DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cana and kif18a

DIOPT Version :9

Sequence 1:	NP_001027247.1	Gene:	cana / 3771934	FlyBaseID:	FBgn0040233	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	NP_956533.1	Gene:	kif18a / 393209	ZFINID:	ZDB-GENE-040426-862	Length:	895	Species:	Danio rerio

Alignment Length:	852	Identity:	214/852 - (25%)
Similarity:	356/852 - (41%)	Gaps:	225/852 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SSIQVCIKVRPCEPGLTSLWQVKEG---RSIQLADSHA---EP---------------------- 43
            |.::|.::|||...      :.|:|   :.:.:.|:|.   :|
Zfish     8 SHVKVVVRVRPLND------KEKDGNFKKVVHVVDNHMLVFDPKEEEVTFFRGQRVGNRDVRKRA 66

  Fly    44 -----YVFDYVFDEGASNQEVFDRMAKHIVHACMQGSNGTIFAYGQTSSGKTYTMMGDEQNPGVM 103
                 :|||.||.|.:|..|||:...|.||...:.|.|.|:||||.|.:|||:||:|...:||||
Zfish    67 NKDLKFVFDSVFGEESSQIEVFENTTKAIVDGVLNGYNCTVFAYGATGAGKTHTMLGTSNSPGVM 131

  Fly   104 VLAAKEIFQQIS-SETERDFLLRVGYIEIYNEKIYDLLNKKNQDLKIHESG-NGIVNVNCKESIV 166
            .|..||:|.::. .:.::.|.:...|:|:|||:|.|||.... .|.:.|.| ||:|.........
Zfish   132 FLTMKELFARMDLIKEDKVFNVAFSYLEVYNEQIRDLLTNSG-PLAVREDGSNGVVVQGLTLHQP 195

  Fly   167 TSEDDLLRQLYMGNKERVVGETNMNERSSRSHAIFRIIIESRKSDHSDNDTVKQSVLSLVDLAGS 231
            .|.:.:|..|..||:.|....|:||..||||||:|:|.:..:....|.|..|:.:.:||:|||||
Zfish   196 KSAEHILEALDYGNRNRTQHPTDMNATSSRSHAVFQIYLRQQDKTASLNPNVRVAKMSLIDLAGS 260

  Fly   232 EQV-----------DPADHASSLMIFRNLVKSLSESVDSKPN-SFRDSKLPRIMLPSLGGNVLTS 284
            |:.           :.|:...||:...|::.:|:.....|.: .:|||||.|::..|||||..|.
Zfish   261 ERASATNTKGARLREGANINRSLLALGNVINTLANPKCKKTHIPYRDSKLTRLLKDSLGGNCRTV 325

  Fly   285 IICTITPSFV--EESSSTISFGTCAKKIR--CKPQVCKIDSE----TTMMRQLDRGISMLKDKLA 341
            :|..::||.:  |::.:|:.:...||:|:  .:..|..:||.    ..:..:....|.|||.|
Zfish   326 MIANVSPSSLSYEDTHNTLKYANRAKEIKSTLRSNVMSLDSHIGQYAIICEKQKAEIVMLKQK-- 388

  Fly   342 KKKIKNESQLVLQELEGRIKRDMLKIVSSASLDDYRLQKRRRTWTLTASGSEGDAPVLALPEPEE 406
                       |:|.|.|       ...:.:|:...:|||...
Zfish   389 -----------LKEYEER-------KAEAPALNPISIQKRAEF---------------------- 413

  Fly   407 SRLPRPSKLTNLPKPLFQRRGIAPKAKGICKTLKEKRLQTDNMDTMPGRAKQLGRETASRIPSVM 471
                  .|::...:.:|..|               .:|:.:::|.    .|||..   ||:....
Zfish   414 ------EKMSESLRSVFSDR---------------LKLRKEHLDI----EKQLNE---SRLTMRH 450

  Fly   472 MSKKYQESVPNCDAPQTEISALTASNQVAKETIEKYEEQVKRLKETIERLE---MENGKAVN--- 530
            ....:|:|:           .....|:..:.|. |||.::..||...|.|:   ||:.|...
Zfish   451 RESWHQQSL-----------IFFPDNKAERATC-KYERKLASLKSHQEHLQQRLMESEKCFQENE 503

  Fly   531 ------------LGEQFETHKAKSKQME-EELLSSISEKDSTIVSLQQSLEELSRDV-LRNSKED 581
                        ||....|.:...|::: .:|...||:       |||.:|.:|..: :::.:..
Zfish   504 GWLHRIENEMKLLGHDGHTPEELKKELQCHQLQLQISD-------LQQHMEHMSHLISVQDQENT 561

  Fly   582 QMRSMCPELESSCER--ICNKCL----------ELERLLPLASASGLDSVACQFDQLRSE----- 629
            ....:...|.|:|.|  :..|.:          |||||:....|      ....||.::|
Zfish   562 HTHKLVNALLSTCRRQHLALKAMSADGDGSEWEELERLVHRERA------VVWADQEKAEDKRDD 620

  Fly   630 --IAATRMKLESMLSTFSHASCEVSQKTTDC------KRLSEQISTAHD--DFG---QLQEKYNN 681
              |.:|.::   .:.:|||.   ||.::|.|      :|.|:::...|.  |.|   |:.|....
Zfish   621 SGIGSTHLR---PILSFSHL---VSHQSTPCSSEKHTRRTSQRLRPTHSSKDCGPHHQVAEAEGV 679

  Fly   682 LKHKWSSQKLAIDTMQVDYN--TIQQKYLQLQDEYRH-----LELRSDEQ--CQQLQDENSKLQA 737
            || |...:||::...::|.:  .:......|||..|.     |:...:.|  ...:.|.||.:
Zfish   680 LK-KPIRRKLSVSPAKLDGDGPVLSHHPPDLQDVLRQEGMFPLQFTPEGQPHTSSIFDPNSTI-- 741

  Fly   738 EIGTLKE 744
            :||.:::
Zfish   742 DIGHIED 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	114/358 (32%)
		Motor_domain	8..310	CDD:277568	113/350 (32%)
		SMC_prok_B	<471..1270	CDD:274008	73/333 (22%)
		Mplasa_alph_rch	924..1647	CDD:275316
		CENP-H	1204..>1266	CDD:283493
		CALCOCO1	<1489..1850	CDD:285171
kif18a	NP_956533.1	KISc	9..354	CDD:214526	113/351 (32%)
kif18a	NP_956533.1	KISc_KIP3_like	9..353	CDD:276821	113/350 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900