DRSC/TRiP Functional Genomics Resources

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Protein Alignment cana and unc-104

DIOPT Version :9

Sequence 1:NP_001027247.1 Gene:cana / 3771934 FlyBaseID:FBgn0040233 Length:1931 Species:Drosophila melanogaster
Sequence 2:NP_611155.3 Gene:unc-104 / 36876 FlyBaseID:FBgn0267002 Length:1739 Species:Drosophila melanogaster


Alignment Length:1882 Identity:383/1882 - (20%)
Similarity:649/1882 - (34%) Gaps:666/1882 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 SSIQVCIKVRPCEPGLTSLWQVKEGRSI-----------------QLADSHAEPYVFDYVF---- 50
            ||::|.::|||    ..|....:|.:.|                 ..:|| .:.:.|||.:    
  Fly     2 SSVKVAVRVRP----FNSREIARESKCIIEMAGATTAITNPKVPPNTSDS-VKRFNFDYSYWSHD 61

  Fly    51 --DEGASNQE-VFDRMAKHIVHACMQGSNGTIFAYGQTSSGKTYTMMG--DEQNPGVMVLAAKEI 110
              |...|.|. |:..:.:.::.....|.|..|||||||.:||:|||||  :||..|::.:..|::
  Fly    62 HHDADFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGIIPMICKDL 126

  Fly   111 FQQISSETERD---FLLRVGYIEIYNEKIYDLLNKKNQ-DLKIHES---GNGIVNVNCKESIVTS 168
            |.:| .:||.|   :.:.|.|:|||.|::.||||.||: :|::.|.   |..:.:::  :..||.
  Fly   127 FTRI-QDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLS--KLAVTD 188

  Fly   169 EDDLLRQLYMGNKERVVGETNMNERSSRSHAIFRIIIESRKSDHSDN-DTVKQSVLSLVDLAGSE 232
            ..|:...:..|||.|.|..|||||.||||||:|.|....|:.|...| .|.|.|.:|||||||||
  Fly   189 YQDIHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKVSKISLVDLAGSE 253

  Fly   233 QVDP-----------ADHASSLMIFRNLVKSLSESVDSKPNS-------FRDSKLPRIMLPSLGG 279
            :.|.           |:...||.....::.:|:|....|.|:       :|||.|..::..:|||
  Fly   254 RADSTGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLRENLGG 318

  Fly   280 NVLTSIICTITPSFV--EESSSTISFGTCAKKIRCKPQVCKIDSETTMMRQLDRGISMLKDKLAK 342
            |..|::|..|:|:.:  :|:.||:.:...||:|.|| .|...|:...::|:|...|..|:|.|..
  Fly   319 NSKTAMIAAISPADINYDETLSTLRYADRAKQIVCK-AVVNEDANAKLIRELKEEIQKLRDLLKA 382

  Fly   343 KKIKNESQLVLQELEGRIKRDMLKIVSSASLDDYRLQKRRRTWTLTASGSE----GDAPVLALPE 403
            :.|:      :||.:...|..::|..:         :.|.|..:.|....:    .:..:..|.|
  Fly   383 EGIE------VQEEDELTKSTVIKSPT---------KSRNRNGSTTEMAVDQLQASEKLIAELNE 432

  Fly   404 PEESRLPRPSKLTNLPKPLFQRRGIAPKAKGICKTL--KEKRLQTDNMDTMPGRAK--------- 457
            ..|.:|.|..::....:.:|...|:|.|..||...:  .:|.....|::..|..::         
  Fly   433 TWEEKLKRTEEIRVQREAVFAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLYYIKEG 497

  Fly   458 --QLGRETASRIPSVMMSKKY----------QES----VPNCDA-----------PQ---TEISA 492
              :||...|:....:.:|..:          :.|    :|:.||           |:   |....
  Fly   498 LTRLGTHEANVPQDIQLSGSHILKEHCTFENKNSTVTLLPHKDAIIYVNGRKLVEPEVLKTGSRV 562

  Fly   493 LTASNQVAKETIEKYEEQVKRLKETIE----------------------------------RLEM 523
            :...|.|.:.|   ..||.:.|::.||                                  :.||
  Fly   563 ILGKNHVFRFT---NPEQARELRDKIETENEAENEVEKTDTQQVDWNFAQCELLEKQGIDLKAEM 624

  Fly   524 ENGKAVNLGEQFETHKAKSKQMEEELLSSISEKDSTIVSLQQSLEELSRDVLRNSKEDQMRSMCP 588
            :. :..||.||::..|.::.|..||...:.   ::.|.:||:.:||.|..:...|      |..|
  Fly   625 KK-RLDNLEEQYKREKLQADQQFEEQRKTY---EARIDALQKQVEEQSMTMSMYS------SYSP 679

  Fly   589 E------------LESSCERICNKCLELERLLPLASASGLDSVAC------QFDQLRSEIAATRM 635
            |            :..||.              .|..:||.:.|.      ||..||.::....:
  Fly   680 EDFHQEEDVYTNPMYESCW--------------TAREAGLAAWAFRKWRYHQFTSLRDDLWGNAI 730

  Fly   636 KLESMLSTFSHASCEVSQKT-------TDC------KRLSEQISTAH--DDFG-----------Q 674
                .|...:..|.|:.:|.       ||.      ..|:..::..|  |:||           :
  Fly   731 ----FLKEANAISVELKKKVQFQFTLLTDTLYSPLPPELASTVAPVHQEDEFGAPPVSKTLVAVE 791

  Fly   675 LQEKYNNLKHKWSSQKL--AIDTMQVDYNTIQQKYLQLQDEYRHLELRS----------DEQCQQ 727
            :.:..|...|.||.:||  .::.|:..||........|.|. ..:|..|          .:|.|.
  Fly   792 VTDTKNGATHHWSLEKLRYRLELMRQIYNVESPPSSMLFDT-SGMEALSGWISPPSQHPGQQAQL 855

  Fly   728 LQDENSKLQAEIGTL--------KERVEEI----HSELLEVP-NPDTHPEDME------------ 767
            |..| ..:::|.|.|        ::|:|.:    |:|....| :||.:.|.:.            
  Fly   856 LPLE-PPVESERGRLTLANLIPSRQRLELMREMYHNEAEMSPTSPDYNVESLTGGDPFYDRFPWF 919

  Fly   768 -------------------------------------------LQNQELK-----KRLSKLQWEF 784
                                                       |..:.:.     |:.::|.:..
  Fly   920 RMVGRSFIYLSNLLYPVPLVHKVAIVNERGDVRGYLRIAVQPVLDEESIDFNNGVKQSARLVFNE 984

  Fly   785 DEIQLNYECLS------------------NEL----------MSTIQECDALRE---EHKQ---- 814
            |:.:..|..|:                  .||          .::..||....|   ||.|    
  Fly   985 DDAKPKYRALNEKDDVQRYIDNGGLDSKLEELEDVDSGRGIDSNSASECHENSEEPGEHLQVGKE 1049

  Fly   815 ---RTTNSDLESMKSSGVGTECSDPENELDTDLLQQFTKLSKSIQQIE---LTDYSGGRRLFIYN 873
               |.|     .::::|:|.|.:        |:..||..|.:..:...   :.:.:.|..|..|:
  Fly  1050 FTFRVT-----VLQATGIGAEYA--------DIFCQFNFLHRHEEAFSTEPVKNSASGAPLGFYH 1101

  Fly   874 HAEQDQSVPSLKLCLEPAKY---------------LEGDGKQ----------------------- 900
              .|:.:||..|..:|..|.               |..|.||                       
  Fly  1102 --VQNITVPVTKSFIEYLKTQPIMFKIFGHYQTHPLHKDAKQDFVSRPPPRRMLPPSIPISQPVR 1164

  Fly   901 ------------------HDA----------------------SDSVFLKG-FLKCQ----RFQI 920
                              ||.                      ||.:..:| ||..|    |.:|
  Fly  1165 SPKFGPLPCAPTSTVLAKHDVLVWFEICELAPNGEYVPSVVEHSDDLPCRGLFLLHQGIQRRIRI 1229

  Fly   921 VKINQEQNLVKEEDRMRDIIFQLKQEVDGKKNLIE------------EEKEVINNLRA------- 966
            ..:::....||.:|....::.:::...:......|            |..||..:.|:       
  Fly  1230 TIVHEPTTEVKWKDINELVVGRIRNTPESSDEQDEDACVLSLGLFPGEALEVPGDDRSFYRFEAA 1294

  Fly   967 ------QITSLNQI----ETI--------KNQN-AKTKILCEELQTKDTVQTANKQESQEVLTLK 1012
                  ....||::    |||        :.:| |:..|:     |||.......::::   |..
  Fly  1295 WDSSLHNSALLNRVSQGGETIYITLSAYLELENCARPAII-----TKDLSMVIYGRDAR---TGP 1351

  Fly  1013 TSLAHLKS------------KVCELQKKLEKQSEDEKISELQSDIGEISECCLSMELKLADIVNW 1065
            .||.||.|            .|.||..:...::....:...|..:.:.|...:..|   .::..|
  Fly  1352 RSLKHLFSGQYRNPEANRLTGVYELALRRASEAGSPGVQRRQRRVLDTSSTYVRGE---ENLHGW 1413

  Fly  1066 QAE----------ELRPLDQLQESGVELQHHSTTAEESLNVEKPIQEQTERTLTTEYERRIEQLE 1120
            :..          ||..|.:|:|.|  ...|.....|.|.::      |....||:.|:.:..|.
  Fly  1414 RPRGDSLIFDHQWELEKLTRLEEVG--RMRHLLLLRERLGMD------TNPNPTTKTEKDVCNLA 1470

  Fly  1121 ESLQRAQEELSILEKRKTDENKSLQL----EYMAKIETSENENRSKFRAYCLDLKETQKRY---- 1177
            .....:...:.|.:..:|......|:    ||        |:........||.|  .|.||    
  Fly  1471 ARAATSPVHMVIPQSPQTPVKDPQQIIPEREY--------NQREQDLMLKCLKL--VQGRYTKSE 1525

  Fly  1178 ------EEQLQQTNEKLASVTTQCQVHLDVIKRSLQEKITQAEKERNELAVRHK----------- 1225
                  :..:..::|..|.:|..|              |:....|.|:..:|.:           
  Fly  1526 ANDTQTQSDVSPSDEGCADMTVSC--------------ISSNSMENNKFVIRRRLCSPDRADAPN 1576

  Fly  1226 -------------------AELEKIR-----------ETLKEKESSYKEKLRQAEEERDKEISRL 1260
                               .|||:||           ..|:...|.:|:              |.
  Fly  1577 GWEAPAPATQPALPLRLYVPELEEIRVSPVVARKGLLNVLEHGGSGWKK--------------RW 1627

  Fly  1261 EVMRNTIAELHKTNSDREVELEGVKMEKCQLKKLYDKSMLELEQLQCTADQKSSDLLPGSSNENI 1325
            .::|.....::::..|        .:|:..|.       |....::|:.||.:...:|.:.:...
  Fly  1628 VIVRRPYVFIYRSEKD--------PVERAVLN-------LATAHVECSEDQAAMVKIPNTFSVVT 1677

  Fly  1326 DD----LQKKCDQYVQDL-----ELLRGE------------KAELLSEIQKINGQHSNTIKK 1366
            ..    ||...|:.|.|.     .||.|:            .::..|:||..|..::|:..|
  Fly  1678 KHRGYLLQTLGDKEVHDWLYAINPLLAGQIKSRLARRTLEPASQTASQIQATNAANANSASK 1739

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
canaNP_001027247.1 KISc 8..316 CDD:214526 121/361 (34%)
Motor_domain 8..310 CDD:277568 118/355 (33%)
SMC_prok_B <471..1270 CDD:274008 206/1228 (17%)
Mplasa_alph_rch 924..1647 CDD:275316 98/579 (17%)
CENP-H 1204..>1266 CDD:283493 14/102 (14%)
CALCOCO1 <1489..1850 CDD:285171
unc-104NP_611155.3 KISc_KIF1A_KIF1B 2..358 CDD:276816 123/364 (34%)
KISc 3..358 CDD:214526 122/363 (34%)
Kinesin_assoc 355..498 CDD:292801 30/157 (19%)
FHA 475..574 CDD:238017 15/101 (15%)
KIF1B 878..923 CDD:289208 8/44 (18%)
DUF3694 1246..1347 CDD:289256 16/105 (15%)
PH_KIFIA_KIFIB 1602..1704 CDD:269939 20/130 (15%)
PH 1607..1700 CDD:278594 18/121 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45437959
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.930

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