DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cana and Kif17

DIOPT Version :9

Sequence 1:	NP_001027247.1	Gene:	cana / 3771934	FlyBaseID:	FBgn0040233	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	XP_038967234.1	Gene:	Kif17 / 500571	RGDID:	1562511	Length:	1075	Species:	Rattus norvegicus

Alignment Length:	1293	Identity:	281/1293 - (21%)
Similarity:	477/1293 - (36%)	Gaps:	432/1293 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ASSIQVCIKVRPC-----EPGLTSLWQVKEGRS---IQ---LADSHAEPYVFDYVFDEGASNQEV 59
            :.|::|.::.||.     |....|:..|...|.   ||   .||...:.:.||..:......:::
  Rat     3 SESVKVVVRCRPMNKRERELNCQSVVTVDCARGQCFIQNPGAADEPPKQFTFDGAYYIEHFTEQI 67

  Fly    60 FDRMAKHIVHACMQGSNGTIFAYGQTSSGKTYTMMGDEQNP---GVMVLAAKEIFQQISSETERD 121
            ::.:|..:|....:|.||||||||||.|||::||.|....|   |::..|.:.:|:.:.......
  Rat    68 YNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQGLPDPPCQRGIIPRAFEHVFESVQCAENTK 132

  Fly   122 FLLRVGYIEIYNEKIYDLL---NKKNQDLKIH-ESGNGI--VNVNCKESIVTSEDDLLRQLYMGN 180
            ||:|..|:|||||.:.|||   .|:..:||.| |.|..:  ::::...::...|    |.:..|.
  Rat   133 FLVRASYLEIYNEDVRDLLGADTKQRLELKEHPEKGVYVKGLSMHTVHNVAQCE----RVMETGW 193

  Fly   181 KERVVGETNMNERSSRSHAIFRIIIESRKSDHSDNDTVKQSVLSLVDLAGSEQVDPADHAS---- 241
            |.|.||.|.||:.|||||:||.|.||....|....|.::...|:||||||||:........
  Rat   194 KNRAVGYTLMNKDSSRSHSIFTINIEIYAVDERGKDHLRAGKLNLVDLAGSERQSKTGATGERLK 258

  Fly   242 -------SLMIFRNLVKSLSESVDS--KPNSFRDSKLPRIMLPSLGGNVLTSIICTITP--SFVE 295
                   ||....|::.:|   ||.  |...:|||||.|::..|||||..|.::..::|  :..:
  Rat   259 EATKINLSLSALGNVISAL---VDGRCKHIPYRDSKLTRLLQDSLGGNTKTLMVACLSPADNNYD 320

  Fly   296 ESSSTISFGTCAKKIRCKPQVCKIDSETTMMRQLDRGISMLKDKLAKKKIKNESQLVLQELEGRI 360
            |:.||:.:...||.|:.||::.: |.:..::|:....|..||..||:           |...|.:
  Rat   321 ETLSTLRYANRAKNIKNKPRINE-DPKDALLREYQEEIKRLKAILAQ-----------QMGPGNL 373

  Fly   361 KRDMLKIVSSASLDDYRLQKRRRTWTLTASGSEGDAPVLALPEPEESRLPRPSKLTNLPKPLFQR 425
                     ||.|.           |.|.||     ||    .||| :||.|:
  Rat   374 ---------SALLS-----------TQTPSG-----PV----HPEE-KLPSPT------------ 396

  Fly   426 RGIAPKAKGICKTLKEKRLQTDNMDTMPGRAKQLGRETASRIPSVMMSKKYQESVPNCDAPQTEI 490
                                |...||
  Rat   397 --------------------TVQQDT--------------------------------------- 402

  Fly   491 SALTASNQVAKETIEKYEEQVKRLKETIERLEMENGKAVNLGEQFETHKAKSKQMEEELLSSISE 555
               .|..|:.:   |:|||::.|||                 ..:|..:....:::|::.:..:.
  Rat   403 ---EAEKQMIR---EEYEERLARLK-----------------ADYEAEQESRVRLQEDITAMRNS 444

  Fly   556 KDSTIVSLQQSLEELSRDVLRNSKEDQMRSMCPEL---ESSCERICNKCLELERLLPLASASGLD 617
            .|..:.:||::|.          ||.:..::||..   .:||             :|...|.|..
  Rat   445 YDVKLSTLQENLR----------KEKETGALCPGAAWEPTSC-------------VPYTWAKGPL 486

  Fly   618 SVACQFDQLRSEIAATRMKLESMLSTFSHASCEVSQKTTDCKRLSEQISTAHDDFGQLQEKYNNL 682
            ..|.    |::|:.                          ||  :|.:|.|....|   .:|
  Rat   487 HEAV----LKAEVL--------------------------CK--TEVMSRAEVTSG---PEY--- 513

  Fly   683 KHKWSSQKLAIDTMQVDYNTIQQKYLQLQDEYRHLELRSDEQCQQLQDENSKLQAEIGTLKERVE 747
                 |..|..:|      .::...|.:.|             ...:.|.::.||.:.:.:..:|
  Rat   514 -----SPPLQYET------AVKPTVLSMPD-------------MLPRGEVTRSQAPLTSEEPNME 554

  Fly   748 EIHSELLEVPNPDTHPEDMEL-QNQELKKRLSKLQWEFDEIQLNYECLSNELMSTIQECDALREE 811
            ...||:.| .|..::.||..: :.....:.||.:::....:........:|.::.......|..|
  Rat   555 PSRSEVFE-SNESSNLEDSSMSEAYPGPEELSNVEFSMPGVLAESRYFPDEYLNPEAAGCPLEAE 618

  Fly   812 HKQRTTNSDLESMKSSGVGTECSDPENELDTDLLQQFTKLSKSIQQIELTDYSGGRRLFIYNHAE 876
            |..:    |..:::...:.....||..|::       .||::....:.:||.|    ..:.....
  Rat   619 HSVQ----DEPTLEPLRILASLQDPFAEVE-------AKLARLSSTVAMTDLS----QTVVPQVP 668

  Fly   877 QDQSVPSLKLCLEPAKYLEGDGKQHDASDSVFLKGFLKCQRFQIVKINQEQNLVKEEDRMRDIIF 941
            |.|  ||....|||             ||:
  Rat   669 QQQ--PSSTDLLEP-------------SDT----------------------------------- 683

  Fly   942 QLKQEVDGKKN-LIEEEKEVINNLRAQITSLNQIETIKNQNAKTKILCE-ELQTKDTVQTANKQE 1004
              |.|||...| |:..|.::...:..::.|          .|:|.:..| |.......|.:.:.:
  Rat   684 --KSEVDVADNVLLRTEPDLSMKVAEEVVS----------EAETGVWMESEAHVAHVAQVSEEAQ 736

  Fly  1005 SQEVLTLKTSLAHLKSKVCELQKKLEKQSEDEKISELQSDIGEISECCLSMELKLADIVNWQAEE 1069
            .|.:|.:.:               :.::|...:::.|                         .||
  Rat   737 PQPLLAMAS---------------VRRESIGVEVAVL-------------------------TEE 761

  Fly  1070 LRPLDQLQE-SGVELQHHSTTAEESLNVEKPIQEQTERTLTTEYERRIEQLEESLQRAQEE---- 1129
            |:|:||.|. :.::|........|... .|.::|:..|......||: :||..:||.:.|:
  Rat   762 LQPVDQQQVLARLQLLEQQVVGGEQAK-NKDLKEKHRRRKRYADERK-KQLVAALQNSDEDSGDW 824

  Fly  1130 --LSILEKRKTDENKSLQLEYMAKIETSENENRSKFRAYCLDLKETQKRYEEQLQQTNEKLASVT 1192
              |::.:        |:|.|..||.:..| :.:.|.||..:::|:.|..:  ||::.:
  Rat   825 VLLNVYD--------SIQEEVRAKSKLLE-KMQKKLRAAEVEIKDLQSEF--QLEKID------- 871

  Fly  1193 TQCQVHLDVIKRSLQEK---ITQAEKERNELAVR---HKAELEKIRETLKEKESSYKE 1244
                 :|..|:|  ||:   :.|...|:.:..:|   :.:.|||||     :|||:.|
  Rat   872 -----YLATIRR--QERDSMLFQQLLEQVQPLIRRDCNYSNLEKIR-----RESSWDE 917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	114/342 (33%)
		Motor_domain	8..310	CDD:277568	111/336 (33%)
		SMC_prok_B	<471..1270	CDD:274008	140/793 (18%)
		Mplasa_alph_rch	924..1647	CDD:275316	67/336 (20%)
		CENP-H	1204..>1266	CDD:283493	15/47 (32%)
		CALCOCO1	<1489..1850	CDD:285171
Kif17	XP_038967234.1	Motor_domain	4..335	CDD:419868	111/337 (33%)
Kif17	XP_038967234.1	Smc	<631..>899	CDD:224117	74/407 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910