DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cana and Kif5c

DIOPT Version :9

Sequence 1:	NP_001027247.1	Gene:	cana / 3771934	FlyBaseID:	FBgn0040233	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	NP_032475.2	Gene:	Kif5c / 16574	MGIID:	1098269	Length:	956	Species:	Mus musculus

Alignment Length:	1162	Identity:	286/1162 - (24%)
Similarity:	493/1162 - (42%)	Gaps:	311/1162 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SIQVCIKVRPCEP-----GLTSLWQVKEGRSIQLADSHAEPYVFDYVFDEGASNQEVFDRMAKHI 67
            ||:|..:.||...     |...:.:.|...::.:  ...:|||||.|.....:.::|::..||.|
Mouse     8 SIKVMCRFRPLNEAEILRGDKFIPKFKGEETVVI--GQGKPYVFDRVLPPNTTQEQVYNACAKQI 70

  Fly    68 VHACMQGSNGTIFAYGQTSSGKTYTMMG---DEQNPGVMVLAAKEIFQQISSETER-DFLLRVGY 128
            |...::|.|||||||||||||||:||.|   |.|..|::...|.:||..|.|..|. :|.::|.|
Mouse    71 VKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIAHDIFDHIYSMDENLEFHIKVSY 135

  Fly   129 IEIYNEKIYDLLNKKNQDLKIHESGNGIVNV-NCKESIVTSEDDLLRQLYMGNKERVVGETNMNE 192
            .|||.:||.|||:....:|.:||..|.:..| .|.|..|:|.::::..:..|...|.|..|||||
Mouse   136 FEIYLDKIRDLLDVSKTNLAVHEDKNRVPYVKGCTERFVSSPEEVMDVIDEGKANRHVAVTNMNE 200

  Fly   193 RSSRSHAIFRIIIESRKSDHSDNDTVKQSVLSLVDLAGSEQVDPA-------DHA----SSLMIF 246
            .|||||:||.|.|   |.::.:.:......|.||||||||:|...       |.|    .||...
Mouse   201 HSSRSHSIFLINI---KQENVETEKKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSAL 262

  Fly   247 RNLVKSLSESVDSKPNSFRDSKLPRIMLPSLGGNVLTSIICTITPS-FVE-ESSSTISFGTCAKK 309
            .|::.:|:|...:.. .:||||:.||:..|||||..|:|:...:|| |.| |:.||:.||..||.
Mouse   263 GNVISALAEGTKTHV-PYRDSKMTRILQDSLGGNCRTTIVICCSPSVFNEAETKSTLMFGQRAKT 326

  Fly   310 IRCKPQVCKIDSETTMMRQLDRGISMLKDKLAKKKIKNES-QLVLQELEGRIKRDMLKIVSSASL 373
            |:           .|:...|:......|.|..|:|.||:: :.|||.||..:.|
Mouse   327 IK-----------NTVSVNLELTAEEWKKKYEKEKEKNKALKSVLQHLEMELNR----------- 369

  Fly   374 DDYRLQKRRRTWTLTASGSEGDAPVLALPEPEESRLPRPSKLTNLP---KPLFQRRGIAPKAKGI 435
                       |      ..|:|      .||:.::....:.:..|   .|:..  .|.|...||
Mouse   370 -----------W------RNGEA------VPEDEQISAKDQKSLEPCDNTPIID--NITPVVDGI 409

  Fly   436 CKTLKEK--------RLQTDNMDTMPGRAKQLGRETASRIPSVMM--------SKKYQESVPNCD 484
             ...|||        ..|.|:.|....:..||    |.::...|:        :::..|.:
Mouse   410 -SAEKEKYDEEITSLYRQLDDKDDEINQQSQL----AEKLKQQMLDQDELLASTRRDYEKI---- 465

  Fly   485 APQTEISALTASNQVAKETIEKYEEQVKRLKETIERLEMENGKAVNLGEQFETHKAKSKQMEEEL 549
              |.|::.|...|:.||       ::||.:.:.:|.|      |||..::.:..:.|:: ..|:|
Mouse   466 --QEELTRLQIENEAAK-------DEVKEVLQALEEL------AVNYDQKSQEVEDKTR-ANEQL 514

  Fly   550 LSSISEKDSTIVSLQQSLEELSRDVLRNSKEDQMRSMCPELESSCERICNKCLELERLLPLASAS 614
            ...:::|.:|:.:.|:.|.:|..  |.|.::.:           ...|.|  |.|:.|..:....
Mouse   515 TDELAQKTTTLTTTQRELSQLQE--LSNHQKKR-----------ATEILN--LLLKDLGEIGGII 564

  Fly   615 GLDSVACQFDQLRSEIAATRMKLESMLSTFSHASCEVSQKTTDCKRL---SEQISTAHDDFGQLQ 676
            |.:.|        ..:|.....:|   ..|:.|...:|:..::.|.|   |:|:.:|..|
Mouse   565 GTNDV--------KTLADVNGVIE---EEFTMARLYISKMKSEVKSLVNRSKQLESAQMD----- 613

  Fly   677 EKYNNLKHKWSSQKLAIDTMQVDYNTIQQKYLQLQDEYRHLELRSDEQCQQLQDENSKLQAEIGT 741
               :|.|...|.::||...:.:..:  :.|...|.|..:::|    ::.:||::....|..|:..
Mouse   614 ---SNRKMNASERELAACQLLISQH--EAKIKSLTDYMQNME----QKRRQLEESQDSLSEELAK 669

  Fly   742 LKERVEEIHSELLEVPNPDTHPEDMELQNQELKKRLSKLQWEFDEIQLNYECLSNELMSTIQECD 806
            |:.: |::|              ::..|::| |:.|::|| :.:|::...|          |:.:
Mouse   670 LRAQ-EKMH--------------EVSFQDKE-KEHLTRLQ-DAEEVKKALE----------QQME 707

  Fly   807 ALREEHKQRTTNSDLESMKSSGVGTECSDPENELDTDLLQQFTKLSKSIQQIELTDYSGGRRLFI 871
            :.||.|:::.:....|..:...:..|..|...:|.   |:| .:||....::::.|
Mouse   708 SHREAHQKQLSRLRDEIEEKQRIIDEIRDLNQKLQ---LEQ-ERLSSDYNKLKIED--------- 759

  Fly   872 YNHAEQDQSVPSLKLCLEPAKYLEGDGKQHDASDSVFLKGFLKCQRFQIVKINQEQNLVKEEDRM 936
                 |::.|...||.|                                  :|.::.
Mouse   760 -----QEREVKLEKLLL----------------------------------LNDKRE-------- 777

  Fly   937 RDIIFQLKQEVDGKKNLIEEEKEVINNLRAQITSLNQIETIKNQNAKTKILCEELQT--KDTVQT 999
                 |.::::.|.:..:..|.:.::|||                   |:..::|.|  |.:|:.
Mouse   778 -----QAREDLKGLEETVSRELQTLHNLR-------------------KLFVQDLTTRVKKSVEL 818

  Fly  1000 ------ANKQESQEVLTLKTSLAHLKSKV------------CELQKKLEK--QSEDEKISELQSD 1044
                  .:..:.|::..|:.:|..| :||            ||| .||||  ::..|::..|:|.
Mouse   819 DSDDGGGSAAQKQKISFLENNLEQL-TKVHKQLVRDNADLRCEL-PKLEKRLRATAERVKALESA 881

  Fly  1045 IGEISECCLSMELKLADIVNWQAEELRPLDQLQESGVELQHHSTTAEESLNVEKPIQ 1101
            :.|      :.|..:.|...:|.|    :|:::|: |..::.:..| .|..:.|||:
Mouse   882 LKE------AKENAMRDRKRYQQE----VDRIKEA-VRAKNMARRA-HSAQIAKPIR 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cana	NP_001027247.1	KISc	8..316	CDD:214526	126/330 (38%)
		Motor_domain	8..310	CDD:277568	125/324 (39%)
		SMC_prok_B	<471..1270	CDD:274008	126/664 (19%)
		Mplasa_alph_rch	924..1647	CDD:275316	41/200 (21%)
		CENP-H	1204..>1266	CDD:283493
		CALCOCO1	<1489..1850	CDD:285171
Kif5c	NP_032475.2	KISc_KHC_KIF5	6..327	CDD:276820	125/324 (39%)
		KISc	8..334	CDD:214526	127/342 (37%)
		Microtubule-binding	174..315		55/144 (38%)
		Lebercilin	605..798	CDD:292252	49/298 (16%)
		BAR	636..817	CDD:299863	48/295 (16%)
		Globular	859..956		23/81 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	910..956		5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000669
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910