DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cana and klp-18

DIOPT Version :9

Sequence 1:	NP_001027247.1	Gene:	cana / 3771934	FlyBaseID:	FBgn0040233	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	NP_501093.1	Gene:	klp-18 / 177474	WormBaseID:	WBGene00002228	Length:	932	Species:	Caenorhabditis elegans

Alignment Length:	1089	Identity:	265/1089 - (24%)
Similarity:	473/1089 - (43%)	Gaps:	284/1089 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 GRSIQL-ADSHAEPYVFDYVFDEGASNQEVFDRMAKHIVHACMQGSNGTIFAYGQTSSGKTYTMM 94
            ||.:.: .|:.::.|...::||..:|.::||..:||.||..|::|.|||:||||||.||||:||:
Worm    28 GRVVTIETDNGSKRYELHHIFDSSSSQEDVFGTVAKKIVEDCVEGYNGTVFAYGQTGSGKTHTML 92

  Fly    95 G------DEQNPGVMVLAAKEIFQQISSETER----DFLLRVGYIEIYNEKIYDLLNKKNQDLKI 149
            |      |::..|::..:.:.:||.:.::.:.    .|.:.|.::|:|||.||||||.||: :::
Worm    93 GPCDSWTDQELMGLIPRSVEHVFQHLDTKAKECQKLTFSVSVEFVELYNEVIYDLLNAKNK-VQL 156

  Fly   150 HESGNGIVNVNCKESIVTSEDDLLRQLYMGNKERVVGETNMNERSSRSHAIFRIIIESRKSDHSD 214
            .:||..|..|......|.:..||:..:..|.:||..|.|.||..||||||:..|.|   |:....
Worm   157 RDSGKDIQLVGALSKNVDNPLDLMHLVQKGWQERSTGSTAMNAESSRSHALLIIRI---KTQERT 218

  Fly   215 NDTVKQ--SVLSLVDLAGSEQ-----------VDPADHASSLMIFRNLVKSLSESVDSKPN-SFR 265
            .:.||:  |:|:||||||||:           .:..:..|||.:....::.|::...:|.: .:|
Worm   219 GELVKERSSILNLVDLAGSERQTHTKSSGDRLKEATNINSSLTVLGRCIRLLADPSKAKGHVPYR 283

  Fly   266 DSKLPRIMLPSLGGNVLTSIICTITP--SFVEESSSTISFG---TCAKKIRCKPQVCKIDSETTM 325
            ||.|..|:..|||||..|::|..:.|  .|.:||:||:.|.   |....|..:.:|...|.|::
Worm   284 DSHLTHILKNSLGGNSKTAVIVNMHPDRDFAQESNSTLMFAQSCTMIMNIATRNEVMTGDQESS- 347

  Fly   326 MRQLDRGISMLKDKL--AKKKIKNE--SQLVLQELEG-RIKRD----MLKIVSSASLDDYRLQKR 381
               ..:.|..|:.::  .::|::.|  |||...|:|. |:|.:    .|:.|...:..|:.|.|
Worm   348 ---YKKAIQELRQEVDETREKVRTEFASQLDEAEVEQLRLKTENNSLRLENVDLRAKYDFALLK- 408

  Fly   382 RRTWTLTASGSEGDAPVLALPEPEESRLPRPSKLTNLPKPLFQRRGIAPKAKGICKTLKEKRLQT 446
               :|:   |||.:..|     .|..::.......|...| |:           |..||.:.||.
Worm   409 ---YTI---GSENEQIV-----NEFKKIISEFSAANSSSP-FE-----------CIALKNQTLQL 450

  Fly   447 DNMDTMPGRAKQLGRETASRIPSVMMSKKYQESVPNCDAPQTEISALTASNQVAKETIEKYEEQV 511
            : ::....|.::|.:||::      :..:|||   |.||      .:......|||  .:...:.
Worm   451 E-IEASEKRYQELQKETSA------LRNRYQE---NLDA------TILMQTPSAKE--RRSSSRP 497

  Fly   512 KRLKETIERLEMENGKAVNLGEQFETHKAKSKQMEEELLSSISEKDSTIVSLQQSLEELSRDVLR 576
            || :||                |:....|:.     .|.:.:...:..::.||...|:||.::
Worm   498 KR-RET----------------QYRPSPARM-----ALFAEVETSEDAVLDLQCQNEKLSCEL-- 538

  Fly   577 NSKEDQMRSMCPELESSCERICNKCLELERLLPLASASGLDSVACQFDQLRSEIAATRMKLESML 641
                       ..|:...|...:|.:|.|||                  |:.||.|
Worm   539 -----------SSLKDKHEEATSKSIETERL------------------LQGEIVA--------- 565

  Fly   642 STFSHASCEVSQKTTDCKRLSEQISTAHDDFGQLQEKYNNLKHKWSSQKLAIDTMQVDYNTIQQK 706
                               |.:::|...:...:.:......|.|.::..|.:|.:.:..:..:::
Worm   566 -------------------LQKEVSIVSESLRKSEAVAEGYKEKVTANNLTLDKLLLHIDASRKR 611

  Fly   707 YLQLQDEYRHLELRSDEQCQQ--------LQDENSKLQAEIGTLKERVEE--IHSELLEVPNPDT 761
            ..:|:...:..|.||.|:.::        ::|...|...|...|:|.:.:  :.|.||:|
Worm   612 IAELELSSKESENRSSEELEEQRLYYVSMIEDLERKASDEYAALREELNQKTLSSNLLQV----- 671

  Fly   762 HPEDMELQNQELKKRLSKLQWEFDEIQLNYECLSNELMSTIQECDALREEHKQRTTNSDLESMKS 826
            ..::::|.|..:||             ||.: ||.: ...|:..:...|:..|..|..:.:::..
Worm   672 QVDELQLSNATIKK-------------LNAD-LSTK-AGLIRSLEDSIEKKSQMITRLEEQAVLD 721

  Fly   827 SGVGTECSDPENELDTDLLQ--QFTKLSK---SIQQIELTDYSGGRRLFIYNHAEQDQ------- 879
            |   :|.|..:.:|:...|:  |:.|:|:   |..|.:|.|:          ..:.||
Worm   722 S---SELSSTKRQLEHSRLEAIQWRKISEETTSAMQTQLKDH----------QKDIDQCRHKKKL 773

  Fly   880 SVPSLKLCLEPA-----------KYLEGDGKQHDASDSVFLKGFLKCQRFQIVKINQEQNLVKEE 933
            .:.|::|.|:.|           |.|:.|.|                |:|. :|:::.:|..||:
Worm   774 EIQSMQLSLDNANARVKESEAMMKKLQNDEK----------------QKFD-MKMSEIENTFKEK 821

  Fly   934 DRMRDIIFQLKQEVDGKKNLIEEEKEVINNLRAQITSLNQ--IETIKNQNAKTKILCEELQTKDT 996
                 :...||::.|              .:|.|..:.||  :|.::|:|   ::|.|      |
Worm   822 -----LSVSLKKQED--------------TIRRQSLAENQGKLEVMENKN---RVLSE------T 858

  Fly   997 VQTANKQESQEVLTLKTSLAHLKSKVCELQK-KLEKQSEDEKISELQSD 1044
            :::...|.||:...:...|.....:|..:.| ::||::.:|.||:|:|:
Worm   859 IESLQSQHSQDTEVINAGLRTRGDRVGYVDKLRVEKKALEETISQLRSE 907

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	110/314 (35%)
		Motor_domain	8..310	CDD:277568	109/308 (35%)
		SMC_prok_B	<471..1270	CDD:274008	118/610 (19%)
		Mplasa_alph_rch	924..1647	CDD:275316	29/124 (23%)
		CENP-H	1204..>1266	CDD:283493
		CALCOCO1	<1489..1850	CDD:285171
klp-18	NP_501093.1	KISc	5..328	CDD:276812	108/303 (36%)
klp-18	NP_501093.1	SbcC	342..913	CDD:223496	154/771 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000669
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000