DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cana and KIF5B

DIOPT Version :9

Sequence 1:NP_001027247.1 Gene:cana / 3771934 FlyBaseID:FBgn0040233 Length:1931 Species:Drosophila melanogaster
Sequence 2:NP_004512.1 Gene:KIF5B / 3799 HGNCID:6324 Length:963 Species:Homo sapiens


Alignment Length:1158 Identity:292/1158 - (25%)
Similarity:483/1158 - (41%) Gaps:304/1158 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 SIQVCIKVRPCEPGLTSLWQVKEG----RSIQLADS---HAEPYVFDYVFDEGASNQEVFDRMAK 65
            :|:|..:.||....     :|..|    ...|..|:   .::||.||.||....|.::|::..||
Human     8 NIKVMCRFRPLNES-----EVNRGDKYIAKFQGEDTVVIASKPYAFDRVFQSSTSQEQVYNDCAK 67

  Fly    66 HIVHACMQGSNGTIFAYGQTSSGKTYTMMG---DEQNPGVMVLAAKEIFQQISSETER-DFLLRV 126
            .||...::|.|||||||||||||||:||.|   |.:..|::....::||..|.|..|. :|.::|
Human    68 KIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDENLEFHIKV 132

  Fly   127 GYIEIYNEKIYDLLNKKNQDLKIHESGNGIVNV-NCKESIVTSEDDLLRQLYMGNKERVVGETNM 190
            .|.|||.:||.|||:....:|.:||..|.:..| .|.|..|.|.|:::..:..|...|.|..|||
Human   133 SYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEGKSNRHVAVTNM 197

  Fly   191 NERSSRSHAIFRIIIESRKSDHSDNDTVKQSVLSLVDLAGSEQVDPA-------DHA----SSLM 244
            ||.|||||:||.|.:   |.:::..:......|.||||||||:|...       |.|    .||.
Human   198 NEHSSRSHSIFLINV---KQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLS 259

  Fly   245 IFRNLVKSLSESVDSKPNSFRDSKLPRIMLPSLGGNVLTSIICTITPSFVEES--SSTISFGTCA 307
            ...|::.:|:|.....|  :||||:.||:..|||||..|:|:...:||...||  .||:.||..|
Human   260 ALGNVISALAEGSTYVP--YRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRA 322

  Fly   308 KKIRCKPQVCKIDSETTMMRQLDRGISMLKDKLAKKKIKNE-SQLVLQELEGRIKR--------- 362
            |.|  |..|| ::.|.|        ....|.|..|:|.||: .:..:|.||..:.|         
Human   323 KTI--KNTVC-VNVELT--------AEQWKKKYEKEKEKNKILRNTIQWLENELNRWRNGETVPI 376

  Fly   363 DMLKIVSSASLDDYRLQKRRRTWTLTASGSEGDAPVLALPEPEESRLPRPSKLTNLPKPLFQRRG 427
            |.......|:|:.:.:.|   ..|||     .|.|..|:           ..:.|....  :||.
Human   377 DEQFDKEKANLEAFTVDK---DITLT-----NDKPATAI-----------GVIGNFTDA--ERRK 420

  Fly   428 IAPKAKGICKTLKEKRLQTDNMDTMPGRAK--QLGRETASRIPSVMMSKKYQESVPNCDAPQTEI 490
            ...:...:.|.|.:|..:.:....:..:.|  .|.:|      .::.|.:..:     |..|.|:
Human   421 CEEEIAKLYKQLDDKDEEINQQSQLVEKLKTQMLDQE------ELLASTRRDQ-----DNMQAEL 474

  Fly   491 SALTASNQVAKETIEKYEEQVKRLKETIERLEMENGKAVNLGEQFETHKAKSKQMEEELLS-SIS 554
            :.|.|.|..:|       |:||.:.:.:|.|      |||..:  ::.:.:.|..|.|||| .::
Human   475 NRLQAENDASK-------EEVKEVLQALEEL------AVNYDQ--KSQEVEDKTKEYELLSDELN 524

  Fly   555 EKDSTIVSLQQSLEELSRDVLRNSKEDQMRSMCPELESSCERICNKCLELERLLPLASASGLDSV 619
            :|.:|:.|:...|::|..  :.|.::.:...|...|             |:.|..:..|.|.:.|
Human   525 QKSATLASIDAELQKLKE--MTNHQKKRAAEMMASL-------------LKDLAEIGIAVGNNDV 574

  Fly   620 -----ACQFDQLRSEIAATRMKLESMLSTFSHASCEVSQKTTDCKRLSEQISTAHDDFGQLQEKY 679
                 ....|:   |....|:.:..|.|       ||......||:|.   ||         :..
Human   575 KQPEGTGMIDE---EFTVARLYISKMKS-------EVKTMVKRCKQLE---ST---------QTE 617

  Fly   680 NNLKHKWSSQKLAIDTMQVDYNTIQQK----YLQ-LQDEYRHLELRSDEQCQQLQDENSKLQAEI 739
            :|.|.:.:.::||...:::..:..:.|    ||| ::.:.|.||    |....|.:|..:|:|: 
Human   618 SNKKMEENEKELAACQLRISQHEAKIKSLTEYLQNVEQKKRQLE----ESVDALSEELVQLRAQ- 677

  Fly   740 GTLKERVEEIHSELLEVPNPDTHPEDMELQNQELKKRLSKLQWEFDEIQLNYECLSNELMSTI-Q 803
                   |::|              :||      |:.|:|:|            .:||:...: |
Human   678 -------EKVH--------------EME------KEHLNKVQ------------TANEVKQAVEQ 703

  Fly   804 ECDALREEHKQRTTNSDLESMKSSGVGTECSDPENELDTDLLQQFTKLSKSIQQIELTDYSGGRR 868
            :..:.||.|:::.::...|....:.:.|:..|...::   :|:| .:|....::::.||....|:
Human   704 QIQSHRETHQKQISSLRDEVEAKAKLITDLQDQNQKM---MLEQ-ERLRVEHEKLKATDQEKSRK 764

  Fly   869 LFIYNHAEQDQSVPSLKLCLEPAKYLEGDGKQHDASDSVFLKGFLKCQRFQIVKINQEQNLVKEE 933
            |                               |:                          |...:
Human   765 L-------------------------------HE--------------------------LTVMQ 772

  Fly   934 DRMRDIIFQLKQEVDGKKNLIEEEKEVINNLRAQITSLNQIETIKNQNAKTKI-LCEELQTKDTV 997
            ||..    |.:|::.|.:..:.:|.:.::|||....          |:..|:: ...|:.:.||.
Human   773 DRRE----QARQDLKGLEETVAKELQTLHNLRKLFV----------QDLATRVKKSAEIDSDDTG 823

  Fly   998 QTANKQESQEVLTLKTSLAHLKSKV------------CELQKKLEK--QSEDEKISELQSDIGEI 1048
            .:|  .:.|::..|:.:|..| :||            ||| .||||  ::..|::..|:|.:.|.
Human   824 GSA--AQKQKISFLENNLEQL-TKVHKQLVRDNADLRCEL-PKLEKRLRATAERVKALESALKEA 884

  Fly  1049 SECCLSMELKLADIVNWQAEELRPLDQLQESGVELQHHSTTAEESLNVEKPIQ 1101
            .|.. |.:.|     .:|.|..|..:.::...:..:.||.      .:.|||:
Human   885 KENA-SRDRK-----RYQQEVDRIKEAVRSKNMARRGHSA------QIAKPIR 925

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
canaNP_001027247.1 KISc 8..316 CDD:214526 127/332 (38%)
Motor_domain 8..310 CDD:277568 125/326 (38%)
SMC_prok_B <471..1270 CDD:274008 132/658 (20%)
Mplasa_alph_rch 924..1647 CDD:275316 44/193 (23%)
CENP-H 1204..>1266 CDD:283493
CALCOCO1 <1489..1850 CDD:285171
KIF5BNP_004512.1 KISc_KHC_KIF5 6..325 CDD:276820 125/326 (38%)
KISc 8..332 CDD:214526 129/336 (38%)
DUF4337 <462..>538 CDD:290935 25/95 (26%)
TACC 467..662 CDD:282818 57/255 (22%)
TMPIT 598..>686 CDD:285135 28/138 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 908..963 5/24 (21%)
Globular 915..963 5/17 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000669
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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