DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cana and KIF3B

DIOPT Version :9

Sequence 1:	NP_001027247.1	Gene:	cana / 3771934	FlyBaseID:	FBgn0040233	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	NP_004789.1	Gene:	KIF3B / 9371	HGNCID:	6320	Length:	747	Species:	Homo sapiens

Alignment Length:	670	Identity:	190/670 - (28%)
Similarity:	302/670 - (45%)	Gaps:	115/670 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KNASSIQVCIKVRPC---EPGLT---------SLWQVKEGRSIQLADSHAEPYVFDYVFDEGASN 56
            |::.|::|.::.||.   |...:         .|.||........|....:.:.||.|:|..|..
Human     5 KSSESVRVVVRCRPMNGKEKAASYDKVVDVDVKLGQVSVKNPKGTAHEMPKTFTFDAVYDWNAKQ 69

  Fly    57 QEVFDRMAKHIVHACMQGSNGTIFAYGQTSSGKTYTM---MGDEQNPGVMVLAAKEIFQQISSET 118
            .|::|...:.:|.:.:||.||||||||||.:||||||   .||.:..||:..:...||..||...
Human    70 FELYDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEGIRGDPEKRGVIPNSFDHIFTHISRSQ 134

  Fly   119 ERDFLLRVGYIEIYNEKIYDLLNK-KNQDLKIHESGNGIVNVNCKESIVT-SEDDLLRQLYMGNK 181
            .:.:|:|..|:|||.|:|.|||:| :.:.|::.|..:..|.|....|.|| |..::...:.:||:
Human   135 NQQYLVRASYLEIYQEEIRDLLSKDQTKRLELKERPDTGVYVKDLSSFVTKSVKEIEHVMNVGNQ 199

  Fly   182 ERVVGETNMNERSSRSHAIFRIIIESRKSDHSDNDTVKQSVLSLVDLAGSE-------QVDPADH 239
            .|.||.|||||.||||||||.|.||..:......:.::...|:||||||||       |.:....
Human   200 NRSVGATNMNEHSSRSHAIFVITIECSEVGLDGENHIRVGKLNLVDLAGSERQAKTGAQGERLKE 264

  Fly   240 AS----SLMIFRNLVKSLSESVDSKPN--SFRDSKLPRIMLPSLGGNVLTSIICTITPSF--VEE 296
            |:    ||....|::.:|   ||.|..  .:|||||.|::..|||||..|.::..:.|:.  |||
Human   265 ATKINLSLSALGNVISAL---VDGKSTHIPYRDSKLTRLLQDSLGGNAKTVMVANVGPASYNVEE 326

  Fly   297 SSSTISFGTCAKKIRCKPQVCKIDSETTMMRQLDRGISMLKDKLAKKKIKNESQLVLQELEGRIK 361
            :.:|:.:...||.|:.||:|.: |.:..::|:....|:.||.:|.|:.|            ||.|
Human   327 TLTTLRYANRAKNIKNKPRVNE-DPKDALLREFQEEIARLKAQLEKRSI------------GRRK 378

  Fly   362 RDMLKIVSSASLDDYRLQKRRRTWTLTASGSEGDAPVLALPEPEESR-------LPRPSKLTNLP 419
                           |.:|||..   ..||..|:.......|.||..       ..:..||....
Human   379 ---------------RREKRREG---GGSGGGGEEEEEEGEEGEEEGDDKDDYWREQQEKLEIEK 425

  Fly   420 KPLFQRRGIAPKAKGICKTLKEKRLQTDNMDTMPGRAKQLGRETASRIPSVMMSKK-----YQES 479
            :.:.:...:..:.|  .:.||||..:.:::......|:.||.:..:....:::..|     ..|.
Human   426 RAIVEDHSLVAEEK--MRLLKEKEKKMEDLRREKDAAEMLGAKIKAMESKLLVGGKNIVDHTNEQ 488

  Fly   480 VPNCDAPQTEISALTASNQVAKETIEKYEEQVKRLKETIERLEME----NGKAVNLGEQFETHKA 540
            ....:..:.||:......:..::.:|..:|:...||||...|:.|    ..|...|..:.:..||
Human   489 QKILEQKRQEIAEQKRREREIQQQMESRDEETLELKETYSSLQQEVDIKTKKLKKLFSKLQAVKA 553

  Fly   541 KSKQMEEELLSSISEKDSTIVSLQQSLEELSRDVLRNSKEDQMRSMCPELESSCERICNKCLELE 605
            :...::||.:....|       |:|:..||:|::..                       |.|.:|
Human   554 EIHDLQEEHIKERQE-------LEQTQNELTRELKL-----------------------KHLIIE 588

  Fly   606 RLLPLASASGLDSVACQFDQ 625
            ..:||...|.:.:.|. ||:
Human   589 NFIPLEEKSKIMNRAF-FDE 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	124/339 (37%)
		Motor_domain	8..310	CDD:277568	121/333 (36%)
		SMC_prok_B	<471..1270	CDD:274008	33/164 (20%)
		Mplasa_alph_rch	924..1647	CDD:275316
		CENP-H	1204..>1266	CDD:283493
		CALCOCO1	<1489..1850	CDD:285171
KIF3B	NP_004789.1	KISc_KIF3	8..340	CDD:276822	121/334 (36%)
		Smc	<352..>614	CDD:224117	63/319 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	374..412		14/67 (21%)
		Globular	580..747		9/52 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	699..747
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910