DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cana and Kif6

DIOPT Version :9

Sequence 1:	NP_001027247.1	Gene:	cana / 3771934	FlyBaseID:	FBgn0040233	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	XP_006244542.1	Gene:	Kif6 / 171291	RGDID:	621070	Length:	802	Species:	Rattus norvegicus

Alignment Length:	982	Identity:	221/982 - (22%)
Similarity:	399/982 - (40%)	Gaps:	277/982 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SIQVCIKVRPC----EPGLTSLWQ-VKEGRSIQ------LAD----SHAEPYVFDY--VFDEGAS 55
            :||:..:|:|.    :.|:.|:.: .|...|::      |||    :..|.|.|.:  :||:.|.
  Rat     5 TIQIFARVKPSVRKQQQGIYSIDEDEKLASSLEIVLPRDLADGFVNNKRESYKFKFQRIFDQEAK 69

  Fly    56 NQEVFDRMAKHIVHACMQGSNGTIFAYGQTSSGKTYTMMGDEQ---NPGVMVLAAKEIFQQISSE 117
            .:.:|:.:||.:..:.:.|.||||||||||.||||:|:.|..:   :.|::......||:|:..:
  Rat    70 QEIIFEIIAKPVAESTLAGYNGTIFAYGQTGSGKTFTITGGAERYSDRGIIPRTLSYIFEQLQKD 134

  Fly   118 TERDFLLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIV------NVNCKESIV---TSEDDLL 173
            :.:.:...:.|:|||||..||||:.:::..|:.:.....:      |::.|...:   |:|::.|
  Rat   135 SSKIYTTHISYLEIYNECGYDLLDPRHEASKLEDLPKVTILEDPDQNIHLKNLSLHQATTEEEAL 199

  Fly   174 RQLYMGNKERVVGETNMNERSSRSHAIFRIIIESRKSDHSDNDTVKQSVLSLVDLAGSEQVDPAD 238
            ..|::|:..|::.||.||:.|:|||.||.:.:.|::...:   ||:.:.|.||||||||:|....
  Rat   200 NLLFLGDTNRMIAETPMNQASTRSHCIFTVHLSSKEPGSA---TVRHAKLHLVDLAGSERVSKTG 261

  Fly   239 HAS-----------SLMIFRNLVKSLSESVDSKPNS---FRDSKLPRIMLPSLGGNVLTSIICTI 289
            ...           ||.....::.:|||    |..:   :|:|.:..::..|||||.:|::|.|:
  Rat   262 VGGLLLTEAKYINLSLHYLEQVIIALSE----KHRTHIPYRNSMMTSVLRDSLGGNCMTTMIATL 322

  Fly   290 TPSFVEESSSTISFGTCAKKIRCKPQVCKIDSETTMMRQLDRGISMLKDKLAKKKIKNESQLVL- 353
            :   :|:.:...|..||    |...:|..|.:|..:..::|..:.:::.:.....:|.|..:|.
  Rat   323 S---LEKRNIDESISTC----RFAQRVALIKNEAILNEEIDPRLMIVRLQKEIADLKAELAMVTG 380

  Fly   354 -QELEGRIKRDMLKIVSSASLDDYRLQKRRRTWTLTASGSEGDAPVLALPEPEESRLPRPSKLTN 417
             |..|...:.::|           :|:|      |.||..|...|        ||||...:.|..
  Rat   381 EQRTEALTEAELL-----------QLEK------LIASFVEDQDP--------ESRLEVGADLRK 420

  Fly   418 LPKPLFQRRGIAPKAKGIC-----KTLKEKRLQTDNMDTMPGRAKQLGRETASRIPSVMMSKKYQ 477
            :               ..|     |.|.:|:
  Rat   421 I---------------HYCFHHFKKLLNDKK---------------------------------- 436

  Fly   478 ESVPNCDAPQTEISALTASNQVAKETIEKYEEQVKRLKETIERLEMENGKAVNLGEQFETHKAKS 542
             ::.|.|      |:.:.:.|..:|.::  :|:..:|:..:::.:.|....||:.::
  Rat   437 -TLENTD------SSESTTQQACQEPVK--DEEYTKLRSLLKQRDNEINILVNMLKK-------- 484

  Fly   543 KQMEEELLSSISEKDSTIVSLQQSLEELSRDVLRNSKEDQMRSMCPELESSCERICNKCLELERL 607
                        ||..|..:||.|..|.|                                 |..
  Rat   485 ------------EKKKTQDALQYSSTEKS---------------------------------EAR 504

  Fly   608 LPLASASGLDSVACQFDQLRSEIAATRMKLESMLSTFSHASCEVSQKTTDCKRLSEQISTAHDDF 672
            .|..|.....|.|.|.....|.::.|:     .||.:.|.|..:.:||    .:.|::|...
  Rat   505 PPPNSPFIAGSPAGQRTSFSSSLSQTQ-----DLSVYRHRSSLLHKKT----GMREEMSLGR--- 557

  Fly   673 GQLQEKYNNLKHKWSSQKLAIDTMQVDYNTIQQKYLQLQDEYRHLELRSDEQCQQLQDENSKLQA 737
               ||.:...|...:......|..||    ::|::               .:.:.|.:..::.::
  Rat   558 ---QEAFEIFKRDHADSVTIEDNKQV----LKQRF---------------SEAKALGESINEARS 600

  Fly   738 EIGTLKERVEEIH--------SELLEVPN-PDTHPEDMELQNQELKK-------RLSKLQWEFDE 786
            :||.|||.:.:.|        :|.:..|: ||...:.:..|.:|.|.       ||..|:.|.:.
  Rat   601 KIGQLKEAISQRHLQQVALGIAESMAPPSTPDPQEQKLRAQLEEEKSRYKTTFMRLKALKVEIEH 665

  Fly   787 IQLNYECLSNELMSTIQECDALREEHKQRTTNSDLESMKSSGVGTECSDPENELD-TDLLQQFTK 850
            :||..:....:|....:...|  ||......||...:::      :.:.|..:.| |.||.:
  Rat   666 LQLLMDKAKLKLQKEFEAWWA--EEASSLQVNSPATNLQ------DAAKPFPQQDQTQLLSK--- 719

  Fly   851 LSKSIQQIELTDYSG--------GRRLF---IYNHAEQDQSVPSLKLCLEPAKY-LEGDGKQHDA 903
              ||.|.:|:.:.:|        .||:.   ..:...|:.|..|::|...|:.. |.|| :|.|:
  Rat   720 --KSSQGLEVENGAGKLDVCGRNARRILPSPCPSPHSQEPSGSSIQLQDRPSSIPLTGD-RQTDS 781

  Fly   904 SDSVFLK 910
            ....|:|
  Rat   782 DILAFIK 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	104/350 (30%)
		Motor_domain	8..310	CDD:277568	103/344 (30%)
		SMC_prok_B	<471..1270	CDD:274008	91/469 (19%)
		Mplasa_alph_rch	924..1647	CDD:275316
		CENP-H	1204..>1266	CDD:283493
		CALCOCO1	<1489..1850	CDD:285171
Kif6	XP_006244542.1	KISc_KIF9_like	5..343	CDD:276826	104/351 (30%)
Kif6	XP_006244542.1	Kinesin	28..345	CDD:278646	99/330 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900