Protein Alignment cana and KIP2

DIOPT Version :10

• Sequence 1: NP_001027247.1
• Gene: cana / 3771934
• FlyBaseID: FBgn0040233
• Length: 1931
• Species: Drosophila melanogaster
• Sequence 2: NP_015170.1
• Gene: KIP2 / 855948
• SGDID: S000006076
• Length: 706
• Species: Saccharomyces cerevisiae
• Alignment Length: 692
• Identity: 180/692 - (26%)
• Similarity: 285/692 - (41%)
• Gaps: 199/692 - (28%)

  Fly     2 STKN---ASSIQVCIKVRPCEPG---------------------------LTSLWQVKEGRSIQL 36
            |.||   ..||.|.|:.:|...|                           :...|.:...::|
Yeast    93 SRKNDTYTGSITVTIRPKPRSVGTSRDHVGLKSPRYSQPRSNSHHGSNTFVRDPWFITNDKTI-- 155

  Fly    37 ADSHAE--PYVFDYVFDEGASNQEVFDRMAKHIVHACMQGSNGTIFAYGQTSSGKTYTMMGDEQN 99
              .|.|  .:.||:||....:|.||::|.:|.::...:.|.|.||||||.|.||||:||.|:||.
Yeast   156 --VHEEIGEFKFDHVFASHCTNLEVYERTSKPMIDKLLMGFNATIFAYGMTGSGKTFTMSGNEQE 218

  Fly   100 PGVMVLAAKEIFQQISSET---ERDFLLRVGYIEIYNEKIYDLL-------------------NK 142
            .|::.|:...:|..|..::   ::.|.:.:.|:|||||:|||||                   :|
Yeast   219 LGLIPLSVSYLFTNIMEQSMNGDKKFDVIISYLEIYNERIYDLLESGLEESGSRISTPSRLYMSK 283

  Fly   143 KNQ-----DLKIH-ESGNGIVNVNCKESIVTSEDDLLRQLYMGNKERVVGETNMNERSSRSHAIF 201
            .|.     :|||. :|..|:..:...|....|.::|||.:.:|:|.|.:|||:.|.||||||||.
Yeast   284 SNSNGLGVELKIRDDSQYGVKVIGLTERRCESSEELLRWIAVGDKSRKIGETDYNARSSRSHAIV 348

  Fly   202 RIIIESRKSDHSDNDTVKQSVLSLVDLAGSEQVDPADHA--------SSLMIFRNLVKSLS---- 254
            .|.:   .|.:..|.|.:.|.|||.||||||:.......        .||:....::..||
Yeast   349 LIRL---TSTNVKNGTSRSSTLSLCDLAGSERATGQQERRKEGSFINKSLLALGTVISKLSADKM 410

  Fly   255 ESVDS----------------------KPNS---FRDSKLPRIMLPSLGGNVLTSIICTITP--S 292
            .||.|                      .|::   :|||||.|::.|:|.|:.:.:.|||:..  .
Yeast   411 NSVGSNIPSPSASGSSSSSGNATNNGTSPSNHIPYRDSKLTRLLQPALSGDSIVTTICTVDTRND 475

  Fly   293 FVEESSSTISFGTCAKKIRCKPQVCKIDSETTMMRQLDRGISMLKDKLAKKKIKNESQLVLQELE 357
            ...|:.:|:.|.:.||.:........|.|........||.|.:|:.:|      .|.:.::.||:
Yeast   476 AAAETMNTLRFASRAKNVALHVSKKSIISNGNNDGDKDRTIELLRRQL------EEQRRMISELK 534

  Fly   358 GR--IKRDMLKIVSSASLDDYRLQKRRRTWTLTASGSEGDAPVLALPEPEESRLPRPSKLTNLPK 420
            .|  |...:.|..:.::..|           :.|:|::|| |.|||...|...|  ..||.|
Yeast   535 NRSNIGEPLTKSSNESTYKD-----------IKATGNDGD-PNLALMRAENRVL--KYKLEN--- 582

  Fly   421 PLFQRRGIAPKAKGICKTLKEKRLQTDNMDTMPGRAKQLGRETASRIPSVMMSKKYQESVPNCDA 485
                           |    ||.|..|.:|...           |.|..::      |.:|
Yeast   583 ---------------C----EKLLDKDVVDLQD-----------SEIMEIV------EMLP---- 607

  Fly   486 PQTEISALTASN-QVAKETIEKYEEQVKRLKETIERLEMENGKAVNLGEQFETHKAKSKQMEEEL 549
              .|:..|..:. |..:..|.:|.:..::|::.|..||.....|:
Yeast   608 --FEVGTLLETKFQGLESQIRQYRKYTQKLEDKIMALEKSGHTAM-------------------- 650

  Fly   550 LSSISEKDST-IVSLQQSLEELSR--DVLRNSKEDQMRSMCP 588
              |::..|.| ::.||:.||...:  :.|:::|..:.|::.|
Yeast   651 --SLTGCDGTEVIELQKMLERKDKMIEALQSAKRLRDRALKP 690

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	Motor_domain	8..310	CDD:473979	119/397 (30%)
		CCDC158	<505..>729	CDD:464943	17/87 (20%)
		SMC_prok_B	622..1285	CDD:274008
		SMC_prok_B	1110..1875	CDD:274008
KIP2	NP_015170.1	KISc_CENP_E	102..493	CDD:276825	119/397 (30%)
		SMC_prok_B	<445..>698	CDD:274008	75/333 (23%)