DRSC/TRiP Functional Genomics Resources

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Protein Alignment cana and Khc-73

DIOPT Version :9

Sequence 1:NP_001027247.1 Gene:cana / 3771934 FlyBaseID:FBgn0040233 Length:1931 Species:Drosophila melanogaster
Sequence 2:NP_001261000.1 Gene:Khc-73 / 36718 FlyBaseID:FBgn0019968 Length:1957 Species:Drosophila melanogaster


Alignment Length:2266 Identity:452/2266 - (19%)
Similarity:824/2266 - (36%) Gaps:659/2266 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 ASSIQVCIKVRP-----CEPGLTSLWQVKEGRSI--------QLADSHAEPYVFDYVF------D 51
            :..|:|.::|||     .|.....:.::::.::|        ::.....:.:.||:.|      |
  Fly     3 SDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNPED 67

  Fly    52 EGASNQE-VFDRMAKHIVHACMQGSNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAKEIFQQIS 115
            |..::|| |||.:.:.|:....||.|..|||||||.|||:|||||.:::.|::.....::|..|:
  Fly    68 ENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFSAIA 132

  Fly   116 SET--ERDFLLRVGYIEIYNEKIYDLLNKK--NQDLKIHESGNGIVNV------NCKESIVTSED 170
            :::  |..:.:.|.|:||||||::|||:.|  .|.||:.|.     ||      ...:..|||..
  Fly   133 NKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREH-----NVMGPYVDGLSQLAVTSYQ 192

  Fly   171 DLLRQLYMGNKERVVGETNMNERSSRSHAIFRIIIESRKSDHSDN-DTVKQSVLSLVDLAGSEQV 234
            |:...:..|||.|.|..||||..||||||:|.:::....:|.:.. ...|.|.:|||||||||:.
  Fly   193 DIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERA 257

  Fly   235 -----------DPADHASSLMIFRNLVKSLSESVDSKPNS------FRDSKLPRIMLPSLGGNVL 282
                       :.::...||.....::..|::..:.|.:.      :|||.|..::..:||||..
  Fly   258 VKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNSR 322

  Fly   283 TSIICTITPSF--VEESSSTISFGTCAKKIRCKPQVCKIDSETTMMRQLDRGI----SMLK---- 337
            |.::.||:||.  .||:.||:.:...||:| ....|...|....::|:|...:    ||||    
  Fly   323 TVMVATISPSADNYEETLSTLRYADRAKRI-VNHAVVNEDPNARIIRELRHEVETLRSMLKHATG 386

  Fly   338 -------DKLAKKKIKNESQLVLQELEGRIKRDMLKIVSSASLDDYRLQKRRRTWTLTASGSEGD 395
                   ||||:.:                  :::|.:|             :||          
  Fly   387 SPVGDVQDKLAESE------------------NLMKQIS-------------QTW---------- 410

  Fly   396 APVLALPEPEESRLPRPSKLTNLPKPLFQRRGIAPKAKGICKTLKEKRLQTDNMDTMPGRAKQL- 459
                      |.:|.:..::.|..:...::.||:.:|.||  .:::.:....|::..|...:.| 
  Fly   411 ----------EEKLVKTERIQNERQQALEKMGISVQASGI--KVEKNKYYLVNLNADPSLNELLV 463

  Fly   460 ----------GRETASRIPSVMMSKKYQESVPNCDAPQTEISALTASNQVAKETIEK---YEEQV 511
                      ||..:.:.|.:                  ::|.|....:....|||.   |.|.|
  Fly   464 YYLKDRTLIGGRTISGQQPDI------------------QLSGLGIQPEHCVITIEDSGLYMEPV 510

  Fly   512 KRLK------ETIERLEMENGKAVNLGEQ--FETHKAKSKQMEEELLSSISEKDSTIVSLQQSLE 568
            :..:      ..:|:..::||..:..|..  |..:..||.  ...:.:|..:..:.::....:.:
  Fly   511 QGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSN--NTSMCASEPQTPAQLIDYNFARD 573

  Fly   569 ELSRDVLRNSKEDQMRSMCPELESSCERICNKCLELERLLPLASASGLDSVACQFDQLRSEIAAT 633
            |:.::.|.|   |.:::....||...|......||.:|          .....||.|||:.::. 
  Fly   574 EIMQNELSN---DPIQTAIARLERQHEEDKQVALEKQR----------QEYERQFQQLRNILSP- 624

  Fly   634 RMKLESMLSTFSHASCEVSQKTTDCKRLSEQISTAHDDFGQLQEKYNNLKHKWSSQKLAIDTMQV 698
                                            ||.:..:.    .|:.|:....:.......|:|
  Fly   625 --------------------------------STPYAPYA----PYDPLRMGKITPNTPTSQMRV 653

  Fly   699 DYNTIQQKYLQLQDEY--RHL-ELRSDEQCQQLQDENSKLQAEIGTLKERVEE--IHSELLEVPN 758
                  :|:.|.:||.  |.| :|::|     :...||.:| |...|.|.:|:  ..|..|::|.
  Fly   654 ------EKWAQERDEMFRRSLGQLKTD-----IMRANSLVQ-EANFLAEEMEKKTKFSVTLQIPP 706

  Fly   759 PDTHPEDMELQNQE-----------LKKRLSKLQ-WEFDEIQLNYECLSNELMSTIQECDALREE 811
            .:..|      |:.           :|:..|..| |..::       |.|:|:    :...:.:|
  Fly   707 ANLSP------NRRRGAFVSEPAILVKRTNSGSQIWTMEK-------LENKLI----DMREMYQE 754

  Fly   812 HKQRTTNS-DLESMKSSGVGTECSDPEN----------------ELD--TDLLQQFTKLSKSIQQ 857
            ||:|..|. |.::.|......|..:..|                :||  |.::.|..:::..: |
  Fly   755 HKERVLNGLDEDNAKPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRL-Q 818

  Fly   858 IELTDYSGGRRLFIYNHAEQDQSVPSLKLCLEPAKYLEGDGK-QHD-----ASDSVFLKGFLKC- 915
            :|:...:|              .:|..::| |......||.: ::|     .|:.:..:..:|| 
  Fly   819 VEIERIAG--------------QMPQDRMC-ESVSESSGDSRDEYDDPVDPTSNQITCRVTIKCA 868

  Fly   916 --------------------QRFQIVKINQE-----QNLVKEEDRMRDIIFQLKQE-----VDGK 950
                                |...:..||.|     ||:|.:.:..:|....:.:|     ::|.
  Fly   869 SGLPLSLSNFVFCQYTFWGHQEMVVPVINAESTAHDQNMVFKFEHTQDFTVTINEEFLEHCIEGA 933

  Fly   951 KNLIEEEKEVINNLRAQITSLNQIETIKNQNAKTKILCEELQTKDTVQTANKQESQEVLTLKTSL 1015
            .::     ||..:..|..:.....| ::.|.||.:.|.:                          
  Fly   934 LSI-----EVWGHRSAGFSKTKGWE-VEQQQAKARSLVD-------------------------- 966

  Fly  1016 AHLKSKVCELQKKLEKQSEDEKISELQSDIGEIS--ECCLSMELKLADIVNWQAEELRPLD---- 1074
                 :..||.:|:|...|   |.|| :|.||.|  |.....|:....|...:..:.|.::    
  Fly   967 -----RWAELSRKIELWVE---IHEL-NDNGEYSPVEVTNRNEVLTGGIYQLRQGQQRRVNVRVK 1022

  Fly  1075 QLQESG---------VELQHHSTTAEESLNVEKPIQEQTERTLTTEYERRIEQLEESLQRAQEEL 1130
            .:|.||         |.:...|.|....|  ::|:....|..||...|:..|.|....|...:::
  Fly  1023 PVQNSGTLPIICQSIVNVAIGSVTVRSRL--QRPLDSYQEEDLTVLREKWSEALGRRRQYLDQQI 1085

  Fly  1131 SIL----EKRKTDENKSLQLEYMAKIETSENENRSKFRAYCLDLKETQKRYEEQLQQTNEKLASV 1191
            .:|    ||.:.:..:.|.|.:. .:..:|..|.....|....:......:|.            
  Fly  1086 QMLIKKEEKNEQERERELSLVHQ-WVSLTEERNAVLVPAPGSGIPGAPASWEP------------ 1137

  Fly  1192 TTQCQVHLDVIKRSLQEKITQAEKERNELAVRHKAELEKIRETLKEKESSYKEKLRQAEEERDKE 1256
            .:..:.|:.|:..:|......|:...:||:|   |.:..|    ..||..:|....|..:..||:
  Fly  1138 PSGMEPHVPVLFLNLNGDDLSAQNTNDELSV---AGINSI----LSKEHGHKFYTLQILQHLDKD 1195

  Fly  1257 ISRLEVMRNTIAELHKTNSDREVELEGVKMEKCQLKKLYDKSMLELEQLQCTADQKSSDLLPGSS 1321
            :..:....:::.:....|...|.. |.|.:......:|...:.::|             :|....
  Fly  1196 VCCVASWDSSMHDSQALNRVTEAN-ERVYLILRTTVRLSHPAPMDL-------------VLRKRL 1246

  Fly  1322 NENIDDLQKKCDQYVQDLELLRGEKA--------ELLSEIQKINGQHSNTIKKLEEIEAEMITLT 1378
            :.||...|...|: ::...|:|||.|        |::|.|.|.:          ||:|.......
  Fly  1247 SINIKKGQTLTDR-LKKFRLVRGENAIWQSGVTYEVVSNIPKAS----------EELEDRESLAQ 1300

  Fly  1379 TQKELERCEIAEKLETFKSKEADIKEALHCAQLRLHAYDKLVCEYERLKGCLSDSNKLSENLQ-K 1442
            .....:.|..::. ||:..|                 |.:.|...|    .:...::|.:|:. |
  Fly  1301 LAASGDDCSASDG-ETYIEK-----------------YTRGVSAVE----SILTLDRLRQNVAVK 1343

  Fly  1443 KVERLHAEQLALQEGISGRD-SEIKQLRSELKDAIDENKTVREAKVGLENSLKAVQENMSAQEGQ 1506
            ::|..|.:.|::::.:|..: |:|.:..:.::..::..::  |:...|.||...   |.....|.
  Fly  1344 ELETAHGQPLSMRKTVSVPNFSQIMRFDASMESLLNVGRS--ESFADLNNSALG---NKFTPAGH 1403

  Fly  1507 FKQKIADI---------KGSVDE----------------LQIKLKSLQE--VRDHLESRNEELKR 1544
            .......:         |||.|:                |.:::.:|.|  :..| .|.:||.:.
  Fly  1404 SPAGAGGVIRSRHSFGGKGSSDDSPGKAFGIASPATSKLLGMRMTTLHEEPLGGH-RSLDEEPED 1467

  Fly  1545 KLKDA----------QELQNMVDKERKLNSSLREDF----DKLEQTKLDLEEQLRAKKVEI---- 1591
            ...|:          |:.::|..:.|...|...:.|    ....|:.|.......|....:    
  Fly  1468 SYSDSEYAAEYEQERQQNKSMATRSRLTASKTMDSFMDVSSHSNQSYLSYTSSANANMKHLTGLA 1532

  Fly  1592 ----------------------------DRRSKELGEVTKDCENIRS----DLEAQTNDFLKERE 1624
                                        ..||..:.| |.|.:.:.|    :.:|:.|.|||:..
  Fly  1533 TLSMSSSTSSGYGSQAVSCNNLSNEDIASMRSMSIDE-TPDFDRVNSNSPPNRQARVNPFLKDMP 1596

  Fly  1625 TLNL---------TISDLRLHNEQLLETSKNYLSD------ITAANNLNLEMKKNLHDLTKECKS 1674
            ...:         .:.:...|..:.||:|:|..||      :...||.||       ||..|.|.
  Fly  1597 KAKIQEQPEQQAKKLQEAFTHPLEQLESSQNAQSDDDECAQLPKNNNNNL-------DLVNEPKP 1654

  Fly  1675 LRSDLQSKEEYFQTQKQLLDETISNLKEENRKMEEKLSSGNKALKEDCEKLRSTLESKELILQQ- 1738
            |.|....:|...|.:.:  .|..::.:..||..:| ||..::.|.|....:|..|.:.:::.:: 
  Fly  1655 LSSQTDLEESMSQPKSK--TEFATDNQNGNRSSDE-LSHSSEDLLEGDGIVREELPAGKVVRRKK 1716

  Fly  1739 -NKQELEERLTVINEKNGKN------------------ALLDAQLKSNETAFTSLRK-------A 1777
             |.|......::.|..||..                  |.||:.:.::.|......|       .
  Fly  1717 SNTQPPSNGNSINNNNNGTTQAPRINHRASVAKMEGLAAYLDSSIMTSSTEVDEESKDVELVLPE 1781

  Fly  1778 WI--KQSLAIEAANKR-----------------SLEMEQKVDKRTREYEELR-STLKTREINF-R 1821
            ||  .:|:.|...|..                 .:|::....|.....:.:: ...|.:...| |
  Fly  1782 WIVVGESVLIRPYNTSGVIRFVGTTEFQPGAWIGVELDTPTGKNDGSVKGVQYFQCKPKHGMFVR 1846

  Fly  1822 SEKERMDGTISSLLEDKRNLEEKLCTVTELLAKLKRE----LPALHTQKVNGGDVSIELNSSNG- 1881
            |:|         |:.|||....:.....|....:.:|    :....|:..:.|| |:.|::... 
  Fly  1847 SDK---------LMLDKRGKAMRAYKAAEKSNSISKEMSTSMTGSMTRSKSRGD-SLNLSARKXL 1901

  Fly  1882 ------------SPTPAAVPATKKPLDCNSAECVPKKSSSLETAER--KNRRMTAY 1923
                        :...:.|..:.:|..|:........:.:....::  .|||.||:
  Fly  1902 YPKCSHQLQRWTNCRQSTVATSSQPATCHRLRATSGAADANSHGKKCYANRRSTAF 1957

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
canaNP_001027247.1 KISc 8..316 CDD:214526 114/357 (32%)
Motor_domain 8..310 CDD:277568 113/351 (32%)
SMC_prok_B <471..1270 CDD:274008 162/901 (18%)
Mplasa_alph_rch 924..1647 CDD:275316 151/847 (18%)
CENP-H 1204..>1266 CDD:283493 13/61 (21%)
CALCOCO1 <1489..1850 CDD:285171 91/500 (18%)
Khc-73NP_001261000.1 KISc_KIF1A_KIF1B 4..359 CDD:276816 115/360 (32%)
KISc 6..359 CDD:214526 115/358 (32%)
Kinesin_assoc 356..468 CDD:292801 27/164 (16%)
FHA 446..546 CDD:238017 19/117 (16%)
KIF1B 741..786 CDD:289208 12/48 (25%)
DUF3694 <1196..1252 CDD:289256 9/69 (13%)
CAP_GLY 1786..1850 CDD:279625 10/72 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45437761
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.930

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