DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cana and pav

DIOPT Version :9

Sequence 1:	NP_001027247.1	Gene:	cana / 3771934	FlyBaseID:	FBgn0040233	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	NP_477025.1	Gene:	pav / 38515	FlyBaseID:	FBgn0011692	Length:	887	Species:	Drosophila melanogaster

Alignment Length:	1008	Identity:	216/1008 - (21%)
Similarity:	359/1008 - (35%)	Gaps:	307/1008 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 STKNASSIQVCIKVRP--CEPGLTSLWQVKEGRSIQLAD-----SHAEP---------YVFDYVF 50
            |.|....:.|..:|||  .:..|||| :||...:|.|..     .|.:|         |:|.:||
  Fly    30 SDKARDPVNVFCRVRPLQSDADLTSL-RVKNSTTIALNPQDQLLQHHKPHNGAQREVQYIFKHVF 93

  Fly    51 DEGASNQEVFDRMAKHIVHACMQGSNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAKEIFQQIS 115
            ...|:.|:|:..:|:.:|...::|.|..:|.||.|.|||||||.|:.::.|:|......:|:.||
  Fly    94 QPDATQQDVYAAVAQPLVENLLKGRNSLLFTYGVTGSGKTYTMTGNLRHRGIMPRCLDVLFRTIS 158

  Fly   116 SE------------------TERDFLLR------------------------------------- 125
            ..                  :|.|.||.
  Fly   159 DYQAKKFVFKPDKLNGFEILSEEDALLERQHEMNQRFAGSGRFAFRHKDSDPEIASQASVEPIPL 223

  Fly   126 ------------VGYIEIYNEKIYDLL-----NKKNQDLKIHESGN------GIVNVNCKESIVT 167
                        |.||||||..:||||     .|..|...|.|..|      |:..|..|
  Fly   224 LGLDEDNMYSVFVTYIEIYNNSVYDLLEDSGIQKTLQSKIIREDANRHMFVHGVTEVEVK----- 283

  Fly   168 SEDDLLRQLYMGNKERVVGETNMNERSSRSHAIFRIIIESRKSDH------SDNDTVKQSVLSLV 226
            :.:|.|....||.|.:.:|.|.:|..|||||::|.|.:....:|.      .|...:..|.||||
  Fly   284 TVEDALEVFQMGQKRKRMGHTVLNAESSRSHSVFNIRLVQAPTDSQGENVVQDRQNITVSQLSLV 348

  Fly   227 DLAGSEQVDPADHA-----------SSLMIFRNLVKSLSESVDSKPNS-------FRDSKLPRIM 273
            ||||||:.....:.           :|||..|..::.|.|:..:..|.       :||||:..:.
  Fly   349 DLAGSERSSRTKNTGVRLREAGNINNSLMTLRTCLEYLRENQLAASNGLAPKKVPYRDSKITHMF 413

  Fly   274 LPSLGGNVLTSIICTITPSF--VEESSSTISFGTCAKKIRCKPQVCKIDSETTMMRQLDRGIS-- 334
            .....|....|:|..|.|..  .:|:...:.|....::::.        :..|.|:| |.|::
  Fly   414 KNYFDGEGQVSMIVCINPRIEDYDENMQVMKFAEMTQEVQI--------ARATPMKQ-DLGLTPG 469

  Fly   335 -MLKDKLAKKKIKNESQLVLQELEGRIKRDMLKIVSSASLDDYRLQKRRRTWTLTASGSEGDAPV 398
             ...:||.|..:.|.::|.:.|.:. ::.|:..:.|...                      |.|.
  Fly   470 RRKANKLFKIAVNNLNELGIPEAKD-LEVDVGLVYSLGP----------------------DFPA 511

  Fly   399 LALPEPE------------ESRLPRPSKLTNLPKPLFQRRGIAPKAKGICKTLKE--KRLQTDNM 449
            ..:..||            |.|:.:..||         |..:..|    |.:.::  ..|..||:
  Fly   512 YEMDSPEAQIKIRELMHYLEQRIEKRKKL---------RANLDIK----CDSFRQMLMNLDRDNL 563

  Fly   450 DTMPGRAKQLGRETASRIPSVMMSKKYQESVPNCDAPQTEISALTASNQVAKETIEKYEEQVKRL 514
                    ||..|.||      :...|::......|.:.::....:|..|...|:.|.|.|::.|
  Fly   564 --------QLRTELAS------LKAVYKQERDRSAALEKKVRIHESSIDVLNNTLSKQERQIEEL 614

  Fly   515 KETIERLEMENGKAVNLGEQFETHKAKSKQMEEELLSSISEKDSTIVSLQQSLEELSRDVLRNSK 579
              |.:..|.|     |:..|.|..|.|.|:.....|:..|:|:.....|:          ||..:
  Fly   615 --TFKLNEKE-----NMLTQKEHEKEKQKKKFSSKLAVESDKNKREFELK----------LREQR 662

  Fly   580 ---EDQMRSMCPELESSCERICNKCLELERLLPLASASGLDSVACQFDQ-------LRSEIAATR 634
               :::||....:|     |:.:..|:.|.|..|..:...:::..:.|:       ..|.:.|||
  Fly   663 VKLQERMRIKDEKL-----RLVSNILQSEDLPSLPRSQSSENILNEKDRGAYTARTEESSVPATR 722

  Fly   635 MKLESMLSTFSHASCEVSQKTTDCKRLSEQISTAHDDFGQLQEKYNNLKHKWSSQKLAIDTMQVD 699
               ..:.:|..|.:...:.:                     ..:..:...||...:.|   ..|.
  Fly   723 ---TDIYATPRHGAAAANNR---------------------HRRSRSAGDKWLEHRAA---NPVP 760

  Fly   700 YNTIQQKYLQLQDEYRHLELRSDEQCQQLQDENSKLQAEIGTLKERVEEIHSE-LLEVPNPDTHP 763
            ..||.|.||                      :|.|...::..|||......:: .|...:.||
  Fly   761 LGTIMQPYL----------------------KNRKSVTKLTDLKELTAHGTTKYCLVSQDADT-- 801

  Fly   764 EDMELQNQELKKRL-----SKLQWEFDEIQLNYECLSNELMSTIQECDALREEHKQRTTNSDLES 823
             |.:::.:..|..:     ...|..|:::    |||..:        ..:....::|.:|.::.:
  Fly   802 -DGDVETKLYKGNVIPTCGGGAQVVFNDV----ECLKQK--------SPVHSPTRKRPSNGNISA 853

  Fly   824 MKSSGVG---TECSDPENELDTDLLQQFTKLSK 853
            :....|.   |...|..:..:..:....:|.||
  Fly   854 LGGGAVPSTVTSAQDVASRCNLGIEGHSSKKSK 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	111/427 (26%)
		Motor_domain	8..310	CDD:277568	111/421 (26%)
		SMC_prok_B	<471..1270	CDD:274008	71/402 (18%)
		Mplasa_alph_rch	924..1647	CDD:275316
		CENP-H	1204..>1266	CDD:283493
		CALCOCO1	<1489..1850	CDD:285171
pav	NP_477025.1	KISc_KIF23_like	35..450	CDD:276819	111/420 (26%)
		Kinesin	42..452	CDD:278646	110/415 (27%)
		MKLP1_Arf_bdg	735..837	CDD:293148	24/162 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437971
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930