DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cana and KIF5C

DIOPT Version :9

Sequence 1:	NP_001027247.1	Gene:	cana / 3771934	FlyBaseID:	FBgn0040233	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	NP_004513.1	Gene:	KIF5C / 3800	HGNCID:	6325	Length:	957	Species:	Homo sapiens

Alignment Length:	1160	Identity:	288/1160 - (24%)
Similarity:	492/1160 - (42%)	Gaps:	306/1160 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SIQVCIKVRPCEP-----GLTSLWQVKEGRSIQLADSHAEPYVFDYVFDEGASNQEVFDRMAKHI 67
            ||:|..:.||...     |...:.:.|...::.:  ...:|||||.|.....:.::|::..||.|
Human     8 SIKVMCRFRPLNEAEILRGDKFIPKFKGDETVVI--GQGKPYVFDRVLPPNTTQEQVYNACAKQI 70

  Fly    68 VHACMQGSNGTIFAYGQTSSGKTYTMMG---DEQNPGVMVLAAKEIFQQISSETER-DFLLRVGY 128
            |...::|.|||||||||||||||:||.|   |.|..|::...|.:||..|.|..|. :|.::|.|
Human    71 VKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIAHDIFDHIYSMDENLEFHIKVSY 135

  Fly   129 IEIYNEKIYDLLNKKNQDLKIHESGNGIVNV-NCKESIVTSEDDLLRQLYMGNKERVVGETNMNE 192
            .|||.:||.|||:....:|.:||..|.:..| .|.|..|:|.::::..:..|...|.|..|||||
Human   136 FEIYLDKIRDLLDVSKTNLAVHEDKNRVPYVKGCTERFVSSPEEVMDVIDEGKANRHVAVTNMNE 200

  Fly   193 RSSRSHAIFRIIIESRKSDHSDNDTVKQSVLSLVDLAGSEQVDPA-------DHA----SSLMIF 246
            .|||||:||.|.|   |.::.:.:......|.||||||||:|...       |.|    .||...
Human   201 HSSRSHSIFLINI---KQENVETEKKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSAL 262

  Fly   247 RNLVKSLSESVDSKPNSFRDSKLPRIMLPSLGGNVLTSIICTITPS-FVE-ESSSTISFGTCAKK 309
            .|::.:|:|...:.. .:||||:.||:..|||||..|:|:...:|| |.| |:.||:.||..||.
Human   263 GNVISALAEGTKTHV-PYRDSKMTRILQDSLGGNCRTTIVICCSPSVFNEAETKSTLMFGQRAKT 326

  Fly   310 IRCKPQVCKIDSETTMMRQLDRGISMLKDKLAKKKIKNES-QLVLQELEGRIKRDMLKIVSSASL 373
            |:           .|:...|:......|.|..|:|.||:: :.|:|.||..:.|
Human   327 IK-----------NTVSVNLELTAEEWKKKYEKEKEKNKTLKNVIQHLEMELNR----------- 369

  Fly   374 DDYRLQKRRRTWTLTASGSEGDAPVLALPEPEESRLPRPSKLTNLPK-PLFQRRGIAPKAKGICK 437
                       |      ..|:    |:||.|:........|..... |:..  .|||...||..
Human   370 -----------W------RNGE----AVPEDEQISAKDQKNLEPCDNTPIID--NIAPVVAGIST 411

  Fly   438 TLKEK--------RLQTDNMDTMPGRAKQLGRETASRIPSVMM--------SKKYQESVPNCDAP 486
            ..|||        ..|.|:.|....:..||    |.::...|:        :::..|.:
Human   412 EEKEKYDEEISSLYRQLDDKDDEINQQSQL----AEKLKQQMLDQDELLASTRRDYEKI------ 466

  Fly   487 QTEISALTASNQVAKETIEKYEEQVKRLKETIERLEMENGKAVNLGEQFETHKAKSKQMEEELLS 551
            |.|::.|...|:.||       ::||.:.:.:|.|      |||..::.:..:.|:: ..|:|..
Human   467 QEELTRLQIENEAAK-------DEVKEVLQALEEL------AVNYDQKSQEVEDKTR-ANEQLTD 517

  Fly   552 SISEKDSTIVSLQQSLEELSRDVLRNSKEDQMRSMCPELESSCERICNKCLELERLLPLASASGL 616
            .:::|.:|:.:.|:.|.:|..  |.|.::.:           ...|.|  |.|:.|..:....|.
Human   518 ELAQKTTTLTTTQRELSQLQE--LSNHQKKR-----------ATEILN--LLLKDLGEIGGIIGT 567

  Fly   617 DSVACQFDQLRSEIAATRMKLESMLSTFSHASCEVSQKTTDCKRL---SEQISTAHDDFGQLQEK 678
            :.|        ..:|.....:|   ..|:.|...:|:..::.|.|   |:|:.:|..|
Human   568 NDV--------KTLADVNGVIE---EEFTMARLYISKMKSEVKSLVNRSKQLESAQMD------- 614

  Fly   679 YNNLKHKWSSQKLAIDTMQVDYNTIQQKYLQLQDEYRHLELRSDEQCQQLQDENSKLQAEIGTLK 743
             :|.|...|.::||...:.:..:  :.|...|.|..:::|    ::.:||::....|..|:..|:
Human   615 -SNRKMNASERELAACQLLISQH--EAKIKSLTDYMQNME----QKRRQLEESQDSLSEELAKLR 672

  Fly   744 ERVEEIHSELLEVPNPDTHPEDMELQNQELKKRLSKLQWEFDEIQLNYECLSNELMSTIQECDAL 808
            .: |::|              ::..|::| |:.|::|| :.:|::...|          |:.::.
Human   673 AQ-EKMH--------------EVSFQDKE-KEHLTRLQ-DAEEMKKALE----------QQMESH 710

  Fly   809 REEHKQRTTNSDLESMKSSGVGTECSDPENELDTDLLQQFTKLSKSIQQIELTDYSGGRRLFIYN 873
            ||.|:::.:....|..:...:..|..|...:|.   |:| .|||....::::.|
Human   711 REAHQKQLSRLRDEIEEKQKIIDEIRDLNQKLQ---LEQ-EKLSSDYNKLKIED----------- 760

  Fly   874 HAEQDQSVPSLKLCLEPAKYLEGDGKQHDASDSVFLKGFLKCQRFQIVKINQEQNLVKEEDRMRD 938
               |::.:...||.|                                  :|.::.
Human   761 ---QEREMKLEKLLL----------------------------------LNDKRE---------- 778

  Fly   939 IIFQLKQEVDGKKNLIEEEKEVINNLRAQITSLNQIETIKNQNAKTKILCEELQT--KDTVQTAN 1001
               |.::::.|.:..:..|.:.::|||                   |:..::|.|  |.:|:..|
Human   779 ---QAREDLKGLEETVSRELQTLHNLR-------------------KLFVQDLTTRVKKSVELDN 821

  Fly  1002 KQ------ESQEVLTLKTSLAHLKSKV------------CELQKKLEK--QSEDEKISELQSDIG 1046
            ..      :.|::..|:.:|..| :||            ||| .||||  ::..|::..|:|.:.
Human   822 DDGGGSAAQKQKISFLENNLEQL-TKVHKQLVRDNADLRCEL-PKLEKRLRATAERVKALESALK 884

  Fly  1047 EISECCLSMELKLADIVNWQAEELRPLDQLQESGVELQHHSTTAEESLNVEKPIQ 1101
            |      :.|..:.|...:|.|    :|:::|: |..::.:..| .|..:.|||:
Human   885 E------AKENAMRDRKRYQQE----VDRIKEA-VRAKNMARRA-HSAQIAKPIR 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	126/330 (38%)
		Motor_domain	8..310	CDD:277568	125/324 (39%)
		SMC_prok_B	<471..1270	CDD:274008	127/664 (19%)
		Mplasa_alph_rch	924..1647	CDD:275316	42/200 (21%)
		CENP-H	1204..>1266	CDD:283493
		CALCOCO1	<1489..1850	CDD:285171
KIF5C	NP_004513.1	KISc_KHC_KIF5	6..327	CDD:276820	125/324 (39%)
		Microtubule-binding	174..315		55/144 (38%)
		Smc	<460..801	CDD:224117	88/492 (18%)
		PRK03918	<715..>916	CDD:235175	51/297 (17%)
		Globular	859..956		23/82 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..957		5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000669
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910