DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cana and kif3a

DIOPT Version :9

Sequence 1:	NP_001027247.1	Gene:	cana / 3771934	FlyBaseID:	FBgn0040233	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	NP_001017604.2	Gene:	kif3a / 550267	ZFINID:	ZDB-GENE-050417-71	Length:	701	Species:	Danio rerio

Alignment Length:	839	Identity:	212/839 - (25%)
Similarity:	330/839 - (39%)	Gaps:	227/839 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ASSIQVCIKVRPCEP-----GLTSLWQVKEGR---SIQLADSHAEP---YVFDYVFDEGASNQEV 59
            :.:::|.::.||...     |......|.|.|   ::...|..:||   :.||.||...:...:|
Zfish    15 SDNVKVVVRCRPLNEKEKIMGHKQSVTVDEIRGTITVNKLDISSEPPKTFTFDTVFGPDSKQLDV 79

  Fly    60 FDRMAKHIVHACMQGSNGTIFAYGQTSSGKTYTMMGDEQNP---GVMVLAAKEIFQQIS-SETER 120
            ::..|:.|:.:.::|.||||||||||.:|||:||.|....|   |::..:...:|..|: :|.:.
Zfish    80 YNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPELRGIIPNSFAHVFGHIAKAEGDT 144

  Fly   121 DFLLRVGYIEIYNEKIYDLLNK-KNQDLKIHESGN-GIVNVNCKESIVTSEDDLLRQLYMGNKER 183
            .||:||.|:|||||::.|||.| :.|.|::.|..: |:...:....:|.:.||:.|.:.:|:|.|
Zfish   145 RFLVRVSYLEIYNEEVRDLLGKDQMQRLEVKERPDVGVYIKDLSGYVVNNADDMDRIMTLGHKNR 209

  Fly   184 VVGETNMNERSSRSHAIFRIIIESRKSDHSDNDTVKQSVLSLVDLAGSEQVDPADHAS------- 241
            .||.|||||.||||||||.|.||..:.....|..|:...|.||||||||:........
Zfish   210 SVGATNMNEHSSRSHAIFTITIECSEKGVDGNQHVRMGKLHLVDLAGSERQGKTGATGQRLKEAT 274

  Fly   242 ----SLMIFRNLVKSLSESVDSKPN--SFRDSKLPRIMLPSLGGNVLTSIICTITPS--FVEESS 298
                ||....|::.:|   ||.|..  .:|:|||.|::..|||||..|.:...|.|:  ..:|:.
Zfish   275 KINLSLSTLGNVISAL---VDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYNYDETI 336

  Fly   299 STISFGTCAKKIRCKPQVCKIDSETTMMRQLDRGISMLKDKLAKKKIKNESQLVLQELEGRIKRD 363
            ||:.:...||.|:.|.::.: |.:..::||..:.|..||.||.               ||.
Zfish   337 STLRYANRAKNIKNKARINE-DPKDALLRQFQKEIEELKKKLE---------------EGE---- 381

  Fly   364 MLKIVSSASLDDYRLQKRRRTWTLTASGSEGDAPVLALPEPEESRLPRPSKLTNLPKPLFQRRGI 428
                                    ..|||:|..
Zfish   382 ------------------------EISGSDGSG-------------------------------- 390

  Fly   429 APKAKGICKTLKEKRLQTDNMDT------MPGRAKQLGRETASRIPSVMMSKKYQESVPNCDAPQ 487
                             :|:||.      ...|.|:.||:..|....|.|..|.:|
Zfish   391 -----------------SDDMDEDDVGDGGERRRKRRGRKKVSPDKMVEMQAKIEE--------- 429

  Fly   488 TEISALTASNQVAKETIEKYEEQVKRLKETIERLEMENGKAVNLGEQFETH--KAKSKQMEE--- 547
             |..||.|.       ::..||:..:.:..:|:.|.:..||     |.|.|  ..|...:|:
Zfish   430 -ERKALEAK-------LDMEEEERNKARAELEKREKDLLKA-----QQEHHLLLEKLSALEKRVI 481

  Fly   548 ----ELLSSISEKDSTIVSLQQSLEELSRDVLRNSKEDQMRSMCPELESSCERICNKCLELERLL 608
                :||:...|::..:......|||      |..:.:|:|.   |||..         |.|||
Zfish   482 VGGVDLLAKAEEQEKLLEESNNELEE------RRKRAEQLRR---ELEEK---------EQERL- 527

  Fly   609 PLASASGLDSVACQFDQLRSEIAATRMKLESMLSTFSHASCEVSQKTTDCKRLSEQISTAHDDFG 673
                     .:..::..|:.|......||:.:.:....|..|::.       |.::   .|.:..
Zfish   528 ---------DIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMAD-------LQQE---HHREIE 573

  Fly   674 QLQEKYNNLKHKWSSQKLAIDTMQVDYNTIQQKYLQLQDEYRHLELRSDE---QCQQLQDENSKL 735
            .|.|....|..:...|.|.||      |.|.|:|.::.:.|.|......|   :|......|.:.
Zfish   574 GLLENIRQLSRELRLQMLIID------NFIPQEYQEMIENYVHWNEDIGEWQLKCVAYTGNNMRK 632

  Fly   736 QAEIGTLKER---------------VEEIHSELLEVPNPDTHPEDMELQNQELKKRLSK 779
            |..:...||:               .|.:...|:::..|.|............:||.||
Zfish   633 QTPVSDKKEKDPFEVDLSHVYLAYTEESMRQSLMKLERPRTSKNGKSRPKTGRRKRSSK 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	120/339 (35%)
		Motor_domain	8..310	CDD:277568	118/333 (35%)
		SMC_prok_B	<471..1270	CDD:274008	69/336 (21%)
		Mplasa_alph_rch	924..1647	CDD:275316
		CENP-H	1204..>1266	CDD:283493
		CALCOCO1	<1489..1850	CDD:285171
kif3a	NP_001017604.2	KISc_KIF3	16..348	CDD:276822	118/334 (35%)
kif3a	NP_001017604.2	Kinesin	23..348	CDD:278646	117/327 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910