DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cana and Cenpe

DIOPT Version :9

Sequence 1:NP_001027247.1 Gene:cana / 3771934 FlyBaseID:FBgn0040233 Length:1931 Species:Drosophila melanogaster
Sequence 2:NP_776123.3 Gene:Cenpe / 229841 MGIID:1098230 Length:2471 Species:Mus musculus


Alignment Length:2293 Identity:544/2293 - (23%)
Similarity:969/2293 - (42%) Gaps:636/2293 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 SSIQVCIKVRPC-----EPG-LTSLWQVKEGRSIQLADSHAEPYVFDYVFDEGASNQEVFDRMAK 65
            :|:.||::|||.     |.| .|.::...:..:|..:|. .:.:.||.|||...:.:.|::.:|.
Mouse     5 ASVAVCVRVRPLNSREEELGEATHIYWKTDKNAIYQSDG-GKSFQFDRVFDSNETTKNVYEEIAV 68

  Fly    66 HIVHACMQGSNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAKEIFQQISSETERDFLLRVGYIE 130
            .|:.:.:||.||||||||||:||||:||||.|...||:..|..:|||:|....||:|||||.|:|
Mouse    69 PIISSAIQGYNGTIFAYGQTASGKTHTMMGSEDCLGVIPRAIHDIFQRIKKFPEREFLLRVSYME 133

  Fly   131 IYNEKIYDLL--NKKNQDLKIHESGNGIVNV-NCKESIVTSEDDLLRQLYMGNKERVVGETNMNE 192
            ||||.|.|||  .:|.:.|.|.|..|..|.| :..|.:|.:.:..|:.|..|.|.|..|.|.||:
Mouse   134 IYNETITDLLCNAQKMKPLIIREDTNRTVYVSDLTEEVVYTAEMALKWLATGEKNRHYGITKMNQ 198

  Fly   193 RSSRSHAIFRIIIESR-KSDHSDND-TVKQSVLSLVDLAGSEQVDPADHAS-----------SLM 244
            ||||||.|||:|:||| |::.|:.| :||.|.|:||||||||:........           :|.
Mouse   199 RSSRSHTIFRMILESREKAEPSNCDGSVKVSHLNLVDLAGSERAAQTGAEGVRLKEGCFINRNLF 263

  Fly   245 IFRNLVKSLSESVDSKPNSFRDSKLPRIMLPSLGGNVLTSIICTITPSFVEESSSTISFGTCAKK 309
            |...::|.||:.......::|||||.||:..|||||..|.|||||||:.::|:.:|:.|.:.||.
Mouse   264 ILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNAKTRIICTITPASLDETLTTLQFASTAKY 328

  Fly   310 IRCKPQVCKIDSETTMMRQLDRGISMLKDKLAKKKIKNESQLVLQELEGRIKRDMLKIVSSASLD 374
            ::..|.|.::.::..::::..|.|:.|:.:|.:...|..:    ||:|   |..:.:::....| 
Mouse   329 MKNTPYVNEVSNDEALLKRYRREIADLRKQLEEVNTKTRA----QEME---KDQLAQLLDEKDL- 385

  Fly   375 DYRLQKRRRTWTLTASGSEGDAPVLALPEPEESRLPRPSKLTNLPKPLFQRRGIAPKAKGICKTL 439
               |||                             .:..|:.||.:.|.....||.:.:   ..:
Mouse   386 ---LQK-----------------------------VQDEKINNLKRMLVTSSSIALQQE---LEI 415

  Fly   440 KEKRLQTDNMDTMPGRAKQLGRETASRIPSVMMSKKYQESVPNC----------DAPQTEISAL- 493
            |.||..|    ...|:.|....|...::|:.:.::|.:.||.:.          .|..:|...| 
Mouse   416 KRKRRVT----WCYGKMKDSNYEKEFKVPTSITTRKRKTSVTSLRENSLMKFGESAASSEFEMLN 476

  Fly   494 ------------TASNQVAKETIE----KYEEQVKRLKETIERLEMENG------KAVNLGEQFE 536
                        :|:..:::|.:|    ....|...|....|:|..||.      |..|..|:||
Mouse   477 NTLESLAEVEWSSATTLLSEENVESELNSLNAQYNDLVLDYEQLRRENEDLKLKLKEKNELEEFE 541

  Fly   537 THKAKSKQMEE-ELLSSISEKDSTIVSLQQSLEELSRDV-----LRNSKEDQMRSMCPELES-SC 594
            ..:.|.::.:| :|:..:|...:.|...::..::|..|:     |...||:|::::...::: ..
Mouse   542 LLEQKEERDQEMQLMHEVSNLKNLIKHAEEYNQDLENDLSSKVKLLKEKEEQIKNLQEYIDAQKS 606

  Fly   595 ERI-------CNKCLELERLLPLASASGLDSVACQFDQ----LRS----------EIAATRMKLE 638
            |::       .:...:|::  .:.:.|.||:||....:    |||          |::.:|.::|
Mouse   607 EKMKIDLSYTSDATEDLKQ--AMRTLSDLDTVALDAKKESAFLRSENLELKEKINELSDSRKQME 669

  Fly   639 SMLSTFSH------------------------------------ASCEVSQKTTDCKRLSEQIST 667
            |.:..:..                                    ::.|:.::.||   |.::::.
Mouse   670 SDIQMYQRQLEAKKKMQTDLDKELQLAFQEISKLSALVDGKGLLSNLELEKRITD---LQKELNK 731

  Fly   668 AHDDFGQLQEKYNNLKHKWSSQKLAIDTMQVDYNTIQQKYLQLQDEYRHLELRSDEQCQQLQDEN 732
            ..::...|||:.|.|..        :.::..:..|::::..:..:|...:....::...::..::
Mouse   732 EAEEKQTLQEEVNLLSE--------LKSLPSEVETLRRELYEKSEELHIITTEREKLFSEMAHKD 788

  Fly   733 SKLQA---EIGTLK-----------------ERVEEIHSELLEVPNPDTHPEDMELQNQELKKRL 777
            |::|.   |||..:                 :.:|.:|:||     ...|...:| :.:.||:.:
Mouse   789 SRIQGLLEEIGNTRDDLATSQLSRRGSDGEWQALESLHAEL-----EHRHAGVLE-ERERLKQEI 847

  Fly   778 SKLQWEFDEIQLNYECLSNELMSTIQE--------------CDALREEHKQRTTNSDLESMKSSG 828
            ..|..|.:.:..:.:.:..||....||              .:|||||.:.|  :|.|:|:    
Mouse   848 GALSKEAESLAFSLDSVKAELSHKTQELEQKTVEGQERLNKMEALREELESR--DSSLQSV---- 906

  Fly   829 VGTECSDPENELDTDLLQQFTKLSKSIQQIELTDYSGGRRLFIYNHAEQDQSVPSLKLCLEPAKY 893
                  :.|..|.|:.|||..|..|::.|                   :.:::..|:..|:    
Mouse   907 ------EKEKVLLTEKLQQALKEVKALTQ-------------------EKKNLKQLQESLQ---- 942

  Fly   894 LEGDGKQHDASDSV---------FLKGFLKCQRFQ----IVKINQEQNL-----VKEEDRMRDII 940
            .|.|..:.|..|:|         .|......::.|    ::|:...:.|     ||:....||  
Mouse   943 TERDQLRSDIQDTVNMNIDTQEQLLNALESLKQHQETINMLKMKAAEELSDNLHVKDRGGARD-- 1005

  Fly   941 FQLKQEVD---------------GKKNLIEEEKEVINNLRAQITSLNQ----------------- 973
             :.:|::|               ||.|.:.||:..|::|..:.:.|.|                 
Mouse  1006 -EAQQKMDGIDEQNESAHTLLGGGKDNEVTEEQRKIDSLMQENSGLQQTLESVRAEKEQLKMDLK 1069

  Fly   974 --IE-TIKNQNAKTKILCEELQTKDTVQTANKQESQEVLTLKT-SLAHLKSKVCELQKKLEKQSE 1034
              || :|:||. :.:||.:||:.:..|....|..:.|    || .|:..:.::.:.::|||:  :
Mouse  1070 ENIEMSIENQE-ELRILRDELKRQQEVAAQEKDHATE----KTQELSRTQERLAKTEEKLEE--K 1127

  Fly  1035 DEKISELQSDIGEISECCLSMELKLADIVNWQAEELR----PLDQLQESGVELQ---HHSTTAEE 1092
            ::|:.|.|..:....|....::.|:.|:.:.| .|.|    .|::::...:||.   |.|....:
Mouse  1128 NQKLQETQQQLLSTQEAMSKLQAKVIDMESLQ-NEFRNQGLALERVETEKLELAQRLHESYEEVK 1191

  Fly  1093 SLNVE----KPIQE--QTERTLTTEYERRIE----QLEESLQRA--------------------- 1126
            |:..|    |.:||  :.|:....||.|.||    |.:|.|..|                     
Mouse  1192 SITKERNDLKELQESFEIEKKQLKEYAREIEAAGLQTKEELNIAHANLKEYQEIITELRGSISEN 1256

  Fly  1127 -----------------------QEELSILEKRKTDENKSLQLE---------YMAKIETSENEN 1159
                                   ||.|.::::.:....|...||         :...:|..|.||
Mouse  1257 EAQGASTQDTAKSAPELQGEVPEQELLPVVKEARHSAEKVNGLEPVGAHSRTVHSMTMEGIEIEN 1321

  Fly  1160 --------RSKFRAYCL-----DLKETQKRYEEQLQQTNE----KLAS-VTTQCQVHL------- 1199
                    .|:....||     ||:.||:..:.:..|..|    .||: :.|:.:::|       
Mouse  1322 LRLTKKLEESQMEISCLTREREDLRRTQETLQVECTQLKEDARRTLANHLETEEELNLARCCLKE 1386

  Fly  1200 -----DVIKRSLQEKITQAEKERNELAVRHKAELEKIRETLKEKESSYKEKLRQAEEERDKEISR 1259
                 |.:..||.::.|:....|.:||:. .||||:..:.|.||:   :|..|:...|...::|.
Mouse  1387 QENKIDTLITSLSQRETELSSVRGQLALT-TAELERKVQELCEKQ---EELTRKETSEAQGKMSE 1447

  Fly  1260 LEVMRNTI----AELHKTNSDR----------EVELEGVKMEKCQLKKLYDKSMLELEQLQCTAD 1310
            ||.:|..:    :.|....|||          :.|::.::.|:.:|:::.:...:|.||.:.:..
Mouse  1448 LEQLRELLLAQASALQNAESDRLRLNTQLEESQEEMKTLREEREELRRMQEALHVESEQQKESMK 1512

  Fly  1311 QKSSDLLPGSSNENIDDLQKKCDQY----VQDLELLRGEKAELLSEIQKINGQHSNTIKKLEEIE 1371
            :.||.|         .:||.|  :|    ::.:...:|.:.|:....|::..|.|.    ||::|
Mouse  1513 EISSKL---------QELQNK--EYECLAMKTINETQGSRCEMDHLNQQLEAQKST----LEKVE 1562

  Fly  1372 AEMITLTTQKELERCEIAEKLETFKS--KEADIKEALHCAQLRLHAYDKLVCEYERLKGCLSDSN 1434
            .|.:.||.:       :.|.||..:|  ||.|...::.         ::|..|.::||..|.:: 
Mouse  1563 MENVNLTQR-------LHETLEEMRSVAKERDELWSME---------ERLTVERDQLKKSLEET- 1610

  Fly  1435 KLSENLQKKVERLHAEQLALQEGISGRDSEIKQLRSELKDAIDENKTVREAKVGLENS---LKAV 1496
             :::.::|: |.|....:.|:|    ....|.:||..:.|..||   :...:..|:::   ::|.
Mouse  1611 -VTKGMEKE-EELRVAHVHLEE----HQETINKLRKMVSDYTDE---ISHTQGDLKHTNAVVEAQ 1666

  Fly  1497 QENMSAQEGQFKQKIADIKGSVDELQIKLKSLQEVRDHLESRNEELKRKLKDAQELQ------NM 1555
            .:::..:|.|..|..||::.:||:::...|.|:.....||||..|   ||:..|:|.      .:
Mouse  1667 NQDLREKEHQLSQVKADLRETVDQMEQLKKKLEAQSSTLESREIE---KLELTQQLNENLKKITL 1728

  Fly  1556 VDKE----RKLNSSLREDFDK----LEQTKL-DLEEQ---------LRAKKVEIDRRSKELGEVT 1602
            |.||    :.::.:|||:.|:    |:||:. |||.|         |:..:..|||..:.:.|.|
Mouse  1729 VTKENDSLKIMDEALREERDQLRKSLQQTEARDLENQEKLRIAHMNLKEHQETIDRLMETMSEKT 1793

  Fly  1603 KDCENIRSDLE------------------------AQTNDFLKERETLNLTISDLRLHNEQLLET 1643
            ::..|::.:||                        |..::..||.:...||:|.:.:        
Mouse  1794 EEISNMKMELENVNMKLQEKVQELKTSERQRVKLKADASEAKKELKEQGLTLSKIEM-------- 1850

  Fly  1644 SKNYLSDITAANNLNLEMKKNLHDLTKECKSL---RSDLQSKEEYFQTQKQLLDETISNLKE--- 1702
                       .||||..|  :|:..:|.||:   |.||:..||..:.::   |:...||:|   
Mouse  1851 -----------ENLNLAQK--IHENLEEMKSVRKERDDLKKLEEILRMER---DQLKDNLREAML 1899

  Fly  1703 -ENRKMEEKLSSG----------NKALKEDC---EKL----------------------RSTLES 1731
             .::..||.:..|          ...|:|.|   |||                      |.|...
Mouse  1900 KAHQNHEETMKCGKGLLCAGEYCTGRLREKCFRIEKLLKRYSEMANDYECLNKVSLDLERETKTQ 1964

  Fly  1732 KEL-ILQQNKQELEERLTVINEKNGKNALLDAQLKSNETAFTSLRK-AWIKQSLA------IEAA 1788
            ||| :..:.|..|....|...||     ||.|..:.:.....:|:: .::..|:|      .|:.
Mouse  1965 KELSVTVRTKLSLPHTQTKEMEK-----LLTANQRCSLEFHRALKRLKYVLSSIARIKEEQHESI 2024

  Fly  1789 NKRSLEMEQKVDKRTREYEELRSTLKT-----REINFRSEKERMDGTISSLLED---------KR 1839
            |||.:...|:|:|:.....:::|..:|     |::..:..:| ||..|..:|:|         |.
Mouse  2025 NKREMAFIQEVEKQNELQIQIQSLSQTYRIPARDLQIKLSQE-MDLHIEEMLKDFSENDFLTIKT 2088

  Fly  1840 NLEEKLCT---VTELLAK 1854
            .:::.|..   :||.|.|
Mouse  2089 EVQQVLNNRKEITEFLGK 2106

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
canaNP_001027247.1 KISc 8..316 CDD:214526 141/329 (43%)
Motor_domain 8..310 CDD:277568 140/323 (43%)
SMC_prok_B <471..1270 CDD:274008 210/1087 (19%)
Mplasa_alph_rch 924..1647 CDD:275316 207/934 (22%)
CENP-H 1204..>1266 CDD:283493 20/61 (33%)
CALCOCO1 <1489..1850 CDD:285171 110/478 (23%)
CenpeNP_776123.3 KISc 6..336 CDD:214526 141/330 (43%)
KISc_CENP_E 6..329 CDD:276825 140/323 (43%)
SMC_prok_B 586..1436 CDD:274008 177/918 (19%)
DUF972 1041..>1119 CDD:283750 18/82 (22%)
SCP-1 1100..1841 CDD:114219 178/795 (22%)
SbcC 1570..2128 CDD:223496 137/596 (23%)
Kinetochore binding domain. /evidence=ECO:0000250|UniProtKB:Q02224 1959..2249 38/154 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2193..2214
Globular autoinhibitory domain. /evidence=ECO:0000250 2283..2468
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2368..2438
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167830780
Domainoid 1 1.000 263 1.000 Domainoid score I1916
eggNOG 1 0.900 - - E2759_KOG0242
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 480 1.000 Inparanoid score I1448
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm43058
orthoMCL 1 0.900 - - OOG6_101662
Panther 1 1.100 - - O PTHR47968
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X5166
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
109.880

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