DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cana and Kif3a

DIOPT Version :9

Sequence 1:	NP_001027247.1	Gene:	cana / 3771934	FlyBaseID:	FBgn0040233	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	XP_006246409.1	Gene:	Kif3a / 84392	RGDID:	621536	Length:	726	Species:	Rattus norvegicus

Alignment Length:	820	Identity:	209/820 - (25%)
Similarity:	345/820 - (42%)	Gaps:	192/820 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KNASSIQVCIKVRP--------CEPGLTSLWQVKEGRSIQLADSHAEP---YVFDYVFDEGASNQ 57
            ::..:::|.::.||        |.....|:.:::...::...||..||   :.||.||...:...
  Rat    10 ESCDNVKVVVRCRPLNEREKSMCYRQAVSVDEMRGTITVHKTDSSNEPPKTFTFDTVFGPESKQL 74

  Fly    58 EVFDRMAKHIVHACMQGSNGTIFAYGQTSSGKTYTMMGDEQNP---GVMVLAAKEIFQQIS-SET 118
            :|::..|:.|:.:.::|.||||||||||.:|||:||.|....|   ||:..:...||..|: :|.
  Rat    75 DVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPGLRGVIPNSFAHIFGHIAKAEG 139

  Fly   119 ERDFLLRVGYIEIYNEKIYDLLNK-KNQDLKIHESGN-GIVNVNCKESIVTSEDDLLRQLYMGNK 181
            :..||:||.|:|||||::.|||.| :.|.|::.|..: |:...:....:|.:.||:.|.:.:|:|
  Rat   140 DTRFLVRVSYLEIYNEEVRDLLGKDQTQRLEVKERPDVGVYIKDLSAYVVNNADDMDRIMTLGHK 204

  Fly   182 ERVVGETNMNERSSRSHAIFRIIIESRKSDHSDNDTVKQSVLSLVDLAGSEQVDPADHAS----- 241
            .|.||.|||||.||||||||.|.||..:.....|..|:...|.||||||||:........
  Rat   205 NRSVGATNMNEHSSRSHAIFTITIECSEKGVDGNMHVRMGKLHLVDLAGSERQAKTGATGQRLKE 269

  Fly   242 ------SLMIFRNLVKSLSESVDSKPN--SFRDSKLPRIMLPSLGGNVLTSIICTITPS--FVEE 296
                  ||....|::.:|   ||.|..  .:|:|||.|::..|||||..|.:...|.|:  ..:|
  Rat   270 ATKINLSLSTLGNVISAL---VDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYNYDE 331

  Fly   297 SSSTISFGTCAKKIRCKPQVCKIDSETTMMRQLDRGISMLKDKLAKKKIKNESQLVLQE----LE 357
            :.||:.:...||.|:.|.::.: |.:..::||..:.|..||.||.:.:..:.|.:...|    .|
  Rat   332 TISTLRYANRAKNIKNKARINE-DPKDALLRQFQKEIEELKKKLEEGEEVSGSDISGSEEDDNEE 395

  Fly   358 GRIKRDMLKIVSSASLDDYRLQKRRRTWTLTASGSEGDAPVLALPEPEESRLPRPSKLTNLPKPL 422
            |.:..|..|            :|:||.   ::|.|..|:....:.:|.:..||.
  Rat   396 GELGEDGEK------------RKKRRG---SSSSSSSDSTCSVIEKPLDEFLPH----------- 434

  Fly   423 FQRRGIAPKAKGICKTLKEKRLQTDNMDTMPGRAKQLGRETASRIPSVMMSKKYQESVPNCDAPQ 487
                                               |.|::..|  |..||
  Rat   435 -----------------------------------QAGKKKVS--PDKMM--------------- 447

  Fly   488 TEISALTASNQVAKETIEKYEEQVKRLKETIERLEMENGKAVNLGEQFETHKAKSKQMEEELLSS 552
             |:.|             |.:|:.|.|:..::..|.|..||          :|:.::.|::||.:
  Rat   448 -EMQA-------------KIDEERKALETKLDMEEEERNKA----------RAELERREKDLLKA 488

  Fly   553 ISEKDSTIVSLQQSLEELSRDVLRNSKEDQMRSMCPELESSCERICNKCLELERLLPLASASGLD 617
            ..|..    ||.:.|..|.:.|:....:                :..|..|.|:||. .|...|:
  Rat   489 QQEHQ----SLLEKLSALEKKVIVGGVD----------------LLAKAEEQEKLLE-ESNMELE 532

  Fly   618 SVACQFDQLRSEIAATRMKLESMLSTFSHASCEVSQKTTDCKRLSEQISTAHDDFGQLQEKY--- 679
            ....:.:|||.|:.....:...:...::....|...||...|::...:..|..:...||:::
  Rat   533 ERRKRAEQLRKELEEKEQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADLQQEHQRE 597

  Fly   680 -----NNLKHKWSSQKLAIDTMQVDYNTIQQKYLQLQDEYRHLELRSDE---QCQQLQDENSKLQ 736
                 .|::.  .|::|.:..:.:| |.|.|.|.::.:.|.|......|   :|......|.:.|
  Rat   598 IEGLLENIRQ--LSRELRLQMLIID-NFIPQDYQEMIENYVHWNEDIGEWQLKCVAYTGNNMRKQ 659

  Fly   737 AEIGTLKER---------------VEEIHSELLEVPNPDT 761
            ..:...|||               .|.:...|:::..|.|
  Rat   660 TPVPDKKERDPFEVDLSHVYLAYTEESLRQSLMKLERPRT 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	121/339 (36%)
		Motor_domain	8..310	CDD:277568	119/333 (36%)
		SMC_prok_B	<471..1270	CDD:274008	61/317 (19%)
		Mplasa_alph_rch	924..1647	CDD:275316
		CENP-H	1204..>1266	CDD:283493
		CALCOCO1	<1489..1850	CDD:285171
Kif3a	XP_006246409.1	KISc_KIF3	13..345	CDD:276822	119/334 (36%)
		Kinesin	20..345	CDD:278646	118/327 (36%)
		CENP-F_leu_zip	434..574	CDD:287450	40/247 (16%)
		GBP_C	<446..611	CDD:303769	42/226 (19%)
		coiled coil	597..608	CDD:293879	1/12 (8%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910