DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cana and Kif19A

DIOPT Version :9

Sequence 1:	NP_001027247.1	Gene:	cana / 3771934	FlyBaseID:	FBgn0040233	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	NP_996208.1	Gene:	Kif19A / 41717	FlyBaseID:	FBgn0038205	Length:	750	Species:	Drosophila melanogaster

Alignment Length:	725	Identity:	189/725 - (26%)
Similarity:	293/725 - (40%)	Gaps:	145/725 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VCIKVRPCEPGLTSLWQVKEGRSIQLAD---SHAEPYVFDYVFDEGASNQEVFDRMAKHIVHACM 72
            |.::|||.........:|..|.|:...|   |....|.:|:||.|..|.::|:......:|...:
  Fly    38 VAVRVRPSMEATERCIEVISGGSLLYDDGGKSRPRQYSYDHVFRENDSQEQVYKTTTAPLVRDVL 102

  Fly    73 QGSNGTIFAYGQTSSGKTYTMMG------------------------DEQNPGVMVLAAKEIFQQ 113
            .|.|..:||||.|.||||:||:|                        ..|:.|:||.|.::||..
  Fly   103 NGLNAAVFAYGATGSGKTHTMLGPVPRKKPQTSDRAPPTASCDSTDVSSQDIGLMVRAIEDIFSH 167

  Fly   114 ISSETERDFLLRVGYIEIYNEKIYDLLNKKNQ-DLKIHESGNGIVNVNCKESIVTSEDDLLRQLY 177
            |.|.......:.:.|:|||||.|.||||.... :|:....|..|......|...:|..:::..|.
  Fly   168 IESAEAYSCRVSISYLEIYNELIRDLLNPGGPLELREDHRGQRITVAGLSEITTSSRKEVVSLLL 232

  Fly   178 MGNKERVVGETNMNERSSRSHAIFRIIIESRKSDHSDNDTVKQSVLSLVDLAGSEQV-------- 234
            .|||.|.:..|..|:.||||||:..|::::|....:     ||..|.|.||||||:.
  Fly   233 KGNKARTMEPTAANQTSSRSHALLSIMVQARTPLGT-----KQGRLFLTDLAGSERAKKTKNRGK 292

  Fly   235 ---DPADHASSLMIFRNLVKSLSESVDSKPNSFRDSKLPRIMLPSLGGNVLTSIICTITP--SFV 294
               :.|....||:...|::..||..  ::..::|||||.|::..:|.|...|.:|..:.|  ...
  Fly   293 RLQEGAHINRSLLALGNVINGLSGG--ARYVNYRDSKLTRLLKEALSGRCKTVMIAHVAPESKHR 355

  Fly   295 EESSSTISFGTCAKKIRCKPQVCKIDSETTMMRQLDRGISMLKDKLAKKKIKNESQLVLQELEGR 359
            :|:.:|:.:...|..|            ||.::.     |:..|:......|:...|| .||...
  Fly   356 DETKNTLVYADRANSI------------TTKLQN-----SVYIDEFKDFPTKHYQSLV-SELRDE 402

  Fly   360 IKRDMLKIVSSASLDDYRLQKRRRTW------TLTASGSEGDAPVLALPEP-EESRLPRPSKLTN 417
            :.|...|:          |.:|.|:.      ...||||.|.|...|..|. :|....|.::|..
  Fly   403 VSRLRTKM----------LTERPRSGAAAAAAAAAASGSAGTAGSGAGSEAVQEQDEQRKTELRY 457

  Fly   418 LPKPLFQRRGIAPKAKGICKTLKEKRLQTDNMDTMPGRAKQLGRETASRIPSVMMS-------KK 475
            |      |..|....|...| |:.|.|:.:        :..||.|..:....:::|       |.
  Fly   458 L------REQIVLTFKQQMK-LRRKLLEAE--------SHLLGLELDAERQHMIISHWQGRIGKL 507

  Fly   476 YQESVPNCDAPQTEISALTASNQVAKETIEKYEEQVKRLKETIERLEMENGKAVNLGEQFETHKA 540
            |.....:....:..::...|..::|  .|||   :.:|.||..||.|.|..:....|.:.|....
  Fly   508 YDAMGDDDIESEGSVALKNAWGELA--AIEK---ETRRYKEIRERTEHELEQCRQKGVKLEDELP 567

  Fly   541 KSKQMEEE-----LLSSISEKDSTIVSLQQS----LEELSRDVLRNSKEDQMRSMCPELESSCER 596
            :....:||     ||..:.|.::..||||..    ..||.|..|:..:.::.|.:|.::.||..|
  Fly   568 ERISSDEERELLALLCRVHELEADKVSLQAERLARQAELRRRDLQLLRAERQRRLCEDIISSQRR 632

  Fly   597 ICNKCLELERLLPLASASGLDSVACQFDQLRSEIAATRMKLESMLSTFSHASCEVSQKTTDCKRL 661
            :..   |....||              |:||        :|..:.....||.. |:..|::.:|.
  Fly   633 LIE---EGNVDLP--------------DELR--------ELYGLYQQEIHAGV-VTPSTSNYERK 671

  Fly   662 SEQISTAHDD 671
            ...|.||..|
  Fly   672 LPPIYTAGSD 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	102/345 (30%)
		Motor_domain	8..310	CDD:277568	101/339 (30%)
		SMC_prok_B	<471..1270	CDD:274008	51/217 (24%)
		Mplasa_alph_rch	924..1647	CDD:275316
		CENP-H	1204..>1266	CDD:283493
		CALCOCO1	<1489..1850	CDD:285171
Kif19A	NP_996208.1	Motor_domain	35..371	CDD:277568	101/339 (30%)
Kif19A	NP_996208.1	Kinesin	41..371	CDD:278646	100/336 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438004
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830