DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cana and kif5c

DIOPT Version :9

Sequence 1:	NP_001027247.1	Gene:	cana / 3771934	FlyBaseID:	FBgn0040233	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	NP_001116747.1	Gene:	kif5c / 565563	ZFINID:	ZDB-GENE-081105-14	Length:	985	Species:	Danio rerio

Alignment Length:	1046	Identity:	281/1046 - (26%)
Similarity:	457/1046 - (43%)	Gaps:	221/1046 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 QVCIKV----RPCEP-----GLTSLWQVKEGRSIQLADSHAEPYVFDYVFDEGASNQEVFDRMAK 65
            :.|:||    ||...     |...:.:.|...::.:|   .:||:||.|.....:.::|:|..||
Zfish     6 ECCVKVMCRFRPLNESEINRGDKYIPKFKGEDTVVIA---GKPYIFDRVLPPNTTQEQVYDTCAK 67

  Fly    66 HIVHACMQGSNGTIFAYGQTSSGKTYTMMGDEQNP---GVMVLAAKEIFQQISSETER-DFLLRV 126
            .||...:.|.|||||||||||||||:||.|...|.   |::...|::||:.|.|..|. :|.::|
Zfish    68 QIVKDVLDGYNGTIFAYGQTSSGKTHTMEGQLHNAQLMGIIPRIAQDIFEHIYSMDENLEFHIKV 132

  Fly   127 GYIEIYNEKIYDLLNKKNQDLKIHESGNGIVNV-NCKESIVTSEDDLLRQLYMGNKERVVGETNM 190
            .|.|||.:||.|||:....:|.:||..|.:..| .|.|..|:|.:|::..:..|...|.|..|||
Zfish   133 SYFEIYLDKIRDLLDVSKTNLAVHEDKNRVPFVKGCTERFVSSPEDVMDVIDEGKANRHVAVTNM 197

  Fly   191 NERSSRSHAIFRIIIESRKSDHSDNDTVKQSVLSLVDLAGSEQVDPA-------DHA----SSLM 244
            ||.|||||:||.|.|   |.::.:.:......|.||||||||:|...       |.|    .||.
Zfish   198 NEHSSRSHSIFLINI---KQENVETEKKLSGKLYLVDLAGSEKVSKTGAEGSVLDEAKNINKSLS 259

  Fly   245 IFRNLVKSLSESVDSKPNSFRDSKLPRIMLPSLGGNVLTSIICTITPSFVE--ESSSTISFGTCA 307
            ...|::.:|:|...:.. .:||||:.||:..|||||..|:|:...:||...  |:.||:.||..|
Zfish   260 ALGNVISALAEGTKTHV-PYRDSKMTRILQDSLGGNCRTTIVICCSPSVYNEAETKSTLMFGQRA 323

  Fly   308 KKIRCKPQVCKIDSETTMMRQLDRGISMLKDKLAKKKIKNES-QLVLQELEGRIKRDMLKIVSSA 371
            |.|:           .|:...::......|.|..|:|.|..: ::::|.||..:||  .:...:.
Zfish   324 KTIK-----------NTVSVNMELTAEEWKKKYEKEKEKTRNLKIIIQRLENELKR--WRKGETV 375

  Fly   372 SLDDYRLQKRRRTWTLTASGSEGDAPVLALPEPEESRLPRPSKLTNLPKPLFQRRGIAPKAKGIC 436
            .:::....|..:....        |||:      ::..|.|..|::..|..::
Zfish   376 PVNEQHSNKESKNCEA--------APVI------DTSAPPPEPLSDAEKTQYE------------ 414

  Fly   437 KTLKEKRLQTDNMDTMPGRAKQLGRETASRIPS----VMMSKKYQESVPNCDAPQTEISALTASN 497
            :.:.:...|.|:.|....:..||..:...::..    :..:::..|.:      |.:::.|...|
Zfish   415 ELINDLYQQLDDKDDEINQHSQLAEDLKQQMVDQDELLASTRRDYEKI------QEDLNRLQREN 473

  Fly   498 QVAKETIEKYEEQVKRLKETIERLEMENGKAVNLGEQFETHKAKSK---QMEEELLSSISEKDST 559
            :.||       |:||.:.:.:|.|      |||..::....:.|||   |:.:||:    :|.|.
Zfish   474 ETAK-------EEVKEVLQALEEL------AVNYDQKSHEVEEKSKTNNQLSDELV----QKSSA 521

  Fly   560 IVSLQQ---SLEELSRDVLRNSKED---QMRSMCPELESSCERICNKCLELE----------RLL 608
            :..:::   ||:|||....|.|.|.   .:|.:| |:.|......:|..||.          ||.
Zfish   522 LAGVERDLSSLKELSEHHRRRSAEILSLLLRDLC-EIGSVIALNDHKLSELNGGMEEEFTMARLF 585

  Fly   609 PLASASGLDSVACQFDQLRSEIAATRMKLESMLSTFSHASCE--VSQKTTDCKRLSEQISTAHDD 671
            .....|.:.|:..:..||.|..:.|..|:::  :....|||:  :||.....|.|::.:......
Zfish   586 ISKMKSEVKSLVNRSKQLESTQSDTMRKMQA--NEKELASCQMLISQHQAKIKSLTDYMQNMEQK 648

  Fly   672 FGQLQEKYNNLKHKWSSQKLAIDTMQVDYNTIQQKYLQLQDEYRHLELRSDEQ------CQQLQD 730
            ..||:|.:::|..:.:  ||..:....:.:.       |..|..|:....|.:      .||::.
Zfish   649 KRQLEESHDSLTEELA--KLHAEERMHEVSV-------LDKEKEHMSRMQDAEEMKKALEQQMES 704

  Fly   731 ENSKLQAEIGTLKERVEE---IHSELLEVPNPDTHPEDMELQNQELKKRLSKLQWEFDEIQLNYE 792
            .....|.::..|::.:||   |..||.:|             ||.|:....||..:::::|
Zfish   705 HRETHQKQLSRLRDEIEEKQRILDELKDV-------------NQALELEQKKLMSDYEKLQ---- 752

  Fly   793 CLSNELMSTIQECDALREEHKQRT--TNSDLESMKSSGVGTECSDPENELDT--DLLQQFTK-LS 852
                      || |..::|..|:.  .|...|..|....|.| .....||.|  ||.:.|.: ::
Zfish   753 ----------QE-DQKKDERLQKLLFLNEKKEQAKEDLKGLE-ETVAKELQTLHDLRKLFIQDIN 805

  Fly   853 KSI-QQIEL-TDYSGG------RRLFIYNHAEQDQSVPSLKLCLEPAKYLEGDGKQ--HDASDSV 907
            ..| :.:|| ||.|||      :.:|:.|:.||...|                .||  ||.:|
Zfish   806 NRIGRSVELDTDESGGSLAQKQKIIFLENNLEQLTKV----------------HKQLVHDNAD-- 852

  Fly   908 FLKGFLKCQRFQI----------VKINQEQNLVKEEDRMRDIIFQLKQEVDGKKNLIEEEKEVIN 962
                 |:|:..::          |||.:......:|..||| ..:.:||||..|.:|..:.:...
Zfish   853 -----LRCELPKLEKRLRATAERVKILESALREAKESAMRD-RKKYQQEVDRIKEVIRAKNQSRR 911

  Fly   963 NLRAQI 968
            |..|||
Zfish   912 NHTAQI 917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	125/332 (38%)
		Motor_domain	8..310	CDD:277568	124/326 (38%)
		SMC_prok_B	<471..1270	CDD:274008	132/553 (24%)
		Mplasa_alph_rch	924..1647	CDD:275316	14/45 (31%)
		CENP-H	1204..>1266	CDD:283493
		CALCOCO1	<1489..1850	CDD:285171
kif5c	NP_001116747.1	KISc_KHC_KIF5	6..326	CDD:276820	124/326 (38%)
		Kinesin	14..326	CDD:278646	121/318 (38%)
		GBP_C	<638..766	CDD:303769	32/164 (20%)
		PKK	656..804	CDD:289257	39/185 (21%)
		coiled coil	733..744	CDD:293879	4/23 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000669
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910