DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cana and Kif19

DIOPT Version :9

Sequence 1:	NP_001027247.1	Gene:	cana / 3771934	FlyBaseID:	FBgn0040233	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	XP_038942111.1	Gene:	Kif19 / 303659	RGDID:	1559936	Length:	997	Species:	Rattus norvegicus

Alignment Length:	1004	Identity:	220/1004 - (21%)
Similarity:	387/1004 - (38%)	Gaps:	276/1004 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IQVCIKVRP-----CEPGLTSLWQVKEGRSIQLADSHAEP-------------YVFDYVFDEGAS 55
            :.|.::|||     .|.|.|.:....:.:.:.|.|...:|             |:||..||..|:
  Rat    12 LMVALRVRPISVSELEEGATLIAHKVDEQMVVLMDPMEDPDDILRAHRSREKSYLFDVAFDFTAT 76

  Fly    56 NQEVFDRMAKHIVHACMQGSNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAKEIFQQISSETER 120
            .:.|:....|.::...:.|.|.|:||||.|..||||||:|.:..||:.|....::|:.| .||..
  Rat    77 QEMVYQATTKSLIEGVISGYNATVFAYGPTGCGKTYTMLGTDHEPGIYVRTLNDLFRAI-EETSN 140

  Fly   121 D--FLLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIVNV-NCKESIVTSEDDLLRQLYMGNKE 182
            |  :.:.:.|:|||||.|.||||.....|::.|...|::.| ...|....:..::::.|..||::
  Rat   141 DMEYEVSMSYLEIYNEMIRDLLNPALGYLELREDSKGVIQVAGITEVSTINAKEIMQLLMKGNRQ 205

  Fly   183 RVVGETNMNERSSRSHAIFRIIIESRKSDHSDNDTVKQSVLSLVDLAGSEQVDPADHAS------ 241
            |....|..|:.||||||:.::.:..|....:....|:|..|.::||||||:.....:..
  Rat   206 RTQEPTAANQTSSRSHAVLQVAVRQRNRVKNILQEVRQGRLFMIDLAGSERASQTQNRGQRMKEG 270

  Fly   242 -----SLMIFRNLVKSLSESVDSKPNSFRDSKLPRIMLPSLGGNVLTSIICTITPSFV--EESSS 299
                 ||:...|.:.:||:...:|..::|||||.|::..|||||..|.:|..|:|:..  |||.:
  Rat   271 AHINRSLLALGNCINALSDKGGNKYINYRDSKLTRLLKDSLGGNSRTVMIAHISPASTAFEESRN 335

  Fly   300 TISFGTCAKKIRCKPQ---------------------------VCKIDSET---TMMRQLDRG-- 332
            |:::...||.||.:.:                           .||||.:.   ....:||||
  Rat   336 TLTYAGRAKNIRTRVKQNLLNVSYHIAQYTSIIADLRGEIQRLKCKIDQQAGRGQARGKLDRGDI 400

  Fly   333 ------------------ISMLKDKL----------AKKKIKNESQLVLQELEGRIKRDMLKIVS 369
                              :..|:::|          .::.::.|:|.:  |::....|.:|.|.|
  Rat   401 RHIQAEVQLHSGQEEQAEMGQLREQLISAFHEQMDVRRRLLELENQAM--EVQIDTSRHLLTIAS 463

  Fly   370 -----SASLDDYRLQKRRRTWTLTASGSEGDAPVLALPEPEESRLPRPSKLTNL--PKPLFQRRG 427
                 |.....:|.::|:.::|...|..:.|..    .||:           ||  |:....|..
  Rat   464 WEHEKSRRALKWREERRKESYTKEDSEKDSDTG----DEPD-----------NLEPPEVASAREN 513

  Fly   428 IAPKAKGICKTLKEKRLQTDNMDTMPGRAKQLGRETASRIPSVMMSKKYQESVPNCDAPQTEISA 492
            ||... |..|.|::::|..:          |..||..:|      .::.:|::|.....:.:...
  Rat   514 IAALV-GEQKKLRKEKLALE----------QRCRELRAR------GRRLEETLPRRIGSEEQREV 561

  Fly   493 LTASNQVAKETIEKYEEQ---------VKRLKETIERLEMENGKAVNLGEQFETHKAKSKQM--- 545
            |:...:|.:..:|..|.|         ::..:|.:.|||.              |::...::
  Rat   562 LSLLCRVHELEVENTEMQSHALLRDSALRHRREAVRRLEQ--------------HRSLCDEIIQG 612

  Fly   546 EEELLSSISEKDSTIVSLQQSLEELSRDVLRNSKEDQMRSMCPELESSCERICNKCLE---LERL 607
            :.:::      |...:.:.:.||||....||..:|..:     |..:..:|:.::.|:   |.::
  Rat   613 QRQII------DDYNLEIPRHLEELYEVYLRELEEGSL-----ERATIMDRVASRALQDSSLPKI 666

  Fly   608 LPLASASGLDSVACQFDQLRSEIAATRMKLESMLSTFSHASCE---------------------- 650
            .|..:....||                 .|||:.:..|.|.|.
  Rat   667 TPAGTTLTPDS-----------------DLESVKTLSSEAQCPQNNTLPPLGTDSDSYHMFKASP 714

  Fly   651 ---------------------VSQKTTDCKRLSEQISTAHDDFGQLQEKYNNLKHKWSSQKLAID 694
                                 |:|:......|..||:::.|....|.|..  |.|| ..:::...
  Rat   715 RAWQVKSSSVPTPPPIQVGSLVTQEAPPQDSLGSQINSSPDSSENLSEIL--LSHK-ERKEILTR 776

  Fly   695 TMQVDYNTIQQKYLQLQDEYRHLELRSDEQCQQLQDENSKLQAEIGTLKERVEEIHSELLEVPNP 759
            |..:.....|::...|..|.|||          |.....:....:.:|.|      ::.:..|.|
  Rat   777 TKCISVKAAQRRSRALGTEGRHL----------LAPATERSSLSLHSLSE------ADDVRPPGP 825

  Fly   760 --DTHPEDMELQNQELKKRLSKLQWEFDE-------------IQLNYECLSNELMSTIQECDALR 809
              ...|....||:...:..||....|...             ::...:|||.:...::   :|.|
  Rat   826 LACKRPPSPTLQHAISEDNLSSSTGEGPARAVGPRGDGSGPWVRGQKKCLSKKREESL---EAKR 887

  Fly   810 EEHKQRT---TNSDLESMKSSGVGTECSD 835
            .:.:.|:   |...|...|:..:|...|:
  Rat   888 RKRRSRSFEVTGQGLSRSKTHLLGPRPSE 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	108/367 (29%)
		Motor_domain	8..310	CDD:277568	106/334 (32%)
		SMC_prok_B	<471..1270	CDD:274008	73/441 (17%)
		Mplasa_alph_rch	924..1647	CDD:275316
		CENP-H	1204..>1266	CDD:283493
		CALCOCO1	<1489..1850	CDD:285171
Kif19	XP_038942111.1	KISc_KIP3_like	11..346	CDD:276821	106/334 (32%)
Kif19	XP_038942111.1	Smc	<326..661	CDD:224117	70/393 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900