DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cana and Kif18b

DIOPT Version :9

Sequence 1:	NP_001027247.1	Gene:	cana / 3771934	FlyBaseID:	FBgn0040233	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	XP_008766505.1	Gene:	Kif18b / 303575	RGDID:	1310360	Length:	841	Species:	Rattus norvegicus

Alignment Length:	730	Identity:	182/730 - (24%)
Similarity:	303/730 - (41%)	Gaps:	175/730 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SSIQVCIKVRP----------------------------CEPGLTSL-WQ------VKEGRSIQL 36
            |.::|.::|||                            |:.|...| |.      .|:|:.:
  Rat     8 SVVRVVVRVRPPTPKELESQRRPVIQVVDERMLVFDPEECDGGFPGLKWSGSLSGPKKKGKDL-- 70

  Fly    37 ADSHAEPYVFDYVFDEGASNQEVFDRMAKHIVHACMQGSNGTIFAYGQTSSGKTYTMMGDEQNPG 101
                  .:|||.||.|.|:.|:||.....:|:.:.:||.|.::||||.|.:|||:||:|.|.:||
  Rat    71 ------TFVFDRVFSEVATQQDVFQHTTHNILDSFLQGYNCSVFAYGATGAGKTHTMLGREGDPG 129

  Fly   102 VMVLAAKEIFQQISS-ETERDFLLRVGYIEIYNEKIYDLLNKKNQDLKIHES-GNGIVNVNCKES 164
            :|.|...|:::::.: :.|:.|.:.:.|:|:|||:|||||..|. .|.|.|. ..|:|.......
  Rat   130 IMYLTTMELYRRLEACQEEKQFEVLISYLEVYNEQIYDLLEPKG-PLTIREDPDKGVVVPGLSFH 193

  Fly   165 IVTSEDDLLRQLYMGNKERVVGETNMNERSSRSHAIFRIIIESRKSDHSDNDTVKQSVLSLVDLA 229
            ...|...||..|..||..|....|:.|..||||||||:|.::.:.........::.:.:||:|||
  Rat   194 QPASAQQLLEMLTRGNCSRTQHPTDANATSSRSHAIFQIFVKQQDRVPGLTQALRVAKMSLIDLA 258

  Fly   230 GSEQVDPADHAS------------SLMIFRNLVKSLSESVDSKPN-SFRDSKLPRIMLPSLGGNV 281
            |||:.. :.||.            ||:...|::.:|:::...|.: .:|||||.|::..|:|||.
  Rat   259 GSERAS-STHAKGERLREGANINRSLLALINVLNALADAKGRKSHVPYRDSKLTRLLKDSIGGNC 322

  Fly   282 LTSIICTITPSFV--EESSSTISFGTCAKKIR--CKPQVCKIDSE----TTMMRQLDRGISMLKD 338
            .|.:|..::||.:  |::.:|:.:...||:||  .|..|..:|..    .|:.:||...::.|::
  Rat   323 RTVMIAAVSPSSLTYEDTYNTLKYADRAKEIRLTLKSNVISLDHHISQYATICQQLQAEVAALRE 387

  Fly   339 KLAKKKIKNESQLVLQELEGRIKRDMLKIVSSASLDDYRLQKRRRTWTLTASGSEGDAPVLALPE 403
            ||                                          :|:       |..|..|....
  Rat   388 KL------------------------------------------QTY-------EAGAQALQQRS 403

  Fly   404 PEESRLPRPSKLTNLP-KPLFQRRGIAPKAKGICKTLKEKRLQTDNMDTMPGRAKQLGRETASRI 467
            |:..:|..|..|::.| :|....:..||:........:|:.|.||:      :.:....|.|...
  Rat   404 PQPPKLSIPQNLSSSPLQPGHSSQSCAPEFHAKYDAPQEESLGTDS------QGQGTVEENAPEQ 462

  Fly   468 PSVMMSKKYQESVPNCDAPQT---EISALTASNQVAKETIEKYEEQVKRLKETIERLEMENGKAV 529
            ......|::...:|..:.|.:   .:.|....||                 .:::||:.|:.|
  Rat   463 EQPPQDKQFPTQMPEPNLPGSPCPTVQAKQGMNQ-----------------HSLQRLDAEHSK-- 508

  Fly   530 NLGEQFETHKAKSKQMEEELLSSISEKDSTIVSLQQSLEELSRDVLRNSKEDQMRS-MCPELESS 593
                |......:..|.:..||.:.:.....::|..::|::|   ||..|.|....| ..|.|...
  Rat   509 ----QLALRVLRLAQRQYSLLQAANLLTPDMISEFETLQQL---VLEESMEHGAESPRSPGLARG 566

  Fly   594 ---CERICNKCLELERLLPLASASGLDSVACQFDQLRSEIAATRMKLESMLSTFSH--------- 646
               .:.:|::..|....|.|..       ||..:..|.....|| .:...||..:|
  Rat   567 IPLAQELCSESSECPLSLSLRP-------ACSQESSRYCGPVTR-TMAKQLSGLTHTLGIPLAPD 623

  Fly   647 -ASCEVSQKTTDCKR 660
             .|.:.|||.|..|:
  Rat   624 CTSDKTSQKPTKEKK 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	113/361 (31%)
		Motor_domain	8..310	CDD:277568	110/353 (31%)
		SMC_prok_B	<471..1270	CDD:274008	42/207 (20%)
		Mplasa_alph_rch	924..1647	CDD:275316
		CENP-H	1204..>1266	CDD:283493
		CALCOCO1	<1489..1850	CDD:285171
Kif18b	XP_008766505.1	KISc	18..360	CDD:214526	110/351 (31%)
Kif18b	XP_008766505.1	KISc_KIP3_like	18..353	CDD:276821	107/344 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900