DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cana and klp6

DIOPT Version :9

Sequence 1:	NP_001027247.1	Gene:	cana / 3771934	FlyBaseID:	FBgn0040233	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	NP_001342739.1	Gene:	klp6 / 2539700	PomBaseID:	SPBC1685.15c	Length:	784	Species:	Schizosaccharomyces pombe

Alignment Length:	646	Identity:	169/646 - (26%)
Similarity:	272/646 - (42%)	Gaps:	154/646 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KNASSIQVCIKVRP----------------------------------CEPGLTSLWQVKEGRSI 34
            |..|||.|.::|||                                  |..|:..:.:|.:...:
pombe     2 KEGSSISVAVRVRPFTEREKGLLAETPKSKEFLGDGSLAVSNTSSNTFCTNGIRKIVRVLDDNVL 66

  Fly    35 QLADSHAEP-------------------YVFDYVFDEGASNQEVFDRMAKHIVHACMQGSNGTIF 80
            ........|                   |.||.:|.|.||.::|:....:.::.:.:||.|.|:|
pombe    67 IFDPPEENPLAKVQKSLLPAGKRFRDVRYAFDRLFGEEASQEDVYKGTTEPLLDSVLQGYNATVF 131

  Fly    81 AYGQTSSGKTYTMMGDEQNPGVMVLAAKEIFQQISS-ETERDFLLRVGYIEIYNEKIYDLL---- 140
            |||.|..|||:|:.|...:||::.|..:.:..::.. :...:..:.|.|:|||||||.|||
pombe   132 AYGATGCGKTHTISGRPDDPGIIFLTMRALLDRVEGLKRTMNVDISVSYLEIYNEKIRDLLVQDP 196

  Fly   141 --NKKNQDLKIHESGNGIVNV-NCKESIVTSEDDLLRQLYMGNKERVVGETNMNERSSRSHAIFR 202
              .:|.:.|.|.|.....|:| .......|:.::::..:..||..|.:..|..|..||||||:.:
pombe   197 LSMEKPKSLNICEDAEQNVSVPGLSYFTPTNLEEVMEIIIRGNSNRTMSPTEANAVSSRSHAVLQ 261

  Fly   203 III-------ESRKSDHSDNDTVKQSVLSLVDLAGSEQ-----------VDPADHASSLMIFRNL 249
            |.|       |.::...|.|....:||.|.:||||||:           |:.|:...||:...|.
pombe   262 IYITQTPKSGEKQEESESQNSHKVRSVFSFIDLAGSERASATKNRGKRLVEGANINRSLLALGNC 326

  Fly   250 VKSLSESVDSKPNSFRDSKLPRIMLPSLGGNVLTSIICTITPS--FVEESSSTISFGTCAKKIRC 312
            :.||.|....:...:|||||.|::..|||||..|.:|..|:||  ..:|:.:|:.:|..||.|:.
pombe   327 INSLCEPRRRQHVPYRDSKLTRLLKFSLGGNCRTCMIVCISPSSEHYDETHNTLKYGNRAKNIKT 391

  Fly   313 K--PQVCKIDSETTMMRQLDRGISMLKDKLA--KKKIKNES-QLVLQELEGRIKRDMLKIVSSAS 372
            |  ..|..:|...:   :..|.|..|:.|::  :|:|..|| ||.|.:...:|....:|::.:.|
pombe   392 KVSRNVVSVDRHVS---EYVRTIYELRQKVSILQKRIAEESKQLALNKEVRKISSREIKMLDARS 453

  Fly   373 L-----DDYR-LQK---------RR--------RTWTLTASGSEGDAPVLALPEPEESRLPRPSK 414
            :     |..| |||         ||        :.|...|  .|.||......:..|:||   :|
pombe   454 MLKNSFDGSRDLQKSLIEHVRTLRRIEDEITLTKMWISIA--KESDAMSGHNIKSVETRL---AK 513

  Fly   415 LTNLPKPLFQRRGIAPKA--KGICKTLKEKRLQTDNMDTMPGRAKQLGRETASRIPSVMMSKKYQ 477
            |.:      ||..|..|.  :.||||.:                        :.|..::.|.|.:
pombe   514 LYD------QRSLITAKVNPEEICKTFQ------------------------NSISHIVSSFKGE 548

  Fly   478 ESVPNCDAPQTEISALTA--SNQV--AKETIEKYEEQVKRLKETIERL-EMENGKAVNLGE 533
            .:....|..|.::..|.:  .||:  ||...|.:....::|.:.:..| .:..|.|:::.|
pombe   549 GADMYADMLQDDVDLLKSIIENQILDAKHESETFSSTSRKLIQNLFLLFPLLPGNAIDVNE 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	110/390 (28%)
		Motor_domain	8..310	CDD:277568	108/382 (28%)
		SMC_prok_B	<471..1270	CDD:274008	15/68 (22%)
		Mplasa_alph_rch	924..1647	CDD:275316
		CENP-H	1204..>1266	CDD:283493
		CALCOCO1	<1489..1850	CDD:285171
klp6	NP_001342739.1	KISc_KIP3_like	6..389	CDD:276821	108/382 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900