DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cana and unc-116

DIOPT Version :9

Sequence 1:	NP_001027247.1	Gene:	cana / 3771934	FlyBaseID:	FBgn0040233	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	NP_001370811.1	Gene:	unc-116 / 176179	WormBaseID:	WBGene00006840	Length:	815	Species:	Caenorhabditis elegans

Alignment Length:	932	Identity:	247/932 - (26%)
Similarity:	367/932 - (39%)	Gaps:	256/932 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IQVCIKVRPCE-----------PGLTSLWQVKEGRSIQLADSHAEPYVFDYVFDEGASNQEVFDR 62
            :||..::||..           |...|...:..|..:         ||||.||....:.::|:..
Worm    12 VQVFCRIRPLNKTEEKNADRFLPKFPSEDSISLGGKV---------YVFDKVFKPNTTQEQVYKG 67

  Fly    63 MAKHIVHACMQGSNGTIFAYGQTSSGKTYTM---MGDEQNPGVMVLAAKEIFQQISSETER-DFL 123
            .|.|||...:.|.|||:|||||||||||:||   :||....|::.....:||..|.|..|. .|.
Worm    68 AAYHIVQDVLSGYNGTVFAYGQTSSGKTHTMEGVIGDNGLSGIIPRIVADIFNHIYSMDENLQFH 132

  Fly   124 LRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIVNV-NCKESIVTSEDDLLRQLYMGNKERVVGE 187
            ::|.|.|||||||.|||:.:..:|.|||..|.:..| ...|..|...|::|:.:..|...|:|..
Worm   133 IKVSYYEIYNEKIRDLLDPEKVNLSIHEDKNRVPYVKGATERFVGGPDEVLQAIEDGKSNRMVAV 197

  Fly   188 TNMNERSSRSHAIFRIIIESRKSDHSDNDTVKQSVLSLVDLAGSEQV-----------DPADHAS 241
            |||||.|||||::|.|.:   |.:|..........|.||||||||:|           :..:...
Worm   198 TNMNEHSSRSHSVFLITV---KQEHQTTKKQLTGKLYLVDLAGSEKVSKTGAQGTVLEEAKNINK 259

  Fly   242 SLMIFRNLVKSLSESVDSKPNSFRDSKLPRIMLPSLGGNVLTSIICTITPS-FVE-ESSSTISFG 304
            ||.....::.:|:|...|.. .:|||||.||:..|||||..|::|...:|| |.| |:.||:.||
Worm   260 SLTALGIVISALAEGTKSHV-PYRDSKLTRILQESLGGNSRTTVIICASPSHFNEAETKSTLLFG 323

  Fly   305 TCAKKIRCKPQVCKIDSETTMMRQLDRGISMLKDKLAKKKIKNESQLVLQELEGRIKRDMLKIVS 369
            ..||.|:   .|.:|:.|.|        ....|.:..|:|.||..              :..::.
Worm   324 ARAKTIK---NVVQINEELT--------AEEWKRRYEKEKEKNTR--------------LAALLQ 363

  Fly   370 SASLDDYRLQKRRRTWTLTASGSE------GDAPVLAL--------PEPEESRLPRPSKLTNLPK 420
            :|:|:..|       |....|.||      .|:..:|:        |..|.|..|.|..||:...
Worm   364 AAALELSR-------WRAGESVSEVEWVNLSDSAQMAVSEVSGGSTPLMERSIAPAPPMLTSTTG 421

  Fly   421 PLFQRRGIAPKAKGICKTLKEKRLQTDNMDTMPGRAKQLGRETASRIPSVMMSKKYQES----VP 481
            |:               |.:||                               |||:|.    ..
Worm   422 PI---------------TDEEK-------------------------------KKYEEERVKLYQ 440

  Fly   482 NCDAPQTEISALTASNQVAKETIEKYEEQVKRLKETIERLEMENGKAVNLGEQFETHKAKSKQME 546
            ..|....||..::...:..::.:...||.:..::|..|.:..||.:       |: .:|:.||.|
Worm   441 QLDEKDDEIQKVSQELEKLRQQVLLQEEALGTMRENEELIREENNR-------FQ-KEAEDKQQE 497

  Fly   547 --------EELLSSISEKDSTIVSLQQSLEELSRDVLRNSKEDQMRSM----------C-PELES 592
                    ||:..::..:.:....|::.||.:..|  ..|.||:|...          | |::..
Worm   498 GKEMMTALEEIAVNLDVRQAECEKLKRELEVVQED--NQSLEDRMNQATSLLNAHLDECGPKIRH 560

  Fly   593 SCERICNKCLELERLLPLASASGLDSVACQFDQLRSE--IAATRMKLESMLSTFSHASCEVSQKT 655
            ..|.|.|...|.          .:..:|.|.|||...  :...|:.:..:.|.:|.|
Worm   561 FKEGIYNVIREF----------NIADIASQNDQLPDHDLLNHVRIGVSKLFSEYSAA-------- 607

  Fly   656 TDCKRLSEQISTA--HDDFGQLQEKYNNLKHKWSSQKLAIDTMQVDYNTIQQKYLQLQDEYRHLE 718
                   ::.|||  ||                :..|||.|..:|:......:..||
Worm   608 -------KESSTAAEHD----------------AEAKLAADVARVESGQDAGRMKQL-------- 641

  Fly   719 LRSDEQCQQLQDENSKLQAEIGTLKERVEEIHSELLE--VPNPDTHPEDMELQNQELKKRLSKLQ 781
            |..|:..::::....::..|:.|||...:|....|:.  ..|.||..|| .|.....|:|:
Worm   642 LVKDQAAKEIKPLTDRVNMELTTLKNLKKEFMRVLVARCQANQDTEGED-SLSGPAQKQRI---- 701

  Fly   782 WEFDEIQLNYECLSNELMSTIQECDALREEHKQRT-TNSDLE----SMKSSGVGTECSDPENELD 841
                      :.|.|.|       |.|.:.|||.. .|:||.    .|::...|.|  |....|:
Worm   702 ----------QFLENNL-------DKLTKVHKQLVRDNADLRVELPKMEARLRGRE--DRIKILE 747

  Fly   842 TDLLQQFTKLSKSIQQIELTDY 863
            |.|     :.||...|.|...|
Worm   748 TAL-----RDSKQRSQAERKKY 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	124/335 (37%)
		Motor_domain	8..310	CDD:277568	123/329 (37%)
		SMC_prok_B	<471..1270	CDD:274008	94/427 (22%)
		Mplasa_alph_rch	924..1647	CDD:275316
		CENP-H	1204..>1266	CDD:283493
		CALCOCO1	<1489..1850	CDD:285171
unc-116	NP_001370811.1	KISc_KHC_KIF5	9..329	CDD:276820	123/329 (37%)
unc-116	NP_001370811.1	SMC_prok_A	440..>782	CDD:274009	90/413 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000669
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910