREAQEM-ADSLGVKIFQADIIYHLFDKFT 994

  Fly   470 SNPKMIKQQGRDTMDISNAALFP-----EPHSIKEYYEPLVLGTII--------TP-----TEYV 516
            :..:.:||:.|:  :..:.|:||     .|..:....:|:|:|.::        ||     .|:|
  Fly   995 AYREELKQKKRE--EFRSVAVFPCKLRILPQFVFNSRDPIVMGVMVENGIVKVGTPICVPSKEFV 1057

  Fly   517 GQVISLCVE---------RRGLQQSSVNID 537
            ...|...:|         |:| |:..|.||
  Fly  1058 DIGIVTSIESNHKQIEFARKG-QEICVKID 1086

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
waw	NP_001027089.1	PRK05433	94..695	CDD:235462	124/571 (22%)
		LepA	100..277	CDD:206677	57/197 (29%)
		EF4_II	285..370	CDD:293900	20/118 (17%)
		EF4_III	386..461	CDD:293917	18/111 (16%)
		lepA_C	502..581	CDD:239680	15/58 (26%)
		LepA_C	589..695	CDD:283959
eIF5B	NP_001246599.1	PRK04004	553..1129	CDD:235195	126/577 (22%)
		IF2_eIF5B	557..769	CDD:206674	59/226 (26%)
		aeIF5B_II	779..889	CDD:293904	21/133 (16%)
		IF-2	890..993	CDD:288813	18/103 (17%)
		IF2_aeIF5B_IV	1016..1110	CDD:293911	16/72 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464675
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840