DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cana and Kif18a

DIOPT Version :9

Sequence 1:	NP_001027247.1	Gene:	cana / 3771934	FlyBaseID:	FBgn0040233	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	XP_038961378.1	Gene:	Kif18a / 362186	RGDID:	1561740	Length:	886	Species:	Rattus norvegicus

Alignment Length:	953	Identity:	214/953 - (22%)
Similarity:	379/953 - (39%)	Gaps:	272/953 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IQVCIKVRPCEPGLTSLWQVKEGRSIQLADSHA---EP--------------------------- 43
            ::|.::|||..   |....|:..:.:.:.|.|.   :|
  Rat    12 MKVVVRVRPEN---TKEKAVQFHKVVHVVDKHILVFDPKQEEISFFHRKKTTNFDITKRQNKDLK 73

  Fly    44 YVFDYVFDEGASNQEVFDRMAKHIVHACMQGSNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAK 108
            :|||.||||.::..|||:...|.|:|:.:.|.|.|:||||.|.||||:||:|....||||.|...
  Rat    74 FVFDAVFDETSTQMEVFEHTTKPILHSFLNGYNCTVFAYGATGSGKTHTMLGSTAEPGVMYLTML 138

  Fly   109 EIFQQISS-ETERDFLLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIVNVNCKESIVT----- 167
            ::|:.:.. :.|::....|.|:|:|||:|.|||.         .||...|..:.::.:|.
  Rat   139 DLFKCMDEVKDEKECSTAVSYLEVYNEQIRDLLT---------NSGPLAVREDAQKGVVVQGLTL 194

  Fly   168 ----SEDDLLRQLYMGNKERVVGETNMNERSSRSHAIFRIIIESRKSDHSDNDTVKQSVLSLVDL 228
                |.:::|:.|..|||.|....|:||..||||||:|:|.:..:....|.|..|..:.:||:||
  Rat   195 HQPKSSEEILQLLDNGNKNRTQHPTDMNAASSRSHAVFQIYLRQQDKTASINQNVHIAKMSLIDL 259

  Fly   229 AGSEQ-----------VDPADHASSLMIFRNLVKSLSESVDSKPNS----FRDSKLPRIMLPSLG 278
            ||||:           |:..:...||:...|::.:|:   |:|..:    :|:|||.|::..|||
  Rat   260 AGSERASISGTKGTRFVEGTNINKSLLALGNVINALA---DTKRRNQHIPYRNSKLTRLLKDSLG 321

  Fly   279 GNVLTSIICTITPS--FVEESSSTISFGTCAKKIR---CKPQVCKIDSETTM------MRQLDRG 332
            ||..|.:|..::||  |.:::.:|:.:...||.|:   .|..|..:.|..:.      |::.:
  Rat   322 GNCQTIMIAAVSPSSLFYDDTYNTLKYANRAKDIKSSQLKSNVVNLSSHISQYVKICNMQKAE-- 384

  Fly   333 ISMLKDKL---------------AK--------KKIKNESQL---VLQELEGR----IKRDML-- 365
            |.|||:||               ||        |:|:...::   :.|..||.    :|.:||
  Rat   385 ILMLKEKLKAYEGQKALTDRNDCAKLVHSNVEDKEIERFQEILNCLFQNREGMRQEYLKVEMLLK 449

  Fly   366 -----------------------KIVSSASLDDYRLQKRRRTWTLTASGSEGDAPVLALPEPEES 407
                                   |:..:....|:||:|.:....:             |.:.:|.
  Rat   450 ENELKSSYHQQCHKQIEMMCSEDKLEKATCRRDHRLEKLKSNRCV-------------LEKKKEE 501

  Fly   408 RLPRPSKLTN------LPKPLFQRRGIAPKAKGICKTL---------KEKRLQTDNMDTMPGRAK 457
            .|.:..:.||      ....|..:.|..|  :|:.|.|         |:.:.|..:|.|:....:
  Rat   502 MLKQFDENTNWLHRVESEMRLLGQNGDIP--EGLNKDLHCHHLHLQNKDLKTQMGHMMTLAALQE 564

  Fly   458 QLGRETASRIPSVM--MSKKY-----------------------------------------QES 479
            |...:|.:.:.:::  :.|:|                                         |..
  Rat   565 QQHGQTEAVLNALLPVLRKQYWRLKETGLSNAAFDSDFKDIEHLVERKKVVAWADQTAEHSNQSD 629

  Fly   480 VPNCDAPQT-----EISALTASNQVAKETIEKYEEQVKRLKETI-ERLEMENGKAVNLGEQFETH 538
            ||......|     .|.::...:.::..:|.|...|.:..::.| ..|::::.:...|.|:.:.:
  Rat   630 VPGTSLLMTFPQLGPIQSIPCCSSMSDPSILKITPQRRTKRKLIPSPLKVKHTQKSALSERTQLN 694

  Fly   539 KAKSKQMEEELLSSISEKDSTIVSLQQSLEELSRDVLRNSKEDQMRSMCPELESSCERICNKCLE 603
            .:.||:: :.::.:..:...|:..|...|...|........::.::::| ..||...|  .:|.|
  Rat   695 DSFSKEL-QPIVYTPEDSRRTVQDLSPPLARASSHSANGMNDNSLKALC-RTESPLSR--TECKE 755

  Fly   604 LERLLPLASASGLDSVACQFDQLRSEIAATRMKLESMLSTFSHASCEVSQKTTDCKRLSEQISTA 668
                       ||.|.:...|.::|........|.|..||. |.....|..|.|    |..:||:
  Rat   756 -----------GLYSTSAICDGIKSLKNNLPEPLPSSKSTL-HRVESSSFPTKD----SRSVSTS 804

  Fly   669 HDDFGQLQEKYNNLKHKWSSQKLAIDTMQVDYNTIQQKYLQLQDEYRHLELRSDEQC---QQLQD 730
            ...:..:.   ...|.||.......|.                      .|:|||.|   ::::.
  Rat   805 VPSYMAMT---TAAKRKWKFMSSTSDA----------------------SLKSDESCGLAKRIRQ 844

  Fly   731 ENSKL------QAEIGTLKERVEEIHSELLEVPNPDTHPEDME 767
            :||.:      :..:| .|:...:.:|.:|.....:|..|:::
  Rat   845 DNSSVKLIRENRLRVG-YKKTTNKTNSNMLRKFRRNTSKENVQ 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	114/366 (31%)
		Motor_domain	8..310	CDD:277568	112/357 (31%)
		SMC_prok_B	<471..1270	CDD:274008	59/355 (17%)
		Mplasa_alph_rch	924..1647	CDD:275316
		CENP-H	1204..>1266	CDD:283493
		CALCOCO1	<1489..1850	CDD:285171
Kif18a	XP_038961378.1	KISc_KIP3_like	11..355	CDD:276821	112/357 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900