DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cana and Kif22

DIOPT Version :9

Sequence 1:	NP_001027247.1	Gene:	cana / 3771934	FlyBaseID:	FBgn0040233	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	NP_001009645.1	Gene:	Kif22 / 293502	RGDID:	1311886	Length:	657	Species:	Rattus norvegicus

Alignment Length:	655	Identity:	158/655 - (24%)
Similarity:	277/655 - (42%)	Gaps:	143/655 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IQVCIKVR---------PCEPGLTSLWQVKEGRSIQLAD----SHAEPYVFDYVFDEGASNQEVF 60
            ::|.:::|         ||..|:.|.       |:::|:    .....|.||..:.|.::.|:|:
  Rat    39 VRVAVRLRPFMDEAKEPPCVRGIDSC-------SLEVANWRKYQETLKYQFDAFYGEKSTQQDVY 96

  Fly    61 DRMAKHIVHACMQGSNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAKEIFQQISSETER----D 121
            ....:.|:...::|.|.::.|||.|.:|||:||:|..:.|||:..|..::.|....|:..    |
  Rat    97 VGSVQPILRHLLEGQNASVLAYGPTGAGKTHTMLGSPEQPGVIPRALMDLLQLTREESAEGRPWD 161

  Fly   122 FLLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNG-IVNVNCKESIVTSEDDLLRQLYMGNKERVV 185
            ..:.:.|:|||.||:.|||:..:.||.|.|...| |:.....:..:||..:..:.....::.|||
  Rat   162 ISVAMSYLEIYQEKVLDLLDPASGDLVIREDCRGNILIPGLTQKPITSFSEFEQHFLPASRNRVV 226

  Fly   186 GETNMNERSSRSHAIFRIIIESRKSDHSDNDTVKQSVLSLVDLAGSEQ-----------VDPADH 239
            |.|.:|:|||||||:..:.:|.|  :.......::..|.|:||||||.           .:....
  Rat   227 GATRLNQRSSRSHAVLLVKVEQR--ERLTPFRQREGKLYLIDLAGSEDNRRTGNQGIRLKESGAI 289

  Fly   240 ASSLMIFRNLVKSLSESVDSKPNSFRDSKLPRIMLPSLGGNVLTSIICTITPS--FVEESSSTIS 302
            .:||.:...:|.:|::.:...|  :|||||.|::..||||:..:.:|..|.|.  |.:::.|.::
  Rat   290 NTSLFVLGKVVDALNQGLPRIP--YRDSKLTRLLQDSLGGSAHSILIANIAPERRFYQDTISALN 352

  Fly   303 FGTCAKKIRCKPQVCKIDSETTMMRQLDRGISMLKDKLAKKKIKNESQLVLQELEGRIKRDMLKI 367
            |...:|::..:|    ..:|:....      ::...||.:|::...|:
  Rat   353 FTARSKEVINRP----FTNESLQPH------ALAPVKLPQKELLGPSE----------------- 390

  Fly   368 VSSASLDDYRLQKRRRTWTLTASGSE----GDAPVLALPEPEESRLPRPSKLTNLPKPLFQR--- 425
                              ...|.|.|    |.....|.|.....:|....||:|:...:.:.
  Rat   391 ------------------AKKAKGPEEESTGSPESTAAPASASQKLSLLQKLSNMDPAMLENLLS 437

  Fly   426 ----------RGI----APKAKG--ICKTLKEKRLQTD--NMDTMPGRAKQLGRETASRIPSVMM 472
                      :||    .||.:.  :.||::||.|:.:  .|......||.|.:|.        :
  Rat   438 MERLLGSQGSQGIPLLNTPKRERMVLIKTVEEKNLEIERLKMKQKELEAKVLAQEA--------L 494

  Fly   473 SKKYQESVPNCDAPQTEISALTASNQVAKETIEKYEEQVKRLKETIERLEMENGKAVNLGEQFET 537
            ..|.:|:.|....|.:     :.|..|||...:.....::|:::     :.|:...::|.:  :.
  Rat   495 DPKEKENTPTILQPSS-----SCSGSVAKPLKKAVVMPLQRIQK-----QSESSNKIHLLK--KG 547

  Fly   538 HKAKSKQMEEELLSSISEKDSTIVSLQQSLEELSR---DVLRNSKEDQMRSMCPELESSCERICN 599
            ||.|.:...|   |...|||.....:|.|.|.|:|   .:|....|...|.:     .|.:||..
  Rat   548 HKRKLESSHE---SEAVEKDEDYWEIQISPELLARGRKKLLHLLNEGSARDL-----RSLQRIGQ 604

  Fly   600 KCLEL 604
            |..:|
  Rat   605 KKAQL 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	97/337 (29%)
		Motor_domain	8..310	CDD:277568	96/331 (29%)
		SMC_prok_B	<471..1270	CDD:274008	32/137 (23%)
		Mplasa_alph_rch	924..1647	CDD:275316
		CENP-H	1204..>1266	CDD:283493
		CALCOCO1	<1489..1850	CDD:285171
Kif22	NP_001009645.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		KISc	38..367	CDD:214526	97/342 (28%)
		KISc_KID_like	38..358	CDD:276827	95/329 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..415		7/61 (11%)
		HHH_3	588..638	CDD:289597	7/27 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900