DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cana and Klp98A

DIOPT Version :9

Sequence 1:	NP_001027247.1	Gene:	cana / 3771934	FlyBaseID:	FBgn0040233	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster

Alignment Length:	1432	Identity:	315/1432 - (21%)
Similarity:	528/1432 - (36%)	Gaps:	421/1432 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SSIQVCIKVRP-----------------------CEPGLTSLWQVKEGRSIQLADSHAEPYVFDY 48
            ||::|.::|||                       .:|.|.|:...  ||     |:|.: :.|||
  Fly     2 SSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDA--GR-----DNHHD-FTFDY 58

  Fly    49 ---VFD----EGASNQEVFDRMAKHIVHACMQGSNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLA 106
               .||    ..|:.::|:..:...:|....:|.|..:||||||.||||:||||...|||::...
  Fly    59 SYWSFDAEDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNPGLIPRI 123

  Fly   107 AKEIF--QQISSETERDFLLRVGYIEIYNEKIYDLL--NKKNQDLKIHESGN-GIVNVNCKESIV 166
            .:|:|  .::..|:...:.....|:|||||::.|||  ......|::.|..: |....|..:..|
  Fly   124 CEELFARMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAV 188

  Fly   167 TSEDDLLRQLYMGNKERVVGETNMNERSSRSHAIFRI-IIESRKSDHSDNDTVKQSVLSLVDLAG 230
            :..|::...:..||.:|....||||:.||||||||.| .:::...:...::||  |.:.||||||
  Fly   189 SDFDEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPSETV--SKIHLVDLAG 251

  Fly   231 SEQV-----------DPADHASSLMIFRNLVKSLSESVDSKPNS--------------------F 264
            ||:.           :.|....||:...:::.:|:|......||                    :
  Fly   252 SERANATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPY 316

  Fly   265 RDSKLPRIMLPSLGGNVLTSIICTITPS--FVEESSSTISFGTCAKKIRCKPQVCKIDSETTMMR 327
            |||.|..::..|||||..|.:|..::|:  ...|:.||:.:...||.|..||.|.: |:...::|
  Fly   317 RDSILTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNE-DTNVKLIR 380

  Fly   328 QLDRGISMLKDKL---------------------AKKKIKNE--------SQLVLQELEG-RIKR 362
            :|...|:.||..|                     |::|:..|        :|.:|||.:. .:::
  Fly   381 ELREEINKLKSMLAGDIHSLQPSLKVLADLQKKEAQEKVLTEEWTEKWKVAQSILQEQKSLGLRK 445

  Fly   363 DMLKIVSSASLDD--------------YRLQKRRRTWTLTASGSEGDAPVL--------ALPEPE 405
            ..:.:|..:.:..              |.|::..     |..||| ||.|.        .:....
  Fly   446 SGVGVVLDSEMPHLIGIHNDVTTGVTLYSLKEGE-----TRIGSE-DADVAQDIELAGDGIRAQH 504

  Fly   406 ESRLPRPSKLTNLPKPLFQRRGIAPKAKGICKTLKEKRLQTDNMDTMPGRAKQLGRETASRIPSV 470
            .|...:...:|..|.||.|           |..  ...|..:......|....|||....|..:.
  Fly   505 CSIFLKGGVVTLHPWPLAQ-----------CWV--NAHLIDEPKQISQGDIILLGRTNIFRFNNP 556

  Fly   471 MMSKKYQESVPNCDAPQTEISALTASNQ-----------------------------VAKETIEK 506
            ..:.|.::.:.......:.:|.:|:|.:                             ::::..|.
  Fly   557 AEAAKLRKDLSRSQLDMSRLSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPEL 621

  Fly   507 YEEQVKRLKETIER-LEMENGKAVNLGEQFETHKAKSKQMEEELLSSISEKDSTIVSLQQSLEEL 570
            .:|. :::.:|||. |:..|.:.|.:.:|::|   |.:::.|||           :.|:|  ||:
  Fly   622 QDEN-RKILDTIENALKQLNVERVQMHDQYKT---KVRKLTEEL-----------IRLEQ--EEM 669

  Fly   571 SRDVLRNSKEDQMRSMCPEL--ESSCERICNKCLELERLLPLASASGLDSVACQFDQLRSEIAAT 633
            ....|.|.:|.::.:....|  |.:.|::                        |.|.:..:|:|.
  Fly   670 DGLQLLNCREQELIARKDMLLWEKNNEKV------------------------QIDIVCRQISAF 710

  Fly   634 RMKLESMLSTFSHASCEVSQKTTDCKRLSEQISTAHDDFGQLQEKYNNLKHK---WSSQKLAIDT 695
            :.:|:|....||....:..|:..||.:|        |:.|...|:...|..:   ..|..|.:..
  Fly   711 QTQLDSKKRDFSEYVAKELQELQDCGKL--------DEMGMKIEEGTPLNDELLLQVSDSLDLFA 767

  Fly   696 MQVDYNTIQQKYLQLQDEYRHLELRSDEQCQQLQDENSKLQAEIGTLKERVEEIHSEL--LEVPN 758
            .|...:|:::.    .:|.|.|    |||..:.:...:....:|..:.|.:.||.::|  |.:..
  Fly   768 AQFIKDTVRRN----NEEIRKL----DEQIAEKERILNASTTKIAKVDETMLEIQAQLERLRLER 824

  Fly   759 PDTHPEDMELQNQELKKRLSKLQWEFDEIQLNYECLSNELMS---------------TIQECDAL 808
            .::   :.|.|....||:..|||            |.|:.||               |.:.||..
  Fly   825 AES---EAESQAMRAKKQNMKLQ------------LGNKSMSTSTSTNEADDVSKSDTYETCDTF 874

  Fly   809 REEHKQRTTNSDLESMKSSGVGTE--------CS-DPENEL-DTDLLQQFTKLSKSIQQIELT-- 861
                  .|..|:| |:.||...||        || |.|:|. ||    :...||.|.::...|
  Fly   875 ------HTAQSNL-SLVSSPTITEGQQSPLSNCSCDAEDEAEDT----RKDDLSGSSEETSRTCT 928

  Fly   862 ----DYSGGRRLFIYNHAEQDQSVPSLKLCLEPAKYLEGDGKQHDASDSVFLKGFLKCQRFQIVK 922
                ..||...:.|..........||               .|...|||    |.....|.|.:.
  Fly   929 AGPSSGSGSGSVGIGGSGSAPSCTPS---------------SQAIMSDS----GVCLDSRNQAIL 974

  Fly   923 INQEQNLVKEEDRMRDIIFQLKQEVDGKKNLIE--EEKEV------INNLRAQITSLNQIETIKN 979
            .|...|..|:..|..|       |..|..:..|  ...:|      :::||.:|.
  Fly   975 QNGHLNNYKQAVRTSD-------EDTGSCSSCELGRHSDVARPYCPLHSLRRKIA---------- 1022

  Fly   980 QNAKTKILCEELQTKDTVQTANKQESQEVLTLKTSLAHLKSKVCELQKKLEK--QSEDEKISELQ 1042
              |:..::.:.|:|     ..||             |.|...:.:||....:  |.|.|.:..:|
  Fly  1023 --AQKALIMKNLET-----DLNK-------------AQLDEHIADLQDLQRRYIQMEQEMLQSVQ 1067

  Fly  1043 SDIGEISECCLSMELKLADIVNWQAEELRPLDQLQESGVELQHHSTTAEESLNVEKP--IQEQTE 1105
             |:...::||       ||               :.||:|.|:...::....:|..|  ::|.|.
  Fly  1068 -DLEAHAQCC-------AD---------------ERSGMERQYELASSIMRSSVMSPTSMEESTS 1109

  Fly  1106 RTLTTEYERRIEQLEESLQRAQEELSILEKRKTDENKSLQLEYMAKIETSENENRSKFRAYCLDL 1170
            :..:....|....:.| ....:..::|.........|....||..:|...:.:         |::
  Fly  1110 QIYSPSMTRSCPSMRE-FPEGEHFITIPSFVMRGAGKQTHYEYEVRIALPDGK---------LNI 1164

  Fly  1171 KETQKRYEEQLQQTNEKLASVTTQCQVHLDVIKRSLQEKITQAEKERNELAVRHKAELEKIRETL 1235
            .....|:.|                 :|| .:|.....||:.....|.||...:...:.|.|..|
  Fly  1165 LRRYSRFRE-----------------LHL-CMKHCYGAKISALPFPRRELFASNSEPVAKHRRRL 1211

  Fly  1236 KE 1237
            .|
  Fly  1212 LE 1213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	111/376 (30%)
		Motor_domain	8..310	CDD:277568	108/370 (29%)
		SMC_prok_B	<471..1270	CDD:274008	165/847 (19%)
		Mplasa_alph_rch	924..1647	CDD:275316	60/326 (18%)
		CENP-H	1204..>1266	CDD:283493	9/34 (26%)
		CALCOCO1	<1489..1850	CDD:285171
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	112/378 (30%)
		KISc	3..371	CDD:214526	111/377 (29%)
		Kinesin_assoc	370..478	CDD:292801	18/108 (17%)
		FHA	456..555	CDD:238017	22/117 (19%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784	20/110 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437738
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930