DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cana and cmet

DIOPT Version :9

Sequence 1:	NP_001027247.1	Gene:	cana / 3771934	FlyBaseID:	FBgn0040233	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster

Alignment Length:	2146	Identity:	941/2146 - (43%)
Similarity:	1277/2146 - (59%)	Gaps:	400/2146 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTKNASSIQVCIKVRPCEPGLTSLWQVKEGRSIQLADSHAEPYVFDYVFDEGASNQEVFDRMAK 65
            ||.|||||||||||||||||||||||||||.|||.||||||||||||||||||||||||||||||
  Fly     1 MSAKNASSIQVCIKVRPCEPGLTSLWQVKERRSIHLADSHAEPYVFDYVFDEGASNQEVFDRMAK 65

  Fly    66 HIVHACMQGSNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAKEIFQQISSETERDFLLRVGYIE 130
            |||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly    66 HIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAKEIFQQISSETERDFLLRVGYIE 130

  Fly   131 IYNEKIYDLLNKKNQDLKIHESGNGIVNVNCKESIVTSEDDLLRQLYMGNKERVVGETNMNERSS 195
            |||||||||||||||||||||||||||||||:|.|:|||.||||.|.:|||||.|||||||||||
  Fly   131 IYNEKIYDLLNKKNQDLKIHESGNGIVNVNCEECIITSEVDLLRLLCLGNKERTVGETNMNERSS 195

  Fly   196 RSHAIFRIIIESRKSDHSDNDTVKQSVLSLVDLAGSEQVD----------PADHAS-SLMIFRNL 249
            ||||||:||||||||||||:|.|.||||:||||||||:.|          ...|.: ||:...|:
  Fly   196 RSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGSERADQTGARGARLKEGGHINKSLLFLSNV 260

  Fly   250 VKSLSESVDSKPNSFRDSKLPRIMLPSLGGNVLTSIICTITPSFVEESSSTISFGTCAKKIRCKP 314
            :|||||:.|::..::|||||.||:..|||||..|||||||.||.:|||.||:||.|.|||||.||
  Fly   261 IKSLSENADNRFTNYRDSKLTRILQASLGGNAFTSIICTIKPSIMEESQSTLSFATRAKKIRIKP 325

  Fly   315 QVCKIDSETTMMRQLDRGISMLKDKLAKKKIKNESQLVLQELEGRIKRDMLKIVSSASLDDYRLQ 379
            ||.::.|:.|||::|:|.|.:||||||:::.|||:|..::.||.:||.||.||:...||.|...|
  Fly   326 QVNEMVSDATMMKRLEREIKVLKDKLAEEERKNENQQKVEHLERQIKHDMHKIICGHSLSDKGQQ 390

  Fly   380 KRRRTWTLTASGSEGDAPVLALPEPEESRLPRPSKLTNLPKPLF-------QRRGIAPKA----- 432
            ||||||..|||||..:   ||.....|.|:.:..|:::||||:|       :|....||.
  Fly   391 KRRRTWCPTASGSHLE---LAETGTTEDRIDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTINILG 452

  Fly   433 -----------------------------------------------KGICKTLK-EKRLQTDNM 449
                                                           ||...|.| :|.:|...|
  Fly   453 SLDIGTESNSISEEFLPAECIDFGSPRPDVLKPMLTIRQLPDLPLTPKGPLTTDKIKKEIQDLQM 517

  Fly   450 DT------------MPGRAKQLGRETASRIPSVMMSKKYQESV---PNCDAPQTEISALTASNQV 499
            .|            :.|..::|...||.|      ....|||:   ...||.:.|:::|.|.|:.
  Fly   518 FTSLEKHFEVECEEVQGLKEKLAEVTAQR------DNLEQESLAEKERYDALEKEVTSLRADNEA 576

  Fly   500 AKETIEKYEEQVKRLKETIERLEMENGKAVNLGEQFETHKAKSKQMEEELLSSISEKDSTIVSLQ 564
            |...|.:.||::..||:|:..:|:||..||.|..:||.||..||...::|||::.||:|||.|||
  Fly   577 ANSKISELEEKLSTLKQTMRIMEVENQVAVGLEFEFEAHKKSSKLRVDDLLSALLEKESTIESLQ 641

  Fly   565 QSLEELSRDVLRNSKEDQMRSMCPELES-SCERICNKCLELERLLPLASASGLDSV--ACQFDQL 626
            :||:.|:|||||||||..|.|:.||.|. :.:.|||||.|||:|:     :.|:|.  :|:.|||
  Fly   642 KSLDNLTRDVLRNSKEGHMLSIAPEQEDIAGDSICNKCEELEKLI-----ADLESKKNSCECDQL 701

  Fly   627 RSEIAATRMKLESMLSTFSHASCEVSQKTTDCKRLSEQISTAHDDFGQLQEKYNNLKHKWSSQKL 691
            |.||.:.|.||||:.|.|:.||.|:.||.|||:|||:::||:.:.||||||:|:.|..:|.:|:.
  Fly   702 RLEIVSVRDKLESVESAFNLASSEIIQKATDCERLSKELSTSQNAFGQLQERYDALDQQWQAQQA 766

  Fly   692 AIDTMQVDYNTIQQKYLQLQDEYRHLELR----SDEQCQQLQDENSKLQAEIGTLKERVEEIHSE 752
            .|.|:...:..:|:||.:||:||..||.|    |..:.|:||::|:|.||:|.:|.||:||..:.
  Fly   767 GITTLHEKHEHVQEKYQKLQEEYEQLESRARSASSAEFQRLQNDNTKFQADIASLNERLEEAQNM 831

  Fly   753 LLEVPNPDTHPEDMELQNQELKKRLSKLQWEFDEIQLNYECLSNELMSTIQECDALREEHKQRTT 817
            |.||.|.::..|.:.:||.||..::.:|:..|:|:|..|:||||:||.::||.||||||.|||.|
  Fly   832 LTEVQNSESTVEKLRIQNHELTAKIKELETNFEEMQREYDCLSNQLMESVQENDALREEIKQRPT 896

  Fly   818 NSDLESMKSSGVGTECSDPENELDTDLLQQFTKLSKSIQQIELTDYSGGRRLFIYNHAEQDQSVP 882
            :...|||:|||:.::..  |.:.|.:||.||.:||:|:|||||..:||..|||..|..:.|||.|
  Fly   897 SHVEESMRSSGISSDFD--EQKQDINLLHQFVQLSESVQQIELQHHSGISRLFRANQMKLDQSEP 959

  Fly   883 SLKLCLEPAKYLEGDGKQHDASDSVFLKGFLKCQRFQIVKINQEQNLVKEEDRMRDIIFQLKQEV 947
            .||||||.|:|:|.|.:|.||::.:.||||||..||||.:::||...:.||.|:.|||.||:||:
  Fly   960 GLKLCLESAEYIEEDNRQSDATEPICLKGFLKRHRFQIKRLSQEHVDMGEEKRLLDIISQLEQEI 1024

  Fly   948 DGKKNLIEEEKEVINNLRAQITSL------------------NQIETIKNQNAKTKILCEELQTK 994
            :.|..|:|..:..||.:|.|:|:|                  .|||:::.|||:..::.||||.:
  Fly  1025 EEKSALMEATEATINEMREQMTNLESALLEKSVIINKVEDYQRQIESLEKQNAEMTMVYEELQDR 1089

  Fly   995 ------------------DTV---QTANKQESQEVLTLKTSLAHLKSKVCELQKKLEK-----QS 1033
                              ||:   .|:..:..|||.|||||:..|:|:|.:|:.:||.     |.
  Fly  1090 VTRESSMSESLLRVPPDEDTLPGCPTSPSRREQEVATLKTSITELQSQVSDLKAELENHLRQIQL 1154

  Fly  1034 EDEKISELQSDIGEISECCLSMELKLA----------DIVNWQAEELRP----LDQLQESGVEL- 1083
            :|..|:.||:|..|:||.|||||::||          ::::.||::|..    :||||:...:|
  Fly  1155 KDGNIARLQTDFEEMSERCLSMEVRLAELDEDTKQKQELLDRQAQKLSDDLCLIDQLQKKNAQLV 1219

  Fly  1084 -QHHSTTAEESLNVEKPIQEQTERTLTTEYERRIEQLEESLQRAQEELSILEKRKTDENKSLQLE 1147
             |:|..|...||...||.|    ..|:::|:.:||:|.:.|..|::||..:.:.|.||..:|::|
  Fly  1220 EQYHKATESLSLADAKPDQ----ILLSSQYDSQIEKLNQLLNAAKDELHDVRRIKDDEISALRME 1280

  Fly  1148 YMAKIETSENENRSKFRAYCLDLKETQKRYE-------EQLQQTNEKLASVTTQCQVHLDVIKRS 1205
            ::.:|||:|.||::||.|   :|:||:.|||       |:|.|..|.|:|||.:||..|:.:|.:
  Fly  1281 FLLQIETNEKENQAKFYA---ELQETKDRYESNVAELKEKLLQVEETLSSVTVRCQAELEALKSA 1342

  Fly  1206 LQEKITQAEKERNELAVRHKAELEKIRETLKEK-----------ESSYK-----------EKLRQ 1248
            .:|.|:||.:|||.|.|:|:||:|.||||||.|           |.:::           |:|.|
  Fly  1343 HKENISQAVEERNNLIVQHQAEMETIRETLKNKLAEASTQQSKMEDAFRAEINEVRATLMEQLNQ 1407

  Fly  1249 AEEERDKEISRLE--------------VMRNTIAELHKTNSDREVELEGVKMEKCQLKKLYDKSM 1299
            .:|:|||..|:||              ||.:|||||.||.:::::.:..:..:..:|:|...|:.
  Fly  1408 TKEDRDKGASKLEEVKKTLEQMINGGRVMSDTIAELEKTKAEQDLAVNKLTKDNIELEKQCSKTQ 1472

  Fly  1300 LELEQLQCTADQ---------KSSDLLPGSSNENIDDLQKKCDQYVQDLELLRGEKAELLSEIQK 1355
            .:|:....|.||         |..:|:..||.:.|.:|::||||.|.:|:..|.||..|.|||||
  Fly  1473 EQLQMESLTRDQISFEIEAHIKKLELIVASSKKRIIELEEKCDQQVLELDKCRLEKLSLESEIQK 1537

  Fly  1356 INGQHSNTIKKLEEIEAEMITLTTQKELERCEIAEKLETFKSKEADIKEALHCAQLRLHAYDKLV 1420
            .|.:||.|::||:|::|||..|:.:.|.|:|:...|||||..|..|::|.|..||.::..||.||
  Fly  1538 ANSEHSCTMEKLQELQAEMKVLSNRNEKEKCDFETKLETFTFKITDLEEVLKEAQHKVILYDDLV 1602

  Fly  1421 CEYERLKGCLSDSNKLSENLQKKVERLHAEQLALQEGISGRDSEIKQLRSELKDAIDENKTVREA 1485
            .::||||.||:::|:||.||||||..||.|.:..|:|||.||.||.:||.|||.|:|...|....
  Fly  1603 SQHERLKICLAEANELSSNLQKKVMSLHTELIDSQKGISSRDVEINELREELKAAMDAKATASAE 1667

  Fly  1486 KVGLENSLKAVQENMSAQEGQFKQKIADIKGSVDELQIKLKSLQEVRDHLESRNEELKRKLKDAQ 1550
            ::.|...||.|:|.|:.|..:|.::.|::|||::||.:||.|:||.:|.|||.|||||.:|:::|
  Fly  1668 QMTLVTQLKDVEERMANQAEKFTREAANLKGSINELLLKLNSMQETKDMLESGNEELKEQLRNSQ 1732

  Fly  1551 ELQNMVDKERKLNSSLREDFDKLEQTKLDLEEQLRAKKVEIDRRSKEL-----------GEVTKD 1604
            .|:||:|:|.|:..||:|...|||..|..||:|||..|.||.:|..||           ||:||.
  Fly  1733 NLRNMLDEESKMCISLKEKLVKLEDAKTSLEQQLRDNKSEIYQRHTELTKEVELGRNRIGELTKK 1797

  Fly  1605 CENIRSDLEAQTNDFLKERETLNLTISDLRLHNEQLLETSKNYLSDITAANNLNLEMKKNLHDLT 1669
            ||.:.||||  .:|.::         .||:...|||.:|.:|           ||..::.:.::|
  Fly  1798 CEELCSDLE--NSDQIR---------LDLQETKEQLKKTLEN-----------NLGWQQKVDEVT 1840

  Fly  1670 KECKSLRSDLQSKEEYFQTQKQLLDETISNLKEENRKMEEKLSSGNKALKEDCEKLRSTLESKEL 1734
            :||:.||.|:||||
  Fly  1841 RECEKLRFDMQSKE--------------------------------------------------- 1854

  Fly  1735 ILQQNKQELEERLTVINEKNGKNALLDAQLKSNETAFTSLRKAWIKQSLAIEAANKRSLEMEQKV 1799
                                                                      ::.|.||
  Fly  1855 ----------------------------------------------------------VQNESKV 1861

  Fly  1800 DKRTREYEELRSTLKTREINFRSEKERMDGTISSLLEDKRNLEEKLCTVTELLAKLKRELPALHT 1864
            .:...|.||||||||::|.:|:||||.||.|||||||||||||||||:..:::|||:.|:.||.
  Fly  1862 QELISECEELRSTLKSKEASFQSEKESMDRTISSLLEDKRNLEEKLCSANDIVAKLETEIAALR- 1925

  Fly  1865 QKVNGGDVSIELNSSNGSPTPAAVPATKKPLDCNSAECVPKKSSSLETAERKNRRMTAYDENRKQ 1929
                                      .:|.||.|.   ||:||.:.|:..|||||::.:||.|:.
  Fly  1926 --------------------------PRKSLDRNP---VPRKSITFESEIRKNRRISVHDERRQS 1961

  Fly  1930 F 1930
            :
  Fly  1962 Y 1962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	256/318 (81%)
		Motor_domain	8..310	CDD:277568	251/312 (80%)
		SMC_prok_B	<471..1270	CDD:274008	372/911 (41%)
		Mplasa_alph_rch	924..1647	CDD:275316	323/845 (38%)
		CENP-H	1204..>1266	CDD:283493	33/97 (34%)
		CALCOCO1	<1489..1850	CDD:285171	121/371 (33%)
cmet	NP_524993.3	KISc	8..328	CDD:214526	257/319 (81%)
		Motor_domain	8..321	CDD:277568	251/312 (80%)
		Smc	<680..1449	CDD:224117	315/782 (40%)
		TMPIT	779..>867	CDD:285135	36/87 (41%)
		Smc	1042..1910	CDD:224117	356/1005 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438277
Domainoid	1	1.000	287	1.000	Domainoid score	I372
eggNOG	1	0.900	-	-		E2759_KOG0242
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	349	1.000	Inparanoid score	I619
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53505
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000669
OrthoInspector	1	1.000	-	-		otm26081
orthoMCL	1	0.900	-	-		OOG6_101662
Panther	1	1.100	-	-	P	PTHR47968
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5166
	11	10.800