DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cana and Klp59C

DIOPT Version :9

Sequence 1:	NP_001027247.1	Gene:	cana / 3771934	FlyBaseID:	FBgn0040233	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	NP_611759.1	Gene:	Klp59C / 37671	FlyBaseID:	FBgn0034824	Length:	626	Species:	Drosophila melanogaster

Alignment Length:	492	Identity:	134/492 - (27%)
Similarity:	218/492 - (44%)	Gaps:	107/492 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NASSIQVCIKVRPC--------EPGLTSL-----WQVKEGRS----IQLADSHAEPYVFDYVFDE 52
            |...|.||::.||.        |..:.|:     ..|.|.|.    ::..::|:  :.|||||||
  Fly   184 NCHQIMVCVRKRPLRRKELADREQDVVSIPSKHTLVVHEPRKHVNLVKFLENHS--FRFDYVFDE 246

  Fly    53 GASNQEVFDRMAKHIVHACMQGSNGTIFAYGQTSSGKTYTMMGDEQNP--------GVMVLAAKE 109
            ..||..|::..|:.::.....|...|.||||||.|||||||.|  |.|        |:..:|||:
  Fly   247 ECSNATVYEFTARPLIKHIFDGGMATCFAYGQTGSGKTYTMGG--QFPGRHQSSMDGIYAMAAKD 309

  Fly   110 IFQQISSETERDFLLRV--GYIEIYNEKIYDLLNKKNQDLKIHESGNGIVN-VNCKESIVTSEDD 171
            :|..:.:.......|:|  .:.|||..:::|||......|::.|..|..|. |...::.|.:..:
  Fly   310 VFSTLKTVPYNKLNLKVYCSFFEIYGTRVFDLLMPGKPQLRVLEDRNQQVQVVGLTQNPVQNTAE 374

  Fly   172 LLRQLYMGNKERVVGETNMNERSSRSHAIFRIIIESRKSD--HSDNDTVKQSVLSLVDLAGSEQV 234
            :|..|.:||..|..|.|:.|.:||||||:|:|::.|...:  |..        .||:||||:|:
  Fly   375 VLDLLELGNSVRTSGHTSANSKSSRSHAVFQIVLRSAAGEKLHGK--------FSLIDLAGNER- 430

  Fly   235 DPADHAS--------------SLMIFRNLVKSLSESVDSKPNSFRDSKLPRIMLPS-LGG-NVLT 283
             .||::|              ||::.:..:::|.......|  ||.|||.:::..| :|| .|.|
  Fly   431 -GADNSSADRQTRLEGSEINKSLLVLKECIRALGRQSSHLP--FRGSKLTQVLRDSFIGGKKVKT 492

  Fly   284 SIICTITPSF--VEESSSTISFGTCAKKIRCKPQVCKIDSETTMMRQLDRGISMLKDKLAKKKIK 346
            .:|..|:|..  ||.:.:|:.:....|::    .|..|.|:  .|...:.|.:.:.|
  Fly   493 CMIAMISPCLHSVEHTLNTLRYADRVKEL----SVESIPSK--RMPDANLGSTSMSD-------- 543

  Fly   347 NESQLVLQELEGRIKRDMLKIVSSASLDDYRLQKRRRTWTLTASGSEGDAPVLALPEPEESRLPR 411
                :|.|....|    :....||.|:.....|.::.|.|..                :.:|..:
  Fly   544 ----IVCQSSTQR----LFPCASSTSMPGGGNQAQQHTNTAN----------------DLNRSQK 584

  Fly   412 PSKLTNLP---KPLFQRRGIAPKAKG--ICKTLKEKR 443
            |:.....|   :.|.||:|.:.:...  :.|:|.:.|
  Fly   585 PTSKPTYPTSGQQLVQRKGSSQREASMMLTKSLAQFR 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	108/355 (30%)
		Motor_domain	8..310	CDD:277568	108/349 (31%)
		SMC_prok_B	<471..1270	CDD:274008
		Mplasa_alph_rch	924..1647	CDD:275316
		CENP-H	1204..>1266	CDD:283493
		CALCOCO1	<1489..1850	CDD:285171
Klp59C	NP_611759.1	KISc_KIF2_like	187..519	CDD:276818	107/347 (31%)
Klp59C	NP_611759.1	Kinesin	193..520	CDD:278646	104/342 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437836
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930