DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cana and kif19

DIOPT Version :9

Sequence 1:	NP_001027247.1	Gene:	cana / 3771934	FlyBaseID:	FBgn0040233	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	XP_005156460.1	Gene:	kif19 / 565913	ZFINID:	ZDB-GENE-080215-2	Length:	1015	Species:	Danio rerio

Alignment Length:	981	Identity:	230/981 - (23%)
Similarity:	395/981 - (40%)	Gaps:	238/981 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IQVCIKVRP-----CEPGLTSLWQVKEGRSIQLADSHAEP-------------YVFDYVFDEGAS 55
            :.|.:::||     .|.|.|.:....:.:.:.|.|...:|             |:||..||..|:
Zfish    12 LTVALRIRPLSDAELEEGATIIAHKVDDQMVVLLDPMEDPDDILRAHRSREKTYMFDVAFDYSAT 76

  Fly    56 NQEVFDRMAKHIVHACMQGSNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAKEIFQQISSETER 120
            ..||:....|.::...:.|.|.|:||||.|..||||||:|.::.||:.|....::|:.| .||..
Zfish    77 QDEVYRYTTKGLIEGLISGYNATVFAYGPTGCGKTYTMLGTDREPGIYVRTLNDLFKAI-EETSD 140

  Fly   121 D--FLLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIVNV-NCKESIVTSEDDLLRQLYMGNKE 182
            |  :.:.:.|:|||||.|.||||..:..|.:.|...|.:.| ...|....:..:::..|..|||:
Zfish   141 DMQYSVSMSYLEIYNEMIRDLLNPSSGFLDLREDSKGEIQVAGITEVSTINAREIMELLMKGNKQ 205

  Fly   183 RVVGETNMNERSSRSHAIFRIIIESRKSDHSDNDTVKQSVLSLVDLAGSEQVDPADHAS------ 241
            |....|..|:.||||||:.::::..:.........|:.:.|.::||||||:.....:..
Zfish   206 RTQEPTAANQTSSRSHAVLQVVVRQQSRCRDILQEVRFARLFMIDLAGSERASQTQNRGQRLKEG 270

  Fly   242 -----SLMIFRNLVKSLSESVDSKPNSFRDSKLPRIMLPSLGGNVLTSIICTITPSFV--EESSS 299
                 ||:...|.:.:|||...:|..::|||||.|::..|||||..|.:|..|:|:.:  |:|.:
Zfish   271 AHINRSLLALGNCINALSEKNGNKYVNYRDSKLTRLLKDSLGGNSRTVMIAHISPASLAFEDSRN 335

  Fly   300 TISFGTCAKKIRCKPQ------VCKIDSETTMMRQLDRGISMLKDKLAKKKIK--NESQLVLQEL 356
            |:::...||.||.:.:      ...|...|:::..|...|..||.|:|.:..:  |..:..::.:
Zfish   336 TLTYADRAKSIRTRVKRNLLNVSYHIAQYTSIISDLRSEIQRLKKKIADQASRQINPDRTDIRHV 400

  Fly   357 ----------EGRIKRDMLKIVSSASLDDYRLQK--RRRTWTLTASGSE----GDAPVLALPEPE 405
                      :.|.:.|.|:   ...:|.:|.|.  |:|...|..|..|    ....:|.:.:.|
Zfish   401 QAEVQAHSSQQSRAEMDQLR---EQLIDAFRQQMDIRKRLMELDNSNMEIQIDTSKHLLTIADWE 462

  Fly   406 ESRLPRPSKLTNLPKPLFQRRGIAPKAKGICKTLKEKRLQTDNMDTMPGRAKQLGRETASRIPSV 470
            :.|              |:||   .|.:|      |:|.::.|.|.         .|..|..|
Zfish   463 QER--------------FRRR---KKWQG------ERRKESFNKDE---------SEKDSDSP-- 493

  Fly   471 MMSKKYQESVPNCDAPQTEISALTASNQVAKETIEKYEEQVKRLKETIERLEMENGKAVNLGEQF 535
                   ||:|  |:.:|:..|:...|.|   |:...::::::.|..:|:         .|.|..
Zfish   494 -------ESLP--DSTETQEVAIARENLV---TLMAEQKKIQKQKAGLEQ---------RLAELR 537

  Fly   536 ETHKAKSKQMEEELLSSISEKDSTIVSLQQSLEELSRDVLRNSKEDQMRSMCPELESSCERICNK 600
            |    |::::||.|...:|.::             .|:||                      |..
Zfish   538 E----KARRLEELLPRRVSSEE-------------QREVL----------------------CLL 563

  Fly   601 C----LELERLLPLASASGLDSVACQFDQLRSEIAATRMKLESMLSTFSHASCEVSQKTTDCKRL 661
            |    ||:|.....:||...|:|..|     ..:...|.:....|                |..:
Zfish   564 CKVHELEIENAEMQSSALLKDNVIRQ-----KNVVVQRFEQHRHL----------------CHEI 607

  Fly   662 SEQISTAHDDFG-----QLQEKY---------NNLKHKWSSQKLAIDTMQVDYNTIQQKYLQLQD 712
            .:|.....||..     .|||.|         .||....:..|..|.|::|.:.....|..
Zfish   608 IQQQRQFIDDHSLLVPPHLQELYEMYMKEMDEKNLDRVVALDKFTIRTLKVHHEGSLPKIT---- 668

  Fly   713 EYRHLELRSDEQCQQLQDENSKLQAEIGTLKERVEEIHSELLEVPNPDTHPED-----MELQNQE 772
                |..|..:..|:|..:    |..:.||.....:..::|.....|...||.     .:..:::
Zfish   669 ----LPSRGRDPLQELDSD----QESVRTLASDNRQGRTKLRRHTLPPILPEPDGERVFKSSHKQ 725

  Fly   773 LKKRLSKLQWEFDEIQLNYECLSNELMSTIQECDALREEHKQRTTNSDLESMKSSGVGTECSDPE 837
            :|..:....   ..|.:|.:. :.||:.::.: :|||..|...:.:|.|:|...|.        |
Zfish   726 MKNTVVMTP---PPIHINGQG-NRELLPSVLD-EALRCSHLSHSMSSHLDSSPESS--------E 777

  Fly   838 NELDTDLL-QQFTKLSKSIQQIELTDYSGGRRLFIYNHAEQDQSVPSLKLCLEPAKYLEGDGKQH 901
            |..|..|. ::..::.:.:|.|.:   ...||      ..:...:.:|:|...|:..   |.|:|
Zfish   778 NGTDAPLTPKERQQILRGVQNIAV---KAARR------RSKVLEIDALRLPPPPSPL---DPKKH 830

  Fly   902 DASDSV 907
            .::.|:
Zfish   831 KSNLSL 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	107/346 (31%)
		Motor_domain	8..310	CDD:277568	105/334 (31%)
		SMC_prok_B	<471..1270	CDD:274008	88/461 (19%)
		Mplasa_alph_rch	924..1647	CDD:275316
		CENP-H	1204..>1266	CDD:283493
		CALCOCO1	<1489..1850	CDD:285171
kif19	XP_005156460.1	KISc	11..353	CDD:214526	107/341 (31%)
kif19	XP_005156460.1	KISc_KIP3_like	11..346	CDD:276821	105/334 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900