DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cana and klp-20

DIOPT Version :9

Sequence 1:	NP_001027247.1	Gene:	cana / 3771934	FlyBaseID:	FBgn0040233	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	NP_497178.1	Gene:	klp-20 / 3565057	WormBaseID:	WBGene00002230	Length:	646	Species:	Caenorhabditis elegans

Alignment Length:	659	Identity:	181/659 - (27%)
Similarity:	281/659 - (42%)	Gaps:	159/659 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KNASSIQVCIKVRPCEPGLTSLWQVKEGRSIQLADSHAE---------------PYVFDYVFDEG 53
            :.|..::|.::.||     .|..:..:|..|.:..:..|               .:.||.||...
Worm     2 EGAEKVKVVVRCRP-----ISTTEKLQGHKIAVTCNDEEKAVNIKSLSQEDPPRTFYFDAVFSPN 61

  Fly    54 ASNQEVFDRMAKHIVHACMQGSNGTIFAYGQTSSGKTYTMMGD---EQNPGVMVLAAKEIFQQIS 115
            .....|::..|:.||...::|.||||||||||.:|||:||.||   .:..|::..:...||..|:
Worm    62 TDQMTVYNVAARPIVENVLKGYNGTIFAYGQTGTGKTFTMAGDLEPVEMRGIIPNSFAHIFDHIA 126

  Fly   116 S-ETERDFLLRVGYIEIYNEKIYDLLNK-KNQDLKIHESGN-GIVNVNCKESIVTSEDDLLRQLY 177
            . :.:..||:||.|:|||||:|.|||:| .|.:|:|.|..: |:...|.....|.:...:...:.
Worm   127 KCQHDTTFLVRVSYLEIYNEEIRDLLSKDHNGNLEIKERPDVGVYVRNLSNPTVENASKMQALME 191

  Fly   178 MGNKERVVGETNMNERSSRSHAIFRIIIESRKSDHSDNDTVKQSVLSLVDLAGSEQ--------- 233
            .|:|.|.||.|.||..||||||:|.:.|||.:     |..|.|..|.||||||||:
Worm   192 FGSKNRKVGATAMNLESSRSHAMFTVTIESCR-----NGLVTQGKLQLVDLAGSERQSKTGAQGE 251

  Fly   234 --VDPADHASSLMIFRNLVKSLSESVDSKPN--SFRDSKLPRIMLPSLGGNVLTSIICTITPSF- 293
              .:.|....||....|::.||   ||.|..  .:|:|||.|::..|||||..|.:|..:.|:.
Worm   252 RLKEAAKINLSLSTLGNVISSL---VDGKSTHIPYRNSKLTRLLQDSLGGNSKTVMIANVGPATY 313

  Fly   294 -VEESSSTISFGTCAKKIRCKPQVCKI--DSETTMMRQLDRGISMLKDKLAKKKIKN-------- 347
             .:|:.||:.:...||.|:   .|.||  |.:...:|:....|..|:..|.::...:
Worm   314 NYDETLSTLRYANRAKNIQ---NVAKINEDPKDAQLRKFQLEIEALRKILDEENPGDDENQEEAW 375

  Fly   348 ESQLVLQELEGRIKRDMLKIVSSASLDDYRLQKRRRTWTLTASGSEGDAPV-LALPEPEESRLPR 411
            |:::..:|:|...||.:|:...:::::|      ..|..|.....|.:|.: .|..|.|:.|
Worm   376 EAKMQEREVEMEKKRKILEERVNSAVND------EETHRLVKEMMENEAELKKARSEHEKLR--- 431

  Fly   412 PSKLTNLPKPLFQRRGIAPKAKGICKTLKEKRLQTDNMDTMPGRAKQLGRETASRIPSVMMSKKY 476
             |||..:.|.|.                                   :|.|
Worm   432 -SKLEKIEKKLI-----------------------------------VGGE-------------- 446

  Fly   477 QESVPNCDAPQTEISALTASNQVAKETIEKYEEQVKRLKETIERLEMENGKAVNLGEQFETHKAK 541
                                     ..:||.|||.|.|:...:.||....:..:|..|.|...|.
Worm   447 -------------------------NLLEKVEEQAKLLEVNNKELEQSKFQEAHLRTQLEERTAV 486

  Fly   542 SKQMEEELLSSISE----KDSTIVSLQQSLEELSRDVLRNSKEDQMRSMCPELESSCERICNKCL 602
            ..::||. .||:.|    |...|..:...|:: :|..|::.:||..|    ::|:..:.|  :.|
Worm   487 KVEIEER-YSSLQEEAFVKSKKIKKVSNELKD-ARAELKDLEEDHQR----QVEAMLDDI--RQL 543

  Fly   603 ELERLLPLA 611
            ..|.||.:|
Worm   544 RKELLLNIA 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	117/343 (34%)
		Motor_domain	8..310	CDD:277568	116/337 (34%)
		SMC_prok_B	<471..1270	CDD:274008	33/145 (23%)
		Mplasa_alph_rch	924..1647	CDD:275316
		CENP-H	1204..>1266	CDD:283493
		CALCOCO1	<1489..1850	CDD:285171
klp-20	NP_497178.1	Motor_domain	5..331	CDD:328930	116/338 (34%)
klp-20	NP_497178.1	SMC_N	<325..>569	CDD:330553	66/323 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910