DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cana and Kif18a

DIOPT Version :9

Sequence 1:	NP_001027247.1	Gene:	cana / 3771934	FlyBaseID:	FBgn0040233	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	XP_006499322.1	Gene:	Kif18a / 228421	MGIID:	2446977	Length:	919	Species:	Mus musculus

Alignment Length:	1014	Identity:	230/1014 - (22%)
Similarity:	399/1014 - (39%)	Gaps:	288/1014 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 YVFDYVFDEGASNQEVFDRMAKHIVHACMQGSNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAK 108
            :|||.||||.::..|||:...|.|:|:.:.|.|.|:||||.|.||||:||:|....||||.|...
Mouse    74 FVFDAVFDETSTQMEVFEHTTKPILHSFLNGYNCTVFAYGATGSGKTHTMLGSAAEPGVMYLTML 138

  Fly   109 EIFQQISS-ETERDFLLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIVNVNCKESIVTSEDDL 172
            ::|:.|.. :.|::....|.|:|:|||:|.|||..........:|..|:|..........|.:::
Mouse   139 DLFKCIDEIKEEKECSTAVSYLEVYNEQIRDLLTNSGPLAVREDSQKGVVVQGLTLHQPKSSEEI 203

  Fly   173 LRQLYMGNKERVVGETNMNERSSRSHAIFRIIIESRKSDHSDNDTVKQSVLSLVDLAGSEQ---- 233
            |:.|..|||.|....|::|..||||||:|:|.:..:....|.|..|:.:.:||:||||||:
Mouse   204 LQLLDNGNKNRTQHPTDVNAVSSRSHAVFQIYLRQQDKTASINQNVRIAKMSLIDLAGSERASVS 268

  Fly   234 -------VDPADHASSLMIFRNLVKSLSESVDSKPNS---FRDSKLPRIMLPSLGGNVLTSIICT 288
                   |:..:...||:...|::.:|:.:  .:.|.   :|:|||.|::..|||||..|.:|..
Mouse   269 GAKGSRFVEGTNINKSLLALGNVINALANT--KRRNQHIPYRNSKLTRLLKDSLGGNCQTIMIAA 331

  Fly   289 ITPS--FVEESSSTISFGTCAKKIR--CKPQVCKIDSETTM------MRQLDRGISMLKDKLAKK 343
            ::||  |.:::.:|:.:...||:|:  .|..|..::|..:.      |::.:  |.|||:||.
Mouse   332 VSPSSLFYDDTYNTLKYANRAKEIKSSLKSNVLNLNSHISQYVKICNMQKAE--ILMLKEKLK-- 392

  Fly   344 KIKNESQLVLQELEGRIKRDMLKIVSSASLDDYRLQKRRRTWTLTASGSEGDAPVLALPEPEESR 408
              ..|.|..|.:     :.|..|:|.|                                .||:..
Mouse   393 --AYEEQKALSD-----RNDCAKLVHS--------------------------------NPEDRE 418

  Fly   409 LPRPSKLTNLPKPLFQ-RRGIAPKAKGICKTLKEKRLQTDNMDTMPGRAKQLGRETASRIPSVMM 472
            ..|..::.|.   ||| |.||..:...:...||...|:
Mouse   419 TERFQEILNC---LFQNREGIRQEYLKLEMLLKANALK--------------------------- 453

  Fly   473 SKKYQESVPNCDAPQTEISALTASNQVAKET----------------IEKYEEQV-KRLKETIER 520
            |..:|:    |   ..:|..:.:.::|.|.|                :||.:|:| |:..|....
Mouse   454 SSYHQQ----C---HKQIEMMCSEDKVEKATCKRDHRLEKLKTNSCFLEKKKEEVSKQFDENTNW 511

  Fly   521 LEMENGKAVNLGEQFETHKAKSKQM--------EEELLSSISEKDSTIVSLQQSLEELSRDVLRN 577
            |.....:...||:..:..:|.:|::        .:||.:.::.. :.:..||:...:.:..||
Mouse   512 LHRVENEMRLLGQNGDIPEALNKELHCHHLHLQNKELKTQMAHM-TALACLQEQQHKQTEAVL-- 573

  Fly   578 SKEDQMRSMCPELESSCERICNKCLELERLLPLASASGLDSVACQFDQLRSEIAATRMKLE---- 638
                  .::.|.|.....::              ..:||.:.|...|....|....|.|:.
Mouse   574 ------NALLPVLRKQYWKL--------------KETGLSNAAFDSDFKDIEHLVERKKVVAWAD 618

  Fly   639 --------------SMLSTFSHASCEVSQKTTDCKRLSEQISTAHDDFGQLQEKYNNLK---HKW 686
                          |:|.||  ...|..|..:.|..:|:.               |.||   .:.
Mouse   619 QTNEHSNRNDLPGISLLMTF--PQLEPIQSISCCTSVSDP---------------NVLKLTPQRR 666

  Fly   687 SSQKLAIDTMQVDYNTIQQKYLQLQDEYRHLELRSDEQCQQLQDENSK-LQAEIGTLKE--RVEE 748
            :.:|:....::|                :|.:..:..:..||.|..|| ||..:.|.::  :.::
Mouse   667 TRRKIIPSPLKV----------------QHTQKSALSESTQLNDSFSKELQPIVYTPEDCKKAQD 715

  Fly   749 IHSELLEVPNPDTHPEDMELQNQELKKRLSKLQWEFDEIQLNYECLSNELMSTIQECDALR---- 809
            :...|..     |..:...:.|...:|.|.:::......    || ...|.||...||::|
Mouse   716 LFPSLTR-----TSSQSANVMNDNSQKALCRIESPLSRT----EC-KQGLYSTSTLCDSIRGLKN 770

  Fly   810 ---EEHKQRTTNSDLESMKSSGVGTECSDPENELDTDLLQQFTKLSKSIQQIELTDYSGGRRLFI 871
               |:....::.|.:..::||...|:.|.||:......:...|...:..:|:..|
Mouse   771 KWPEQEPLASSKSSVHRIESSSFSTKDSMPESAGVPSYMAMTTAAKRKWKQMSST---------- 825

  Fly   872 YNHAEQDQSVPSLKLCLEPAKYLEGDGKQHDASDSVFLKGFLKCQRFQIVKINQEQNLVK--EED 934
                 .:.|:.|.:.|                       ||.|       :|.::.:.||  :|:
Mouse   826 -----SNASIKSDESC-----------------------GFAK-------RIRRDNSSVKPMQEN 855

  Fly   935 RMRDIIFQLKQEVDGK------KNLIEEEKEVINNLRAQ 967
            |::.|     :|:..|      :||.|..::.:.|.:.|
Mouse   856 RLKAI-----KEIPTKQIQTCLENLEETLQKKMYNKKNQ 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	103/290 (36%)
		Motor_domain	8..310	CDD:277568	101/282 (36%)
		SMC_prok_B	<471..1270	CDD:274008	98/561 (17%)
		Mplasa_alph_rch	924..1647	CDD:275316	12/52 (23%)
		CENP-H	1204..>1266	CDD:283493
		CALCOCO1	<1489..1850	CDD:285171
Kif18a	XP_006499322.1	KISc_KIP3_like	11..355	CDD:276821	101/282 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900