DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment waw and guf1

DIOPT Version :9

Sequence 1:	NP_001027089.1	Gene:	waw / 3771960	FlyBaseID:	FBgn0024182	Length:	696	Species:	Drosophila melanogaster
Sequence 2:	XP_002933495.1	Gene:	guf1 / 100489624	XenbaseID:	XB-GENE-983364	Length:	676	Species:	Xenopus tropicalis

Alignment Length:	659	Identity:	350/659 - (53%)
Similarity:	473/659 - (71%)	Gaps:	17/659 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 RHSAWLVARSKSLLVRNL------------STTN--QVKGETEEPSQADLLREFAHMPVERIRNF 102
            ||:  :.|:.:.|..:||            .|.|  .:....:..||.:.| :.:...|:.||||
Frog    17 RHT--ISAQQRHLASQNLFGTTLFGLHHLQKTVNPMNILSPRQFSSQKEKL-DMSEYAVDYIRNF 78

  Fly   103 SIIAHVDHGKSTLADRLLELTGAIARNGGQHQVLDNLQVERERGITVKAQTASIFHRHKGQLYLL 167
            .||||||||||||||||||:||.|.:.....||||.|||||||||||||||||:|:..:|:.|||
Frog    79 CIIAHVDHGKSTLADRLLEITGRIPKTDSNKQVLDKLQVERERGITVKAQTASLFYTFEGKKYLL 143

  Fly   168 NLIDTPGHVDFSNEVSRSLAACDGVVLLVDACHGVQAQTVANYHLAKQRQLAVVPVLNKIDIKHA 232
            ||||||||||||.||||||:||.||:|:|||..|:|||||||:.||.:.||:::||:||||:|:|
Frog   144 NLIDTPGHVDFSYEVSRSLSACQGVLLVVDANEGIQAQTVANFFLAFEAQLSIIPVINKIDLKNA 208

  Fly   233 NPDQVCQDLKLLFGIDPDEVLRVSAKLGTGVSEVLERVIETVPPPQVQRDSDFRALIFDSWFDKY 297
            :|::..:.::.:|.|...:.:|:|||.||.|..||:.||..:|||:::|.|..:||:|||.||.|
Frog   209 DPERAEKQIEKMFDIPRSDCIRISAKFGTNVERVLQEVITKIPPPKMERMSPLKALLFDSTFDHY 273

  Fly   298 RGALNLIYVLNGKLEQNQDIQSLATKKVYSVKSISVLRPAECPVPDVSAGQVGLIACNMRNSKES 362
            ||.:..:.:..|::.:...|.|..|.|.|.|..:.:|.|.|.|...:.|||||.:...|:..||:
Frog   274 RGVVANVALFGGEVTKGHKILSAHTGKSYEVNEVGILTPEEVPADKLYAGQVGYLIAGMKEVKEA 338

  Fly   363 IVGDTIHLKNQAVAAAGSYRPQQPLVFAGVFPADQSKHVALRSAIDKMVLNDSAVTVKIDSSPAL 427
            .:|||::|:.|.|.....::..:|:||||::|.|||::..|:.|::|:.||||:|||..|||.||
Frog   339 QIGDTLYLQKQPVEPLPGFKSAKPMVFAGMYPVDQSEYNNLKGALEKLTLNDSSVTVHRDSSAAL 403

  Fly   428 GQGWRLGFLGLLHMEVFCQRLEQEHGAEPIITAPSVTYRLVLSNPKMIKQQGRDTMDISNAALFP 492
            |.|||||||||||:|||.||||||:.|..|:|:|:|.||.:||:||:||:.|...:.|.|.|.||
Frog   404 GAGWRLGFLGLLHLEVFNQRLEQEYNASVIMTSPTVPYRAILSSPKLIKEYGEKEITIVNPAEFP 468

  Fly   493 EPHSIKEYYEPLVLGTIITPTEYVGQVISLCVERRGLQQSSVNIDDTRVLMKYVLPLSEIILDFH 557
            :...:.||.||:||||||:|.|::.:::|||..|||:|:|.|.|||.|::|||:.||:||::||:
Frog   469 DKSQVLEYLEPMVLGTIISPDEFMSKILSLCQSRRGIQKSLVYIDDHRIMMKYLFPLNEIVVDFY 533

  Fly   558 DRLKSLSSGYASFSYEDHGYHPSHLVRLDIHLNGKPVEELCRIVHVSKATGVARQMVLKLRELIP 622
            |.|||||||||||.|||.||..:.||::||.|||:|||||..|.|..||..|.:.:..:|.|.||
Frog   534 DGLKSLSSGYASFDYEDAGYQSADLVKMDILLNGRPVEELVTIAHREKAYPVGKAICERLCESIP 598

  Fly   623 KQMVQIAIQACVGSKVLARETIKAYRKDVTAKLYGGDVTRRMKLLKQQAEGKKKMRMFANIRVPH 687
            :|:.:|||||.:||||:||||:|||||:|.||.||||:||:|||||:|||||||||...|:.||.
Frog   599 RQLFEIAIQASIGSKVIARETVKAYRKNVLAKCYGGDITRKMKLLKRQAEGKKKMRKIGNVEVPK 663

  Fly   688 ETFINVLKR 696
            :.||:||||
Frog   664 DAFISVLKR 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
waw	NP_001027089.1	PRK05433	94..695	CDD:235462	336/600 (56%)
		LepA	100..277	CDD:206677	111/176 (63%)
		EF4_II	285..370	CDD:293900	32/84 (38%)
		EF4_III	386..461	CDD:293917	48/74 (65%)
		lepA_C	502..581	CDD:239680	49/78 (63%)
		LepA_C	589..695	CDD:283959	65/105 (62%)
guf1	XP_002933495.1	PRK05433	73..671	CDD:235462	335/597 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	227	1.000	Domainoid score	I2452
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H6505
Inparanoid	1	1.050	684	1.000	Inparanoid score	I697
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003399
OrthoInspector	1	1.000	-	-		oto102710
Panther	1	1.100	-	-	LDO	PTHR43512
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2295
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.150