Protein Alignment cana and unc-104

DIOPT Version :10

• Sequence 1: NP_001027247.1
• Gene: cana / 3771934
• FlyBaseID: FBgn0040233
• Length: 1931
• Species: Drosophila melanogaster
• Sequence 2: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Alignment Length: 1882
• Identity: 383/1882 - (20%)
• Similarity: 649/1882 - (34%)
• Gaps: 666/1882 - (35%)

  Fly     7 SSIQVCIKVRPCEPGLTSLWQVKEGRSI-----------------QLADSHAEPYVFDYVF---- 50
            ||::|.::|||    ..|....:|.:.|                 ..:|| .:.:.|||.:
  Fly     2 SSVKVAVRVRP----FNSREIARESKCIIEMAGATTAITNPKVPPNTSDS-VKRFNFDYSYWSHD 61

  Fly    51 --DEGASNQE-VFDRMAKHIVHACMQGSNGTIFAYGQTSSGKTYTMMG--DEQNPGVMVLAAKEI 110
              |...|.|. |:..:.:.::.....|.|..|||||||.:||:|||||  :||..|::.:..|::
  Fly    62 HHDADFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGIIPMICKDL 126

  Fly   111 FQQISSETERD---FLLRVGYIEIYNEKIYDLLNKKNQ-DLKIHES---GNGIVNVNCKESIVTS 168
            |.:| .:||.|   :.:.|.|:|||.|::.||||.||: :|::.|.   |..:.:::  :..||.
  Fly   127 FTRI-QDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLS--KLAVTD 188

  Fly   169 EDDLLRQLYMGNKERVVGETNMNERSSRSHAIFRIIIESRKSDHSDN-DTVKQSVLSLVDLAGSE 232
            ..|:...:..|||.|.|..|||||.||||||:|.|....|:.|...| .|.|.|.:|||||||||
  Fly   189 YQDIHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKVSKISLVDLAGSE 253

  Fly   233 QVDP-----------ADHASSLMIFRNLVKSLSESVDSKPNS-------FRDSKLPRIMLPSLGG 279
            :.|.           |:...||.....::.:|:|....|.|:       :|||.|..::..:|||
  Fly   254 RADSTGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLRENLGG 318

  Fly   280 NVLTSIICTITPSFV--EESSSTISFGTCAKKIRCKPQVCKIDSETTMMRQLDRGISMLKDKLAK 342
            |..|::|..|:|:.:  :|:.||:.:...||:|.|| .|...|:...::|:|...|..|:|.|..
  Fly   319 NSKTAMIAAISPADINYDETLSTLRYADRAKQIVCK-AVVNEDANAKLIRELKEEIQKLRDLLKA 382

  Fly   343 KKIKNESQLVLQELEGRIKRDMLKIVSSASLDDYRLQKRRRTWTLTASGSE----GDAPVLALPE 403
            :.|:      :||.:...|..::|..:         :.|.|..:.|....:    .:..:..|.|
  Fly   383 EGIE------VQEEDELTKSTVIKSPT---------KSRNRNGSTTEMAVDQLQASEKLIAELNE 432

  Fly   404 PEESRLPRPSKLTNLPKPLFQRRGIAPKAKGICKTL--KEKRLQTDNMDTMPGRAK--------- 457
            ..|.:|.|..::....:.:|...|:|.|..||...:  .:|.....|::..|..::
  Fly   433 TWEEKLKRTEEIRVQREAVFAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLYYIKEG 497

  Fly   458 --QLGRETASRIPSVMMSKKY----------QES----VPNCDA-----------PQ---TEISA 492
              :||...|:....:.:|..:          :.|    :|:.||           |:   |....
  Fly   498 LTRLGTHEANVPQDIQLSGSHILKEHCTFENKNSTVTLLPHKDAIIYVNGRKLVEPEVLKTGSRV 562

  Fly   493 LTASNQVAKETIEKYEEQVKRLKETIE----------------------------------RLEM 523
            :...|.|.:.|   ..||.:.|::.||                                  :.||
  Fly   563 ILGKNHVFRFT---NPEQARELRDKIETENEAENEVEKTDTQQVDWNFAQCELLEKQGIDLKAEM 624

  Fly   524 ENGKAVNLGEQFETHKAKSKQMEEELLSSISEKDSTIVSLQQSLEELSRDVLRNSKEDQMRSMCP 588
            :. :..||.||::..|.::.|..||...:.   ::.|.:||:.:||.|..:...|      |..|
  Fly   625 KK-RLDNLEEQYKREKLQADQQFEEQRKTY---EARIDALQKQVEEQSMTMSMYS------SYSP 679

  Fly   589 E------------LESSCERICNKCLELERLLPLASASGLDSVAC------QFDQLRSEIAATRM 635
            |            :..||.              .|..:||.:.|.      ||..||.::....:
  Fly   680 EDFHQEEDVYTNPMYESCW--------------TAREAGLAAWAFRKWRYHQFTSLRDDLWGNAI 730

  Fly   636 KLESMLSTFSHASCEVSQKT-------TDC------KRLSEQISTAH--DDFG-----------Q 674
                .|...:..|.|:.:|.       ||.      ..|:..::..|  |:||           :
  Fly   731 ----FLKEANAISVELKKKVQFQFTLLTDTLYSPLPPELASTVAPVHQEDEFGAPPVSKTLVAVE 791

  Fly   675 LQEKYNNLKHKWSSQKL--AIDTMQVDYNTIQQKYLQLQDEYRHLELRS----------DEQCQQ 727
            :.:..|...|.||.:||  .::.|:..||........|.|. ..:|..|          .:|.|.
  Fly   792 VTDTKNGATHHWSLEKLRYRLELMRQIYNVESPPSSMLFDT-SGMEALSGWISPPSQHPGQQAQL 855

  Fly   728 LQDENSKLQAEIGTL--------KERVEEI----HSELLEVP-NPDTHPEDME------------ 767
            |..| ..:::|.|.|        ::|:|.:    |:|....| :||.:.|.:.
  Fly   856 LPLE-PPVESERGRLTLANLIPSRQRLELMREMYHNEAEMSPTSPDYNVESLTGGDPFYDRFPWF 919

  Fly   768 -------------------------------------------LQNQELK-----KRLSKLQWEF 784
                                                       |..:.:.     |:.::|.:..
  Fly   920 RMVGRSFIYLSNLLYPVPLVHKVAIVNERGDVRGYLRIAVQPVLDEESIDFNNGVKQSARLVFNE 984

  Fly   785 DEIQLNYECLS------------------NEL----------MSTIQECDALRE---EHKQ---- 814
            |:.:..|..|:                  .||          .::..||....|   ||.|
  Fly   985 DDAKPKYRALNEKDDVQRYIDNGGLDSKLEELEDVDSGRGIDSNSASECHENSEEPGEHLQVGKE 1049

  Fly   815 ---RTTNSDLESMKSSGVGTECSDPENELDTDLLQQFTKLSKSIQQIE---LTDYSGGRRLFIYN 873
               |.|     .::::|:|.|.:        |:..||..|.:..:...   :.:.:.|..|..|:
  Fly  1050 FTFRVT-----VLQATGIGAEYA--------DIFCQFNFLHRHEEAFSTEPVKNSASGAPLGFYH 1101

  Fly   874 HAEQDQSVPSLKLCLEPAKY---------------LEGDGKQ----------------------- 900
              .|:.:||..|..:|..|.               |..|.||
  Fly  1102 --VQNITVPVTKSFIEYLKTQPIMFKIFGHYQTHPLHKDAKQDFVSRPPPRRMLPPSIPISQPVR 1164

  Fly   901 ------------------HDA----------------------SDSVFLKG-FLKCQ----RFQI 920
                              ||.                      ||.:..:| ||..|    |.:|
  Fly  1165 SPKFGPLPCAPTSTVLAKHDVLVWFEICELAPNGEYVPSVVEHSDDLPCRGLFLLHQGIQRRIRI 1229

  Fly   921 VKINQEQNLVKEEDRMRDIIFQLKQEVDGKKNLIE------------EEKEVINNLRA------- 966
            ..:::....||.:|....::.:::...:......|            |..||..:.|:
  Fly  1230 TIVHEPTTEVKWKDINELVVGRIRNTPESSDEQDEDACVLSLGLFPGEALEVPGDDRSFYRFEAA 1294

  Fly   967 ------QITSLNQI----ETI--------KNQN-AKTKILCEELQTKDTVQTANKQESQEVLTLK 1012
                  ....||::    |||        :.:| |:..|:     |||.......::::   |..
  Fly  1295 WDSSLHNSALLNRVSQGGETIYITLSAYLELENCARPAII-----TKDLSMVIYGRDAR---TGP 1351

  Fly  1013 TSLAHLKS------------KVCELQKKLEKQSEDEKISELQSDIGEISECCLSMELKLADIVNW 1065
            .||.||.|            .|.||..:...::....:...|..:.:.|...:..|   .::..|
  Fly  1352 RSLKHLFSGQYRNPEANRLTGVYELALRRASEAGSPGVQRRQRRVLDTSSTYVRGE---ENLHGW 1413

  Fly  1066 QAE----------ELRPLDQLQESGVELQHHSTTAEESLNVEKPIQEQTERTLTTEYERRIEQLE 1120
            :..          ||..|.:|:|.|  ...|.....|.|.::      |....||:.|:.:..|.
  Fly  1414 RPRGDSLIFDHQWELEKLTRLEEVG--RMRHLLLLRERLGMD------TNPNPTTKTEKDVCNLA 1470

  Fly  1121 ESLQRAQEELSILEKRKTDENKSLQL----EYMAKIETSENENRSKFRAYCLDLKETQKRY---- 1177
            .....:...:.|.:..:|......|:    ||        |:........||.|  .|.||
  Fly  1471 ARAATSPVHMVIPQSPQTPVKDPQQIIPEREY--------NQREQDLMLKCLKL--VQGRYTKSE 1525

  Fly  1178 ------EEQLQQTNEKLASVTTQCQVHLDVIKRSLQEKITQAEKERNELAVRHK----------- 1225
                  :..:..::|..|.:|..|              |:....|.|:..:|.:
  Fly  1526 ANDTQTQSDVSPSDEGCADMTVSC--------------ISSNSMENNKFVIRRRLCSPDRADAPN 1576

  Fly  1226 -------------------AELEKIR-----------ETLKEKESSYKEKLRQAEEERDKEISRL 1260
                               .|||:||           ..|:...|.:|:              |.
  Fly  1577 GWEAPAPATQPALPLRLYVPELEEIRVSPVVARKGLLNVLEHGGSGWKK--------------RW 1627

  Fly  1261 EVMRNTIAELHKTNSDREVELEGVKMEKCQLKKLYDKSMLELEQLQCTADQKSSDLLPGSSNENI 1325
            .::|.....::::..|        .:|:..|.       |....::|:.||.:...:|.:.:...
  Fly  1628 VIVRRPYVFIYRSEKD--------PVERAVLN-------LATAHVECSEDQAAMVKIPNTFSVVT 1677

  Fly  1326 DD----LQKKCDQYVQDL-----ELLRGE------------KAELLSEIQKINGQHSNTIKK 1366
            ..    ||...|:.|.|.     .||.|:            .::..|:||..|..::|:..|
  Fly  1678 KHRGYLLQTLGDKEVHDWLYAINPLLAGQIKSRLARRTLEPASQTASQIQATNAANANSASK 1739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	Motor_domain	8..310	CDD:473979	118/355 (33%)
		CCDC158	<505..>729	CDD:464943	61/313 (19%)
		SMC_prok_B	622..1285	CDD:274008	166/1012 (16%)
		SMC_prok_B	1110..1875	CDD:274008	55/333 (17%)
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	123/364 (34%)
		Kinesin_assoc	355..498	CDD:465047	30/157 (19%)
		FHA_KIF1	474..574	CDD:438757	15/102 (15%)
		YhaN	<575..>666	CDD:443752	18/94 (19%)
		KIF1B	878..924	CDD:463574	8/45 (18%)
		DUF3694	1199..1347	CDD:463599	27/152 (18%)
		PH_KIFIA_KIFIB	1602..1704	CDD:269939	20/130 (15%)