DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cana and AT3G10180

DIOPT Version :9

Sequence 1:	NP_001027247.1	Gene:	cana / 3771934	FlyBaseID:	FBgn0040233	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	NP_187629.3	Gene:	AT3G10180 / 820180	AraportID:	AT3G10180	Length:	1273	Species:	Arabidopsis thaliana

Alignment Length:	1556	Identity:	375/1556 - (24%)
Similarity:	626/1556 - (40%)	Gaps:	465/1556 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IQVCIKVRP--CEPGLTSLWQVKEGRSIQLADSHAEPYVFDYVFDEGASNQEVFDRMAKHIVHAC 71
            |.|.::.||  .|...||.|::... ||.:.:..:..:.||.:|.|.....:|::...|.||.|.
plant     4 IHVSVRARPLSSEDAKTSPWKISSD-SIFMPNHSSLAFEFDRIFREDCKTVQVYEARTKEIVSAA 67

  Fly    72 MQGSNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAKEIFQQISSETERDFLLRVGYIEIYNEKI 136
            ::|.|||:||||||:||||:||.|....|||:.||..::|..|..:..|:||||:.|:|||||.|
plant    68 VRGFNGTVFAYGQTNSGKTHTMRGSPIEPGVIPLAVHDLFDTIYQDASREFLLRMSYLEIYNEDI 132

  Fly   137 YDLLNKKNQDLKIHES-GNGIVNVNCKESIVTSEDDLLRQLYMGNKERVVGETNMNERSSRSHAI 200
            .|||..:::.|:|||: ..||.....:|.||.|...:|..:..|...|.:||||||..|||||.|
plant   133 NDLLAPEHRKLQIHENLEKGIFVAGLREEIVASPQQVLEMMEFGESHRHIGETNMNLYSSRSHTI 197

  Fly   201 FRIIIESRKSDHSDN-----DTVKQSVLSLVDLAGSE----------QVDPADHAS-SLMIFRNL 249
            ||:|||||:....:.     |.|:.|||:||||||||          ::....|.: |||....:
plant   198 FRMIIESRQKMQDEGVGNSCDAVRVSVLNLVDLAGSERAAKTGAEGVRLKEGSHINKSLMTLGTV 262

  Fly   250 VKSLSESVDSKPN--SFRDSKLPRIMLPSLGGNVLTSIICTIT--PSFVEESSSTISFGTCAKKI 310
            :|.|||.|:::..  .:|||||.||:.|:||||..|:|||.||  |...:|:.|::.|.:.|.::
plant   263 IKKLSEGVETQGGHVPYRDSKLTRILQPALGGNANTAIICNITLAPIHADETKSSLQFASRALRV 327

  Fly   311 RCKPQVCKIDSETTMMRQLDRGISMLKDKL----------------------------------A 341
            .....|.:|.::..::::..:.|..|:.||                                  .
plant   328 TNCAHVNEILTDAALLKRQKKEIEELRSKLKTSHSDHSEEEILNLRNTLLKSELERERIALELEE 392

  Fly   342 KKKIKNESQLVLQELEGRIKRDMLKIVSSASLDDYRLQ------KRRRTWTL----TASGSEGDA 396
            :||.:.:.:.||||...:|| ::..:|..::.|:.|.|      |||.||.:    ..|.||..:
plant   393 EKKAQAQRERVLQEQAKKIK-NLSSMVLLSNRDEKREQDHFKKGKRRDTWCIGKLSRDSTSEDQS 456

  Fly   397 PVL--------ALPEPEESRLPRPSKLTNLPKPLFQRRGIAPKAKGICKTLKEKRLQTDNMDTMP 453
            .||        |..|.|...|...|:|.|  :||:                   .:..::.|::.
plant   457 NVLSRGSSLESARSERETGPLLPFSELVN--EPLY-------------------NINEEDEDSIE 500

  Fly   454 GRAKQ--------LGRETASRIPSVMMSKKYQESVPN-CDAPQTEISALTASNQVAKETIEKYEE 509
            |..:.        |...|:.:.||:  .:|....|.| .|..|.|..||          :.:||.
plant   501 GTLEDSVLPDPCALVNVTSRKKPSI--KQKNPVVVENELDRIQREYEAL----------LLQYET 553

  Fly   510 QVKRLKETIERLEMENGKAVNLGEQFETHKAKSKQME-------EE------------LLSSISE 555
            :     ..|..:::|..| |.|||...:..||.||.|       ||            |:..:.|
plant   554 E-----RIISEIQIECLK-VKLGEDGLSGDAKCKQSEVVGNVHCEEHVVNLRDPEAILLIKQLQE 612

  Fly   556 K----------------DSTIVSLQQSL------EELSRDVLRNSKEDQM-RSMCPELESSCERI 597
            |                |..:|:.:|::      .|:..::....:|.|: |......||....:
plant   613 KINMLELEKSSSNRNLDDLVMVATEQNICAREKFAEIQEEIHAAREEAQVAREQLVSKESEVIDV 677

  Fly   598 CNKCLELERLLPLASASGLDSVACQFDQLRSEIAATRMKLESM-------LSTFSHASCEVSQKT 655
            .|:           :.:.|.:||.:.:.|.||....:..:|::       |..|:..|..:...|
plant   678 INE-----------NFNSLVNVATEIEVLESEFQKYKASVETISSVMNEGLQDFAFFSPLIHDFT 731

  Fly   656 TDCKRLSEQISTAHDDFGQLQEKYNNLKHKWSSQKLAIDTMQVDYNTIQQKYLQLQDEYRHLELR 720
            ...::.|||    ||..                    |::.|...:::::|.|.:::|    :|.
plant   732 LFVRQSSEQ----HDSL--------------------INSYQTVQSSLKKKVLDVENE----KLL 768

  Fly   721 SDEQC-------QQLQDENSKLQAEIGTLKERVEEIHSELLEVPNPDTHPEDME-----LQNQEL 773
            ..|||       ::|..|..|.:..:..|.|..|...|:||      :|.|.:|     |.:..|
plant   769 LQEQCAGLQSQIEELNQEAQKHETSLKMLSEHHESERSDLL------SHIECLEKDIGSLSSSSL 827

  Fly   774 KKRLSKLQWEFDEIQLNYECLSNELMSTIQECDALREEHKQRTTNSDLESMKSSGVGTECSDPEN 838
            .|....|:.:|::.:...:...::|.:::|:             .:.||:.|:|.        |.
plant   828 AKEKENLRKDFEKTKTKLKDTESKLKNSMQD-------------KTKLEAEKASA--------ER 871

  Fly   839 ELDTDLLQQFTKLSKSIQQIELTDYSGGRR--LFIYNHAEQDQSVPSLKLCLEPAKYLEGDGKQH 901
            ||.. |..|...|.:.|.:.|  .::|.||  |.:...|.|.               |:.:.||
plant   872 ELKR-LHSQKALLERDISKQE--SFAGKRRDSLLVERSANQS---------------LQEEFKQ- 917

  Fly   902 DASDSVFLKGFLKCQRFQIVKINQEQNLVKEEDRMRDIIFQLKQEVDGKKNLIEEEKEVINN--L 964
                       |:...|:                |...|..|::|:..::.  |:|:.:..|  |
plant   918 -----------LEVLAFE----------------METTIASLEEELAAERG--EKEEALCRNDGL 953

  Fly   965 RAQITSLNQIETIKNQNAKTKILCEELQTKDTVQTANKQESQEVLTLKTSLAHLKSKVCELQKKL 1029
            .::||.|.  |.:::.|                               |.|.||::.|.||:.:|
plant   954 GSEITDLT--EKLEHSN-------------------------------TKLEHLQNDVTELKTRL 985

  Fly  1030 EKQSEDEKISELQSDIGEISECCLSMELKLADIVNWQAEELRPLDQLQESGVELQHHSTTAEESL 1094
            |..|.|::  :|::::                            .||.|...||..|...:...:
plant   986 EVSSSDQQ--QLETNV----------------------------KQLLEEKEELAMHLANSLLEM 1020

  Fly  1095 NVEKPIQEQTERTLTTEYERRIEQLEESLQRAQEELSILEKRKTDENKSLQLEYMAKIETSENEN 1159
            ..||.|....|:.||...|.:|...                      |::|:|.::|..:.|.:.
plant  1021 EEEKAIWSSKEKALTEAVEEKIRLY----------------------KNIQIESLSKEMSEEKKE 1063

  Fly  1160 RSKFRAYCLDLKETQKRYEEQLQQTNEKLASVTTQCQV--------HLDVIKRSLQEKITQAEKE 1216
            ....|..|:.|.:..:..||..:|  :|.:|:....::        ..|.:.:..|| :.:::.:
plant  1064 LESCRLECVTLADRLRCSEENAKQ--DKESSLEKSLEIDRLGDELRSADAVSKQSQE-VLKSDID 1125

  Fly  1217 RNELAVRHKAELEKIRETLKEKESSYKEKLRQA----EEERDKEIS-----RLEVMRNTIAEL-- 1270
            ..:..|:|..   |:.:|. ::|..|....||.    .||..||::     ::|..:|.|.:|
plant  1126 ILKSEVQHAC---KMSDTF-QREMDYVTSERQGLLARIEELSKELASSNRWQIENAKNPIQDLTL 1186

  Fly  1271 ----HKTNSDREVELEGVKMEKCQLKKLYDKSMLELEQLQCTADQKSSDLLPGSSNENIDDLQKK 1331
                .:||..::...|  ..||.:||       :.|..:|.                .:|.:..:
plant  1187 KISSQETNLHKDAAAE--NKEKAKLK-------MRLRGMQA----------------RLDAISLR 1226

  Fly  1332 CDQYVQDLELLRGEKAELLSEIQKINGQHSNTIKKLEEIEAEMITLTTQKELERCEIAEKL 1392
            ..|.||:.||:.                     :|.:|..|::......|.||..::.::|
plant  1227 YKQSVQESELMN---------------------RKFKEASAKLKEKLASKALEVLDLKKQL 1266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	135/329 (41%)
		Motor_domain	8..310	CDD:277568	135/323 (42%)
		SMC_prok_B	<471..1270	CDD:274008	174/881 (20%)
		Mplasa_alph_rch	924..1647	CDD:275316	93/494 (19%)
		CENP-H	1204..>1266	CDD:283493	15/70 (21%)
		CALCOCO1	<1489..1850	CDD:285171
AT3G10180	NP_187629.3	KISc_CENP_E	4..327	CDD:276825	135/323 (42%)
		Kinesin	9..324	CDD:278646	132/315 (42%)
		Tropomyosin	829..1065	CDD:278679	72/389 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	287	1.000	Domainoid score	I372
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	349	1.000	Inparanoid score	I619
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm1081
orthoMCL	1	0.900	-	-		OOG6_101662
Panther	1	1.100	-	-	O	PTHR47968
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.910