Protein Alignment cana and KIF18A

DIOPT Version :9

• Sequence 1: NP_001027247.1
• Gene: cana / 3771934
• FlyBaseID: FBgn0040233
• Length: 1931
• Species: Drosophila melanogaster
• Sequence 2: NP_112494.3
• Gene: KIF18A / 81930
• HGNCID: 29441
• Length: 898
• Species: Homo sapiens
• Alignment Length: 1139
• Identity: 237/1139 - (20%)
• Similarity: 400/1139 - (35%)
• Gaps: 382/1139 - (33%)

  Fly    44 YVFDYVFDEGASNQEVFDRMAKHIVHACMQGSNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAK 108
            :|||.||||.::..|||:...|.|:.:.:.|.|.|:.|||.|.:|||:||:|....||||.|...
Human    74 FVFDAVFDETSTQSEVFEHTTKPILRSFLNGYNCTVLAYGATGAGKTHTMLGSADEPGVMYLTML 138

  Fly   109 EIFQQISS-ETERDFLLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIVNVNCKESIVT----- 167
            .:::.:.. :.|:.....|.|:|:|||:|.|||         ..||...|..:.::.:|.
Human   139 HLYKCMDEIKEEKICSTAVSYLEVYNEQIRDLL---------VNSGPLAVREDTQKGVVVHGLTL 194

  Fly   168 ----SEDDLLRQLYMGNKERVVGETNMNERSSRSHAIFRIIIESRKSDHSDNDTVKQSVLSLVDL 228
                |.:::|..|..|||.|....|:||..||||||:|:|.:..:....|.|..|:.:.:||:||
Human   195 HQPKSSEEILHLLDNGNKNRTQHPTDMNATSSRSHAVFQIYLRQQDKTASINQNVRIAKMSLIDL 259

  Fly   229 AGSEQ-----------VDPADHASSLMIFRNLVKSLSESVDSKPNS---FRDSKLPRIMLPSLGG 279
            ||||:           |:..:...||:...|::.:|::|  .:.|.   :|:|||.|::..||||
Human   260 AGSERASTSGAKGTRFVEGTNINRSLLALGNVINALADS--KRKNQHIPYRNSKLTRLLKDSLGG 322

  Fly   280 NVLTSIICTITPS--FVEESSSTISFGTCAKKIR--CKPQVCKIDSETTMMRQLDRGISMLKDKL 340
            |..|.:|..::||  |.:::.:|:.:...||.|:  .|..|..:::..|..
Human   323 NCQTIMIAAVSPSSVFYDDTYNTLKYANRAKDIKSSLKSNVLNVNNHITQY-------------- 373

  Fly   341 AKKKIKNESQLVLQELEGRIKRDMLKIVSSASLDDYRLQKRRRTWTLTASGSEGDAPVLALPEPE 405
              .||.||.:..:..|:.::|.             |..||        |..:|.|...|.:..|:
Human   374 --VKICNEQKAEILLLKEKLKA-------------YEEQK--------AFTNENDQAKLMISNPQ 415

  Fly   406 ESRLPRPSKLTNLPKPLFQRRGIAPKAKGICKTLKEKRLQTDNMDTMPGRAKQLGRETASRIPSV 470
            |..:.|..::.|.   |||.|
Human   416 EKEIERFQEILNC---LFQNR-------------------------------------------- 433

  Fly   471 MMSKKYQESVPNCDAPQTEISALTASNQVAKETIEKYEEQVKRLKETIERLEMENGKAVNLGEQF 535
                                                  |::::....:|.|..||
Human   434 --------------------------------------EEIRQEYLKLEMLLKEN---------- 450

  Fly   536 ETHKAKSKQMEEELLSSISEKDSTIVSLQQSLEELSRDVLRNSKEDQMRSMCPELESSCERICNK 600
                                                                 ||:|..::.|:|
Human   451 -----------------------------------------------------ELKSFYQQQCHK 462

  Fly   601 CLELERLLPLASASGLDSVACQFDQLRSEIAATRMKLESMLSTFSHASCEVSQKTTDCKRLSEQI 665
            .:|:     :.|...::....:.|...:.:...|..||                    ||..|::
Human   463 QIEM-----MCSEDKVEKATGKRDHRLAMLKTRRSYLE--------------------KRREEEL 502

  Fly   666 STAHDDFGQLQEKYNNLKHKWSSQKLAIDTMQVDYNTIQQKYLQLQDEYRHL--ELRSDEQCQQL 728
            .       |..|..|.| |:                  .:|.:.|..:..|:  ||:.|..|..|
Human   503 K-------QFDENTNWL-HR------------------VEKEMGLLSQNGHIPKELKKDLHCHHL 541

  Fly   729 QDENSKLQAEIGTLKERV---EEIHSELLEVPN---PDTHPEDMELQNQELKKRLSKLQWEFDEI 787
            ..:|..|:|:|..:.:..   |:.|.:...|.|   |....:...|:...|..  :..:.:|.||
Human   542 HLQNKDLKAQIRHMMDLACLQEQQHRQTEAVLNALLPTLRKQYCTLKEAGLSN--AAFESDFKEI 604

  Fly   788 QLNYECLSNELMSTIQECDALREEHKQRTTNSDLESMKSSGVGTECSDPENELDTDLLQQFTKLS 852
            :...     |....:...|...|:.||    :||..:                  .:|..|.:|.
Human   605 EHLV-----ERKKVVVWADQTAEQPKQ----NDLPGI------------------SVLMTFPQLG 642

  Fly   853 KSIQQIELTDYSGGRRLFIYNHAEQDQSVPS-----LKLCLEPAKYLEGDGKQHDASDSVFLKGF 912
             .:|.|.....|||..|.         .:|:     .||...|.|      .||.
Human   643 -PVQPIPCCSSSGGTNLV---------KIPTEKRTRRKLMPSPLK------GQHT---------- 681

  Fly   913 LKCQRFQIVKINQEQNLVKEEDRMRDIIFQLKQEVDGKKNLIEEEKEVINNLRAQITSLNQIETI 977
            ||....|.|::|  .:|.||   ::.|::..:   |.:|.........:....:..||...|.:.
Human   682 LKSPPSQSVQLN--DSLSKE---LQPIVYTPE---DCRKAFQNPSTVTLMKPSSFTTSFQAISSN 738

  Fly   978 KNQNAKTKILCEELQTKDTVQTANKQESQEVLTLKTSLAHLKSKVCELQKKLEKQSEDEKISELQ 1042
            .|.:...|:|||.....:..:...:::.....|:   ...:||..|:|       .|.|.:....
Human   739 INSDNCLKMLCEVAIPHNRRKECGQEDLDSTFTI---CEDIKSSKCKL-------PEQESLPNDN 793

  Fly  1043 SDIGEISECCLSMELKLADIVNWQAEELRPLDQLQESGVELQHHSTTAEESLNVEKPIQEQTERT 1107
            .||           |:..|..::..:...|:..:..|.:.:    |||.:  ...|.....:..:
Human   794 KDI-----------LQRLDPSSFSTKHSMPVPSMVPSYMAM----TTAAK--RKRKLTSSTSNSS 841

  Fly  1108 LTTE----YERRIEQLEESLQRAQEELSILEKRK 1137
            ||.:    :.:|:.|...|.:..||....:|.::
Human   842 LTADVNSGFAKRVRQDNSSEKHLQENKPTMEHKR 875

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	101/299 (34%)
		Motor_domain	8..310	CDD:277568	99/291 (34%)
		SMC_prok_B	<471..1270	CDD:274008	113/684 (17%)
		Mplasa_alph_rch	924..1647	CDD:275316	40/218 (18%)
		CENP-H	1204..>1266	CDD:283493
		CALCOCO1	<1489..1850	CDD:285171
KIF18A	NP_112494.3	KISc_KIP3_like	11..355	CDD:276821	99/291 (34%)
		Kinesin	17..355	CDD:278646	99/291 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	667..690		9/38 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	830..871		8/40 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810