DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cana and nod

DIOPT Version :9

Sequence 1:	NP_001027247.1	Gene:	cana / 3771934	FlyBaseID:	FBgn0040233	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	NP_001285129.1	Gene:	nod / 32107	FlyBaseID:	FBgn0002948	Length:	666	Species:	Drosophila melanogaster

Alignment Length:	704	Identity:	166/704 - (23%)
Similarity:	275/704 - (39%)	Gaps:	168/704 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTKNASSIQVCIKVRPC-------EPGLTSLWQVKEGRSIQLADSHAEPYVFDYVFDEGASNQE 58
            |.....|::::.::..|.       ||.:.......:|:|: :.|.:  .:.||:.|....|..|
  Fly     1 MEGAKLSAVRIAVREAPYRQFLGRREPSVVQFPPWSDGKSL-IVDQN--EFHFDHAFPATISQDE 62

  Fly    59 VFDRMAKHIVHACMQGSNGTIFAYGQTSSGKTYTM----MGD--EQNPGVMVLAAKEIFQQISS- 116
            ::..:...:|...::|...|..|||||.:||:|:|    .|:  .::.|::..|..:||:::::
  Fly    63 MYQALILPLVDKLLEGFQCTALAYGQTGTGKSYSMGMTPPGEILPEHLGILPRALGDIFERVTAR 127

  Fly   117 -ETERDFL-LRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIVNVNCKESI---VTSEDDLLRQL 176
             |..:|.: :...:|||||||.:|||.....        ..:|...|:...   :.|:.||...|
  Fly   128 QENNKDAIQVYASFIEIYNEKPFDLLGSTPH--------MPMVAARCQRCTCLPLHSQADLHHIL 184

  Fly   177 YMGNKERVVGETNMNERSSRSHAIFRIIIESRKSDHSDNDTVKQSVLSLVDLAGSEQVDPADHAS 241
            .:|.:.|.|..||||..|||||||..|.::| |:.||.        :::|||||||.|....|..
  Fly   185 ELGTRNRRVRPTNMNSNSSRSHAIVTIHVKS-KTHHSR--------MNIVDLAGSEGVRRTGHEG 240

  Fly   242 -----------SLMIFRNLVKSLSESVDSKPNSFRDSKLPRIMLPSLGGNVLTSIICTITP--SF 293
                       .|:....:|.|::......|  :|||.|..::..||......:.:..|:|  ..
  Fly   241 VARQEGVNINLGLLSINKVVMSMAAGHTVIP--YRDSVLTTVLQASLTAQSYLTFLACISPHQCD 303

  Fly   294 VEESSSTISFGTCAKKIRCKP-QVCK----IDSETT-MMRQLDRGISMLKDKLAKKKIKNESQLV 352
            :.|:.||:.|||.|||:|..| ||.:    :.:.|| :.||     ::......|....|.:.:|
  Fly   304 LSETLSTLRFGTSAKKLRLNPMQVARQKQSLAARTTHVFRQ-----ALCTSTAIKSNAANHNSIV 363

  Fly   353 LQELEGRIKRDMLKIVSSASLDDYRLQKRRRTWTLTASGSEGDAPVLALPEPEESRLPRPS---- 413
            :.    :.|....|.:|:.      |.:.|....:|....:....:|.|   ||:.|...|
  Fly   364 VP----KSKYSTTKPLSAV------LHRTRSELGMTPKAKKRARELLEL---EETTLELSSIHIQ 415

  Fly   414 ----KLTNLPKPLFQRRGIAPKAKGICKTLKEKRLQTDNMDTMPGRAKQLGRETASRIPSVMMSK 474
                .|........:.|.:.|...|     :|.|..:....|:.|..::...:.:|::...|::.
  Fly   416 DSSLSLLGFHSDSDKDRHLMPPPTG-----QEPRQASSQNSTLMGIVEETEPKESSKVQQSMVAP 475

  Fly   475 KYQESVPNCDAPQTEISALTASNQVAKETIEKYEEQVKRLKETIERLEMENGKAVNLGEQFETHK 539
            ....:| .|....|.||.::.                                           :
  Fly   476 TVPTTV-RCQLFNTTISPISL-------------------------------------------R 496

  Fly   540 AKSKQMEEELLSSISEKDSTIV-SLQQSLEELSRDV-LRNSKEDQMRSMCPELESSCERICNKCL 602
            |.|.|.|   ||.|...:.|:| |.||..  |.|.| |.:|...|.....|           |.:
  Fly   497 ASSSQRE---LSGIQPMEETVVASPQQPC--LRRSVRLASSMRSQNYGAIP-----------KVM 545

  Fly   603 ELERLLPLASASGLDSVACQFDQLRSEIAATRMKLESMLSTFSHASCEVSQKTT 656
            .|.|...||.             :|..  ||.:.:::......|....|.:|.|
  Fly   546 NLRRSTRLAG-------------IREH--ATSVVVKNETDAIPHLRSTVQKKRT 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	97/340 (29%)
		Motor_domain	8..310	CDD:277568	94/333 (28%)
		SMC_prok_B	<471..1270	CDD:274008	37/188 (20%)
		Mplasa_alph_rch	924..1647	CDD:275316
		CENP-H	1204..>1266	CDD:283493
		CALCOCO1	<1489..1850	CDD:285171
nod	NP_001285129.1	KISc	8..325	CDD:214526	96/338 (28%)
		KISc	8..318	CDD:276812	92/331 (28%)
		ComEA	540..648	CDD:224472	13/71 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437928
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930