DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cana and Kif5a

DIOPT Version :9

Sequence 1:	NP_001027247.1	Gene:	cana / 3771934	FlyBaseID:	FBgn0040233	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	NP_997688.1	Gene:	Kif5a / 314906	RGDID:	1303035	Length:	1027	Species:	Rattus norvegicus

Alignment Length:	1027	Identity:	279/1027 - (27%)
Similarity:	433/1027 - (42%)	Gaps:	215/1027 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TKNASSIQVCIKVRPCEPGLTSLWQVKEGRS----IQLADS---HAEPYVFDYVFDEGASNQEVF 60
            |.|..||:|..:.||....     ::..|..    .|..||   ..:|||||.||....:.::|:
  Rat     4 TNNECSIKVLCRFRPLNQA-----EILRGDKFIPIFQGDDSVIIGGKPYVFDRVFPPNTTQEQVY 63

  Fly    61 DRMAKHIVHACMQGSNGTIFAYGQTSSGKTYTMMG---DEQNPGVMVLAAKEIFQQISSETER-D 121
            ...|..||...:.|.|||||||||||||||:||.|   |.|..|::...|::||..|.|..|. :
  Rat    64 HACAMQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHIYSMDENLE 128

  Fly   122 FLLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIVNV-NCKESIVTSEDDLLRQLYMGNKERVV 185
            |.::|.|.|||.:||.|||:....:|.:||..|.:..| .|.|..|:|.:::|..:..|...|.|
  Rat   129 FHIKVSYFEIYLDKIRDLLDVTKTNLSVHEDKNRVPFVRGCTERFVSSPEEILDVIDEGKSNRHV 193

  Fly   186 GETNMNERSSRSHAIFRIIIESRKSDHSDNDTVKQSVLSLVDLAGSEQVDPA-------DHA--- 240
            ..|||||.|||||:||.|.|   |.::.:.:......|.|.||||||:|...       |.|
  Rat   194 AVTNMNEHSSRSHSIFLINI---KQENIETEQKLSGKLYLADLAGSEKVSKTGAEGAVLDEAKNI 255

  Fly   241 -SSLMIFRNLVKSLSESVDSKPNSFRDSKLPRIMLPSLGGNVLTSIICTITPSFVE--ESSSTIS 302
             .||....|::.:|:|...|.. .:||||:.||:..|||||..|::....:||...  |:.||:.
  Rat   256 NKSLSALGNVISALAEGTKSYV-PYRDSKMTRILQDSLGGNCRTTMFICCSPSSYNDAETKSTLM 319

  Fly   303 FGTCAKKIRCKPQVCKIDSETTMMRQLDRGISMLKDKLAKKKIKNESQL-VLQELEGRIKRDMLK 366
            ||..||.|:           .|....|:......|.|..|:|.|.::|. .:.:||..:.|
  Rat   320 FGQRAKTIK-----------NTASVNLELTAEQWKKKYEKEKEKTKAQKETIAKLEAELSR---- 369

  Fly   367 IVSSASLDDYRLQKRRRTWTLTASGSE-----GDAPVLALPEPEESRLPRPSKLTNLPKPLFQRR 426
                              |....:..|     |:...||....||:.:...|.:.....| .:|:
  Rat   370 ------------------WRNGENVPETERLAGEDSALAAEICEETPVNDNSSIVVRIAP-EERQ 415

  Fly   427 GIAPKAKGICKTLKEKRLQTDNMDTMPGRAKQLGRETASRIPSVMMSKKYQESVPNCDAPQTEIS 491
            ....:.:.:.|.|.:|   .|.::......::|.::...:...::.::...|.|      |.|:|
  Rat   416 KYEEEIRRLYKQLDDK---DDEINQQSQLIEKLKQQMLDQEELLVSTRGDNEKV------QRELS 471

  Fly   492 ALTASNQVAKETIEKYEEQVKRLKETIERLEMENGKAVNLGEQFETHKAKSKQMEEELLSSISEK 556
            .|.:.|..||       |:||.:.:.:|.|      |||..::.:..:.||:| .:.|:..:|:|
  Rat   472 HLQSENDAAK-------EEVKEVLQALEEL------AVNYDQKSQEVEEKSQQ-NQLLVDELSQK 522

  Fly   557 DSTIVSLQ---QSLEELSRDVLRNSKEDQMRSMCPELESSCERICNKCLELERLLPLASASGLDS 618
            .:|::||:   |.|:|:|.. .|....:.:..:..:|......:.|.    |..||:..:..::
  Rat   523 VATMLSLESEPQRLQEVSGH-QRKRIAEVLNGLMKDLSEFSVIVGNG----EIKLPVEISGAIE- 581

  Fly   619 VACQFDQLRSEIAATRMKLESMLSTFSHASCEVSQKTTDCKRLSEQISTAHDDFGQLQEKYNNLK 683
                     .|....|:.:..:.|       ||......|::|.......|       .|.....
  Rat   582 ---------EEFTVARLYISKIKS-------EVKSVVKRCRQLENLQVECH-------RKMEVTG 623

  Fly   684 HKWSSQKLAIDTMQVDYNTIQQKYLQLQDEYRHLELRSDEQCQQLQDENSKLQAEIGTLKERVEE 748
            .:.||.:|.|...:....::.:....::.:.||||    |....|.||.:||||:        |.
  Rat   624 RELSSCQLLISQHEAKIRSLTEYMQTVELKKRHLE----ESYDSLSDELAKLQAQ--------ET 676

  Fly   749 IHSELLEVPNPDTHPED-----MELQNQ-------------------------ELKKRLSKLQWE 783
            :|...|:...|||...:     :|||.:                         |||....|||.|
  Rat   677 VHEVALKDKEPDTQDAEEVKKALELQMENHREAHHRQLARLRDEINEKQKTIDELKDLDQKLQLE 741

  Fly   784 FDEIQLNYECL---SNELMSTIQECDALREEHKQRTTNSDLESMKSSGVGTECSDPENELDTDLL 845
            .:::|.:||.|   .||..:.:||...|.|.|:|  :..||:.::.: |..|.....| |....:
  Rat   742 LEKLQADYERLKNEENEKSAKLQELTFLYERHEQ--SKQDLKGLEET-VARELQTLHN-LRKLFV 802

  Fly   846 QQFTKLSKSIQQIELTDYSGG------RRLFIYNHAEQDQSV---------------PSLKLCL- 888
            |..|...|...::|..| |||      :..|:.|:.||...|               |.|:..|
  Rat   803 QDVTTRVKKSAEMEPED-SGGIHSQKQKISFLENNLEQLTEVHKQLVRDNADLRCELPKLEKRLR 866

  Fly   889 ---EPAKYLEGDGKQHDASDSVFLKGFLKCQRFQIVKINQEQNLVKEEDRMR 937
               |..|.|||..|:..       :|.:|.:|    :..||.:.:||..|.:
  Rat   867 ATAERVKALEGALKEAK-------EGAMKDKR----RYQQEVDRIKEAVRYK 907

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	126/332 (38%)
		Motor_domain	8..310	CDD:277568	125/326 (38%)
		SMC_prok_B	<471..1270	CDD:274008	125/528 (24%)
		Mplasa_alph_rch	924..1647	CDD:275316	5/14 (36%)
		CENP-H	1204..>1266	CDD:283493
		CALCOCO1	<1489..1850	CDD:285171
Kif5a	NP_997688.1	KISc_KHC_KIF5	7..327	CDD:276820	125/328 (38%)
		KISc	9..334	CDD:214526	127/344 (37%)
		Microtubule-binding. /evidence=ECO:0000255	174..315		53/144 (37%)
		Necessary for interaction with ZFYVE27. /evidence=ECO:0000250\|UniProtKB:P33175	271..361		32/101 (32%)
		Interaction with BICD2. /evidence=ECO:0000250\|UniProtKB:Q12840	353..1027		144/658 (22%)
		RX-CC_like	441..>493	CDD:271353	13/64 (20%)
		BAR	637..809	CDD:299863	48/187 (26%)
		TACC	713..884	CDD:282818	47/182 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	906..936		0/2 (0%)
		Globular. /evidence=ECO:0000255	907..1027		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000669
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000